P Comoglio

Summary

Affiliation: Institute for Cancer Research and Treatment
Country: Italy

Publications

  1. ncbi request reprint Invasive growth: a two-way street for semaphorin signalling
    Paolo M Comoglio
    Nat Cell Biol 6:1155-7. 2004
  2. ncbi request reprint p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling
    Davide Barberis
    Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, Torino 10060, Italy
    J Cell Sci 118:4689-700. 2005
  3. ncbi request reprint Cancer: the matrix is now in control
    Paolo M Comoglio
    Nat Med 11:1156-9. 2005
  4. pmc Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition
    Simona Corso
    Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo Torino, Italy
    Mol Cancer 9:121. 2010
  5. pmc Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis
    Pietro Fazzari
    Institute for Cancer Research and Treatment, University of Torino Medical School, Division of Molecular Oncology, Candiolo, Turin, Italy
    BMC Dev Biol 7:55. 2007
  6. ncbi request reprint Interactions between growth factor receptors and adhesion molecules: breaking the rules
    Paolo M Comoglio
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Strada Provinciale 142, 10060 Candiolo Torino, Italy
    Curr Opin Cell Biol 15:565-71. 2003
  7. ncbi request reprint Scatter factor-dependent branching morphogenesis: structural and histological features
    P Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, Torino, Italy
    Eur J Histochem 51:79-92. 2007
  8. doi request reprint Drug development of MET inhibitors: targeting oncogene addiction and expedience
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin School of Medicine, Candiolo, Turin 10060, Italy
    Nat Rev Drug Discov 7:504-16. 2008
  9. ncbi request reprint Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression
    Chiara Bardella
    Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo, Turin, Italy
    Cancer Res 64:5154-61. 2004
  10. pmc An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice
    Massimiliano Mazzone
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    J Clin Invest 114:1418-32. 2004

Collaborators

Detail Information

Publications57

  1. ncbi request reprint Invasive growth: a two-way street for semaphorin signalling
    Paolo M Comoglio
    Nat Cell Biol 6:1155-7. 2004
  2. ncbi request reprint p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling
    Davide Barberis
    Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, Torino 10060, Italy
    J Cell Sci 118:4689-700. 2005
    ..We conclude that p190-RhoGAP is crucially involved in semaphorin signalling to the actin cytoskeleton, via interaction with plexins...
  3. ncbi request reprint Cancer: the matrix is now in control
    Paolo M Comoglio
    Nat Med 11:1156-9. 2005
  4. pmc Activation of HER family members in gastric carcinoma cells mediates resistance to MET inhibition
    Simona Corso
    Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo Torino, Italy
    Mol Cancer 9:121. 2010
    ..Perspective studies are thus mandatory to identify the molecular mechanisms that could cause resistance to these therapies...
  5. pmc Plexin-B1 plays a redundant role during mouse development and in tumour angiogenesis
    Pietro Fazzari
    Institute for Cancer Research and Treatment, University of Torino Medical School, Division of Molecular Oncology, Candiolo, Turin, Italy
    BMC Dev Biol 7:55. 2007
    ..In order to shed light on PlexinB1 function in vivo, we therefore undertook the genomic targeting of the mouse gene to obtain loss of function mutants...
  6. ncbi request reprint Interactions between growth factor receptors and adhesion molecules: breaking the rules
    Paolo M Comoglio
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Strada Provinciale 142, 10060 Candiolo Torino, Italy
    Curr Opin Cell Biol 15:565-71. 2003
    ....
  7. ncbi request reprint Scatter factor-dependent branching morphogenesis: structural and histological features
    P Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, Torino, Italy
    Eur J Histochem 51:79-92. 2007
    ....
  8. doi request reprint Drug development of MET inhibitors: targeting oncogene addiction and expedience
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin School of Medicine, Candiolo, Turin 10060, Italy
    Nat Rev Drug Discov 7:504-16. 2008
    ..Here we discuss recent progress in the development of molecules that inhibit MET function and consider their application in a subset of human tumours that are potentially responsive to MET-targeted therapies...
  9. ncbi request reprint Truncated RON tyrosine kinase drives tumor cell progression and abrogates cell-cell adhesion through E-cadherin transcriptional repression
    Chiara Bardella
    Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo, Turin, Italy
    Cancer Res 64:5154-61. 2004
    ..Altogether, these data show that expression of a naturally occurring, constitutively active truncated RON kinase results in loss of epithelial phenotype and aggressive behavior and, thus, it might contribute to tumor progression...
