Giorgio Iervasi

Summary

Affiliation: Institute of Clinical Physiology
Country: Italy

Publications

  1. ncbi request reprint Presence of a functional TSH receptor on human erythrocytes
    Silvana Balzan
    Institute of Clinical Physiology, CNR, Via Moruzzi 1, Pisa 56124, Italy
    Biomed Pharmacother 61:463-7. 2007
  2. ncbi request reprint Association between increased mortality and mild thyroid dysfunction in cardiac patients
    Giorgio Iervasi
    Clinical Physiology Institute, National Council of Research, Via Moruzzi 1, 56124 Pisa, Italy
    Arch Intern Med 167:1526-32. 2007
  3. doi request reprint Thyroid hormone and coronary artery disease: from clinical correlations to prognostic implications
    Michele Coceani
    Fondazione CNR Regione Toscana Gabriele Monasterio, Pisa, Italy
    Clin Cardiol 32:380-5. 2009
  4. doi request reprint Thyroid hormone and cardiovascular system: from basic concepts to clinical application
    Giorgio Iervasi
    CNR Institute of Clinical Physiology, C N R Tuscany Region G Monasterio Foundation, Pisa, Italy
    Intern Emerg Med 8:S71-4. 2013
  5. ncbi request reprint Clinical relevance of highly sensitive Tg assay in monitoring patients treated for differentiated thyroid cancer
    A Iervasi
    Institute of Clinical Physiology, National Council of Research, Pisa, Italy
    Clin Endocrinol (Oxf) 67:434-41. 2007
  6. ncbi request reprint Diagnostic performance of a new highly sensitive thyroglobulin immunoassay
    A Iervasi
    National Council of Research, Institute of Clinical Physiology, Via Moruzzi, 1, 56124 Pisa, Italy
    J Endocrinol 182:287-94. 2004
  7. ncbi request reprint Low-T3 syndrome: a strong prognostic predictor of death in patients with heart disease
    Giorgio Iervasi
    C N R Clinical Physiology Institute and Scuola Superiore di Studi Univeritari S Anna, Pisa, Italy
    Circulation 107:708-13. 2003
  8. doi request reprint Low triiodothyronine and exercise capacity in heart failure
    Marianna Fontana
    Division of Cardiovascular Medicine, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Int J Cardiol 154:153-7. 2012
  9. doi request reprint Prognostic value of combined measurement of brain natriuretic peptide and triiodothyronine in heart failure
    Claudio Passino
    Department of Cardiovascular Medicine, G Monasterio Foundation, CNR Institute of Clinical Physiology, Pisa, Italy
    J Card Fail 15:35-40. 2009
  10. doi request reprint Prevalence of thyroid dysfunction and effect of contrast medium on thyroid metabolism in cardiac patients undergoing coronary angiography
    Paolo Marraccini
    Istituto di Fisiologia Clinica CNR, Pisa, Italy
    Acta Radiol 54:42-7. 2013

