Antonio L'Abbate

Summary

Affiliation: Institute of Clinical Physiology
Country: Italy

Publications

  1. ncbi request reprint How to study coronary microvascular dysfunction and its clinical relevance
    Antonio L'Abbate
    CNR Institute of Clinical Physiology, Scuola Superiore di Studi Universitari S Anna, Pisa, Italy
    Ital Heart J 3:230-6. 2002
  2. ncbi request reprint Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats
    Antonio L'Abbate
    Scuola Superiore Sant Anna and CNR Institute of Clinical Physiology, University of Pisa, Pisa 56124, Italy
    Am J Physiol Heart Circ Physiol 293:H3532-41. 2007
  3. ncbi request reprint Large and micro coronary vascular involvement in diabetes
    Antonio L'Abbate
    Scuola Superiore S Anna and CNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124 Pisa, Italy
    Pharmacol Rep 57:3-9. 2005
  4. doi request reprint Abnormal glucose and lipid control in non-ischemic left ventricular dysfunction
    Danilo Neglia
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Nucl Cardiol 19:1182-9. 2012
  5. ncbi request reprint Thyroid hormone and coronary artery disease: from clinical correlations to prognostic implications
    Michele Coceani
    Fondazione CNR Regione Toscana Gabriele Monasterio, Pisa, Italy
    Clin Cardiol 32:380-5. 2009
  6. pmc Improved myocardial perfusion in chronic diabetic mice by the up-regulation of pLKB1 and AMPK signaling
    Claudia Kusmic
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Cell Biochem 109:1033-44. 2010
  7. ncbi request reprint Cardiac function and oxygen saturation during maximal breath-holding in air and during whole-body surface immersion
    Claudio Marabotti
    CNR Institute of Clinical Physiology, Extreme Center, Scuola Superiore Sant Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy, Phone 39 0 47 335 7368, Fax 39 0 58 661 4268, E mail
    Diving Hyperb Med 43:131-7. 2013
  8. doi request reprint Stress/Rest Myocardial Perfusion Abnormalities by Gated SPECT: Still the Best Predictor of Cardiac Events in Stable Ischemic Heart Disease
    Alessia Gimelli
    CNR Clinical Physiology Institute, G Monasterio Foundation, Pisa, Italy
    J Nucl Med 50:546-53. 2009
  9. ncbi request reprint Myocardial structural, perfusion, and metabolic correlates of left bundle branch block mechanical derangement in patients with dilated cardiomyopathy: a tagged cardiac magnetic resonance and positron emission tomography study
    Pier Giorgio Masci
    Fondazione G Monasterio Regione Toscana CNR, Scuola Superiore Sant Anna, and Institute of Clinical Physiology CNR, Pisa, Italy
    Circ Cardiovasc Imaging 3:482-90. 2010
  10. ncbi request reprint Does subclinical hypothyroidism affect cardiac pump performance? Evidence from a magnetic resonance imaging study
    Andrea Ripoli
    C N R Institute of Clinical Physiology, S Cataldo Research Campus, Via G Moruzzi 1, 56124 Pisa, Italy
    J Am Coll Cardiol 45:439-45. 2005

Detail Information

Publications78

  1. ncbi request reprint How to study coronary microvascular dysfunction and its clinical relevance
    Antonio L'Abbate
    CNR Institute of Clinical Physiology, Scuola Superiore di Studi Universitari S Anna, Pisa, Italy
    Ital Heart J 3:230-6. 2002
    ....
  2. ncbi request reprint Beneficial effect of heme oxygenase-1 expression on myocardial ischemia-reperfusion involves an increase in adiponectin in mildly diabetic rats
    Antonio L'Abbate
    Scuola Superiore Sant Anna and CNR Institute of Clinical Physiology, University of Pisa, Pisa 56124, Italy
    Am J Physiol Heart Circ Physiol 293:H3532-41. 2007
    ....
  3. ncbi request reprint Large and micro coronary vascular involvement in diabetes
    Antonio L'Abbate
    Scuola Superiore S Anna and CNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124 Pisa, Italy
    Pharmacol Rep 57:3-9. 2005
    ..Extensive research is still required to define the pathogenesis and the actual clinical relevance of coronary microcirculatory dysfunction in diabetes...
  4. doi request reprint Abnormal glucose and lipid control in non-ischemic left ventricular dysfunction
    Danilo Neglia
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Nucl Cardiol 19:1182-9. 2012
    ..We sought to investigate whether risk factors are also associated with left ventricular (LV) dilatation, contractile impairment and reduced myocardial blood flow (MBF) in patients with non-ischemic LV dysfunction...