  10. pmc An uncleavable form of pro-scatter factor suppresses tumor growth and dissemination in mice
    Massimiliano Mazzone
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    J Clin Invest 114:1418-32. 2004
    ..These data show that proteolytic activation of pro-SF is a limiting step in tumor progression, thus suggesting a new strategy for the treatment or prevention of the malignant conversion of neoplastic lesions...
  11. pmc Invasive growth: from development to metastasis
    Paolo M Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo Torino, Italy
    J Clin Invest 109:857-62. 2002
  12. doi request reprint "Active" cancer immunotherapy by anti-Met antibody gene transfer
    Elisa Vigna
    Laboratory for Gene Transfer and Therapy, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Turin, Italy
    Cancer Res 68:9176-83. 2008
    ..These data provide proof of concept both for targeting the Met receptor and for a gene transfer-based immunotherapy strategy...
  13. ncbi request reprint Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene
    Selma Pennacchietti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    Cancer Cell 3:347-61. 2003
    ..These data show that hypoxia promotes tumor invasion by sensitizing cells to HGF stimulation, providing a molecular basis to explain Met overexpression in cancer...
  14. pmc Ab-induced ectodomain shedding mediates hepatocyte growth factor receptor down-regulation and hampers biological activity
    Annalisa Petrelli
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, 10060 Candiolo, Italy
    Proc Natl Acad Sci U S A 103:5090-5. 2006
    ..Interestingly, the "decoy effect" generated by the shed ectodomain, acting as a dominant negative molecule, enhanced the inhibitory effect of the Ab...
  15. ncbi request reprint A differentiation switch for genetically modified hepatocytes
    Carla Boccaccio
    Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
    FASEB J 16:120-2. 2002
    ....
  16. ncbi request reprint Novel somatic mutations of the MET oncogene in human carcinoma metastases activating cell motility and invasion
    Annalisa Lorenzato
    Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, Torino, Italy
    Cancer Res 62:7025-30. 2002
    ..These data suggest that MET might be one of the long sought oncogenes controlling progression of primary cancers to metastasis...
  17. doi request reprint Inhibition of Src impairs the growth of met-addicted gastric tumors
    Andrea Bertotti
    Division of Molecular Oncology and Laboratory of Functional Genomics, The Oncogenomics Center, Institute for Cancer Research and Treatment, University of Torino Medical School, Strada Provinciale 142, Candiolo, Turin, Italy
    Clin Cancer Res 16:3933-43. 2010
    ..We examined whether inhibition of Src tyrosine kinase, a downstream effector of the MET oncogene, can hinder the malignant properties of gastric tumors dependent on Met for growth and survival...
  18. ncbi request reprint p38 MAPK turns hepatocyte growth factor to a death signal that commits ovarian cancer cells to chemotherapy-induced apoptosis
    Nadia Coltella
    Laboratory of Cancer Genetics, Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Italy
    Int J Cancer 118:2981-90. 2006
    ..Therefore, the p38 MAPK pathway might be a suitable target to improve response to conventional chemotherapy in human ovarian cancer...
  19. ncbi request reprint An HGF-MSP chimera disassociates the trophic properties of scatter factors from their pro-invasive activity
    Paolo Michieli
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo, Torino, Italy
    Nat Biotechnol 20:488-95. 2002
    ..In an in vivo murine model of drug-induced nephrotoxicity, intravenous injection of recombinant Metron factor 1 prevented renal damage and preserved tubular integrity...
  20. ncbi request reprint The semaphorin 4D receptor controls invasive growth by coupling with Met
    Silvia Giordano
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy
    Nat Cell Biol 4:720-4. 2002
    ..This work identifies a novel biological function of semaphorins and suggests the involvement of an unexpected signalling mechanism, namely, the coupling of a plexin to a tyrosine kinase receptor...
  21. ncbi request reprint Scatter-factor and semaphorin receptors: cell signalling for invasive growth
    Livio Trusolino
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Italy
    Nat Rev Cancer 2:289-300. 2002
    ..What are the differences between physiological and pathological activation of these signalling molecules, and can we exploit them therapeutically to prevent metastasis?..
