Elzbieta ŁEmpicka

Summary

Affiliation: Institute of Infectious Diseases and Public Health
Country: Italy

Publications

  1. pmc Single-dose intraperitoneal magainins improve survival in a gram-negative-pathogen septic shock rat model
    Oscar Cirioni
    Institute of Infectious Diseases and Public Health, University of Ancona, Italy
    Antimicrob Agents Chemother 46:101-4. 2002
  2. ncbi In vitro activity of citropin 1.1 alone and in combination with clinically used antimicrobial agents against Rhodococcus equi
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    J Antimicrob Chemother 56:410-2. 2005
  3. pmc In vitro activity and killing effect of citropin 1.1 against gram-positive pathogens causing skin and soft tissue infections
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, c o Ospedale Regionale, Via Conca, 71, Ancona, I 60020, Italy
    Antimicrob Agents Chemother 49:2507-9. 2005
  4. ncbi In vitro activity of amphibian peptides alone and in combination with antimicrobial agents against multidrug-resistant pathogens isolated from surgical wound infection
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Clinica Malattie Infettive, Ospedale Regionale, Via Conca 71, I 60020 Ancona, Italy
    Peptides 26:2111-6. 2005
  5. ncbi Effects of pexiganan alone and combined with betalactams in experimental endotoxic shock
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    Peptides 26:207-16. 2005
  6. pmc Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    Antimicrob Agents Chemother 48:3162-4. 2004
  7. ncbi Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Clinica delle Malattie Infettive, Universita Politecnica delle Marche, c o Ospedale Regionale, Via Conca, 60020 Torrette AN, Ancona, Italy
    Peptides 24:1747-52. 2003
  8. ncbi Distinctin improves the efficacies of glycopeptides and betalactams against staphylococcal biofilm in an experimental model of central venous catheter infection
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, c o Ospedale Regionale, Via Conca 71, 60200 Ancona, Italy
    J Biomed Mater Res A 81:233-9. 2007
  9. ncbi Cathelicidin peptide sheep myeloid antimicrobial peptide-29 prevents endotoxin-induced mortality in rat models of septic shock
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, I N R C A I R R C S, Universita Politecnica delle Marche, Ancona, Italy
    Am J Respir Crit Care Med 169:187-94. 2004
  10. pmc Efficacy of quinupristin-dalfopristin in preventing vascular graft infection due to Staphylococcus epidermidis with intermediate resistance to glycopeptides
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Italy
    Antimicrob Agents Chemother 46:2885-8. 2002

Collaborators

  • Oscar Cirioni
  • Wojciech Kamysz
  • Elzbieta Kamysz
  • Margherita Zanetti
  • Naomi Balaban
  • Leonardo Antonicelli
  • Alessandra Riva
  • Andrea Giacometti
  • Giorgio Scalise
  • Carmela Silvestri
  • Giuseppina D'Amato
  • Maria Simona Del Prete
  • Federico Mocchegiani
  • Vittorio Saba
  • Roberto Ghiselli
  • Fiorenza Orlando
  • Alberto Licci
  • Jerzy Lukasiak
  • Jerzy Łukasiak
  • A Giacometti
  • Piotr Nadolski
  • V Saba
  • G Scalise
  • F Mocchegiani
  • R Ghiselli
  • Agnese Della Vittoria
  • Marco Rocchi
  • Valerio Sisti
  • Barbara Skerlavaj
  • Raffaella Circo
  • G D'Amato
  • F Orlando
  • Claudio Viticchi
  • M S Del Prete
  • Giovanni Renzone
  • Andrea Scaloni
  • Irma Testa
  • Matteo De Fusco
  • Mauro Provinciali
  • Piotr Naldoski
  • M Simona Del Prete
  • C Silvestri
  • Jerzy łLukasiak
  • J Lukasiak
  • Zbigniew Mackiewicz
  • G Greganti
  • F Caselli
  • Francesco Barchiesi
  • Franciszek Kasprzykowski
  • A Fineo
  • E Petrelli
  • B Fileni

