Ele Ferrannini

Summary

Affiliation: Institute of Clinical Physiology
Country: Italy

Publications

  1. ncbi request reprint Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency
    G Mingrone
    Department of Internal Medicine, Catholic University, Rome, Italy
    Diabetes 48:1258-63. 1999
  2. ncbi request reprint Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients
    A Gastaldelli
    Metabolism Unit of the C.N.R. Institute of Clinical Physiology and the Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes 50:1807-12. 2001
  3. ncbi request reprint Defective regulation and action of atrial natriuretic peptide in type 2 diabetes
    M Nannipieri
    Metabolism Unit of the C N R Institute of Clinical Physiology, University of Pisa School of Medicine, Via Savi 8, 56100 Pisa, Italy
    Horm Metab Res 34:265-70. 2002
  4. ncbi request reprint Mode of onset of type 2 diabetes from normal or impaired glucose tolerance
    Ele Ferrannini
    Metabolism Unit, Department of Internal Medicine and C N R Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Diabetes 53:160-5. 2004
  5. ncbi request reprint The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives
    S A Hills
    EGIR RISC Coordinating Office, Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100, Pisa, Italy
    Diabetologia 47:566-70. 2004
  6. pmc Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
    Ele Ferrannini
    Corresponding author Ele Ferrannini
    Diabetes Care 36:4015-21. 2013
  7. doi request reprint A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes
    E Ferrannini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Diabetes Obes Metab 15:721-8. 2013
  8. pmc Renal glucose handling: impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes Care 36:1260-5. 2013
  9. doi request reprint SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, 56100 Pisa, Italy
    Nat Rev Endocrinol 8:495-502. 2012
  10. doi request reprint Diabetes and hypertension: the bad companions
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Lancet 380:601-10. 2012

Collaborators

Detail Information

Publications182 found, 100 shown here

  1. ncbi request reprint Triglyceride-induced diabetes associated with familial lipoprotein lipase deficiency
    G Mingrone
    Department of Internal Medicine, Catholic University, Rome, Italy
    Diabetes 48:1258-63. 1999
    ..These cases provide evidence that insulin-resistant diabetes can be caused by extremely high levels of TGs...
  2. ncbi request reprint Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients
    A Gastaldelli
    Metabolism Unit of the C.N.R. Institute of Clinical Physiology and the Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes 50:1807-12. 2001
    ..In type 2 diabetes, the excess GNG of the fasting state is carried over to the insulinized state, thereby contributing to glucose overproduction under both conditions...
  3. ncbi request reprint Defective regulation and action of atrial natriuretic peptide in type 2 diabetes
    M Nannipieri
    Metabolism Unit of the C N R Institute of Clinical Physiology, University of Pisa School of Medicine, Via Savi 8, 56100 Pisa, Italy
    Horm Metab Res 34:265-70. 2002
    ..We conclude that ANP release is resistant to volume stimulation in type 2 diabetic patients, and natriuresis is resistant to ANP action. This dual disruption of ANP control may play a role in blood pressure regulation in diabetes...
  4. ncbi request reprint Mode of onset of type 2 diabetes from normal or impaired glucose tolerance
    Ele Ferrannini
    Metabolism Unit, Department of Internal Medicine and C N R Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Diabetes 53:160-5. 2004
    ..We conclude that, within a 3-year time frame, the onset of diabetes is very often rapid rather than gradual and is in part explained by a fall in glucose-stimulated insulin response...
  5. ncbi request reprint The EGIR-RISC STUDY (The European group for the study of insulin resistance: relationship between insulin sensitivity and cardiovascular disease risk): I. Methodology and objectives
    S A Hills
    EGIR RISC Coordinating Office, Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100, Pisa, Italy
    Diabetologia 47:566-70. 2004
    ....
  6. pmc Long-term safety and efficacy of empagliflozin, sitagliptin, and metformin: an active-controlled, parallel-group, randomized, 78-week open-label extension study in patients with type 2 diabetes
    Ele Ferrannini
    Corresponding author Ele Ferrannini
    Diabetes Care 36:4015-21. 2013
    ..To investigate the long-term safety and efficacy of empagliflozin, a sodium glucose cotransporter 2 inhibitor; sitagliptin; and metformin in patients with type 2 diabetes...
  7. doi request reprint A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetes
    E Ferrannini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Diabetes Obes Metab 15:721-8. 2013
    ..This Phase IIb, randomized, double-blind, placebo-controlled trial evaluated the efficacy, safety, tolerability and pharmacokinetics of empagliflozin in patients with type 2 diabetes...
  8. pmc Renal glucose handling: impact of chronic kidney disease and sodium-glucose cotransporter 2 inhibition in patients with type 2 diabetes
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes Care 36:1260-5. 2013
    ..The objective of this study was to assess the pharmacodynamics of ipragliflozin in T2DM patients with impaired renal function...
  9. doi request reprint SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, 56100 Pisa, Italy
    Nat Rev Endocrinol 8:495-502. 2012
    ....