  22. ncbi request reprint The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness
    Piera Maggiora
    Laboratory of Cancer Genetics of the Institute for Cancer Research and Treatment, University of Torino School of Medicine, SP 142, Km 3 95, 10060 Candiolo Torino, Italy
    Exp Cell Res 288:382-9. 2003
    ..These data suggest that coexpression of the MET and RON receptors confer a selective advantage to ovarian cancer cells and might promote ovarian cancer progression...
  23. ncbi request reprint Cancer therapy: can the challenge be MET?
    Simona Corso
    IRCC, Institute for Cancer Research and Treatment, University of Turin School of Medicine, Division of Molecular Oncology, 10060 Candiolo, Turin, Italy
    Trends Mol Med 11:284-92. 2005
    ..Interfering with Met activation is thus a new and challenging approach to hamper tumorigenic and metastatic processes...
  24. pmc Prevention of hypoxia by myoglobin expression in human tumor cells promotes differentiation and inhibits metastasis
    Maria Galluzzo
    Laboratory of Experimental Therapy, Institute for Cancer Research and Treatment, University of Turin Medical School, Turin, Italy
    J Clin Invest 119:865-75. 2009
    ..Although limited to xenograft models, these data provide experimental proof of the concept that hypoxia is not just a side effect of deregulated growth but a key factor on which the tumor relies in order to promote its own expansion...
  25. ncbi request reprint The MET receptor tyrosine kinase in invasion and metastasis
    Silvia Benvenuti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo Torino, Italy
    J Cell Physiol 213:316-25. 2007
    ..Among those soluble factors a major position is exerted by hepatocyte growth factor (HGF) together with its receptor MET and macrophage-stimulating protein (MSP) in cooperation with its receptor RON...
  26. pmc The tumor suppressor semaphorin 3B triggers a prometastatic program mediated by interleukin 8 and the tumor microenvironment
    Charlotte Rolny
    Institute for Cancer Research and Treatment IRCC, University of Turin, School of Medicine, 10060 Candiolo, Italy
    J Exp Med 205:1155-71. 2008
    ..In conclusion, we report that SEMA3B exerts unexpected functions in cancer progression by fostering a prometastatic environment through elevated IL-8 secretion and recruitment of macrophages coupled to the suppression of tumor growth...
  27. pmc A high affinity hepatocyte growth factor-binding site in the immunoglobulin-like region of Met
    Cristina Basilico
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Turin Medical School, I 10060 Candiolo, Turin, Italy
    J Biol Chem 283:21267-77. 2008
    ..Although the IPT-HGF-alpha interaction provides binding strength, the Sema-HGF-beta contact confers selective sensitivity to the active form of the ligand...
  28. pmc Sema3E-Plexin D1 signaling drives human cancer cell invasiveness and metastatic spreading in mice
    Andrea Casazza
    Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    J Clin Invest 120:2684-98. 2010
    ..In sum, Sema3E-Plexin D1 signaling in cancer cells is crucially implicated in their metastatic behavior and may therefore be a promising target for strategies aimed at blocking tumor metastasis...
  29. ncbi request reprint Mutations in the met oncogene unveil a "dual switch" mechanism controlling tyrosine kinase activity
    Federica Chiara
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo, Torino, Italy
    J Biol Chem 278:29352-8. 2003
    ..This explains why mutant met provides an oncogenic predisposition but needs a second activating "hit," provided by sustained ligand stimulation or receptor overexpression, to achieve a fully transformed phenotype...
  30. doi request reprint MicroRNAs impair MET-mediated invasive growth
    Cristina Migliore
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Candiolo, Torino, Italy
    Cancer Res 68:10128-36. 2008
    ..In conclusion, we have identified miRNAs that behave as oncosuppressors by negatively targeting MET and might thus provide an additional option to inhibit this oncogene in tumors displaying its deregulation...
  31. ncbi request reprint MET overexpression turns human primary osteoblasts into osteosarcomas
    Salvatore Patanè
    Laboratory of Cancer Genetics, University of Turin School of Medicine, Candiolo Turin, Italy
    Cancer Res 66:4750-7. 2006
    ..These data show that MET overexpression is oncogenic and that it is essential for the maintenance of the cancer phenotype...
  32. doi request reprint Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer
    Francesca De Bacco
    IRCC Institute for Cancer Research at Candiolo, University of Turin Medical School, Candiolo, Italy
    J Natl Cancer Inst 103:645-61. 2011
    ..The MET oncogene encodes the hepatocyte growth factor (HGF) receptor and is known to drive "invasive growth", a regenerative and prosurvival program unduly activated in metastasis...