  5. ncbi request reprint Thyroid hormone and coronary artery disease: from clinical correlations to prognostic implications
    Michele Coceani
    Fondazione CNR Regione Toscana Gabriele Monasterio, Pisa, Italy
    Clin Cardiol 32:380-5. 2009
    ..Overt thyroid dysfunction, hypothyroidism in particular, may lead to coronary artery disease (CAD). Whether more subtle anomalies of thyroid hormone metabolism influence the progression of CAD remains a matter of speculation...
  6. pmc Improved myocardial perfusion in chronic diabetic mice by the up-regulation of pLKB1 and AMPK signaling
    Claudia Kusmic
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Cell Biochem 109:1033-44. 2010
    ..The restoration of microvascular function suggests a new therapeutic approach to even advanced cardiac microvascular derangement in diabetes...
  7. ncbi request reprint Cardiac function and oxygen saturation during maximal breath-holding in air and during whole-body surface immersion
    Claudio Marabotti
    CNR Institute of Clinical Physiology, Extreme Center, Scuola Superiore Sant Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy, Phone 39 0 47 335 7368, Fax 39 0 58 661 4268, E mail
    Diving Hyperb Med 43:131-7. 2013
    ..We wished to compare cardiovascular changes during maximal breath-holding (BH) in air and during whole-body immersion at the surface in a group of BH divers...
  8. doi request reprint Stress/Rest Myocardial Perfusion Abnormalities by Gated SPECT: Still the Best Predictor of Cardiac Events in Stable Ischemic Heart Disease
    Alessia Gimelli
    CNR Clinical Physiology Institute, G Monasterio Foundation, Pisa, Italy
    J Nucl Med 50:546-53. 2009
    ..We aimed to investigate whether gated SPECT retains this value in current cardiology if compared with a complete diagnostic work-up and with more recent prognostic indicators...
  9. ncbi request reprint Myocardial structural, perfusion, and metabolic correlates of left bundle branch block mechanical derangement in patients with dilated cardiomyopathy: a tagged cardiac magnetic resonance and positron emission tomography study
    Pier Giorgio Masci
    Fondazione G Monasterio Regione Toscana CNR, Scuola Superiore Sant Anna, and Institute of Clinical Physiology CNR, Pisa, Italy
    Circ Cardiovasc Imaging 3:482-90. 2010
    ..Left bundle branch block (LBBB) influences on regional left ventricular (LV) structure, perfusion, and metabolism have not yet been thoroughly investigated in dilated cardiomyopathy patients...
  10. ncbi request reprint Does subclinical hypothyroidism affect cardiac pump performance? Evidence from a magnetic resonance imaging study
    Andrea Ripoli
    C N R Institute of Clinical Physiology, S Cataldo Research Campus, Via G Moruzzi 1, 56124 Pisa, Italy
    J Am Coll Cardiol 45:439-45. 2005
    ..We sought to assess the effects of subclinical hypothyroidism (SHT) on the cardiac volumes and function...
  11. ncbi request reprint 'False-positive' myocardial perfusion imaging: correlation with cardiovascular risk factors and effect on event-free survival
    Alessia Gimelli
    CNR, Clinical Physiology Institute, Pisa, Italy
    J Cardiovasc Med (Hagerstown) 9:707-13. 2008
    ..Our goal was to investigate how false-positive g-SPECT perfusion abnormalities relate to cardiovascular risk factors and whether they provide any prognostic information...
  12. pmc T(-786)→C polymorphism of the endothelial nitric oxide synthase gene is associated with insulin resistance in patients with ischemic or non ischemic cardiomyopathy
    Cecilia Vecoli
    CNR, Institute of Clinical Physiology, Pisa, Italy
    BMC Med Genet 13:92. 2012
    ..Aim of the study was to assess the reciprocal relationships between T(-786)→C eNOS polymorphism and IR in ischemic and non-ischemic cardiomyopathy...
  13. ncbi request reprint Post-dive ultrasound detection of gas in the liver of rats and scuba divers
    Antonio L'Abbate
    Scuola Superiore Sant Anna, Pisa, Italy
    Eur J Appl Physiol 111:2213-9. 2011
    ..Its application to scuba divers revealed liver gas accumulation in all subjects in the absence of clear-cut evidence of liver damage or of any symptom. The clinical significance of our findings remains to be investigated...
