S Del Ry

Summary

Affiliation: Institute of Clinical Physiology
Country: Italy

Publications

  1. doi request reprint C-type natriuretic peptide plasma levels are reduced in obese adolescents
    S Del Ry
    CNR Institute of Clinical Physiology, CNR, Italy Electronic address
    Peptides 50:50-4. 2013
  2. doi request reprint Recent advances on natriuretic peptide system: new promising therapeutic targets for the treatment of heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy Electronic address
    Pharmacol Res 76:190-8. 2013
  3. doi request reprint High concentration of C-type natriuretic peptide promotes VEGF-dependent vasculogenesis in the remodeled region of infarcted swine heart with preserved left ventricular ejection fraction
    S Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy Electronic address
    Int J Cardiol 168:2426-34. 2013
  4. pmc Regional evidence of modulation of cardiac adiponectin level in dilated cardiomyopathy: pilot study in a porcine animal model
    Chiara Caselli
    Consiglio Nazionale delle Ricerche CNR, Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Cardiovasc Diabetol 11:143. 2012
  5. doi request reprint Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio, Pisa, Italy
    Cytokine 49:325-30. 2010
  6. ncbi request reprint Sequencing and cardiac expression of natriuretic peptide receptor 2 (NPR-B) in Sus Scrofa
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 28:1390-6. 2007
  7. doi request reprint Comparison of NT-proCNP and CNP plasma levels in heart failure, diabetes and cirrhosis patients
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Regul Pept 166:15-20. 2011
  8. ncbi request reprint C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure
    S Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy
    Peptides 29:79-82. 2008
  9. doi request reprint Expression of C-type natriuretic peptide and of its receptor NPR-B in normal and failing heart
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 29:2208-15. 2008
  10. doi request reprint Sequencing and cardiac expression of Apelin in Sus Scrofa
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, 56124 Pisa, Italy
    Pharmacol Res 60:314-9. 2009