  33. doi request reprint Genetic link between cancer and thrombosis
    Carla Boccaccio
    Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Torino, Italy
    J Clin Oncol 27:4827-33. 2009
    ..Targeting the tumor procoagulant activity can fight not only a dangerous tumor adverse effect, but also the core mechanisms of cancer onset and progression...
  34. ncbi request reprint The Met pathway: master switch and drug target in cancer progression
    Massimiliano Mazzone
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, Strada Provinciale 142, Km 3 95, I 10060 Candiolo Torino, Italy
    FASEB J 20:1611-21. 2006
    ..As we suggest possible directions for drug development, we propose the receptor for the hepatocyte growth factor, Met, as an ideal target for tackling cancer progression...
  35. pmc The Slit/Robo system suppresses hepatocyte growth factor-dependent invasion and morphogenesis
    Maria Cristina Stella
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy
    Mol Biol Cell 20:642-57. 2009
    ....
  36. doi request reprint MET signalling: principles and functions in development, organ regeneration and cancer
    Livio Trusolino
    Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, 10060 Candiolo, Torino, Italy
    Nat Rev Mol Cell Biol 11:834-48. 2010
    ..Controlled activation of MET signalling can be exploited in regenerative medicine, whereas MET inhibition might slow down tumour progression...
  37. ncbi request reprint Invasive growth: a MET-driven genetic programme for cancer and stem cells
    Carla Boccaccio
    Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Str Prov 142, 10060 Candiolo, Italy
    Nat Rev Cancer 6:637-45. 2006
    ....
  38. pmc Plexin-B3 is a functional receptor for semaphorin 5A
    Stefania Artigiani
    Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, 10060 Candiolo To, Italy
    EMBO Rep 5:710-4. 2004
    ..We thus conclude that Sema5A is able to elicit multiple functional responses through its receptor plexin-B3...
  39. ncbi request reprint Targeting the tumor and its microenvironment by a dual-function decoy Met receptor
    Paolo Michieli
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, I 10060 Candiolo Torino, Italy
    Cancer Cell 6:61-73. 2004
    ....
  40. ncbi request reprint The MET oncogene drives a genetic programme linking cancer to haemostasis
    Carla Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Turin Medical School, Str Prov 142, I 10060 Candiolo, Torino, Italy
    Nature 434:396-400. 2005
    ..In vivo analysis showed that both proteins support the thrombohaemorrhagic phenotype, thus providing direct genetic evidence for the long-sought-after link between oncogene activation and haemostasis...
  41. pmc To move or not to move? Semaphorin signalling in cell migration
    Luca Tamagnone
    Institute for Cancer Research and Treatment, University of Turin Medical School IRCC, SP 142, 10060 Candiolo, Turin, Italy
    EMBO Rep 5:356-61. 2004
    ..This review focuses on the mechanisms whereby semaphorins are thought to regulate cell migration...
  42. pmc Negative feedback regulation of Met-dependent invasive growth by Notch
    M Cristina Stella
    Institute for Cancer Research and Treatment, University of Turin School of Medicine, Division of Molecular Oncology, IV Floor, Str Prov 142, km 3, 95, 10060 Candiolo, Torino, Italy
    Mol Cell Biol 25:3982-96. 2005
    ..These results unravel an in-built mechanism of negative feedback regulation in which Met activation leads to transcriptional induction of Notch function, which in turn limits HGF activity through repression of the Met oncogene...
  43. ncbi request reprint A functional role for hemostasis in early cancer development
    Carla Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Turino, Italy
    Cancer Res 65:8579-82. 2005
    ..These findings reveal a long-sought mechanistic link between coagulation and cancer, highlighting a clinically important perspective on malignant invasion and metastasis...
  44. ncbi request reprint Hepatocyte growth factor sensitizes human ovarian carcinoma cell lines to paclitaxel and cisplatin
    Andrea Rasola
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    Cancer Res 64:1744-50. 2004
    ..This suggests that HGF may be used to improve response to chemotherapy in a set of human ovarian carcinomas molecularly classified based on the MET oncogene expression...
  45. ncbi request reprint Invasive growth: a genetic program
    Alessandra Gentile
    IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy
    Int J Dev Biol 48:451-6. 2004
    ..Here we discuss the different biological facets of invasive growth and analyze the intracellular signals which lead to its execution...