  14. doi request reprint Low high-density lipoprotein predicts death in patients with mild left ventricular dysfunction regardless of coronary atherosclerosis
    Tiziana Sampietro
    CNR Institute of Clinical Physiology, Italy bScuola Superiore Sant Anna, Pisa, Italy
    J Cardiovasc Med (Hagerstown) 10:898-905. 2009
    ..We investigated whether HDL-cholesterol levels had a prognostic value in patients with mild left ventricular dysfunction, irrespective of the presence of coronary disease...
  15. ncbi request reprint Myocardial metabolic and receptor imaging in idiopathic dilated cardiomyopathy
    Danilo Neglia
    Consiglio Nazionale delle Ricerche CNR, Institute of Clinical Physiology, Pisa, Italy
    Eur J Nucl Med Mol Imaging 29:1403-13. 2002
    ..This article reviews the information provided by metabolic and receptor imaging in patients with IDC, and the role the data may play in patient management...
  16. ncbi request reprint Extension of myocardial necrosis differently affects MIBG retention in heart failure caused by ischaemic heart disease or by dilated cardiomyopathy
    Cecilia Marini
    CNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124, Pisa, Italy
    Eur J Nucl Med Mol Imaging 32:682-8. 2005
    ..This study aims to investigate the relationship between cardiac sympathetic nervous function (CSNF) and myocardial perfusion/function in patients with heart failure (HF) due to dilated cardiomyopathy (DCM) or ischaemic heart disease (CAD)...
  17. doi request reprint Myocardial salvage by CMR correlates with LV remodeling and early ST-segment resolution in acute myocardial infarction
    Pier Giorgio Masci
    MRI Unit, G Monasterio Foundation CNR Regione Toscana, Pisa, Italy
    JACC Cardiovasc Imaging 3:45-51. 2010
    ..The purpose of this study was to assess the association of myocardial salvage by cardiac magnetic resonance (CMR) with left ventricular (LV) remodeling and early ST-segment resolution in patients with acute myocardial infarction (MI)...
  18. doi request reprint Early subclinical increase in pulmonary water content in athletes performing sustained heavy exercise at sea level: ultrasound lung comet-tail evidence
    Alessandro Pingitore
    CNR Institute of Clinical Physiology, Scuola Superiore Sant Anna, Pisa, Italy
    Am J Physiol Heart Circ Physiol 301:H2161-7. 2011
    ..Hemodynamic changes are one of several potential factors contributing to the mechanisms of ULCs...
  19. ncbi request reprint Left ventricle changes early after breath-holding in deep water in elite apnea divers
    Alessandro Pingitore
    Institute of Clinical Physiology, CNR, Pisa, Italy
    Undersea Hyperb Med 37:13-21. 2010
    ..To study by ultrasounds cardiac morphology and function early after breath-hold diving in deep water in elite athletes...
  20. doi request reprint Left ventricular ejection fraction measurements: accuracy and prognostic implications in a large population of patients with known or suspected ischemic heart disease
    Alessia Gimelli
    CNR, Clinical Physiology Institute, San Cataldo Research Area, Via Moruzzi 1, Pisa, Italy
    Int J Cardiovasc Imaging 24:793-801. 2008
    ....
  21. ncbi request reprint Coronary atherosclerosis and alcohol consumption: angiographic and mortality data
    Romana Femia
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Arterioscler Thromb Vasc Biol 26:1607-12. 2006
    ..Moderate alcohol consumption is associated with reduced cardiovascular disease (CVD) risk. Whether this protection is based on a lesser degree of coronary atherosclerosis has not been established...
  22. doi request reprint Paucity of anginal symptoms and stress-induced perfusion abnormalities in ischemic cardiomyopathy
    Alessia Gimelli
    CNR, Institute of Clinical Physiology, Pisa, Italy
    J Nucl Cardiol 15:680-6. 2008
    ..We sought to investigate whether the paucity of anginal symptoms in patients with ischemic cardiomyopathy reflects a reduction in the severity of stress-induced myocardial ischemia...
  23. ncbi request reprint Impaired myocardial metabolic reserve and substrate selection flexibility during stress in patients with idiopathic dilated cardiomyopathy
    Danilo Neglia
    Institute of Clinical Physiology, National Council for Research, Pisa 56124, Italy
    Am J Physiol Heart Circ Physiol 293:H3270-8. 2007
    ..These metabolic abnormalities might contribute to progressive cardiac deterioration and represent a target for therapeutic strategies aimed at modulating cardiac substrate utilization...