Detail Information

Publications34

  1. pmc Single-dose intraperitoneal magainins improve survival in a gram-negative-pathogen septic shock rat model
    Oscar Cirioni
    Institute of Infectious Diseases and Public Health, University of Ancona, Italy
    Antimicrob Agents Chemother 46:101-4. 2002
    ..In general, treatments with the combinations of magainins and piperacillin demonstrated the highest efficacies...
  2. ncbi In vitro activity of citropin 1.1 alone and in combination with clinically used antimicrobial agents against Rhodococcus equi
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    J Antimicrob Chemother 56:410-2. 2005
    ....
  3. pmc In vitro activity and killing effect of citropin 1.1 against gram-positive pathogens causing skin and soft tissue infections
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, c o Ospedale Regionale, Via Conca, 71, Ancona, I 60020, Italy
    Antimicrob Agents Chemother 49:2507-9. 2005
    ..Streptococci and staphylococci were inhibited at concentrations between 1 and 16 mg/liter, respectively. Enterococci showed less susceptibility. Synergy was demonstrated when citropin 1.1 was combined with clarithromycin and doxycycline...
  4. ncbi In vitro activity of amphibian peptides alone and in combination with antimicrobial agents against multidrug-resistant pathogens isolated from surgical wound infection
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Clinica Malattie Infettive, Ospedale Regionale, Via Conca 71, I 60020 Ancona, Italy
    Peptides 26:2111-6. 2005
    ..Finally, all peptides showed synergistic effects with polymyxin E. These results provide evidence for the potential use of these antimicrobial peptides in the topical or systemic treatment of surgical wound infections...
  5. ncbi Effects of pexiganan alone and combined with betalactams in experimental endotoxic shock
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    Peptides 26:207-16. 2005
    ..The use of a novel antimicrobial compound able to bind to LPS associated to potent antibiotics such as betalactams may become an important future consideration for sepsis treatment...
  6. pmc Temporin A soaking in combination with intraperitoneal linezolid prevents vascular graft infection in a subcutaneous rat pouch model of infection with Staphylococcus epidermidis with intermediate resistance to glycopeptides
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    Antimicrob Agents Chemother 48:3162-4. 2004
    ..Linezolid and temporin A, alone or combined, greatly reduced the bacterial numbers compared to the effect with control drugs...
  7. ncbi Antiendotoxin activity of protegrin analog IB-367 alone or in combination with piperacillin in different animal models of septic shock
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Clinica delle Malattie Infettive, Universita Politecnica delle Marche, c o Ospedale Regionale, Via Conca, 60020 Torrette AN, Ancona, Italy
    Peptides 24:1747-52. 2003
    ..Finally IB-367 and piperacillin association showed to be the most effective therapeutic approach...
  8. ncbi Distinctin improves the efficacies of glycopeptides and betalactams against staphylococcal biofilm in an experimental model of central venous catheter infection
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, c o Ospedale Regionale, Via Conca 71, 60200 Ancona, Italy
    J Biomed Mater Res A 81:233-9. 2007
    ..Distinctin displays potential as an adjunctive agent to antibiotics in the treatment of CVC-related infections...
  9. ncbi Cathelicidin peptide sheep myeloid antimicrobial peptide-29 prevents endotoxin-induced mortality in rat models of septic shock
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, I N R C A I R R C S, Universita Politecnica delle Marche, Ancona, Italy
    Am J Respir Crit Care Med 169:187-94. 2004
    ..No statistically significant differences were noted between SMAP-29 and polymyxin B. SMAP-29, because of its double antiendotoxin and antimicrobial activities, could be an interesting compound for septic shock treatment...
  10. pmc Efficacy of quinupristin-dalfopristin in preventing vascular graft infection due to Staphylococcus epidermidis with intermediate resistance to glycopeptides
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Italy
    Antimicrob Agents Chemother 46:2885-8. 2002
    ....
  11. pmc Potential therapeutic role of cationic peptides in three experimental models of septic shock
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy
    Antimicrob Agents Chemother 46:2132-6. 2002
    ..Although the peptides demonstrated lower levels of antimicrobial activity than imipenem, they exhibited the dual properties of antimicrobial and antiendotoxin agents...
  12. ncbi Tachyplesin III and granulocyte-colony stimulating factor enhance the efficacy of tazobactam/piperacillin in a neutropenic mouse model of polymicrobial peritonitis
    Oscar Cirioni
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    Peptides 29:31-8. 2008