  10. doi request reprint Diabetes and hypertension: the bad companions
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Lancet 380:601-10. 2012
    ..In general, the positive effects of antihypertensive drugs on cardiovascular outcomes outweigh the negative effects of antihypertensive drugs on glucose metabolism...
  11. doi request reprint Mechanisms for the antihyperglycemic effect of sitagliptin in patients with type 2 diabetes
    Elza Muscelli
    Department of Internal Medicine, University of Pisa School of Medicine, 56100 Pisa, Italy
    J Clin Endocrinol Metab 97:2818-26. 2012
    ..Dipeptidyl peptidase IV (DPP-4) inhibitors improve glycemic control in patients with type 2 diabetes. The underlying mechanisms (incretin effect, β-cell function, endogenous glucose production) are not well known...
  12. doi request reprint Physiology of glucose homeostasis and insulin therapy in type 1 and type 2 diabetes
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, 56100 Pisa, Italy
    Endocrinol Metab Clin North Am 41:25-39. 2012
    ..Open-loop insulin therapy faces the complexities of insulin pharmacokinetics and pharmacodynamics. Insulin therapy thus remains defiantly empiric...
  13. ncbi request reprint Is insulin resistance the cause of the metabolic syndrome?
    Ele Ferrannini
    Department of Internal Medicine and Metabolism Unit of the C N R Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Ann Med 38:42-51. 2006
    ....
  14. ncbi request reprint Is insulin resistance atherogenic? A review of the evidence
    Ele Ferrannini
    Department of Internal Medicine, Via Roma 67, 56126 Pisa, Italy
    Atheroscler Suppl 7:5-10. 2006
    ..Conclusive proof would require a prospective study in which insulin resistance is measured directly and adequate account is taken of the classical cardiovascular risk factors...
  15. ncbi request reprint Predominant role of reduced beta-cell sensitivity to glucose over insulin resistance in impaired glucose tolerance
    E Ferrannini
    Metabolism Unit, C N R Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetologia 46:1211-9. 2003
    ..Impaired glucose tolerance (IGT) is an insulin-resistant state and a risk factor for Type 2 diabetes. The relative roles of insulin resistance and insulin deficiency in IGT have been disputed...
  16. pmc Progression to diabetes in relatives of type 1 diabetic patients: mechanisms and mode of onset
    Ele Ferrannini
    Department of Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes 59:679-85. 2010
    ..Relatives of type 1 diabetic patients are at enhanced risk of developing diabetes. We investigated the mode of onset of hyperglycemia and how insulin sensitivity and beta-cell function contribute to the progression to the disease...
  17. doi request reprint The stunned beta cell: a brief history
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, 56100 Pisa, Italy
    Cell Metab 11:349-52. 2010
    ..However, longitudinal and intervention studies indicate that beta cell glucose insensitivity (stunning) closely tracks with hyperglycemia and is, at least in part, reversible. Rescuing stunned beta cells is a key therapeutic target...
  18. doi request reprint High-density lipoprotein-cholesterol and not HbA1c was directly related to cardiovascular outcome in PROactive
    E Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes Obes Metab 13:759-64. 2011
    ..As these glycaemic and lipid parameters are major cardiovascular (CV) risk factors, we assessed their separate contribution to the reduced incidence of CV outcomes...
  19. pmc Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trial
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetes Care 33:2217-24. 2010
    ..We evaluated the efficacy and safety of dapagliflozin in treatment-naive patients with type 2 diabetes...
  20. doi request reprint Natural history and physiological determinants of changes in glucose tolerance in a non-diabetic population: the RISC Study
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetologia 54:1507-16. 2011
    ..The natural history and physiological determinants of glucose intolerance in subjects living in Europe have not been investigated. The aim of this study was to increase our understanding of this area...
  21. ncbi request reprint Beta cell function and its relation to insulin action in humans: a critical appraisal
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Italy
    Diabetologia 47:943-56. 2004
    ..In fact, glucose excursions following glucose ingestion (i.e. glucose tolerance) are best explained by dynamic parameters of beta cell function...
  22. ncbi request reprint beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis
    Ele Ferrannini
    Diabetes Division, Department of Internal Medicine, University of Texas Health Science Center, San Antonio 78229 3900, USA
    J Clin Endocrinol Metab 90:493-500. 2005
    ....
  23. ncbi request reprint Metabolic syndrome: a solution in search of a problem
    Ele Ferrannini
    Department of Internal Medicine, Via Savi, 8, 56126 Pisa, Italy
    J Clin Endocrinol Metab 92:396-8. 2007
  24. doi request reprint Plasma glucose levels as predictors of diabetes: the Mexico City diabetes study
    E Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Diabetologia 52:818-24. 2009
    ....
  25. doi request reprint Pathophysiology of prediabetes
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100 Pisa, Italy
    Med Clin North Am 95:327-39, vii-viii. 2011
    ..Although genetic influences affect β-cell function, becoming overweight is the main acquired challenge to insulin action. The phenotype of prediabetes includes dyslipidemia and higher arterial blood pressure...