  24. pmc Adiponectin is associated with abnormal lipid profile and coronary microvascular dysfunction in patients with dilated cardiomyopathy without overt heart failure
    Daniela Giannessi
    Research National Council CNR Institute of Clinical Physiology Laboratory of Cardiovascular Biochemistry, Pisa 56124, Italy
    Metabolism 60:227-33. 2011
    ..76 ± 0.16 vs 2.43 ± 0.19, P = .01). These results could suggest that down-regulation of the adiponectin levels and reduced HDL cholesterol have a key role in causing impaired coronary function and myocardial perfusion in DCM...
  25. ncbi request reprint Coronary microcirculatory vasoconstriction is heterogeneously distributed in acutely ischemic myocardium
    Gianmario Sambuceti
    Institute of Clinical Physiology, Italian National Research Council, Pisa, Italy
    Am J Physiol Heart Circ Physiol 288:H2298-305. 2005
    ..02). In conclusion, the vasoconstrictor response to pacing-induced ischemia is heterogeneously distributed and excludes a tissue fraction from perfusion. Within perfused tissue, the metabolic demand still controls the vasomotor tone...
  26. ncbi request reprint Cardiac imaging improves risk stratification in high-risk patients undergoing surgical revascularization
    Alessia Gimelli
    Nuclear Cardiology, CNR Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy
    J Cardiovasc Med (Hagerstown) 7:51-6. 2006
    ..The aim of this study was to analyse the impact of different imaging variables in predicting perioperative mortality...
  27. doi request reprint Influence of preload and afterload on stroke volume response to low-dose dobutamine stress in patients with non-ischemic heart failure: a cardiac MR study
    Alessandro Pingitore
    CNR Institute of Clinical Physiology, Pisa, Italy
    Int J Cardiol 166:475-81. 2013
    ..However, the role of the afterload and preload in SV changes is underestimated. The aim of the study was to investigate the effects of LDD on preload reserve and afterload in patients with non-ischemic heart failure...
  28. doi request reprint Persistence of mortality risk in patients with acute cardiac diseases and mild thyroid dysfunction
    Sabrina Molinaro
    Clinical Physiology Institute, National Council Research, Pisa, Italy
    Am J Med Sci 343:65-70. 2012
    ..Aim of the study was to assess the incidence and persistence of risk of cardiac and overall deaths in patients with acute cardiac diseases...
  29. ncbi request reprint Coronary flow reserve in severe aortic valve stenosis: a positron emission tomography study
    Clara Carpeggiani
    Cardiology Department, CNR Institute of Clinical Physiology, Pisa, Italy
    J Cardiovasc Med (Hagerstown) 9:893-8. 2008
    ..The purpose was to test whether, in patients with severe aortic stenosis, impaired myocardial blood flow reserve is dependent on myocardial hypertrophy and may improve after valve replacement...
  30. doi request reprint Acute effects of triiodothyronine (T3) replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study
    Alessandro Pingitore
    Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Via Moruzzi 1 Località la Fontina, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:1351-8. 2008
    ..The study aimed to assess the short-term effects of synthetic L-T(3) replacement therapy in patients with low-T(3) syndrome and ischemic or nonischemic dilated cardiomyopathy (DC)...
  31. ncbi request reprint Triiodothyronine levels for risk stratification of patients with chronic heart failure
    Alessandro Pingitore
    Institute of Clinical Physiology, C N R, Pisa, Italy
    Am J Med 118:132-6. 2005
    ..We sought to explore the use of triiodothyronine (T(3)) concentrations as an adjunct to clinical and functional parameters when estimating prognosis in patients with chronic heart failure...
  32. ncbi request reprint Role of thromboxane A2 receptor on the effects of oxidized LDL on microvascular endothelium nitric oxide, endothelin-1, and IL-6 production
    Valter Lubrano
    C N R Institute of Clinical Physiology, Pisa, Italy
    Microcirculation 15:543-53. 2008
    ....
  33. doi request reprint Whole-body evaluation of MIBG tissue extraction in a mouse model of long-lasting type II diabetes and its relationship with norepinephrine transport protein concentration
    Claudia Kusmic
    Institute of Clinical Physiology CNR, Pisa, Italy
    J Nucl Med 49:1701-6. 2008
    ..The aim of this study was to investigate in a mouse model of long-lasting type II diabetes whether the mismatch between MIBG early uptake and washout is the consequence of a more generalized disorder of the autonomic nervous system...