Collaborators

Detail Information

Publications38

  1. doi request reprint C-type natriuretic peptide plasma levels are reduced in obese adolescents
    S Del Ry
    CNR Institute of Clinical Physiology, CNR, Italy Electronic address
    Peptides 50:50-4. 2013
    ..Thus, the availability of drugs promoting the action of natriuretic peptides may represent an attractive therapeutic option to prevent CD...
  2. doi request reprint Recent advances on natriuretic peptide system: new promising therapeutic targets for the treatment of heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy Electronic address
    Pharmacol Res 76:190-8. 2013
    ..This would open new perspectives also in the treatment of heart failure, and identify novel pharmacological targets for drugs inducing and/or modulating the maturation of the pro-hormone into active hormone. ..
  3. doi request reprint High concentration of C-type natriuretic peptide promotes VEGF-dependent vasculogenesis in the remodeled region of infarcted swine heart with preserved left ventricular ejection fraction
    S Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy Electronic address
    Int J Cardiol 168:2426-34. 2013
    ..We explored whether myocardial VEGF-dependent vasculogenesis is affected by CNP...
  4. pmc Regional evidence of modulation of cardiac adiponectin level in dilated cardiomyopathy: pilot study in a porcine animal model
    Chiara Caselli
    Consiglio Nazionale delle Ricerche CNR, Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Cardiovasc Diabetol 11:143. 2012
    ..We tested the regulation of both systemic and myocardial ADN and the relationship with AMP-activated protein kinase (AMPK) activity in a swine model of non-ischemic dilated cardiomyopathy...
  5. doi request reprint Increased plasma levels of osteopontin are associated with activation of the renin-aldosterone system and with myocardial and coronary microvascular damage in dilated cardiomyopathy
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio, Pisa, Italy
    Cytokine 49:325-30. 2010
    ..26, p=0.04). Both in patients with milder or more severe LV dysfunction lower MBF values were associated with higher OPN levels and PRA. These results suggest a interdependent role of RAS and vascular inflammation in cardiomyopathy...
  6. ncbi request reprint Sequencing and cardiac expression of natriuretic peptide receptor 2 (NPR-B) in Sus Scrofa
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 28:1390-6. 2007
    ..Therefore, NPR-B sequencing provides a new tool to investigate the role of CNP under physiological and pathological conditions in the experimental and clinical setting...
  7. doi request reprint Comparison of NT-proCNP and CNP plasma levels in heart failure, diabetes and cirrhosis patients
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio CNR Regione Toscana, Pisa, Italy
    Regul Pept 166:15-20. 2011
    ..Due to its higher analytical feasibility, this determination could become widespread in clinical biochemistry laboratories and serve as a complementary marker of disease conditions...
  8. ncbi request reprint C-type natriuretic peptide and its relation to non-invasive indices of left ventricular function in patients with chronic heart failure
    S Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy
    Peptides 29:79-82. 2008
    ..Group II (>600, n=13): 8.46+/-0.69 and 4.75+/-0.75 pg/ml, respectively, p<0.001. This is the first study that reports a correlation between CNP and dP/dt in CHF patients, thus suggesting a possible role on cardiac contractility...
  9. doi request reprint Expression of C-type natriuretic peptide and of its receptor NPR-B in normal and failing heart
    Silvia Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 29:2208-15. 2008
    ..The co-localization of the CNP system and NPR-B suggests a possible role of CNP in HF and may prompt novel therapeutical strategies...
  10. doi request reprint Sequencing and cardiac expression of Apelin in Sus Scrofa
    Silvia Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, 56124 Pisa, Italy
    Pharmacol Res 60:314-9. 2009
    ..The knowledge of Apelin sequence can be an useful starting point for future studies devoted to better understand the possible alterations of Apelin mRNA expression in different cardiac diseases...
  11. doi request reprint Asymmetrical myocardial expression of natriuretic peptides in pacing-induced heart failure
    Silvia Del Ry
    CNR Institute of Clinical Physiology and G Monasterio Foundation CNR Regione Toscana, Via Giuseppe Moruzzi 1, Pisa, Italy
    Peptides 30:1710-3. 2009
    ..Higher BNP mRNA expression in the PS is consistent with a reduction in contractile function in this region, while higher CNP mRNA expression in the OS suggests the presence of concomitant endothelial dysfunction in the remote region...
  12. ncbi request reprint Increased levels of C-type natriuretic peptide in patients with idiopathic left ventricular dysfunction
    Silvia Del Ry
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Peptides 28:1068-73. 2007