  26. ncbi request reprint Association of fasting glucagon and proinsulin concentrations with insulin resistance
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabetologia 50:2342-7. 2007
    ..Hyperproinsulinaemia and relative hyperglucagonaemia are features of type 2 diabetes. We hypothesised that raised fasting glucagon and proinsulin concentrations may be associated with insulin resistance (IR) in non-diabetic individuals...
  27. ncbi request reprint beta-cell function in obesity: effects of weight loss
    Ele Ferrannini
    Department of Internal Medicine, Via Savi, 8, 56126 Pisa, Italy
    Diabetes 53:S26-33. 2004
    ..Lipid-triggered messages from the gastrointestinal tract to the insulin target tissues and endocrine pancreas are the subject of intense investigation...
  28. ncbi request reprint Haematocrit, type 2 diabetes, and endothelium-dependent vasodilatation of resistance vessels
    Andrea Natali
    Department of Internal Medicine, Via Roma 67, 56100 Pisa, Italy
    Eur Heart J 26:464-71. 2005
    ..In vitro, haemoglobin neutralizes nitric oxide very effectively. Whether red blood cells participate in the regulation of endothelial function in vivo has not been established...
  29. doi request reprint Insulin sensitivity and carotid intima-media thickness: relationship between insulin sensitivity and cardiovascular risk study
    Michaela Kozakova
    Department of Experimental and Clinical Medicine, University of Pisa, Italy
    Arterioscler Thromb Vasc Biol 33:1409-17. 2013
    ..Despite a wealth of experimental data in animal models, the independent association of insulin resistance with early carotid atherosclerosis in man has not been demonstrated...
  30. ncbi request reprint beta-cell function in morbidly obese subjects during free living: long-term effects of weight loss
    Stefania Camastra
    Department of Internal Medicine, Metabolism Unit, National Research Council Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabetes 54:2382-9. 2005
    ..With continued weight loss over a 2-year period, moderately obese subjects become supersensitive to insulin and, correspondingly, insulin hyposecretors...
  31. ncbi request reprint Low-grade systemic inflammation causes endothelial dysfunction in patients with Hashimoto's thyroiditis
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, Via Roma, 67 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:5076-82. 2006
    ..The objective of this study was to assess whether low-grade systemic inflammation might contribute to the pathogenesis of endothelial dysfunction in patients with subclinical hypothyroidism (sHT) and autoimmune thyroiditis...
  32. pmc Long-term effects of bariatric surgery on meal disposal and β-cell function in diabetic and nondiabetic patients
    Stefania Camastra
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Diabetes 62:3709-17. 2013
    ....
  33. doi request reprint Primary cell cultures from anaplastic thyroid cancer obtained by fine-needle aspiration used for chemosensitivity tests
    Alessandro Antonelli
    Department of Internal Medicine, University Hospital of Pisa, Pisa, Italy
    Clin Endocrinol (Oxf) 69:148-52. 2008
    ....
  34. doi request reprint CXCL10 and CCL2 chemokine serum levels in patients with hepatitis C associated with autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Interferon Cytokine Res 29:345-51. 2009
    ....
  35. ncbi request reprint Metabolic effects of visceral fat accumulation in type 2 diabetes
    Amalia Gastaldelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa, Via Savi, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 87:5098-103. 2002
    ..05). We conclude that in patients with established type 2 diabetes, VF accumulation has a significant negative impact on glycemic control through a decrease in peripheral insulin sensitivity and an enhancement of gluconeogenesis...
  36. doi request reprint Biliopancreatic diversion in nonobese patients with type 2 diabetes: impact and mechanisms
    Brenno Astiarraga
    Department of Clinical and Experimental Medicine, University of Pisa School of Medicine, 56100 Pisa, Italy
    J Clin Endocrinol Metab 98:2765-73. 2013
    ..Diabetes remission is frequent after biliopancreatic diversion (BPD) in morbidly obese patients with type 2 diabetes (T2D). Data, mechanisms, and clinical indications in nonobese T2D patients are scanty...
  37. doi request reprint Fatty liver index, gamma-glutamyltransferase, and early carotid plaques
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Hepatology 55:1406-15. 2012
    ..g., body mass index, waist circumference, plasma triglycerides, and GGT), the independent determinants of plaque presence were age (P < 0.001), GGT (P = 0.001), and current smoking (P < 0.05)...
  38. ncbi request reprint Iodine-131 given for therapeutic purposes modulates differently interferon-gamma-inducible alpha-chemokine CXCL10 serum levels in patients with active Graves' disease or toxic nodular goiter
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine, Regional Center of Nuclear Medicine, University of Pisa Medical School, Via Roma, 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:1485-90. 2007
    ..Forty healthy subjects and 40 patients with autoimmune thyroiditis served as control groups...
  39. ncbi request reprint Increased serum CXCL10 in Graves' disease or autoimmune thyroiditis is not associated with hyper- or hypothyroidism per se, but is specifically sustained by the autoimmune, inflammatory process
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    Eur J Endocrinol 154:651-8. 2006
    ..Longitudinal assessment of sCXCL10 in autoimmune hypo- or hyperthyroidism has not yet been performed...
