Carla Boccaccio

Summary

Affiliation: Institute for Cancer Research and Treatment
Country: Italy

Publications

  1. pmc The MET Oncogene as a Therapeutical Target in Cancer Invasive Growth
    Paolo Luraghi
    Division of Experimental Clinical Molecular Oncology, IRCC Institute for Cancer Research and Treatment, University of Turin Medical School Candiolo, Italy
    Front Pharmacol 3:164. 2012
  2. doi The MET oncogene in glioblastoma stem cells: implications as a diagnostic marker and a therapeutic target
    Carla Boccaccio
    Institute for Cancer Research at Candiolo, Center for Experimental Clinical Molecular Oncology, University of Turin Medical School, Candiolo, Italy
    Cancer Res 73:3193-9. 2013
  3. ncbi Cancer and blood coagulation
    C Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Str Prov 142, 10060 Candiolo, Italy
    Cell Mol Life Sci 63:1024-7. 2006
  4. ncbi Genetic link between cancer and thrombosis
    Carla Boccaccio
    Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Torino, Italy
    J Clin Oncol 27:4827-33. 2009
  5. ncbi Invasive growth: a MET-driven genetic programme for cancer and stem cells
    Carla Boccaccio
    Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Str Prov 142, 10060 Candiolo, Italy
    Nat Rev Cancer 6:637-45. 2006
  6. ncbi The MET oncogene drives a genetic programme linking cancer to haemostasis
    Carla Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Turin Medical School, Str Prov 142, I 10060 Candiolo, Torino, Italy
    Nature 434:396-400. 2005
  7. ncbi A functional role for hemostasis in early cancer development
    Carla Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Turino, Italy
    Cancer Res 65:8579-82. 2005
  8. doi Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer
    Francesca De Bacco
    IRCC Institute for Cancer Research at Candiolo, University of Turin Medical School, Candiolo, Italy
    J Natl Cancer Inst 103:645-61. 2011
  9. ncbi MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors
    Paolo Luraghi
    Authors Affiliations Institute for Cancer Research at Candiolo IRCC, Center for Experimental Clinical Molecular Oncology Department of Oncology, University of Torino, Candiolo, Torino, Italy Aveo Oncology Inc, Cambridge, Massachusetts and Janssen Research and Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium
    Cancer Res 74:1857-69. 2014
  10. ncbi The MET oncogene is a functional marker of a glioblastoma stem cell subtype
    Francesca De Bacco
    IRCC Institute for Cancer Research, Center for Experimental Clinical Molecular Oncology, University of Turin Medical School, Candiolo, Italy
    Cancer Res 72:4537-50. 2012