    ..The presence of their positive interaction makes tachyplesin III and G-CSF potentially valuable as an adjuvant for antimicrobial chemotherapy of sepsis...
  13. pmc Administration of protegrin peptide IB-367 to prevent endotoxin induced mortality in bile duct ligated rats
    A Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Italy
    Gut 52:874-8. 2003
    ..Postoperative morbidity in patients with obstructive jaundice remains high because of increased susceptibility to endotoxin and the inflammatory cascade...
  14. pmc Efficacy of the combination of tachyplesin III and clarithromycin in rat models of Escherichia coli sepsis
    Oscar Cirioni
    Clinica Malattie Infettive, c o Ospedale Regionale, Via Conca 71, 60020 Torrette AN, Italy
    Antimicrob Agents Chemother 52:4351-5. 2008
    ..A combination of tachyplesin III and clarithromycin resulted in significant reductions in bacterial counts and proved to be the most-effective treatment in reducing all variables measured...
  15. doi Daptomycin and rifampin alone and in combination prevent vascular graft biofilm formation and emergence of antibiotic resistance in a subcutaneous rat pouch model of staphylococcal infection
    O Cirioni
    Clinic of Infectious Diseases, Università Politecnica delle Marche Ospedali Riuniti, Ancona, Italy
    Eur J Vasc Endovasc Surg 40:817-22. 2010
    ..To investigate the efficacy of daptomycin and rifampin either alone or in combination in preventing prosthesis biofilm in a rat model of staphylococcal vascular graft infection...
  16. ncbi RNAIII-inhibiting peptide significantly reduces bacterial load and enhances the effect of antibiotics in the treatment of central venous catheter-associated Staphylococcus aureus infections
    Oscar Cirioni
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    J Infect Dis 193:180-6. 2006
    ..Medical devices used in clinical practice are often associated with biofilm-associated staphylococcal infections...
  17. pmc In vitro activity of aurein 1.2 alone and in combination with antibiotics against gram-positive nosocomial cocci
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, c o Ospedale Regionale, Via Conca, 71, Ancona, I 60020, Italy
    Antimicrob Agents Chemother 51:1494-6. 2007
    ..All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when aurein 1.2 was combined with clarithromycin and minocycline...
  18. ncbi Experimental study on the efficacy of combination of alpha-helical antimicrobial peptides and vancomycin against Staphylococcus aureus with intermediate resistance to glycopeptides
    Oscar Cirioni
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Clinica delle Malattie Infettive, c o Ospedali Riuniti Ancona, Via Conca 71, 60200 Ancona AN, Italy
    Peptides 27:2600-6. 2006
    ..These results highlight the potential usefulness of these combinations and provide future therapeutic alternative in infections due to glycopeptides resistant staphylococci in the coming years...
  19. doi Efficacy of LL-37 and granulocyte colony-stimulating factor in a neutropenic murine sepsis due to Pseudomonas aeruginosa
    Oscar Cirioni
    Institute of Infectious Diseases and Public Health, Department of General Surgery, I N R C A I R R C S Universita Politecnica delle Marche, Ancona, Italy
    Shock 30:443-8. 2008
    ..Combination therapy between LL-37 and G-CSF is a promising therapeutic strategy for the management of severe Pseudomonas infection complicated by neutropenia...
  20. pmc RNAIII-inhibiting peptide affects biofilm formation in a rat model of staphylococcal ureteral stent infection
    Oscar Cirioni
    Institute of Infectious Diseases and Public Health, Polytechnic University of the Marche Region, A O Ospedali Riuniti, Ancona, Italy
    Antimicrob Agents Chemother 51:4518-20. 2007
    ..Coating ureteral stents with RIP thus increases the efficacy of teicoplanin in preventing ureteral stent-associated staphylococcal infections...
  21. pmc Comparative efficacies of quinupristin-dalfopristin, linezolid, vancomycin, and ciprofloxacin in treatment, using the antibiotic-lock technique, of experimental catheter-related infection due to Staphylococcus aureus
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    Antimicrob Agents Chemother 49:4042-5. 2005
    ..Our findings suggest that the clinically used antibiotics cannot eradicate the CVC infection through the antibiotic-lock technique, even at a concentration of 1,024 microg/ml...
  22. pmc In vitro activity and killing effect of uperin 3.6 against gram-positive cocci isolated from immunocompromised patients
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, c o Ospedale Regionale, Via Conca, 71, Ancona, I 60020, Italy
    Antimicrob Agents Chemother 49:3933-6. 2005
    ..All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when uperin 3.6 was combined with clarithromycin and doxycycline...