  40. ncbi request reprint Clinical and subclinical autoimmune thyroid disorders in systemic sclerosis
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Eur J Endocrinol 156:431-7. 2007
    ..Several studies have reported the association of systemic sclerosis (SSc) with thyroid autoimmune disorders, but most of them have neither an appropriate control group nor include a complete thyroid work-up...
  41. ncbi request reprint Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabetic subjects
    Amalia Gastaldelli
    Division of Diabetes, Department of Medicine, The University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA
    Gastroenterology 133:496-506. 2007
    ..We examined the relationship between visceral/hepatic fat accumulation and hepatic IR/accelerated gluconeogenesis (GNG)...
  42. ncbi request reprint Thiazolidinediones improve beta-cell function in type 2 diabetic patients
    Amalia Gastaldelli
    Diabetes Division, Department of Medicine, University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, TX 78229, USA
    Am J Physiol Endocrinol Metab 292:E871-83. 2007
    ..In T2DM patients, TZD treatment leads to improved beta-cell function, which correlates strongly with improved glycemic control...
  43. ncbi request reprint Separate impact of obesity and glucose tolerance on the incretin effect in normal subjects and type 2 diabetic patients
    Elza Muscelli
    Department of Internal Medicine, Consiglio Nazionale delle Ricerche CNR, Institute of Clinical Physiology, University of Pisa, Italy
    Diabetes 57:1340-8. 2008
    ..To quantitate the separate impact of obesity and hyperglycemia on the incretin effect (i.e., the gain in beta-cell function after oral glucose versus intravenous glucose)...
  44. doi request reprint Variable modulation by cytokines and thiazolidinediones of the prototype Th1 chemokine CXCL10 in anaplastic thyroid cancer
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, 56126 Pisa, Italy
    Cytokine 59:218-22. 2012
    ..However, the pattern of modulation by IFN-γ, TNF-α or thiazolidinediones is extremely variable, suggesting that the intracellular pathways involved in the chemokine modulation in ATC have different types of deregulation...
  45. doi request reprint Monokine induced by interferon gamma (IFNgamma) (CXCL9) and IFNgamma inducible T-cell alpha-chemoattractant (CXCL11) involvement in Graves' disease and ophthalmopathy: modulation by peroxisome proliferator-activated receptor-gamma agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 94:1803-9. 2009
    ..Peroxisome proliferator-activated receptor-gamma (PPARgamma) activation plays an inhibitory role in this process...
  46. ncbi request reprint Thyroid cancer in HCV-related chronic hepatitis patients: a case-control study
    Alessandro Antonelli
    Metabolism Unit Department of Internal Medicine, University of Pisa, Italy
    Thyroid 17:447-51. 2007
    ....
  47. pmc Body weight, not insulin sensitivity or secretion, may predict spontaneous weight changes in nondiabetic and prediabetic subjects: the RISC study
    Eleni Rebelos
    Department of Internal Medicine, University of Pisa, Italy
    Diabetes 60:1938-45. 2011
    ..Previous studies have found that high insulin sensitivity predicts weight gain; this association has not been confirmed. Our aim was to systematically analyze metabolic predictors of spontaneous weight changes...
  48. ncbi request reprint Clustering of insulin resistance with vascular dysfunction and low-grade inflammation in type 2 diabetes
    Andrea Natali
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Diabetes 55:1133-40. 2006
    ..In type 2 diabetes, insulin resistance is associated with vascular dysfunction/damage, impaired fibrinolysis, and low-grade inflammation independently of obesity and poor glycemic control...
  49. ncbi request reprint Increase of interferon-gamma-inducible CXC chemokine CXCL10 serum levels in patients with active Graves' disease, and modulation by methimazole therapy
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Clin Endocrinol (Oxf) 64:189-95. 2006
    ....
  50. ncbi request reprint The effect of rosiglitazone on the liver: decreased gluconeogenesis in patients with type 2 diabetes
    Amalia Gastaldelli
    Metabolism Unit, National Research Center, Institute of Clinical Physiology, Via Moruzzi 1, 56100 Pisa, Italy
    J Clin Endocrinol Metab 91:806-12. 2006
    ..Thiazolidinediones have been shown to improve glycemic control and increase peripheral insulin sensitivity. Whether chronic thiazolidinedione treatment is associated with a decrease in GNG has not been determined...
  51. ncbi request reprint Pattern of expression of inflammatory markers in adipose tissue of untreated hypertensive patients
    Stephanie Madec
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 28:1459-65. 2010
    ....
  52. doi request reprint Decreased whole body lipolysis as a mechanism of the lipid-lowering effect of pioglitazone in type 2 diabetic patients
    Amalia Gastaldelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, 56100 Pisa, Italy
    Am J Physiol Endocrinol Metab 297:E225-30. 2009
    ..20 (58) pmol/l, P = 0.05]. We conclude that, in well-controlled T2DM patients, whole body lipolysis is insulin resistant, and pioglitazone improves the insulin sensitivity of lipolysis...