Collaborators

Detail Information

Publications18

  1. pmc The MET Oncogene as a Therapeutical Target in Cancer Invasive Growth
    Paolo Luraghi
    Division of Experimental Clinical Molecular Oncology, IRCC Institute for Cancer Research and Treatment, University of Turin Medical School Candiolo, Italy
    Front Pharmacol 3:164. 2012
    ..The tight interplay of MET with the protease network has unveiled mechanisms to be exploited to achieve effective inhibition of invasive growth...
  2. doi The MET oncogene in glioblastoma stem cells: implications as a diagnostic marker and a therapeutic target
    Carla Boccaccio
    Institute for Cancer Research at Candiolo, Center for Experimental Clinical Molecular Oncology, University of Turin Medical School, Candiolo, Italy
    Cancer Res 73:3193-9. 2013
    ..Finally, we discuss issues related to identification of tumorigenic clones driven by MET in the context of genetically heterogeneous tumors and strategies aimed at eradicating cancer stem cells...
  3. ncbi Cancer and blood coagulation
    C Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Str Prov 142, 10060 Candiolo, Italy
    Cell Mol Life Sci 63:1024-7. 2006
    ..Fibrin can indeed build up a provisional matrix, supporting the invasive growth of neoplastic tissues and blood vessels. Interference with blood coagulation can thus be considered as part of a multifaceted therapeutic approach to cancer...
  4. ncbi Genetic link between cancer and thrombosis
    Carla Boccaccio
    Institute for Cancer Research and Treatment, University of Turin Medical School, Candiolo, Torino, Italy
    J Clin Oncol 27:4827-33. 2009
    ..Targeting the tumor procoagulant activity can fight not only a dangerous tumor adverse effect, but also the core mechanisms of cancer onset and progression...
  5. ncbi Invasive growth: a MET-driven genetic programme for cancer and stem cells
    Carla Boccaccio
    Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Str Prov 142, 10060 Candiolo, Italy
    Nat Rev Cancer 6:637-45. 2006
    ....
  6. ncbi The MET oncogene drives a genetic programme linking cancer to haemostasis
    Carla Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment, University of Turin Medical School, Str Prov 142, I 10060 Candiolo, Torino, Italy
    Nature 434:396-400. 2005
    ..In vivo analysis showed that both proteins support the thrombohaemorrhagic phenotype, thus providing direct genetic evidence for the long-sought-after link between oncogene activation and haemostasis...
  7. ncbi A functional role for hemostasis in early cancer development
    Carla Boccaccio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Turino, Italy
    Cancer Res 65:8579-82. 2005
    ..These findings reveal a long-sought mechanistic link between coagulation and cancer, highlighting a clinically important perspective on malignant invasion and metastasis...
  8. doi Induction of MET by ionizing radiation and its role in radioresistance and invasive growth of cancer
    Francesca De Bacco
    IRCC Institute for Cancer Research at Candiolo, University of Turin Medical School, Candiolo, Italy
    J Natl Cancer Inst 103:645-61. 2011
    ..The MET oncogene encodes the hepatocyte growth factor (HGF) receptor and is known to drive "invasive growth", a regenerative and prosurvival program unduly activated in metastasis...
  9. ncbi MET signaling in colon cancer stem-like cells blunts the therapeutic response to EGFR inhibitors
    Paolo Luraghi
    Authors Affiliations Institute for Cancer Research at Candiolo IRCC, Center for Experimental Clinical Molecular Oncology Department of Oncology, University of Torino, Candiolo, Torino, Italy Aveo Oncology Inc, Cambridge, Massachusetts and Janssen Research and Development, a division of Janssen Pharmaceutica NV, Beerse, Belgium
    Cancer Res 74:1857-69. 2014
    ..By showing that RAS(wt) CCICs rely on both EGFR and MET signaling, our results offer a strong preclinical proof-of-concept for concurrent targeting of these two pathways in the clinical setting...
  10. ncbi The MET oncogene is a functional marker of a glioblastoma stem cell subtype
    Francesca De Bacco
    IRCC Institute for Cancer Research, Center for Experimental Clinical Molecular Oncology, University of Turin Medical School, Candiolo, Italy
    Cancer Res 72:4537-50. 2012
    ..Together, our findings suggest that Met is a functional marker of glioblastoma stem cells and a candidate target for identification and therapy of a subset of glioblastomas...
  11. ncbi A differentiation switch for genetically modified hepatocytes
    Carla Boccaccio
    Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
    FASEB J 16:120-2. 2002
    ....
  12. ncbi Scatter factor-dependent branching morphogenesis: structural and histological features
    P Comoglio
    Division of Molecular Oncology, Institute for Cancer Research and Treatment IRCC, University of Turin Medical School, Candiolo, Torino, Italy
    Eur J Histochem 51:79-92. 2007
    ....
  13. ncbi Interactions between growth factor receptors and adhesion molecules: breaking the rules
    Paolo M Comoglio
    Institute for Cancer Research and Treatment, University of Torino School of Medicine, Strada Provinciale 142, 10060 Candiolo Torino, Italy
    Curr Opin Cell Biol 15:565-71. 2003
    ....
  14. ncbi Scatter factors and invasive growth
    P M Comoglio
    Division of Molecular Oncology, IRCC, Institute for Cancer Research, Str Provinciale 142, Km 3 95, Candiolo TO, 10060, Italy
    Semin Cancer Biol 11:153-65. 2001
    ..Here we discuss how alterations of these receptors or of their signal transduction pathways are responsible for cancer onset and progression towards metastasis...
  15. ncbi Plasminogen-related growth factor and semaphorin receptors: a gene superfamily controlling invasive growth
    P M Comoglio
    Institute for Cancer Research and Treatment, University of Turin School of Medicine, Candiolo, 10060, Italy
    Exp Cell Res 253:88-99. 1999
    ..Deregulated activation of PRGF or semaphorin ligands or receptors, by mutation or overexpression, confers to cancer cells invasive and metastatic properties...
  16. ncbi Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
    C Boccaccio
    Institute for Cancer Research, University of Torino Medical School, Candiolo, Italy
    Nature 391:285-8. 1998
    ..Activation of signal transducers that directly control transcription is therefore required for morphogenesis...
  17. ncbi Efficient gene delivery and targeted expression to hepatocytes in vivo by improved lentiviral vectors
    A Follenzi
    Laboratory for Gene Transfer and Therapy, Institute for Cancer Research and Treatment, University of Turin Medical School, 10060 Candiolo Turin, Italy
    Hum Gene Ther 13:243-60. 2002
    ....
  18. ncbi HGF/scatter factor selectively promotes cell invasion by increasing integrin avidity
    L Trusolino
    Institute for Cancer Research and Treatment, University of Torino Medical School, 10060 Candiolo Torino, Italy
    FASEB J 14:1629-40. 2000
    ..These data suggest that HGF/SF promotes cell adhesion and invasiveness by increasing the avidity of integrins for their specific ligands...