L Capussotti

..A prospective randomised controlled trial was designed to evaluate the advantages of routine application of the anterior approach during right hepatectomy...

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..HCCs with PVTT or greater than 10 cm in size have very limited options of treatment; the favorable long-term results of our study suggest that they should undergo surgery if a radical resection can be achieved...

..Intraoperative blood loss was 1500 mL. The postoperative course was uneventful. The patient is doing well ten months after operation...

..Neoadjuvant chemotherapy can downstage the tumour and enable surgery in up to 38 per cent of patients whose tumours were initially considered irresectable...

..Its progression towards death and its relationship with sepsis are unclear. This study analysed predictors of mortality in patients with liver dysfunction and the role of sepsis in the death of these patients...

..Despite this progress, however, outcomes of hepatectomy in cirrhotic patients with portal hypertension are still uncertain. The aim of this study was to elucidate early and long-term outcomes of liver resection in these patients...

..The aim of this retrospective study was to analyze prognostic factors after synchronous and delayed liver resections to define selection criteria for choosing timing of hepatectomy...

..The knowledge of risk factors for bile leakage after liver resection could reduce its incidence...

..Surgical strategy in liver metastases synchronous to colorectal cancer remains controversial. The aim of this study was to evaluate feasibility and short-term outcomes of major hepatectomies synchronous to colorectal surgery...

..The current data agrees with the data for the only randomized study reported so far. Both suggest a better outcome for node-positive patients treated by laparoscopy...

..A subset of patients with peripancreatic positive nodes or invasion of adjacent organs seems to benefit from a synchronous pancreaticoduodenectomy...

..CONCLUSIONS: Patients with preserved liver function and small-size, single-node hepatocellular carcinomas are the best candidates for hepatic resection...

..Tumors less than 10cm in size and without satellite nodes are the best candidates for operation. The width of the resection margin is unimportant provided that there is no microscopic infiltration...

..The purpose of this study was to compare the perioperative outcome of liver resection with and without intermittent hepatic pedicle clamping...

..Spontaneous rupture of hepatocellular carcinoma (HCC) is a life-threatening event, particularly in patients with associated cirrhosis. We present our experience of hepatic resection of ruptured HCC...

..To evaluate the impact of postoperative injection into the hepatic artery of 131-iodine-labeled lipiodol on disease-free and overall survival rates in patients who underwent liver surgical resection for hepatocellular carcinoma...

..Portal vein ligation has been suggested to be less effective than embolization in inducing hypertrophy of the remnant liver. Design, Setting, and..

..Moreover, parenchymal sparing strategy allowed a higher re-resection rate in patients with liver recurrence...

..Resection of colorectal cancer in patients with moderate-severe symptoms is mandatory before starting chemotherapy. Surgical treatment of asymptomatic colorectal cancers is still a matter of discussion...

..The aim of this retrospective study is to analyse if an extended lymph node dissection (D2) without adjuvant radiotherapy may achieve comparable loco-regional recurrence rates...

..1% +/- 35.1%, respectively (P = .20 and P = .40). CONCLUSION: Extension of embolization to segment IV portal branches should not be routinely used because a similar volume increase of segments II-III can be simply achieved by right PVE...

..Extended resection permitted better pathological staging and was associated with an early advantage in survival, but long-term survival was possible only in patients with favorable prognostic factors...

..To compare the diagnostic accuracy of single section spiral computed tomography (CT) and magnetic resonance imaging (MRI) with tissue-specific contrast agent mangafodipir trisodium (MnDPDP) in the detection of colorectal liver metastases...

..Objective response, median survival, and local and systemic control are similar to other studies and need further improvement...

..To evaluate the short and long-term results of surgical treatment of calcifying chronic pancreatitis in our center...

..The aim of this study was to analyze 10-year survival outcome in terms of late recurrence rate and prognostic factors of survival...

..The two techniques seem to be comparable in terms of ischemic injury. Our findings suggest that intermittent portal triad clamping may not be necessary. As this is contrary to the normal expectancy, additional studies may be needed...