  53. ncbi request reprint Vascular effects of improving metabolic control with metformin or rosiglitazone in type 2 diabetes
    Andrea Natali
    Department of Internal Medicine, CNR Institute of Clinical Physiology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Diabetes Care 27:1349-57. 2004
    ..The aim of this study was to test whether vascular reactivity is modified by improving metabolic control and peripheral insulin resistance in type 2 diabetes...
  54. ncbi request reprint Chemokine (CXC motif) ligand 9 serum levels in mixed cryoglobulinaemia are associated with circulating levels of IFN-gamma and TNF-alpha
    Alessandro Antonelli
    Department of Internal Medicine University of Pisa School of Medicine, Pisa, Italy
    Clin Exp Rheumatol 30:864-70. 2012
    ..We aimed to measure CXCL9, IFN-γ and TNF-α in a series of MC+HCV to correlate these parameters to different clinical phenotypes...
  55. doi request reprint Peroxisome proliferator-activated receptor-α agonists modulate CXCL9 and CXCL11 chemokines in Graves' ophthalmopathy fibroblasts and preadipocytes
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma 67, I 56100 Pisa, Italy
    Mol Cell Endocrinol 349:255-61. 2012
    ..This study first shows that PPARα activators inhibit CXCL9 and CXCL11 chemokines in normal and GO fibroblasts and preadipocytes, suggesting that PPARα may be involved in the modulation of the immune response in GO...
  56. doi request reprint β (CCL2) and α (CXCL10) chemokine modulations by cytokines and peroxisome proliferator-activated receptor-α agonists in Graves' ophthalmopathy
    Alessandro Antonelli
    Department of Internal Medicine, School of Medicine, University of Pisa, Via Roma 67, I 56100 Pisa, Italy
    J Endocrinol 213:183-91. 2012
    ..PPARα activators inhibit the secretion of the main prototype α (CXCL10) and β (CCL2) chemokines in GO fibroblasts or preadipocytes, suggesting that PPARα may be involved in the modulation of the immune response in GO...
  57. ncbi request reprint Predictors of weight loss and reversal of comorbidities in malabsorptive bariatric surgery
    Maria E Valera-Mora
    Department of Internal Medicine, Catholic University of Rome, Rome, Italy
    Am J Clin Nutr 81:1292-7. 2005
    ..Cardiovascular and metabolic comorbidities are dramatically increased in severe obesity, a condition highly resistant to nonsurgical therapy...
  58. doi request reprint Thyroid uptake of 67Ga-citrate is associated with thyroid autoimmunity and hypothyroidism in patients with sarcoidosis
    Alessandro Antonelli
    Metabolism Unit, Department of Internal Medicine, University of Pisa and CNR Institute of Clinical Physiology, Via Roma, 67, 56126, Pisa, Italy
    Eur J Nucl Med Mol Imaging 36:137-43. 2009
    ..To evaluate the association of gallium-67 ((67)Ga)-citrate thyroid uptake with the presence of thyroid disorders in patients with sarcoidosis (S patients)...
  59. ncbi request reprint Insulin resistance, insulin response, and obesity as indicators of metabolic risk
    Ele Ferrannini
    Department of Internal Medicine, University of Pisa, Via Roma, 67 I 56100 Pisa, Italy
    J Clin Endocrinol Metab 92:2885-92. 2007
    ..Moreover, the differential impact of IR viz. insulin response has not been evaluated...
  60. doi request reprint Improved tolerance to sequential glucose loading (Staub-Traugott effect): size and mechanisms
    Sandra Bonuccelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Am J Physiol Endocrinol Metab 297:E532-7. 2009
    ..7 +/- 2.6 between 180 and 360 min (P < 0.03). Glucose potentiation and stronger suppression of endogenous glucose release are the main mechanisms underlying the Staub-Traugott effect...
  61. doi request reprint Interferon-α, -β and -γ induce CXCL11 secretion in human thyrocytes: modulation by peroxisome proliferator-activated receptor γ agonists
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, School of Medicine, Via Roma 67, 56100 Pisa, Italy
    Immunobiology 218:690-5. 2013
    ..Furthermore, PPAR-γ activation partially inhibits this process...
  62. ncbi request reprint Separate contribution of diabetes, total fat mass, and fat topography to glucose production, gluconeogenesis, and glycogenolysis
    Amalia Gastaldelli
    Metabolism Unit, C N R Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, 56100 Pisa, Italy
    J Clin Endocrinol Metab 89:3914-21. 2004
    ..02). We conclude that obesity per se, and visceral fat accumulation in particular, as well as poorly controlled diabetes are potent stimuli to augment gluconeogenic flux...
  63. ncbi request reprint Visceral fat in hypertension: influence on insulin resistance and beta-cell function
    Anna Maria Sironi
    National Research Council, Institute of Clinical Physiology, Area of research, Via Moruzzi, 1 S Cataldo, 56100 Pisa, Italy
    Hypertension 44:127-33. 2004
    ..Such visceral adiposity is quantitatively related to both height of blood pressure and severity of insulin resistance, but has no impact on the dynamics of beta-cell function...