  46. ncbi request reprint Beta4 integrin is a transforming molecule that unleashes Met tyrosine kinase tumorigenesis
    Andrea Bertotti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino School of Medicine, Candiolo Torino, Italy
    Cancer Res 65:10674-9. 2005
    ....
  47. doi request reprint Only a subset of Met-activated pathways are required to sustain oncogene addiction
    Andrea Bertotti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Torino Medical School, 10060 Candiolo Torino, Italy
    Sci Signal 2:ra80. 2009
    ....
  48. pmc Beta4 integrin activates a Shp2-Src signaling pathway that sustains HGF-induced anchorage-independent growth
    Andrea Bertotti
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060 Candiolo, Torino, Italy
    J Cell Biol 175:993-1003. 2006
    ..These results unravel a novel pathway whereby beta4 directs tyrosine kinase-based signals toward adhesion-unrelated outcomes...
  49. doi request reprint The Met tyrosine kinase receptor in development and cancer
    Alessandra Gentile
    Division of Molecular Oncology, University of Turin Medical School, 10060, Candiolo Torino, Italy
    Cancer Metastasis Rev 27:85-94. 2008
    ..Several approaches have been recently developed to interfere with the tumorigenic and metastatic processes triggered by Met...
  50. ncbi request reprint Functional regulation of semaphorin receptors by proprotein convertases
    Stefania Artigiani
    Institute for Cancer Research and Treatment IRCC, University of Torino School of Medicine, 10060 Candiolo, Italy
    J Biol Chem 278:10094-101. 2003
    ..Thus, we conclude that cleavage by proprotein convertases is a novel regulatory step for semaphorin receptors localized at the cell surface...
  51. ncbi request reprint Tyrosine kinase signal specificity: lessons from the HGF receptor
    Andrea Bertotti
    IRCC, Institute for Cancer Research and Treatment, University of Torino School of Medicine, 10060, Candiolo Torino, Italy
    Trends Biochem Sci 28:527-33. 2003
    ..This suggests that integration of cell-restricted expression of receptor partners that modulate kinase outputs with the intrinsic signalling features of receptors is required for specification of biological responses...
  52. pmc Molecular profiling of the "plexinome" in melanoma and pancreatic cancer
    Asha Balakrishnan
    Laboratory of Molecular Genetics, Institute for Cancer Research and Treatment, University of Torino Medical School, Candiolo, Italy
    Hum Mutat 30:1167-74. 2009
    ..5206C>T, p.H1736Y allele had lost this activity. Our study is the first systematic analysis of the "plexinome" in human tumors, and indicates that multiple mutated plexins may be involved in cancer progression...
  53. ncbi request reprint Reactive oxygen species mediate Met receptor transactivation by G protein-coupled receptors and the epidermal growth factor receptor in human carcinoma cells
    Oliver M Fischer
    Department of Molecular Biology, Max Planck Institute of Biochemistry, Am Klopferspitz 18a, D 82152 Martinsried, Germany
    J Biol Chem 279:28970-8. 2004
    ....
  54. ncbi request reprint Hepatocyte growth factor and its receptor are required for malaria infection
    Margarida Carrolo
    Instituto Gulbenkian de Ciencia, Rua da Quinta Grande 6, 2780 156 Oeiras, Portugal
    Nat Med 9:1363-9. 2003
    ..Our findings identify HGF and MET as potential targets for new approaches to malaria prevention...
  55. ncbi request reprint Feline STK gene expression in mammary carcinomas
    Raffaella De Maria
    Comparative Oncology Center, Institute for Cancer Research and Treatment, University of Torino, SP 142, Km 3 95, 10060 Candiolo Torino Italy
    Oncogene 21:1785-90. 2002
    ....
  56. ncbi request reprint The endophilin-CIN85-Cbl complex mediates ligand-dependent downregulation of c-Met
    Annalisa Petrelli
    CNR CIOS and Department of Genetics, Biology and Biochemistry, University of Torino, 10126 Torino, Italy
    Nature 416:187-90. 2002
    ..These data provide further evidence of a relationship between receptor-mediated signalling and endocytosis, and disclose a novel functional role for Cbl in HGF receptor signalling...
  57. doi request reprint Metron factor-1 prevents liver injury without promoting tumor growth and metastasis
    Terumi Takahara
    Third Department of Internal Medicine, Faculty of Medicine, University of Toyama, Toyama, Japan
    Hepatology 47:2010-25. 2008
    ....