  23. ncbi In vitro activity of MSI-78 alone and in combination with antibiotics against bacteria responsible for bloodstream infections in neutropenic patients
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    Int J Antimicrob Agents 26:235-40. 2005
    ..The checkerboard titration method demonstrated synergy when the peptide was combined with beta-lactams. These results provide evidence for the potential use of MSI-78 in the management of severe infections in neutropenic patients...
  24. ncbi In vitro effect of short-term exposure to two synthetic peptides, alone or in combination with clarithromycin or rifabutin, on Cryptosporidium parvum infectivity
    Andrea Giacometti
    Clinica Malattie Infettive, c o Ospedale Regionale, Via Conca, Ancona, Italy
    Peptides 23:1015-8. 2002
    ..The combination between peptides and azithromycin or rifabutin exerted the highest activities...
  25. ncbi Antiseptic compounds still active against bacterial strains isolated from surgical wound infections despite increasing antibiotic resistance
    A Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Via Conca, 60020 Ancona, Italy
    Eur J Clin Microbiol Infect Dis 21:553-6. 2002
    ..In spite of increasing resistance to the various antibiotics used to treat surgical wound infections, no significant variation in the susceptibility to antiseptics was demonstrated during this 6-year study...
  26. ncbi In vitro effect on Cryptosporidium parvum of short-term exposure to cathelicidin peptides
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Italy
    J Antimicrob Chemother 51:843-7. 2003
    ..SMAP-29 exerted the highest activity against both sporozoites and oocysts...
  27. ncbi Antiendotoxin activity of antimicrobial peptides and glycopeptides
    A Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy
    J Chemother 15:129-33. 2003
    ..Antimicrobial peptides and teicoplanin act as antiendotoxin agents and enhance the efficacy of piperacillin...
  28. ncbi Prevalence of intestinal parasites among individuals with allergic skin diseases
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Ospedale Regionale, Via Conca, 1 60020 Ancona, AN, Italy
    J Parasitol 89:490-2. 2003
    ..046). There was a set of patients with allergic cutaneous diseases in whom the presence of intestinal parasites may not be incidental...
  29. ncbi Prophylactic efficacy of linezolid alone or combined with levofloxacin and vancomycin in a rat subcutaneous pouch model of graft infection caused by Staphylococcus epidermidis with intermediate resistance to glycopeptides
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, Ancona, Italy
    J Antimicrob Chemother 52:724-6. 2003
    ....
  30. ncbi Comparative activities of cecropin A, melittin, and cecropin A-melittin peptide CA(1-7)M(2-9)NH2 against multidrug-resistant nosocomial isolates of Acinetobacter baumannii
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, University of Ancona, c o Ospedale Regionale, Via Conca, I 60020 Ancona, Italy
    Peptides 24:1315-8. 2003
    ..25-16 mg/l) than to cecropin A (0.50-32 mg/l) and melittin (0.50-32 mg/l). Synergy was observed when CA(1-7)M(2-9)NH2 and melittin were combined with beta-lactam antibiotics...
  31. ncbi Therapeutic efficacy of the magainin analogue MSI-78 in different intra-abdominal sepsis rat models
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    J Antimicrob Chemother 54:654-60. 2004
    ..This study was designed to investigate the antimicrobial and anti-endotoxin activity of MSI-78, a synthetic cationic peptide analogue of magainin 2...
  32. ncbi In vitro activity and killing effect of temporin A on nosocomial isolates of Enterococcus faecalis and interactions with clinically used antibiotics
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Universita Politecnica delle Marche, Ancona, Italy
    J Antimicrob Chemother 55:272-4. 2005
    ..Fourteen of these were resistant to vancomycin...
  33. pmc In vitro activity of the histatin derivative P-113 against multidrug-resistant pathogens responsible for pneumonia in immunocompromised patients
    Andrea Giacometti
    Institute of Infectious Diseases and Public Health, Università Politecnica dell Marche, Ancona, Italy
    Antimicrob Agents Chemother 49:1249-52. 2005
    ..The gram-negative isolates were susceptible to P-113. S. aureus showed less susceptibility. Synergy was demonstrated when P-113 was combined with beta-lactams against gram-negative organisms...
  34. doi Lipopeptide Laur-CKK-NH2 dimer preserves daptomycin susceptibility and enhances its activity against Enterococcus faecalis
    Oscar Cirioni
    Clinic of Infectious Diseases, Università Politecnica delle Marche Ospedali Riuniti, Ancona, Italy
    J Antimicrob Chemother 66:859-62. 2011
    ..An experimental study was performed to evaluate both in vitro and in vivo the kind of interaction between the Laur-CKK-NH2 dimer and daptomycin using two Enterococcus faecalis strains with different patterns of susceptibilities...