  64. ncbi request reprint Increase of interferon-gamma inducible alpha chemokine CXCL10 but not beta chemokine CCL2 serum levels in chronic autoimmune thyroiditis
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Eur J Endocrinol 152:171-7. 2005
    ..To measure serum levels of CXCL10 and CCL2 prototype chemokines of the two major subclass (CXC and CC) in patients with newly diagnosed chronic autoimmune thyroiditis (AT), and relate the findings to the clinical phenotype...
  65. ncbi request reprint Increase of CXC chemokine CXCL10 and CC chemokine CCL2 serum levels in normal ageing
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pisa, Italy
    Cytokine 34:32-8. 2006
    ....
  66. doi request reprint Circulating chemokine (CXC motif) ligand (CXCL)9 is increased in aggressive chronic autoimmune thyroiditis, in association with CXCL10
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, 56100 Pisa, Italy
    Cytokine 55:288-93. 2011
    ..A strong relation between circulating CXCL9 and CXCL10 has been first shown, underlining the importance of a T helper 1 immune attack in the initiation of AT...
  67. doi request reprint Thiazolidinediones and antiblastics in primary human anaplastic thyroid cancer cells
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Via Roma, 67, I 56100, Pisa, Italy
    Clin Endocrinol (Oxf) 70:946-53. 2009
    ..No study has evaluated the antiproliferative effects of thiazolidinediones and antiblastics in 'primary cultured human anaplastic thyroid cancer cells'...
  68. doi request reprint High values of CXCL10 serum levels in mixed cryoglobulinemia associated with hepatitis C infection
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    Am J Gastroenterol 103:2488-94. 2008
    ....
  69. ncbi request reprint Rosiglitazone increases matrix production and quenches inflammation: studies in human cells
    Anna Solini
    Department of Internal Medicine, University of Pisa School of Medicine, Italy
    Diabetes Metab Res Rev 24:197-204. 2008
    ..We tested the effect of therapeutic doses of rosiglitazone on proliferative and inflammatory pathways in fibroblasts (HF) from five controls (C) and five T2D patients, and in aortic smooth muscle cells (hSMC)...
  70. doi request reprint High values of CXCL10 serum levels in patients with hepatitis C associated mixed cryoglobulinemia in presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
    Cytokine 42:137-43. 2008
    ..0001). In conclusion, our study is the first to demonstrate high serum levels of CXCL10 in MC and that CXCL10 in MC+AT patients are significantly higher compared to MC patients...
  71. doi request reprint Increase of circulating CXCL9 and CXCL11 associated with euthyroid or subclinically hypothyroid autoimmune thyroiditis
    Alessandro Antonelli
    Metabolism Unit, Department of Medicine and CNR Institute of Clinical Physiology, University of Pisa School of Medicine, I 56100 Pisa, Italy
    J Clin Endocrinol Metab 96:1859-63. 2011
    ..Recently, CXCL9 and CXCL11 have been shown to be involved in autoimmune thyroid disorders; however, no data are present about CXCL9 and CXCL11 circulating levels in thyroid autoimmunity...
  72. doi request reprint Cytokines (interferon-γ and tumor necrosis factor-α)-induced nuclear factor-κB activation and chemokine (C-X-C motif) ligand 10 release in Graves disease and ophthalmopathy are modulated by pioglitazone
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, I 56100 Pisa, Italy
    Metabolism 60:277-83. 2011
    ..Future studies will be needed to verify if new targeted peroxisome proliferator-activated receptor-γ activators may be able to exert the anti-inflammatory effects without the risk of expanding retrobulbar fat mass...
  73. doi request reprint Effect of a fatty meal on inflammatory markers in healthy volunteers with a family history of type 2 diabetes
    Stephanie Madec
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100 Pisa, Italy
    Br J Nutr 106:364-8. 2011
    ....
  74. doi request reprint Metabolic characteristics of prehypertension: role of classification criteria and gender
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Hypertens 27:2394-402. 2009
    ....
  75. ncbi request reprint Influence of ethnicity and familial diabetes on glucose tolerance and insulin action: a physiological analysis
    Ele Ferrannini
    Metabolism Unit, National Research Council Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa 56100, Italy
    J Clin Endocrinol Metab 88:3251-7. 2003
    ..We conclude that the primary physiological target of the propensity to diabetes of Mexican-Americans is insulin resistance of glucose uptake...
  76. doi request reprint CXCL9 and CXCL11 chemokines modulation by peroxisome proliferator-activated receptor-alpha agonists secretion in Graves' and normal thyrocytes
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Via Roma, 67, I 56100, Pisa, Italy
    J Clin Endocrinol Metab 95:E413-20. 2010
    ..However, until now, no data were present in the literature about the effect of PPARα activation on CXCL9 and CXCL11 chemokines in general or on secretion of these chemokines in thyroid cells...
  77. doi request reprint High values of alpha (CXCL10) and beta (CCL2) circulating chemokines in patients with psoriatic arthritis, in presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    Autoimmunity 41:537-42. 2008
    ..Serum CXCL10 (alpha chemokine) levels in psoriatic arthritis patients are significantly higher in presence of AT...