    ..In these patients CNP is also related with both systemic and coronary indicators of endothelial/microvascular damage...
  13. ncbi request reprint [Adrenomedullin plasma levels as indicators of prognosis after cardiac resynchronization therapy]
    Silvia Del Ry
    Istituto di Fisiologia Clinica, Fondazione Toscana G Monasterio, Pisa
    Recenti Prog Med 101:475-9. 2010
    ..The case described illustrates the importance of basal ADM plasma levels in predicting the clinical and functional improvement after treatment with CRT...
  14. ncbi request reprint [Methodological evaluation of an enzyme-immunoassay for plasma Big-et-1 determination]
    S Del Ry
    Laboratorio di Biochimica Cardiovascolare, CNR Istituto di Fisiologia Clinica, Pisa, Italy
    Minerva Endocrinol 29:63-70. 2004
    ..For this reason the analytical performance of an immunoenzimatic assay for plasma Big-ET-1, with or without a preliminary step of extraction, was evaluated...
  15. doi request reprint Adenosine receptor mRNA expression in normal and failing minipig hearts
    Silvia Del Ry
    Laboratory of Cardiovascular Biochemistry, CNR Institute of Clinical Physiology, Pisa, Italy
    J Cardiovasc Pharmacol 58:149-56. 2011
    ..80, P < 0.0001). In this study, A2BR mRNA resulted in being overexpressed in the left ventricle of pigs with HF as well as TNF-α expression possibly testifying a link between AR expression, inflammation, and HF...
  16. doi request reprint Expression of C-type natriuretic peptide and its receptor NPR-B in cardiomyocytes
    S Del Ry
    CNR Institute of Clinical Physiology Laboratory of Cardiovascular Biochemistry, Via Giuseppe Moruzzi 1, 56124 Pisa, Italy
    Peptides 32:1713-8. 2011
    ..By immunostaining of tissue sections, CNP was detected in both endothelium and cardiomyocytes. Expression of CNP in cardiac cells at gene and protein levels suggests that the heart is actively involved in the production of CNP...
  17. doi request reprint Plasma C-type natriuretic peptide levels in healthy children
    S Del Ry
    CNR Institute of Clinical Physiology and Fondazione G Monasterio, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 33:83-6. 2012
    ..According to these data at least five different reference intervals for CNP determinations should be used. These observations may be helpful for future clinical application of CNP in human children...
  18. pmc Pacing-induced regional differences in adenosine receptors mRNA expression in a swine model of dilated cardiomyopathy
    Silvia Del Ry
    Institute of Clinical Physiology, CNR, Pisa, Italy
    PLoS ONE 7:e47011. 2012
    ..These results suggest a possible therapeutic role of adenosine in patients with HF and dyssynchronous LV contraction...
  19. doi request reprint C-type natriuretic peptide: a new cardiac mediator
    S Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 40:93-8. 2013
    ....
  20. ncbi request reprint NPR-B, the C-type natriuretic peptide specific receptor, is the predominant biological receptor in mouse and pig myocardial tissue
    S Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Via Giuseppe Moruzzi 1, Pisa, Italy
    Minerva Endocrinol 35:37-46. 2010
    ..The aim of this study was to assess the cardiac mRNA expression of CNP and NPR-B together with those of BNP and NPR-A in order to evaluate the relative importance of these peptides and of their receptors in cardiovascular system...
  21. ncbi request reprint High density of endothelin binding sites in the hearts of infants and children
    D Giannessi
    CNR Institute of Clinical Physiology, Pisa, Italy
    Life Sci 64:697-705. 1999
    ....
  22. ncbi request reprint Possibility of age regulation of the natriuretic peptide C-receptor in human platelets
    D Giannessi
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Endocrinol Invest 24:8-16. 2001
    ..This observation suggests a possible reduction of the natriuretic peptide clearance with aging, associated to a significant increase of plasma levels of natriuretic peptides...
  23. doi request reprint Relation between adiponectin and brain natriuretic peptide in healthy pediatric subjects: from birth through childhood
    C Caselli
    Consiglio Nazionale delle Ricerche CNR, Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa Research Area, Via G Moruzzi 1, 56100 Pisa, Italy
    Nutr Metab Cardiovasc Dis 23:657-61. 2013
    ....
  24. doi request reprint Sequencing and cardiac expression of natriuretic peptide receptors A and C in normal and heart failure pigs
    M Cabiati
    Scuola Superiore Sant Anna, Pisa, Italy
    Regul Pept 162:12-7. 2010
    ..These sequences will provide a new tool to investigate the role of natriuretic peptides and of their receptors under physiological and pathological conditions and their response to therapeutic interventions...
  25. ncbi request reprint Up-regulation of 'clearance' receptors in patients with chronic heart failure: a possible explanation for the resistance to biological effects of cardiac natriuretic hormones
    M G Andreassi
