Carmine G Fanelli

Summary

Affiliation: Institute of Infectious Diseases and Public Health
Country: Italy

Publications

  1. ncbi request reprint Administration of neutral protamine Hagedorn insulin at bedtime versus with dinner in type 1 diabetes mellitus to avoid nocturnal hypoglycemia and improve control. A randomized, controlled trial
    Carmine G Fanelli
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Ann Intern Med 136:504-14. 2002
  2. pmc Effect of oral amino acids on counterregulatory responses and cognitive function during insulin-induced hypoglycemia in nondiabetic and type 1 diabetic people
    Paolo Rossetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes 57:1905-17. 2008
  3. ncbi request reprint Insulin therapy and hypoglycaemia: the size of the problem
    Carmine G Fanelli
    Section of Internal Medicine, University of Perugia, Italy
    Diabetes Metab Res Rev 20:S32-42. 2004
  4. pmc Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis
    Paola Lucidi
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes 59:1349-57. 2010
  5. pmc Portal vein glucose sensors do not play a major role in modulating physiological responses to insulin-induced hypoglycemia in humans
    Paolo Rossetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes 58:194-202. 2009
  6. pmc Differential effects of adiposity on pharmacodynamics of basal insulins NPH, glargine, and detemir in type 2 diabetes mellitus
    Francesca Porcellati
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes Care 34:2521-3. 2011
  7. pmc Pharmacokinetics and pharmacodynamics of therapeutic doses of basal insulins NPH, glargine, and detemir after 1 week of daily administration at bedtime in type 2 diabetic subjects: a randomized cross-over study
    Paola Lucidi
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes Care 34:1312-4. 2011
  8. ncbi request reprint Comparison of pharmacokinetics and dynamics of the long-acting insulin analogs glargine and detemir at steady state in type 1 diabetes: a double-blind, randomized, crossover study
    Francesca Porcellati
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Diabetes Care 30:2447-52. 2007
  9. ncbi request reprint Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine after 1 week of use compared with its first administration in subjects with type 1 diabetes
    Francesca Porcellati
    University of Perugia, Department of Internal Medicine, Section of Internal Medicine, Endocrinology, and Metabolism, Via E dal Pozzo, 06126 Perugia, Italy
    Diabetes Care 30:1261-3. 2007
  10. doi request reprint Short-term effects of the long-acting insulin analog detemir and human insulin on plasma levels of insulin-like growth factor-I and its binding proteins in humans
    Francesca Porcellati
    University of Perugia, Department of Internal Medicine, Via E dal Pozzo, Perugia, Italy
    J Clin Endocrinol Metab 94:3017-24. 2009