  78. doi request reprint Alpha-chemokine CXCL10 and beta-chemokine CCL2 serum levels in patients with hepatitis C-associated cryoglobulinemia in the presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, I 56100 Pisa, Italy
    Metabolism 57:1270-7. 2008
    ..Future studies in larger series will be needed to evaluate the potential usefulness of serum CXCL10 and CCL2 determination as a prognostic marker in the follow-up of MC patients, also in relation to the presence of AT...
  79. ncbi request reprint Muscle metabolism and exercise tolerance in subclinical hypothyroidism: a controlled trial of levothyroxine
    Nadia Caraccio
    Department of Internal Medicine, and Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, University of Pisa School of Medicine, Via Roma 67, 56126 Pisa, Italy
    J Clin Endocrinol Metab 90:4057-62. 2005
    ..Neuromuscular symptoms and impaired muscle energy metabolism have been described in subclinical hypothyroidism (sHT)...
  80. ncbi request reprint Th1 and Th2 chemokine serum levels in systemic sclerosis in the presence or absence of autoimmune thyroiditis
    Alessandro Antonelli
    Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Rheumatol 35:1809-11. 2008
    ..We evaluated contemporarily serum alpha and beta chemokines in patients with newly diagnosed systemic sclerosis (SSc) in the presence or absence of autoimmune thyroiditis (AT)...
  81. pmc Obesity and type 2 diabetes: what can be unified and what needs to be individualized?
    Robert H Eckel
    Division of Endocrinology, Metabolism, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA
    Diabetes Care 34:1424-30. 2011
    ..This report examines what is known about the relationship between obesity and type 2 diabetes and how future research in these areas might be directed to benefit prevention, interventions, and overall patient care...
  82. ncbi request reprint High prevalence of thyroid autoimmunity and hypothyroidism in patients with psoriatic arthritis
    Alessandro Antonelli
    From the Department of Internal Medicine and the Rheumatology Unit, University of Pisa, and the Endocrinological Laboratory, Azienda Ospedaliera Pisana, Pisa, Italy
    J Rheumatol 33:2026-8. 2006
    ..To evaluate the prevalence of thyroid disorders in a group of patients with psoriatic arthritis (PsA)...
  83. ncbi request reprint Beta-cell dysfunction and glucose intolerance: results from the San Antonio metabolism (SAM) study
    A Gastaldelli
    Metabolism Unit, C N R Institute of Clinical Physiology, Pisa, Italy
    Diabetologia 47:31-9. 2004
    ..The aim of the study was to define the level of glycaemia at which beta-cell dysfunction becomes evident in the context of existing insulin resistance...
  84. ncbi request reprint Impaired endothelium-dependent vasodilatation in subclinical hypothyroidism: beneficial effect of levothyroxine therapy
    Stefano Taddei
    Department of Internal Medicine, University of Pisa, 56100 Pisa, Italy
    J Clin Endocrinol Metab 88:3731-7. 2003
    ..Patients with sHT are characterized by endothelial dysfunction resulting from a reduction in NO availability, an alteration partially independent of dyslipidemia and reversed by levothyroxine supplementation...
  85. ncbi request reprint How to measure insulin sensitivity
    E Ferrannini
    CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa, Italy
    J Hypertens 16:895-906. 1998
    ..Recent developments and future trends are mentioned. Criteria for choice and some reference data are given to aid the clinical investigator...
  86. ncbi request reprint Polymorphisms in the hANP (human atrial natriuretic peptide) gene, albuminuria, and hypertension
    M Nannipieri
    Department of Internal Medicine and Metabolism Unit of the CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Pistoia, Italy
    Hypertension 37:1416-22. 2001
    ..hANP gene variants may exert a protective effect against the development and progression of kidney damage in diabetes...
  87. ncbi request reprint Effect of acute hyperglycemia on insulin secretion in humans
    Elena Toschi
    Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa, Via Savi 8, 56126 Pisa, Italy
    Diabetes 51:S130-3. 2002
    ..We conclude that first-phase insulin secretion is inhibited by short-term modest hyperglycemia, whereas the second-phase insulin secretion increases linearly with hyperglycemia...
  88. ncbi request reprint Metabolic effects of combined antihypertensive treatment in patients with essential hypertension
    Alfredo Quiñones-Galvan
    National Research Council CNR Institute of Clinical Physiology and Department of Internal Medicine, University of Pisa School of Medicine, Pisa, Italy
    J Cardiovasc Pharmacol 40:916-21. 2002
    ....
  89. doi request reprint Fifty-two-week efficacy and safety of vildagliptin vs. glimepiride in patients with type 2 diabetes mellitus inadequately controlled on metformin monotherapy
    E Ferrannini
    Department of Internal Medicine and CNR Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Diabetes Obes Metab 11:157-66. 2009
    ..The primary objective was to demonstrate non-inferiority of vildagliptin vs. glimepiride in glycosylated haemoglobin (HbA(1c)) reduction at week 52...