  34. ncbi request reprint Cardiovascular response to acute hypoxemia induced by prolonged breath holding in air
    Alessandro Pingitore
    CNR Institute of Clinical Physiology, Via Moruzzi 1, Pisa, Italy
    Am J Physiol Heart Circ Physiol 294:H449-55. 2008
    ..This response to acute hypoxemia allows SV,CO, and arterial pressure to be maintained despite the severe reduction in LV contractile function...
  35. doi request reprint Reduction of myocardial blood flow reserve in idiopathic dilated cardiomyopathy without overt heart failure and its relation with functional indices: an echo-Doppler and positron emission tomography study
    Maria Aurora Morales
    CNR Clinical Physiology Institute, Pisa, Italy
    J Cardiovasc Med (Hagerstown) 9:778-82. 2008
    ....
  36. doi request reprint Gas embolization of the liver in a rat model of rapid decompression
    Antonio L'Abbate
    Scuola Superiore Sant Anna, Pisa, Italy
    Am J Physiol Regul Integr Comp Physiol 299:R673-82. 2010
    ..Liver participation in human decompression sickness should be looked for and clinically evaluated...
  37. ncbi request reprint Personality traits and heart rate variability predict long-term cardiac mortality after myocardial infarction
    Clara Carpeggiani
    CNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124 Pisa, Italy
    Eur Heart J 26:1612-7. 2005
    ..To investigate personality traits and sympatho-vagal modulation of heart rate variability (HRV) during acute myocardial infarction (AMI), assessing their relationships and their long-term prognostic value...
  38. ncbi request reprint Advanced instrumentation for research in diving and hyperbaric medicine
    Arne Sieber
    Scuola Superiore Sant Anna, EXTREME Centre, Pisa, Italy
    Undersea Hyperb Med 37:259-69. 2010
    ..Moreover, examples of recordings are presented and discussed...
  39. ncbi request reprint Interactions between immune, stress-related hormonal and cardiovascular systems following strenuous physical exercise
    Danilo Menicucci
    Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Via Savi 10, Pisa, Italy Extreme Centre, Scuola Superiore Sant Anna and Institute of Clinical Physiology, CNR, Via Moruzzi 1, Pisa, Italy Email
    Arch Ital Biol 151:126-36. 2013
    ....
  40. doi request reprint Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease
    Maria Grazia Andreassi
    CNR Istituto di Fisiologia Clinica, Pisa, Italy
    Atherosclerosis 223:409-15. 2012
    ..However, their influence on prognosis remains uncertain. The aim of the study was to investigate the impact of previously identified SNPs and their joint effects in a genetic score (GS) on Major Adverse Cardiac Events (MACEs)...
  41. doi request reprint ABO blood group alleles: A risk factor for coronary artery disease. An angiographic study
    Clara Carpeggiani
    CNR Institute of Clinical Physiology, Pisa, Italy
    Atherosclerosis 211:461-6. 2010
    ..To analyze the impact of ABO groups on coronary heart disease risk factors, coronary involvement and prognosis...
  42. ncbi request reprint Association between increased mortality and mild thyroid dysfunction in cardiac patients
    Giorgio Iervasi
    Clinical Physiology Institute, National Council of Research, Via Moruzzi 1, 56124 Pisa, Italy
    Arch Intern Med 167:1526-32. 2007
    ..The effects of subclinical thyroid dysfunction on cardiac outcome are not well defined...
  43. ncbi request reprint Early assessment of heart rate variability is predictive of in-hospital death and major complications after acute myocardial infarction
    Clara Carpeggiani
    CNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124 Pisa, Italy
    Int J Cardiol 96:361-8. 2004
    ..Aim of this Multicenter Italian Study was to investigate, during acute myocardial infarction, in-hospital prognostic value of heart rate variability and its short-term evolution...
  44. pmc Effects of long-term treatment with carvedilol on myocardial blood flow in idiopathic dilated cardiomyopathy
    Danilo Neglia
    CNR Institute of Clinical Physiology, Pisa, Italy
    Heart 93:808-13. 2007
    ..To assess whether chronic treatment with carvedilol can increase myocardial blood flow (MBF) and MBF reserve in idiopathic dilated cardiomyopathy (IDC)...
  45. pmc Up-regulation of heme oxygenase-1 after infarct initiation reduces mortality, infarct size and left ventricular remodeling: experimental evidence and proof of concept
    Claudia Kusmic
    CNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124 Pisa, Italy
    J Transl Med 12:89. 2014
    ....
