Affiliation: Institute of Food Science
Bergamo P, Maurano F, Rossi M. Phase 2 enzyme induction by conjugated linoleic acid improves lupus-associated oxidative stress. Free Radic Biol Med. 2007;43:71-9 pubmed
..In conclusion our data indicate that the activation of detoxifying enzymes may be one of the mechanisms whereby dietary CLA down-regulates oxidative stress in MRL/lpr mice. ..
Bergamo P, Luongo D, Maurano F, Mazzarella G, Stefanile R, Rossi M. Conjugated linoleic acid enhances glutathione synthesis and attenuates pathological signs in MRL/MpJ-Fas(lpr) mice. J Lipid Res. 2006;47:2382-91 pubmed
..In conclusion, enhanced GSH content and GCLC expression in CLA-treated mice suggest a novel biochemical mechanism underlying its immunomodulatory activity and the beneficial effects on murine SLE signs. ..
Bergamo P, Maurano F, D Arienzo R, David C, Rossi M. Association between activation of phase 2 enzymes and down-regulation of dendritic cell maturation by c9,t11-conjugated linoleic acid. Immunol Lett. 2008;117:181-90 pubmed publisher
..These results demonstrate that c9,t11-CLA renders DCs more resistant to gliadin- or LPS-induced maturation, thus indicating that a cytoprotective mechanism elicited by c9,t11-CLA may modulate DC responsiveness. ..
Bergamo P, Gogliettino M, Palmieri G, Cocca E, Maurano F, Stefanile R, et al
. Conjugated linoleic acid protects against gliadin-induced depletion of intestinal defenses. Mol Nutr Food Res. 2011;55 Suppl 2:S248-56 pubmed publisher
..The beneficial effects of CLA against the depletion of crucial intestinal cytoprotective defenses indicates a novel nutritional approach for the treatment of intestinal disease associated with altered redox homeostasis. ..
Bergamo P, Palmieri G, Cocca E, Ferrandino I, Gogliettino M, Monaco A, et al
. Adaptive response activated by dietary cis9, trans11 conjugated linoleic acid prevents distinct signs of gliadin-induced enteropathy in mice. Eur J Nutr. 2016;55:729-740 pubmed publisher
..The activation of and adaptive response by low doses of c9 supplementation prevents distinct signs of gliadin-induced enteropathy in DQ8 mice. ..
Bergamo P, Cocca E, Monaco A, Cozzolino V, Boscaino F, Ferrandino I, et al
. Protective effect of Rumenic acid rich cow's milk against colitis is associated with the activation of Nrf2 pathway in a murine model. Prostaglandins Leukot Essent Fatty Acids. 2017;125:14-23 pubmed publisher
..01) and macroscopic signs triggered by DSS. It can be concluded that Nrf2 activation by higher RA amount contained in En is, at least in part, responsible for the improved protection associated with En intake against DSS-induced colitis. ..
Monaco A, Ferrandino I, Boscaino F, Cocca E, Cigliano L, Maurano F, et al
. Conjugated linoleic acid prevents age-dependent neurodegeneration in a mouse model of neuropsychiatric lupus via the activation of an adaptive response. J Lipid Res. 2018;59:48-57 pubmed publisher