  90. ncbi request reprint Pattern of expression of adiponectin receptors in human adipose tissue depots and its relation to the metabolic state
    M Nannipieri
    Department of Internal Medicine and C N R Institute of Clinical Physiology, University of Pisa, Pisa, Italy
    Int J Obes (Lond) 31:1843-8. 2007
    ....
  91. ncbi request reprint Metabolic effects of glucose-insulin infusions: myocardium and whole body
    A Quinones-Galvan
    Metabolism Unit, CNR Institute of Clinical Physiology, University of Pisa School of Medicine, Via Savi, 8 I 56100 Pisa, Italy
    Curr Opin Clin Nutr Metab Care 4:157-63. 2001
    ..Its role as an adjunctive therapy in the management of myocardial infarction in non-diabetic individuals has been tested in several clinical trials; however, the evidence emerging from them is inconclusive...
  92. ncbi request reprint Effect of levothyroxine replacement on lipid profile and intima-media thickness in subclinical hypothyroidism: a double-blind, placebo- controlled study
    F Monzani
    Department of Internal Medicine and National Research Council Institute of Clinical Physiology, University of Pisa, Pisa 56126, Italy
    J Clin Endocrinol Metab 89:2099-106. 2004
    ....
  93. ncbi request reprint Independent influence of age on basal insulin secretion in nondiabetic humans. European Group for the Study of Insulin Resistance
    P Iozzo
    Consiglio Nazionale delle Ricerche Institute of Clinical Physiology, Pisa, Italy
    J Clin Endocrinol Metab 84:863-8. 1999
    ..0001) inverse relation to age. We conclude that, in nondiabetic Caucasian subjects of either sex, senescence per se is associated with a progressive decline in both insulin clearance and basal insulin release...
  94. ncbi request reprint Hyperinsulinemia and autonomic nervous system dysfunction in obesity: effects of weight loss
    M Emdin
    Metabolism Unit and Coronary Division, CNR Institute of Clinical Physiology, and Department of Internal Medicine, University of Pisa, Pisa, Italy
    Circulation 103:513-9. 2001
    ..Reversal of these changes by weight loss suggests a causal role for insulin...
  95. ncbi request reprint Insulin resistance in morbid obesity: reversal with intramyocellular fat depletion
    Aldo V Greco
    Department of Medicine, Catholic University, Rome, Italy
    Diabetes 51:144-51. 2002
    ....
  96. doi request reprint Blocking the renin-angiotensin-aldosterone system to prevent diabetes mellitus
    Darren K McGuire
    Department of Internal Medicine, The University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Diab Vasc Dis Res 5:59-66. 2008
    ..Here we review the evidence accumulated to date from animal studies, clinical mechanistic studies and clinical trials regarding the effect of RAAS inhibition and incident DM...
  97. doi request reprint Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals
    Patricia Iozzo
    Turku PET Centre, and Department of Medicine, University of Turku, Turku, Finland
    Gastroenterology 139:846-56, 856.e1-6. 2010
    ..We combined (11)C-palmitate imaging by positron emission tomography (PET) with compartmental modeling to determine rates of hepatic FA uptake, oxidation, and storage, as well as triglyceride release in pigs and human beings...
  98. doi request reprint Insulin sensitivity and beta-cell function in the offspring of type 2 diabetic patients: impact of line of inheritance
    Andrea Natali
    Department of Internal Medicine, University of Pisa, Pisa, Italy
    J Clin Endocrinol Metab 95:4703-11. 2010
    ..What defects in glucose metabolism are present in offspring of type 2 diabetic patients (FHD(+) with a positive family history of diabetes) and to what extent they depend on line of inheritance are uncertain...
  99. ncbi request reprint 18F-FDG assessment of glucose disposal and production rates during fasting and insulin stimulation: a validation study
    Patricia Iozzo
    Turku PET Centre, University of Turku, Turku, Finland
    J Nucl Med 47:1016-22. 2006
    ....
  100. doi request reprint Adiponectin and left ventricular structure and function in healthy adults
    Michaela Kozakova
    Department of Internal Medicine, University of Pisa, Via Roma 67, Pisa, Italy
    J Clin Endocrinol Metab 93:2811-8. 2008
    ..Adiponectin inhibits protein synthesis in cardiac myocytes, thereby opposing the effect of cardiac workload and trophic factors (in particular, insulin) on left ventricular (LV) mass and wall thickness (WT)...
  101. ncbi request reprint Liver uptake of free fatty acids in vivo in humans as determined with 14( R, S)-[18F]fluoro-6-thia-heptadecanoic acid and PET
    Patricia Iozzo
    Turku PET Centre, Department of Nuclear Medicine and Medicine, University of Turku, Turku, Finland
    Eur J Nucl Med Mol Imaging 30:1160-4. 2003
    ..In conclusion, our data provide non-invasive quantification of hepatic FFA uptake in humans, showing the liver to handle a high FFA flux. [(18)F]FTHA-PET appears a valuable tool for the investigation of hepatic FFA turnover in humans...