  46. ncbi request reprint How stressful are 105days of isolation? Sleep EEG patterns and tonic cortisol in healthy volunteers simulating manned flight to Mars
    Angelo Gemignani
    Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, Via Paradisa 2, 56124 Pisa, Italy Extreme Centre, Scuola Superiore Sant Anna, Piazza Martiri della Libertà 33, 56127 Pisa, Italy Institute of Clinical Physiology, National Research Council CNR, Via Moruzzi 1, 56124 Pisa, Italy Electronic address
    Int J Psychophysiol 93:211-9. 2014
    ....
  47. doi request reprint Correlation between vitamin D binding protein expression and angiographic-proven coronary artery disease
    Silvia Rocchiccioli
    Istitute of Clinical Physiology, University of Pisa, Pisa, Italy
    Coron Artery Dis 23:426-31. 2012
    ....
  48. ncbi request reprint Baseline/post-nitrate Tc-99m tetrofosmin mismatch for the assessment of myocardial viability in patients with severe left ventricular dysfunction: comparison with baseline Tc-99m tetrofosmin scintigraphy/FDG PET imaging
    Assuero Giorgetti
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Nucl Cardiol 11:142-51. 2004
    ..The aim of this study was to investigate whether baseline/nitrate technetium 99m tetrofosmin single photon emission computed tomography (SPECT) mismatch may provide equivalent clinical information...
  49. doi request reprint Clinical utility of estimated glomerular filtration rate in patients undergoing gated SPECT
    Michele Coceani
    Fondazione CNR Regione Toscana Gabriele Monasterio, Via Moruzzi 1, 56124, Pisa, Italy
    J Nucl Cardiol 16:384-90. 2009
    ....
  50. pmc Selection of reference genes in different myocardial regions of an in vivo ischemia/reperfusion rat model for normalization of antioxidant gene expression
    Nicoletta Vesentini
    Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa, Italy
    BMC Res Notes 5:124. 2012
    ..Changes in cardiac gene expression due to myocardial injury are usually assessed in whole heart tissue. However, as the heart is a heterogeneous system, spatial and temporal heterogeneity is expected in gene expression...
  51. doi request reprint Long-term prognosis in stable angina; medical treatment or coronary revascularization in patients younger than 70 years?
    Clara Carpeggiani
    CNR Institute of Clinical Physiology, Via Moruzzi, 1, 56123, Pisa, Italy
    Int J Cardiol 148:43-7. 2011
    ..Literature on the appropriateness of coronary revascularization in chronic angina is still scanty. The study aimed to compare long-term effects of revascularization with those of medical therapy in stable angina...
  52. ncbi request reprint Coronary microvascular dysfunction and idiopathic dilated cardiomyopathy
    Danilo Neglia
    Clinical PET Laboratory, CNR Institute of Clinical Physiology, Via G Moruzzi 1, 56124 Pisa, Italy
    Pharmacol Rep 57:151-5. 2005
    ..From these studies it is more and more evident that the coronary microcirculation is involved in the pathogenesis ofDCMand should be considered a new target of treatment in those cardiac diseases at risk to evolve towards heart failure...
  53. ncbi request reprint In vivo total antioxidant capacity: comparison of two different analytical methods
    Cristina Vassalle
    CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 42:84-9. 2004
    ..For this reason, these methods may be considered practicable indicators of total antioxidant capacity, for routinely potential use in every laboratory and useful in all the studies concerning the evaluation of oxidative stress...
  54. doi request reprint Underwater study of arterial blood pressure in breath-hold divers
    Arne Sieber
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Appl Physiol (1985) 107:1526-31. 2009
    ..In conclusion, direct measurements of ABP during apnea diving showed no or only mild increases in ABP. However, our results cannot be extended over environmental conditions different from those of the present study...
  55. doi request reprint MicroPET/CT imaging of αvβ₃ integrin via a novel ⁶⁸Ga-NOTA-RGD peptidomimetic conjugate in rat myocardial infarction
    Luca Menichetti
    CNR Institute of Clinical Physiology IFC, Via Moruzzi 1, 56124 Pisa, Italy
    Eur J Nucl Med Mol Imaging 40:1265-74. 2013
    ....
  56. ncbi request reprint Recommendations for the clinical use of cardiac natriuretic peptides
    Michele Emdin
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Ital Heart J 6:430-46. 2005
  57. ncbi request reprint An underwater blood pressure measuring device
    Arne Sieber
    A researcher at the CNR Institute of Clinical Physiology, Italy and Profactor Research and Solutions GmbH, Austria, CNR, Institute of Clinical Physiology, Pisa, Italy, Phone 39 393 1914261 or 39 050 580018, Fax 39 050315 2627, E mail
    Diving Hyperb Med 38:128-34. 2008
    ..Based on these results we envisage that this device will lead to a better understanding of human cardiovascular physiology in underwater and hyperbaric environments...