..Perioperative steroid administration has been advocated to reduce liver damage. The aim of this prospective, randomized study was to determine whether steroid administration can reduce liver injury and improve short-term outcome...

..The seventh TNM edition introduced a new, specific staging structure for intrahepatic cholangiocarcinoma (IHC)...

..The future remnant liver (FRL) limit for safe major hepatectomy with low risk of postoperative liver failure has not yet been well defined...

..The purpose of this original article was to evaluate the impact of the Pringle maneuver on the survival of patients with colorectal liver metastases...

..Liver surgery for colorectal metastases has moved toward parenchymal sparing strategy with an increasing number of conservative resections. The aim of this study was to elucidate outcomes of bisegmentectomies for right liver metastases...

..The risks associated with the conservative management of bile leakage after hepatectomy and associated cholangiojejunostomy are not well defined...

..The objective of this study is to compare the perioperative outcome of liver resection for carcinoma involving the proximal bile duct in jaundiced patients with and without preoperative biliary drainage...

..1% for the years 2000, 1999, 1998, respectively; 0% for cases embedded during 1997. According to these results, the reliability of the FISH and immunohistochemical assays decreases after prolonged storage of paraffin-embedded specimens...

..Long-term results of liver resections for HCC in the elderly may be even better than in younger patients...

..The most accepted treatment for locally advanced pancreatic cancer is chemoradiotherapy. However, indications to and results of pancreatic resections after chemoradiation are not yet defined...

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..Preservation of hepatic parenchyma should be attempted whenever possible in order to reduce the risk of liver failure and increase the chance to re-resect the recurrence...

..Intraoperative ultrasonography (IOUS) is mandatory, but reliability of laparoscopic IOUS has been poorly evaluated. The aim of this study was to compare laparoscopic versus open IOUS in staging liver tumours...

..Use of recurrence-free survival (RFS) may overcome this limitation. The aim of this study is to evaluate the impact of width of resection margin on RFS and site of recurrence after hepatic resection for colorectal metastases (CRM)...

..CONCLUSIONS: Achievement of low in-hospital mortality rates is possible in specialized surgical departments. Aggressive surgical approaches can allow better longterm results in the subset of Bismuth type I-II carcinomas...

..Nonalcoholic steatohepatitis (NASH) may progress to cirrhosis; whether NASH plays also a role in the development of hepatocellular carcinoma (HCC) is unknown...

..However, patients resected after chemotherapy obtained overall survival similar to that of primary surgery, suggesting a positive role for integrated approaches...

..3; 95% CI: 0.09-0.9; P = .04). In conclusion, IFN does not affect overall prevention of HCC recurrence after resection, but it may reduce late recurrence in HCV-pure patients receiving effective treatment...

..The aim of this study is to evaluate long-term results of reresections after prior non-curative surgery for T2 carcinomas...

..Bile leakage after hepatectomy usually has spontaneous healing, but some patients require interventional procedures. To identify early predictive factors of conservative management failure...

..A randomized clinical trial was performed to compare D1 and D2 gastrectomy in specialized Western centres. This paper reports short-term results...

..The aim of this study was to evaluate the short- and longterm results in patients who had undergone extensive hepatectomies...

..Therefore, we analyzed EGFR mutations and related pathways in gallbladder and bile duct carcinomas to consider the possible application of these alternative therapeutic strategies...

..To examine clinical features and outcome of patients who underwent hepatic resection for colorectal liver metastases (LM) involving the caudate lobe...

..No standard definition of PHI has been established, but one is essential for meaningful comparison of outcomes data across studies...

..Chemotherapy before resection of hepatic colorectal metastases (CRM) may cause hepatic injury and affect postoperative outcome...

..However, the clinical relevance of asymptomatic venography-detected DVT is unclear, and the population of these clinical trials is not necessarily representative of the overall cancer surgery population...

..A predicted margin of <1 cm after resection of hepatic colorectal metastases should not be used as an exclusion criterion for resection...

..Resection should be performed as part of a multidisciplinary approach, because recurrence is common...

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..AR is not superior to WR in terms of tumor clearance, pattern of recurrence, or survival. WR should remain an integral component of the surgical treatment of CLM...