Research Topics
Species | Carla BoccaccioSummaryAffiliation: Institute for Cancer Research and Treatment Country: Italy Publications
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Detail Information
Publications
The MET oncogene drives a genetic programme linking cancer to haemostasisCarla Boccaccio
Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Turin Medical School, Str Prov 142, I 10060 Candiolo, Torino, Italy
Nature 434:396-400. 2005..In vivo analysis showed that both proteins support the thrombohaemorrhagic phenotype, thus providing direct genetic evidence for the long-sought-after link between oncogene activation and haemostasis...
Genetic link between cancer and thrombosisCarla Boccaccio
Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Torino, Italy
J Clin Oncol 27:4827-33. 2009..Targeting the tumor procoagulant activity can fight not only a dangerous tumor adverse effect, but also the core mechanisms of cancer onset and progression...- Invasive growth: a MET-driven genetic programme for cancer and stem cellsCarla Boccaccio
Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Str Prov 142, 10060 Candiolo, Italy
Nat Rev Cancer 6:637-45. 2006.... - Cancer and blood coagulationC Boccaccio
Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Str Prov 142, 10060 Candiolo, Italy
Cell Mol Life Sci 63:1024-7. 2006..Fibrin can indeed build up a provisional matrix, supporting the invasive growth of neoplastic tissues and blood vessels. Interference with blood coagulation can thus be considered as part of a multifaceted therapeutic approach to cancer... - A functional role for hemostasis in early cancer developmentCarla Boccaccio
Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Turino, Italy
Cancer Res 65:8579-82. 2005..These findings reveal a long-sought mechanistic link between coagulation and cancer, highlighting a clinically important perspective on malignant invasion and metastasis... - Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancerFrancesca De Bacco
IRCC Institute for Cancer Research at Candiolo, University of Turin Medical School, Candiolo, Italy
J Natl Cancer Inst 103:645-61. 2011..The MET oncogene encodes the hepatocyte growth factor (HGF) receptor and is known to drive "invasive growth", a regenerative and prosurvival program unduly activated in metastasis... - The MET oncogene is a functional marker of a glioblastoma stem cell subtypeFrancesca De Bacco
IRCC Institute for Cancer Research, Center for Experimental Clinical Molecular Oncology, University of Turin Medical School, Candiolo, Italy
Cancer Res 72:4537-50. 2012..Together, our findings suggest that Met is a functional marker of glioblastoma stem cells and a candidate target for identification and therapy of a subset of glioblastomas... - A differentiation switch for genetically modified hepatocytesCarla Boccaccio
Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
FASEB J 16:120-2. 2002.... - Scatter factor-dependent branching morphogenesis: structural and histological featuresP Comoglio
Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, Torino, Italy
Eur J Histochem 51:79-92. 2007.... - Interactions between growth factor receptors and adhesion molecules: breaking the rulesPaolo M Comoglio
Institute for Cancer Research and Treatment, University of Torino School of Medicine, Strada Provinciale 142, 10060 Candiolo Torino, Italy
Curr Opin Cell Biol 15:565-71. 2003.... - Scatter factors and invasive growthP M Comoglio
Division of Molecular Oncology, IRCC, Institute for Cancer Research, Str Provinciale 142, Km 3 95, Candiolo TO, 10060, Italy
Semin Cancer Biol 11:153-65. 2001..Here we discuss how alterations of these receptors or of their signal transduction pathways are responsible for cancer onset and progression towards metastasis... - Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growthP M Comoglio
Institute for Cancer Research and Treatment, University of Turin School of Medicine, Candiolo, 10060, Italy
Exp Cell Res 253:88-99. 1999..Deregulated activation of PRGF or semaphorin ligands or receptors, by mutation or overexpression, confers to cancer cells invasive and metastatic properties... - Induction of epithelial tubules by growth factor HGF depends on the STAT pathwayC Boccaccio
Institute for Cancer Research, University of Torino Medical School, Candiolo, Italy
Nature 391:285-8. 1998..Activation of signal transducers that directly control transcription is therefore required for morphogenesis... - Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectorsA Follenzi
Laboratory for Gene Transfer and Therapy, Institute for Cancer Research and Treatment, University of Turin Medical School, 10060 Candiolo (Turin, Italy
Hum Gene Ther 13:243-60. 2002.... - HGF/scatter factor selectively promotes cell invasion by increasing integrin avidityL Trusolino
Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
FASEB J 14:1629-40. 2000..These data suggest that HGF/SF promotes cell adhesion and invasiveness by increasing the avidity of integrins for their specific ligands...