  58. ncbi request reprint Inflammatory markers and serum lipids in idiopathic dilated cardiomyopathy
    Tiziana Sampietro
    CNR Institute of Clinical Physiology, Pisa, Italy
    Am J Cardiol 96:1718-20. 2005
    ....
  59. doi request reprint Comparative prognostic value of glomerular filtration rate estimating formulas in ischaemic heart disease
    Michele Coceani
    CNR Institute of Clinical Physiology, Pisa, Italy
    Eur J Cardiovasc Prev Rehabil 15:423-7. 2008
    ..The purpose of the study was to compare the predictive value of GFR, calculated with the Cockcroft-Gault (CG) and revised Modification of Diet in Renal Disease formulas, in a population with ischaemic heart disease (IHD)...
  60. ncbi request reprint The obesity paradox and myocardial infarct size
    Alessandro Pingitore
    CNR Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy
    J Cardiovasc Med (Hagerstown) 8:713-7. 2007
    ..The term 'obesity paradox' underlines the divergence between increased risk and better outcome in sick obese patients. We tested the hypothesis that the obesity paradox could also occur in myocardial infarction...
  61. ncbi request reprint Increased levels of C-type natriuretic peptide in patients with idiopathic left ventricular dysfunction
    Silvia Del Ry
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Peptides 28:1068-73. 2007
    ..In these patients CNP is also related with both systemic and coronary indicators of endothelial/microvascular damage...
  62. ncbi request reprint Paradoxical coronary microcirculatory constriction during ischemia: a synergic function for nitric oxide and endothelin
    Claudia Kusmic
    Area della Ricerca CNR, Istituto di Fisiologia Clinica, Via Moruzzi, 1 56124 Pisa, Italia
    Am J Physiol Heart Circ Physiol 291:H1814-21. 2006
    ..The negative feedback mechanism on ET(B2) subsides during hypotension, and the ensuing vasoconstriction is ascribed to ET-1 activating ET(A) and ET(B2) and reactive nitrogen oxide species originating from ROS-NO interaction...
  63. ncbi request reprint Interaction between nitric oxide and cyclooxygenase pathways in endothelial cells
    Cristina Vassalle
    Institute of Clinical Physiology, CNR, Pisa, Italy
    J Vasc Res 40:491-9. 2003
    ..Our aim was to evaluate the interaction between NO and PG release in human microvascular endothelial cells (HMEC-1) and in umbilical vein endothelial cells (HUVEC)...
  64. ncbi request reprint Low-T3 syndrome: a strong prognostic predictor of death in patients with heart disease
    Giorgio Iervasi
    C N R Clinical Physiology Institute and Scuola Superiore di Studi Univeritari S Anna, Pisa, Italy
    Circulation 107:708-13. 2003
    ..The aim of the present prospective study was to assess the role of thyroid hormones in the prognosis of patient population with heart disease...
  65. ncbi request reprint Erythrocyte sedimentation rate, coronary atherosclerosis, and cardiac mortality
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Italy
    Eur Heart J 24:639-48. 2003
    ..To test whether the erythrocyte sedimentation rate (ESR) is related to the extension of coronary atherosclerosis (ATS) and predicts cardiac mortality...
  66. ncbi request reprint Effects of intravenous amlodipine on coronary hemodynamics in subjects with angiographically normal coronary arteries
    Danilo Neglia
    Consiglio Nazionale delle Ricerche CNR, Institute of Clinical Physiology, Pisa, Italy
    J Cardiovasc Pharmacol 39:884-91. 2002
    ..The coronary vasodilating properties of amlodipine are particularly expressed at the microcirculatory level...
  67. ncbi request reprint Prognostic role of myocardial blood flow impairment in idiopathic left ventricular dysfunction
    Danilo Neglia
    C N R Institute of Clinical Physiology, Pisa, Italy
    Circulation 105:186-93. 2002
    ..The aim of this study was to investigate whether MBF impairment is an independent predictor of prognosis in patients with idiopathic left ventricular (LV) dysfunction...
  68. ncbi request reprint Oxygen sensor signal validation for the safety of the rebreather diver
    Arne Sieber
    Researcher at the CNR Institute of Clinical Physiology, Italy and Profactor Research and Solutions, GmbH, Austria, CNR, Institute of Clinical Physiology, Pisa, Italy, Phone 39 393 1914261 or 39 050 580018, Fax 39 050315 2627, E mail
    Diving Hyperb Med 39:38-45. 2009
    ..The core components of this validation system are two additional solenoids, which allow an injection of oxygen or diluent gas directly across the sensor membrane...