    CNR Institute of Clinical Physiology, Area della Ricerca, Via Moruzzi, 56100 Pisa, Italy
    Eur J Heart Fail 3:407-14. 2001
    ..This suggests that clearance receptor blockade may be of potential therapeutic value in HF...
  26. ncbi request reprint Effects of chronic long-term therapy with calcium antagonists on cytogenetic damage in humans
    M G Andreassi
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Hypertens 17:843-6. 1999
    ....
  27. ncbi request reprint Clinical relevance of cardiac natriuretic peptides measured by means of competitive and non-competitive immunoassay methods in patients with renal failure on chronic hemodialysis
    A Clerico
    CNR Institute of Clinical Physiology, Department of Internal Medicine, University of Pisa, Italy
    J Endocrinol Invest 24:24-30. 2001
    ....
  28. ncbi request reprint Endothelin-1, endothelin-1 receptors and cardiac natriuretic peptides in failing human heart
    S Del Ry
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Life Sci 68:2715-30. 2001
    ....
  29. doi request reprint C-type natriuretic peptide transcriptomic profiling increases in human leukocytes of patients with chronic heart failure as a function of clinical severity
    M Cabiati
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 47:110-4. 2013
    ....
  30. doi request reprint Gene expression of C-type natriuretic peptide and of its specific receptor NPR-B in human leukocytes of healthy and heart failure subjects
    M Cabiati
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 37:240-6. 2012
    ....
  31. doi request reprint The natriuretic peptide time-course in end-stage heart failure patients supported by left ventricular assist device implant: focus on NT-proCNP
    M Cabiati
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Peptides 36:192-8. 2012
    ..The study of new peptides, such as NT-proCNP, would provide additional information for identifying patients who are more likely to recover...
  32. ncbi request reprint Plasma brain natriuretic peptide measured by fully-automated immunoassay and by immunoradiometric assay compared
    S Del Ry
    Laboratory of Cardiovascular Endocrinology, CNR Institute of Clinical Physiology, Pisa, Italy
    Clin Chem Lab Med 39:446-50. 2001
    ..The IRMA method should be preferred for pathophysiological studies, requiring the highest degree of precision and sensitivity for simultaneous measurement of several stored plasma samples or tissue extracts...
  33. pmc IL-33/ST2 Pathway and Classical Cytokines in End-Stage Heart Failure Patients Submitted to Left Ventricular Assist Device Support: A Paradoxic Role for Inflammatory Mediators?
    C Caselli
    Laboratory of Cardiovascular Biochemistry, Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche CNR, Area della Ricerca, Via Moruzzi 1, 56100 Pisa, Italy
    Mediators Inflamm 2013:498703. 2013
    ..IL-33/ST2 pathway was also associated to severity of clinical course. Thus, a better understanding of inflammation is the key to achieving more favorable outcome by new specific therapies. ..
  34. ncbi request reprint The role of endothelins and their receptors in heart failure
    D Giannessi
    Laboratory of Cardiovascular Biochemistry, CNR Institute of Clinical Physiology, Pisa, Italy
    Pharmacol Res 43:111-26. 2001
    ....
  35. ncbi request reprint Measurement of brain natriuretic peptide in plasma samples and cardiac tissue extracts by means of an immunoradiometric assay method
    S Del Ry
    Department of Cardiovascular Surgery, CNR Institute of Clinical Physiology, University of Pisa, Italy
    Scand J Clin Lab Invest 60:81-90. 2000
    ..Therefore, this method should be a reliable tool for the measurement of plasma BNP levels for both experimental studies and routine assay...
  36. ncbi request reprint Adiponectin circulating levels: a new emerging biomarker of cardiovascular risk
    D Giannessi
    CNR Institute of Clinical Physiology, Laboratory of Cardiovascular Biochemistry, Pisa, Italy
    Pharmacol Res 56:459-67. 2007
    ..Particular attention is paid to practical considerations relative to the analytical determination of this protein in humans...
  37. ncbi request reprint Chronic long-term nitrate therapy: possible cytogenetic effect in humans?
    M G Andreassi
    CNR Institute of Clinical Physiology, Via Moruzzi, 1, 56100, Pisa, Italy
    Mutagenesis 16:517-21. 2001
    ..Our results suggest a possible genotoxic activity of nitrate therapy. Further studies focusing on the possible link between nitrate therapy and genotoxicity are warranted at this point...
  38. ncbi request reprint Effects of aging and anti-aging caloric restrictions on carbonyl and heat shock protein levels and expression
    C Colotti
    CNR Institute of Clinical Physiology, Via Moruzzi 1, Pisa, Italy
    Biogerontology 6:397-406. 2005
    ..Our data suggest that cardiac Hsp levels may be a determinant of longevity in rodents, and that generation of new regimens of caloric restriction may eventually show how to improve modulation of cardiac aging...