Sandro De Falco

Summary

Affiliation: Institute of Genetics and Biophysics
Country: Italy

Publications

  1. pmc Antiangiogenesis therapy: an update after the first decade
    Sandro De Falco
    Angiogenesis Lab, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Napoli, Italy
    Korean J Intern Med 29:1-11. 2014
  2. pmc The discovery of placenta growth factor and its biological activity
    Sandro De Falco
    Angiogenesis Laboratory and Stem Cell Fate Laboratory, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Napoli, Italy
    Exp Mol Med 44:1-9. 2012
  3. doi request reprint A placental growth factor variant unable to recognize vascular endothelial growth factor (VEGF) receptor-1 inhibits VEGF-dependent tumor angiogenesis via heterodimerization
    Valeria Tarallo
    Angiogenesis Lab and Stem Cell Fate Lab, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, Naples, Italy
    Cancer Res 70:1804-13. 2010
  4. pmc Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1
    Salvatore Ponticelli
    Angiogenesis Laboratory and Stem Cell Fate Laboratory, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche CNR, 80131 Napoli, Italy
    J Biol Chem 283:34250-9. 2008
  5. pmc The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors
    Valeria Tarallo
    Institute of Genetics and Biophysics, Adriano Buzzati Traverso, Napoli, Italy
    J Biol Chem 286:19641-51. 2011
  6. ncbi request reprint Plgf-/-eNos-/- mice show defective angiogenesis associated with increased oxidative stress in response to tissue ischemia
    Bruna Gigante
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, Via P Castellino, 111, Naples 80131, Italy
    FASEB J 20:970-2. 2006
  7. ncbi request reprint Placenta growth factor is not required for exercise-induced angiogenesis
    Bruna Gigante
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Naples, Italy
    Angiogenesis 7:277-84. 2004
  8. doi request reprint Competitive ELISA-based screening of plant derivatives for the inhibition of VEGF family members interaction with vascular endothelial growth factor receptor 1
    Salvatore Ponticelli
    Angiogenesis Lab and Stem Cell Fate Lab, Istituto di Genetica e Biofisica Adriano Buzzati Traverso, CNR, Napoli, Italy
    Planta Med 74:401-6. 2008
  9. ncbi request reprint Chemical synthesis of mouse cripto CFC variants
    Daniela Marasco
    Istituto di Biostrutture e Bioimmagini del CNR, Sezione Biostrutture, Napoli, Italy
    Proteins 64:779-88. 2006
  10. ncbi request reprint Identification of placenta growth factor determinants for binding and activation of Flt-1 receptor
    Michela Errico
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
    J Biol Chem 279:43929-39. 2004

Collaborators

Detail Information

Publications10

  1. pmc Antiangiogenesis therapy: an update after the first decade
    Sandro De Falco
    Angiogenesis Lab, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Napoli, Italy
    Korean J Intern Med 29:1-11. 2014
    ..This review describes the progress made in the first decade of antiangiogenesis therapy, and addresses both validated and possible targets for future drug development...
  2. pmc The discovery of placenta growth factor and its biological activity
    Sandro De Falco
    Angiogenesis Laboratory and Stem Cell Fate Laboratory, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Napoli, Italy
    Exp Mol Med 44:1-9. 2012
    ..In this review, we describe the discovery and molecular characteristics of PlGF, and discuss the biological role of this growth factor in physiological and pathological conditions...
  3. doi request reprint A placental growth factor variant unable to recognize vascular endothelial growth factor (VEGF) receptor-1 inhibits VEGF-dependent tumor angiogenesis via heterodimerization
    Valeria Tarallo
    Angiogenesis Lab and Stem Cell Fate Lab, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, Naples, Italy
    Cancer Res 70:1804-13. 2010
    ..The PlGF1-DE variant, and not PlGF1wt as previously reported, acts as a "dominant negative" of VEGF and is a new candidate for antiangiogenic gene therapy in cancer treatment...
  4. pmc Modulation of angiogenesis by a tetrameric tripeptide that antagonizes vascular endothelial growth factor receptor 1
    Salvatore Ponticelli
    Angiogenesis Laboratory and Stem Cell Fate Laboratory, Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche CNR, 80131 Napoli, Italy
    J Biol Chem 283:34250-9. 2008
    ..This tetrameric tripeptide represents a new, promising compound for therapeutic approaches in pathologies where Flt-1 activation plays a crucial role...
  5. pmc The biflavonoid amentoflavone inhibits neovascularization preventing the activity of proangiogenic vascular endothelial growth factors
    Valeria Tarallo
    Institute of Genetics and Biophysics, Adriano Buzzati Traverso, Napoli, Italy
    J Biol Chem 286:19641-51. 2011
    ....
  6. ncbi request reprint Plgf-/-eNos-/- mice show defective angiogenesis associated with increased oxidative stress in response to tissue ischemia
    Bruna Gigante
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, Via P Castellino, 111, Naples 80131, Italy
    FASEB J 20:970-2. 2006
    ....
  7. ncbi request reprint Placenta growth factor is not required for exercise-induced angiogenesis
    Bruna Gigante
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, CNR, Naples, Italy
    Angiogenesis 7:277-84. 2004
    ..Our results demonstrate that PlGF is not necessary for exercise-training-induced angiogenesis. We thus suggest that the role of PlGF is confined to the selective regulation of angiogenesis only under pathological conditions...
  8. doi request reprint Competitive ELISA-based screening of plant derivatives for the inhibition of VEGF family members interaction with vascular endothelial growth factor receptor 1
    Salvatore Ponticelli
    Angiogenesis Lab and Stem Cell Fate Lab, Istituto di Genetica e Biofisica Adriano Buzzati Traverso, CNR, Napoli, Italy
    Planta Med 74:401-6. 2008
    ..This activity seems be due to the presence of a combination of compounds acting synergistically...
  9. ncbi request reprint Chemical synthesis of mouse cripto CFC variants
    Daniela Marasco
    Istituto di Biostrutture e Bioimmagini del CNR, Sezione Biostrutture, Napoli, Italy
    Proteins 64:779-88. 2006
    ..A comparative study of receptor binding shows that the CFC domain can bind Alk4 and confirms the importance of W107 and H104 for receptor recognition...
  10. ncbi request reprint Identification of placenta growth factor determinants for binding and activation of Flt-1 receptor
    Michela Errico
    Institute of Genetics and Biophysics Adriano Buzzati Traverso, Consiglio Nazionale delle Ricerche, 80131 Naples, Italy
    J Biol Chem 279:43929-39. 2004
    ..This variant failed to induce in vitro capillary-like tube formation of primary endothelial cells or neo-angiogenesis in an in vivo chorioallantoic membrane assay...