Collaborators

Detail Information

Publications37

  1. ncbi request reprint Presence of a functional TSH receptor on human erythrocytes
    Silvana Balzan
    Institute of Clinical Physiology, CNR, Via Moruzzi 1, Pisa 56124, Italy
    Biomed Pharmacother 61:463-7. 2007
    ..125)I-TSH binding studies and Western blotting data showed the existence of TSHR in the erythrocytes of healthy donors. In conclusion The TSH action on Na(+)/K(+)-ATPase of human erythrocytes can be explained by the presence of TSHR...
  2. ncbi request reprint Association between increased mortality and mild thyroid dysfunction in cardiac patients
    Giorgio Iervasi
    Clinical Physiology Institute, National Council of Research, Via Moruzzi 1, 56124 Pisa, Italy
    Arch Intern Med 167:1526-32. 2007
    ..The effects of subclinical thyroid dysfunction on cardiac outcome are not well defined...
  3. doi request reprint Thyroid hormone and coronary artery disease: from clinical correlations to prognostic implications
    Michele Coceani
    Fondazione CNR Regione Toscana Gabriele Monasterio, Pisa, Italy
    Clin Cardiol 32:380-5. 2009
    ..Overt thyroid dysfunction, hypothyroidism in particular, may lead to coronary artery disease (CAD). Whether more subtle anomalies of thyroid hormone metabolism influence the progression of CAD remains a matter of speculation...
  4. doi request reprint Thyroid hormone and cardiovascular system: from basic concepts to clinical application
    Giorgio Iervasi
    CNR Institute of Clinical Physiology, C N R Tuscany Region G Monasterio Foundation, Pisa, Italy
    Intern Emerg Med 8:S71-4. 2013
    ..The main goal of this mini-review is to examine the main pathophysiological and clinical links between an altered thyroid metabolism and CV diseases, namely HF during progression of disease from organ specific to systemic disorder...
  5. ncbi request reprint Clinical relevance of highly sensitive Tg assay in monitoring patients treated for differentiated thyroid cancer
    A Iervasi
    Institute of Clinical Physiology, National Council of Research, Pisa, Italy
    Clin Endocrinol (Oxf) 67:434-41. 2007
    ..We evaluated the clinical impact of a highly sensitive Tg assay during routine follow-up of DTC patients...
  6. ncbi request reprint Diagnostic performance of a new highly sensitive thyroglobulin immunoassay
    A Iervasi
    National Council of Research, Institute of Clinical Physiology, Via Moruzzi, 1, 56124 Pisa, Italy
    J Endocrinol 182:287-94. 2004
    ..Our results have indicated the optimal analytical and clinical performance of this Tg immunoassay and encourage further studies on larger populations of patients with DTC...
  7. ncbi request reprint Low-T3 syndrome: a strong prognostic predictor of death in patients with heart disease
    Giorgio Iervasi
    C N R Clinical Physiology Institute and Scuola Superiore di Studi Univeritari S Anna, Pisa, Italy
    Circulation 107:708-13. 2003
    ..The aim of the present prospective study was to assess the role of thyroid hormones in the prognosis of patient population with heart disease...
  8. doi request reprint Low triiodothyronine and exercise capacity in heart failure
    Marianna Fontana
    Division of Cardiovascular Medicine, Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Int J Cardiol 154:153-7. 2012
    ....
  9. doi request reprint Prognostic value of combined measurement of brain natriuretic peptide and triiodothyronine in heart failure
    Claudio Passino
    Department of Cardiovascular Medicine, G Monasterio Foundation, CNR Institute of Clinical Physiology, Pisa, Italy
    J Card Fail 15:35-40. 2009
    ..Both low free triiodothyronine (fT3) and high brain natriuretic peptide (BNP) have been separately described as prognostic predictors for mortality in heart failure (HF). We investigated whether their prognostic value is independent...
  10. doi request reprint Prevalence of thyroid dysfunction and effect of contrast medium on thyroid metabolism in cardiac patients undergoing coronary angiography
    Paolo Marraccini
    Istituto di Fisiologia Clinica CNR, Pisa, Italy
    Acta Radiol 54:42-7. 2013
    ..Precautions are generally taken in patients with hyperthyroidism, even if subclinical, whereas the risks in patients with hypothyroidism or low triiodothyronine (T3) syndrome are not considered as appreciable...
  11. doi request reprint Acute effect of TSH on oxygenation state and volume of erythrocytes from subjects thyroidectomized for differentiated thyroid carcinoma
    Silvana Balzan
    Institute of Clinical Physiology, CNR, Via Moruzzi 1, Pisa 56124, Italy
    Biomed Pharmacother 65:381-4. 2011
    ..05). In conclusion, our results indicate that acute stimulation of TSH by rhTSH modifies the oxygenation state and volume of erythrocyte...
  12. doi request reprint Acute effects of triiodothyronine (T3) replacement therapy in patients with chronic heart failure and low-T3 syndrome: a randomized, placebo-controlled study
    Alessandro Pingitore
    Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Via Moruzzi 1 Località la Fontina, 56124 Pisa, Italy
    J Clin Endocrinol Metab 93:1351-8. 2008