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Administration of neutral protamine Hagedorn insulin at bedtime versus with dinner in type 1 diabetes mellitus to avoid nocturnal hypoglycemia and improve control. A randomized, controlled trial
    Carmine G Fanelli
    Department of Internal Medicine, University of Perugia, Via E dal Pozzo, I 06126 Perugia, Italy
    Ann Intern Med 136:504-14. 2002
    ..Intensive insulin treatment of type 1 diabetes mellitus increases the risk for nocturnal hypoglycemia...
  2. pmc Effect of oral amino acids on counterregulatory responses and cognitive function during insulin-induced hypoglycemia in nondiabetic and type 1 diabetic people
    Paolo Rossetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes 57:1905-17. 2008
    ..The aim of this study was to assess the responses to hypoglycemia in nondiabetic and type 1 diabetic subjects after ingestion of an amino acid mixture...
  3. ncbi request reprint Insulin therapy and hypoglycaemia: the size of the problem
    Carmine G Fanelli
    Section of Internal Medicine, University of Perugia, Italy
    Diabetes Metab Res Rev 20:S32-42. 2004
    ..Finally, hypoglycaemia may be fatal. Hypoglycaemia induced by insulin as treatment of type 1 diabetes mellitus (T1 DM) is not the consequence of diabetes, but invariably of the non-physiological replacement of insulin...
  4. pmc Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis
    Paola Lucidi
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes 59:1349-57. 2010
    ..However, it is not known whether FFA plays a role in the development of posthypoglycemic insulin resistance as well...
  5. pmc Portal vein glucose sensors do not play a major role in modulating physiological responses to insulin-induced hypoglycemia in humans
    Paolo Rossetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes 58:194-202. 2009
    ..The aim of the present study was to examine in humans the potential role of portal vein glucose sensors in physiological responses to insulin-induced hypoglycemia mimicking the slow fall of insulin-treated diabetic subjects...
  6. pmc Differential effects of adiposity on pharmacodynamics of basal insulins NPH, glargine, and detemir in type 2 diabetes mellitus
    Francesca Porcellati
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes Care 34:2521-3. 2011
    ....
  7. pmc Pharmacokinetics and pharmacodynamics of therapeutic doses of basal insulins NPH, glargine, and detemir after 1 week of daily administration at bedtime in type 2 diabetic subjects: a randomized cross-over study
    Paola Lucidi
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Perugia, Italy
    Diabetes Care 34:1312-4. 2011
    ..To compare the pharmacokinetics and pharmacodynamics of NPH, glargine, and detemir insulins in type 2 diabetic subjects...
  8. ncbi request reprint Comparison of pharmacokinetics and dynamics of the long-acting insulin analogs glargine and detemir at steady state in type 1 diabetes: a double-blind, randomized, crossover study
    Francesca Porcellati
    Department of Internal Medicine, Section of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Diabetes Care 30:2447-52. 2007
    ..4 +/- 1.6 kg/m2, and A1C 7.2 +/- 0.7%) were studied after a 2-week treatment with either glargine or detemir once daily (randomized, double-blind, crossover study)...
  9. ncbi request reprint Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine after 1 week of use compared with its first administration in subjects with type 1 diabetes
    Francesca Porcellati
    University of Perugia, Department of Internal Medicine, Section of Internal Medicine, Endocrinology, and Metabolism, Via E dal Pozzo, 06126 Perugia, Italy
    Diabetes Care 30:1261-3. 2007
  10. doi request reprint Short-term effects of the long-acting insulin analog detemir and human insulin on plasma levels of insulin-like growth factor-I and its binding proteins in humans
    Francesca Porcellati
    University of Perugia, Department of Internal Medicine, Via E dal Pozzo, Perugia, Italy
    J Clin Endocrinol Metab 94:3017-24. 2009
    ....
  11. pmc Metabolism of insulin glargine after repeated daily subcutaneous injections in subjects with type 2 diabetes
    Paola Lucidi
    Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Care 35:2647-9. 2012
    ..To investigate concentration of plasma insulin glargine after its subcutaneous dosing compared with concentration of its metabolites 1 (M1) and 2 (M2) in subjects with type 2 diabetes...
  12. doi request reprint Prevention of hypoglycemia while achieving good glycemic control in type 1 diabetes: the role of insulin analogs
    Paolo Rossetti
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Care 31:S113-20. 2008
  13. ncbi request reprint Different brain responses to hypoglycemia induced by equipotent doses of the long-acting insulin analog detemir and human regular insulin in humans
    Paolo Rossetti
    Department of Internal Medicine, Endocrinology, and Metabolism, University of Perugia, Via E dal Pozzo, 06126 Perugia, Italy
    Diabetes 57:746-56. 2008
    ..The aim of these studies was to assess the brain/hypothalamus responses to euglycemia and hypoglycemia in humans during intravenous infusion of equipotent doses of detemir and human insulin...
  14. ncbi request reprint Superiority of insulin analogues versus human insulin in the treatment of diabetes mellitus
    Paolo Rossetti
    Department of Internal Medicine, Endocrinology and Metabolism, University of Perugia, Via E dal Pozzo, Perugia, Italy
    Arch Physiol Biochem 114:3-10. 2008
    ..Rapid- and long-acting insulin analogues should always be combined in the treatment of T1 and T2DM...
  15. ncbi request reprint Counterregulatory hormone and symptom responses to insulin-induced hypoglycemia in the postprandial state in humans
    Francesca Porcellati
    Section of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes 52:2774-83. 2003
    ..In conclusion, in the postprandial compared with the fasting hypoglycemic state, total symptoms are less, but counterregulatory hormones are greater and responses of glucagon nearly normalize in type 1 diabetic subjects...
  16. doi request reprint Pharmacokinetics and pharmacodynamics of basal insulins
    Francesca Porcellati
    Department of Internal Medicine, University of Perugia, Perugia, Italy
    Diabetes Technol Ther 13:S15-24. 2011
    ..These differences should be taken into consideration when the individual analogs are introduced to provide basal insulin supplementation to optimize blood glucose control in patients with type 1 and type 2 diabetes as well...
  17. ncbi request reprint Insulin is required for prandial ghrelin suppression in humans
    Giuseppe Murdolo
    Department of Internal Medicine, Section of Internal Medicine and Endocrine and Metabolic Sciences IMISEM, University of Perugia, Perugia, Italy
    Diabetes 52:2923-7. 2003
    ..lack of meal-induced ghrelin suppression caused by severe insulin deficiency may explain hyperphagia of uncontrolled type 1 diabetic subjects...