  69. ncbi request reprint Determination of nitrite plus nitrate and malondialdehyde in human plasma: analytical performance and the effect of smoking and exercise
    Cristina Vassalle
    CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 40:802-9. 2002
    ..The assays evaluated in this study proved to be sensitive, specific and practicable, and therefore suitable for routine application in clinical chemistry laboratories and/or physiopathological studies involving human blood samples...
  70. ncbi request reprint Myocardial perfusion and coronary microcirculation: from pathophysiology to clinical application
    Antonio L'Abbate
    Sant Anna University, and CNR Institute of Clinical Physiology, Area della Recerca, Via Moruzzi 1, 56100 Pisa, Italy
    J Nucl Cardiol 9:328-37. 2002
  71. ncbi request reprint Cardiac phantom measurement validating the methodology for a cardiac multi-centre trial with positron emission tomography
    Johan Nuyts
    Nuclear Medicine, UZ Gasthuisberg, K U Leuven, Herestraat 49, 3000 Leuven, Belgium
    Eur J Nucl Med Mol Imaging 29:1588-93. 2002
    ..6+/-0.8 mm. The same procedure produced a defect size of zero in the studies of normal volunteers. This study indicates that cardiac studies from multiple PET systems can be pooled for statistical analysis...
  72. ncbi request reprint I-123-mIBG myocardial imaging for assessment of risk for a major cardiac event in heart failure patients: insights from a retrospective European multicenter study
    Denis Agostini
    CHU Cote de Nacre, Caen, France
    Eur J Nucl Med Mol Imaging 35:535-46. 2008
    ....
  73. ncbi request reprint Spatial and temporal heterogeneity of regional myocardial uptake in patients without heart disease under fasting conditions on repeated whole-body 18F-FDG PET/CT
    Eugenio Inglese
    Nuclear Medicine Department, University of Eastern Piedmont, Azienda Ospedaliera Maggiore della Carita, Novara, Italy, USA
    J Nucl Med 48:1662-9. 2007
    ..The aim of this study was to retrospectively analyze global and regional (18)F-FDG cardiac images of 49 consecutive cancer patients free of cardiac diseases who submitted to 3 PET scans under fasting conditions...
  74. ncbi request reprint Platelet glycoprotein IIb/IIIa receptor blockade and coronary resistance in unstable angina
    Mario Marzilli
    University of Siena, Italy
    J Am Coll Cardiol 40:2102-9. 2002
    ..We designed a study to explore the effect of glycoprotein (GP) IIb/IIIa blockade on the atherosclerotic plaque and distal coronary vasculature...
  75. ncbi request reprint In vivo imaging shows abnormal function of vascular endothelial growth factor-induced vasculature
    Serena Zacchigna
    Molecular Medicine Laboratory, International Center for Genetic Engineering and Biotechnology, 34012 Trieste, Italy
    Hum Gene Ther 18:515-24. 2007
    ..Taken together, these results challenge the effectiveness of VEGF as a sole factor to induce angiogenesis and suggest the use of factor combinations to achieve competent vessel formation...
  76. ncbi request reprint Migraine during systemic lupus erythematosus: findings from brain single photon emission computed tomography
    Flavio Nobili
    Department of Clinical Neurophysiology, Azienda Ospedale Universita S Martino, Viale Benedetto XV 6, I 16132 Genoa, Italy
    J Rheumatol 33:2184-91. 2006
    ..Perfusion single photon emission computed tomography (SPECT) was performed to investigate brain impairment in SLE patients with migraine-like headache either from the period of diagnosis or later in the course of disease...
  77. ncbi request reprint Recombinant P-selectin glycoprotein ligand-immunoglobulin, a P-selectin antagonist, as an adjunct to thrombolysis in acute myocardial infarction. The P-Selectin Antagonist Limiting Myonecrosis (PSALM) trial
    Paul Mertens
    Department of Cardiology, University of Leuven, Leuven, Belgium
    Am Heart J 152:125.e1-8. 2006
    ..We performed a mechanistic study with positron emission tomography to test the potential benefits of rPSGL-Ig in patients with ST-segment elevation acute myocardial infarction...
  78. ncbi request reprint Differences and similarities between coronary atherosclerosis and ischaemic heart disease: implications for cardiac imaging
    Gianmario Sambuceti
    Eur J Nucl Med Mol Imaging 32:385-8. 2005