    ..The study aimed to assess the short-term effects of synthetic L-T(3) replacement therapy in patients with low-T(3) syndrome and ischemic or nonischemic dilated cardiomyopathy (DC)...
  13. doi request reprint Persistence of mortality risk in patients with acute cardiac diseases and mild thyroid dysfunction
    Sabrina Molinaro
    Clinical Physiology Institute, National Council Research, Pisa, Italy
    Am J Med Sci 343:65-70. 2012
    ..Aim of the study was to assess the incidence and persistence of risk of cardiac and overall deaths in patients with acute cardiac diseases...
  14. doi request reprint Stress/Rest Myocardial Perfusion Abnormalities by Gated SPECT: Still the Best Predictor of Cardiac Events in Stable Ischemic Heart Disease
    Alessia Gimelli
    CNR Clinical Physiology Institute, G Monasterio Foundation, Pisa, Italy
    J Nucl Med 50:546-53. 2009
    ..We aimed to investigate whether gated SPECT retains this value in current cardiology if compared with a complete diagnostic work-up and with more recent prognostic indicators...
  15. doi request reprint Multicentre comparison of free thyroid hormones immunoassays: the Immunocheck study
    Stefania Giovannini
    QualiMedLab Srl, Scuola Superiore Sant Anna, Fondazione CNR Regione Toscana G Monasterio, Istituto di Fisiologia Clinica del CNR, Pisa, Italy
    Clin Chem Lab Med 49:1669-76. 2011
    ....
  16. ncbi request reprint Triiodothyronine levels for risk stratification of patients with chronic heart failure
    Alessandro Pingitore
    Institute of Clinical Physiology, C N R, Pisa, Italy
    Am J Med 118:132-6. 2005
    ..We sought to explore the use of triiodothyronine (T(3)) concentrations as an adjunct to clinical and functional parameters when estimating prognosis in patients with chronic heart failure...
  17. doi request reprint TSH induces co-localization of TSH receptor and Na/K-ATPase in human erythrocytes
    Silvana Balzan
    Institute of Clinical Physiology, CNR, Pisa, Italy
    Cell Biochem Funct 27:259-63. 2009
    ....
  18. ncbi request reprint Thyroid hormone receptor and IGF1/IGFR systems: possible relations in the human heart
    Laura Sabatino
    Clinical Physiology Institute, National Council Research, Via Moruzzi 1, 56124 Pisa, Italy
    Biomed Pharmacother 61:457-62. 2007
    ..001) and among the three TRs in the atrium (p<0.001) suggests the interesting possibility that the two systems, TRs and IGF1R could also be functionally associated...
  19. ncbi request reprint Early activation of an altered thyroid hormone profile in asymptomatic or mildly symptomatic idiopathic left ventricular dysfunction
    Alessandro Pingitore
    Institute of Clinical Physiology, CNR, Pisa, Italy
    J Card Fail 12:520-6. 2006
    ..We wanted to assess the thyroid state in patients with ILVD...
  20. doi request reprint Harmonization of free thyroid hormone tests: a mission impossible?
    Giorgio Iervasi
    CNR Institute of Clinical Physiology, Scuola Superiore Sant Anna, Pisa, Italy
    Clin Chem Lab Med 49:43-8. 2011
    ..In conclusion, further studies are necessary to answer the question of whether standardization and harmonization of the FT3 and FT4 test is an impossible mission (or not)...
  21. doi request reprint Acute myocardial infarction and thyroid function: new pathophysiological and therapeutic perspectives
    Alessandro Pingitore
    Clinical Physiology Institute, CNR Fondazione G Monasterio CNR Regione Toscana, Pisa e Massa, Italy
    Ann Med 44:745-57. 2012
    ..This review is focused on the role of thyroid on AMI evolution and on the potential novel option of thyroid-related treatment of AMI...
  22. ncbi request reprint Does subclinical hypothyroidism affect cardiac pump performance? Evidence from a magnetic resonance imaging study
    Andrea Ripoli
    C N R Institute of Clinical Physiology, S Cataldo Research Campus, Via G Moruzzi 1, 56124 Pisa, Italy
    J Am Coll Cardiol 45:439-45. 2005
    ..We sought to assess the effects of subclinical hypothyroidism (SHT) on the cardiac volumes and function...
  23. doi request reprint Itraconazole inhibits HMEC-1 angiogenesis
    Renata Del Carratore
    Institute of Clinical Physiology, National Research Council CNR, Via Moruzzi 1, Pisa 56124, Italy
    Biomed Pharmacother 66:312-7. 2012
    ..Our results may contribute to novel approaches to block angiogenesis with therapeutic application...
  24. doi request reprint Early long-term L-T3 replacement rescues mitochondria and prevents ischemic cardiac remodelling in rats
    Francesca Forini
    Institute of Clinical Physiology, CNR, Pisa, Italy
    J Cell Mol Med 15:514-24. 2011
    ..This beneficial effect is likely due to enhanced capillary formation and mitochondrial protection...
  25. pmc Thyroid (dys)function in heart failure: is it a potential target for medical treatment?
    Alessandro Pingitore
    Institute of Clinical Physiology, CNR, Pisa, Italy
    Vasc Health Risk Manag 1:97-100. 2005
  26. pmc Does large needle aspiration biopsy add pain to the thyroid nodule evaluation?
    Angelo Carpi
    Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
    PLoS ONE 8:e58016. 2013
    ..Large needle aspiration biopsy after fine needle aspiration biopsy does not add any discomfort or pain and therefore in light of the demonstrable benefits, should be included in clinical algorithms for the evaluation of thyroid nodules...
  27. ncbi request reprint Thyroid and brain natriuretic Peptide response in children undergoing cardiac surgery for congenital heart disease- age-related variations and prognostic value
    Massimiliano Cantinotti
    Fondazione Toscana G Monasterio, Pisa, Italy
    Circ J 77:188-97. 2013
    ..The aim of this study was to test age-related variations and prognostic values of thyroid hormones, and brain natriuretic peptide (BNP) levels before and after surgery...
  28. doi request reprint Galectin-3 detection on large-needle aspiration biopsy improves preoperative selection of thyroid nodules: a prospective cohort study
    Angelo Carpi
    Department of Reproduction and Ageing, University of Pisa, Pisa, Italy
    Ann Med 42:70-8. 2010
    ..New techniques of improving diagnostic reliability of thyroid nodules are needed...
  29. ncbi request reprint The obesity paradox and myocardial infarct size
    Alessandro Pingitore
    CNR Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy
    J Cardiovasc Med (Hagerstown) 8:713-7. 2007
    ..The term 'obesity paradox' underlines the divergence between increased risk and better outcome in sick obese patients. We tested the hypothesis that the obesity paradox could also occur in myocardial infarction...
  30. ncbi request reprint Amiodarone inhibits the 3,5,3'-triiodothyronine-dependent increase of sodium/potassium adenosine triphosphatase activity and concentration in human atrial myocardial tissue
    Francesca Forini
    CNR Institute of Clinical Physiology, Pisa, Italy
    Thyroid 14:493-9. 2004
    ..In conclusion, T3 stimulates the Na+/K(+)-ATPase in human atrial myocardium by increasing the number of ouabain-binding sites, whereas amiodarone decreases the sodium pump function secondarily to the antagonism with thyroid hormone...
  31. doi request reprint Detection of the BRAF(V600E) mutation in fine needle aspiration cytology of thyroid papillary microcarcinoma cells selected by manual macrodissection: an easy tool to improve the preoperative diagnosis
    Ivo Marchetti
    Section of Cytopathology, University of Pisa and Pisa University Hospital, Pisa, Italy
    Thyroid 22:292-8. 2012
    ..We investigated the role of BRAF gene status in preoperative cytological samples, using manual macrodissection as an additional tool to improve the diagnostic accuracy of mPTC...
  32. ncbi request reprint Triiodothyronine (T3) effects on cardiovascular system in patients with heart failure
    Alessandro Pingitore
    Institute of Clinical Physiology, C N R, Pisa, Italy
    Recent Pat Cardiovasc Drug Discov 3:19-27. 2008
    ..The article also discusses recent patents in this field...
  33. ncbi request reprint The role of thyroid hormone in blood pressure homeostasis: evidence from short-term hypothyroidism in humans
    Enza Fommei
    National Council of Research, University of Pisa, Italy
    J Clin Endocrinol Metab 87:1996-2000. 2002
    ..The observed sympathetic and adrenal activation in hypothyroidism, which is reversible with thyroid hormone treatment, may also contribute to the development of arterial hypertension in human hypothyroidism...
  34. ncbi request reprint Is the vascular system a main target for thyroid hormones? From molecular and biochemical findings to clinical perspectives
    Laura Sabatino
    Institute of Clinical Physiology, National Council of Research, Pisa, Italy
    Curr Vasc Pharmacol 3:133-45. 2005
    ..We also discuss the physiological role of deiodinases and their involvement in the TH-mediated regulation of vascular function...
  35. ncbi request reprint [Thyroid function and heart failure: from the new clinical evidences to the potential therapeutical implications]
    Alessandro Pingitore
    Consiglio Nazionale delle Ricerche, Istituto di Fisiologia Clinica, CNR, Pisa
    Recenti Prog Med 96:535-41. 2005
    ..Large, multicenter, placebo controlled prospective studies will provide the safety and prognostic effects of the chronic treatment with thyroid hormones in HF...
  36. ncbi request reprint Low triiodothyronine (T3) state: a predictor of outcome in respiratory failure? Results of a clinical pilot study
    Elvio Scoscia
    Pulmonary Institute and Respiratory Intensive Care Unit, R Silvestrini Hospital, Perugia, Italy
    Eur J Endocrinol 151:557-60. 2004
    ..We assessed thyroid function in patients with severe respiratory failure from pulmonary disorders, and needing invasive or noninvasive mechanical ventilation, in order to evaluate the prognostic value of nonthyroidal illness syndrome...
  37. ncbi request reprint From the bench to the bedside. Galectin-3 immunodetection for improving the preoperative diagnosis of the follicular thyroid nodules
    Alessandra Gasbarri
    Department of Pathology, St Andrea University Hospital, Rome, Italy
    Biomed Pharmacother 58:356-9. 2004
    ..The rationale of this new diagnostic approach, the possibility to improve its performance in selected cases by using large needle aspiration biopsy (LNAB) together with technical and operative details are presented and discussed...