Maria Grazia Andreassi

Summary

Affiliation: Institute of Clinical Physiology
Country: Italy

Publications

  1. ncbi request reprint Cardiac imaging: the biological effects of diagnostic cardiac ultrasound
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, Pisa, Italy
    Prog Biophys Mol Biol 93:399-410. 2007
  2. ncbi request reprint Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease
    Maria Grazia Andreassi
    CNR, Institute of Clinical Physiology, Pisa, Italy
    Eur Heart J 27:2703-8. 2006
  3. doi request reprint N-acetyl cysteine reduces chromosomal DNA damage in circulating lymphocytes during cardiac catheterization procedures: a pilot study
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, Massa and Pisa, Italy
    Int J Cardiol 161:93-6. 2012
  4. doi request reprint Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease
    Maria Grazia Andreassi
    CNR Istituto di Fisiologia Clinica, Pisa, Italy
    Atherosclerosis 223:409-15. 2012
  5. pmc Effects of external irradiation of the neck region on intima media thickness of the common carotid artery
    Maria Elena Gianicolo
    Radiotherapy Department, ASL Brindisi, Ospedale Perrino, Brindisi, Italy
    Cardiovasc Ultrasound 8:8. 2010
  6. ncbi request reprint AMPD1 (C34T) polymorphism and clinical outcomes in patients undergoing myocardial revascularization
    Maria Grazia Andreassi
    Institute of Clinical Physiology, Pisa, Italy
    Int J Cardiol 101:191-5. 2005
  7. pmc The biological effects of diagnostic cardiac imaging on chronically exposed physicians: the importance of being non-ionizing
    Maria Grazia Andreassi
    Laboratory of Cellular Biology and Genetics, CNR Institute of Clinical Physiology, Pisa, Italy
    Cardiovasc Ultrasound 2:25. 2004
  8. doi request reprint DNA damage, vascular senescence and atherosclerosis
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe 54100, Massa, Italy
    J Mol Med (Berl) 86:1033-43. 2008
  9. ncbi request reprint Diabetes and chronic nitrate therapy as co-determinants of somatic DNA damage in patients with coronary artery disease
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Mol Med (Berl) 83:279-86. 2005
  10. ncbi request reprint Somatic DNA damage in interventional cardiologists: a case-control study
    Maria Grazia Andreassi
    Institute of Clinical Physiology CNR, Pisa, Italy
    FASEB J 19:998-9. 2005

Collaborators

Detail Information

Publications70

  1. ncbi request reprint Cardiac imaging: the biological effects of diagnostic cardiac ultrasound
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, Pisa, Italy
    Prog Biophys Mol Biol 93:399-410. 2007
    ....
  2. ncbi request reprint Cardiac catheterization and long-term chromosomal damage in children with congenital heart disease
    Maria Grazia Andreassi
    CNR, Institute of Clinical Physiology, Pisa, Italy
    Eur Heart J 27:2703-8. 2006
    ..Chromosomal aberrations test (CA) and micronucleus assay (MN) in peripheral blood lymphocytes are biomarkers of chromosomal damage and intermediate endpoints in carcinogenesis...
  3. doi request reprint N-acetyl cysteine reduces chromosomal DNA damage in circulating lymphocytes during cardiac catheterization procedures: a pilot study
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, Massa and Pisa, Italy
    Int J Cardiol 161:93-6. 2012
    ..We examined the ability of NAC to confer protection against radiation-induced chromosomal DNA damage during cardiac catheterization procedures...
  4. doi request reprint Individual and summed effects of high-risk genetic polymorphisms on recurrent cardiovascular events following ischemic heart disease
    Maria Grazia Andreassi
    CNR Istituto di Fisiologia Clinica, Pisa, Italy
    Atherosclerosis 223:409-15. 2012
    ..However, their influence on prognosis remains uncertain. The aim of the study was to investigate the impact of previously identified SNPs and their joint effects in a genetic score (GS) on Major Adverse Cardiac Events (MACEs)...
  5. pmc Effects of external irradiation of the neck region on intima media thickness of the common carotid artery
    Maria Elena Gianicolo
    Radiotherapy Department, ASL Brindisi, Ospedale Perrino, Brindisi, Italy
    Cardiovasc Ultrasound 8:8. 2010
    ....
  6. ncbi request reprint AMPD1 (C34T) polymorphism and clinical outcomes in patients undergoing myocardial revascularization
    Maria Grazia Andreassi
    Institute of Clinical Physiology, Pisa, Italy
    Int J Cardiol 101:191-5. 2005
    ..C34T variant of adenosine monophosphate deaminase 1 (AMPD1) gene has been associated with a prolonged survival in heart failure and coronary artery disease, hypothetically linked to an enhanced production of adenosine...
  7. pmc The biological effects of diagnostic cardiac imaging on chronically exposed physicians: the importance of being non-ionizing
    Maria Grazia Andreassi
    Laboratory of Cellular Biology and Genetics, CNR Institute of Clinical Physiology, Pisa, Italy
    Cardiovasc Ultrasound 2:25. 2004
    ..Furthermore, the use of a biological dosimeter could be a reliable tool for the risk quantification on an individual basis...
  8. doi request reprint DNA damage, vascular senescence and atherosclerosis
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe 54100, Massa, Italy
    J Mol Med (Berl) 86:1033-43. 2008
    ..Prevention of DNA-damage-induced cellular vascular senescence may be a novel target for the clinical treatment of atherosclerosis...
  9. ncbi request reprint Diabetes and chronic nitrate therapy as co-determinants of somatic DNA damage in patients with coronary artery disease
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Mol Med (Berl) 83:279-86. 2005
    ..DNA damage might represent an additional pathogenetic dimension and a possible therapeutic target in the still challenging management of coronary artery disease concerning diabetics...
  10. ncbi request reprint Somatic DNA damage in interventional cardiologists: a case-control study
    Maria Grazia Andreassi
    Institute of Clinical Physiology CNR, Pisa, Italy
    FASEB J 19:998-9. 2005
    ....
  11. doi request reprint Genetic polymorphisms in XRCC1, OGG1, APE1 and XRCC3 DNA repair genes, ionizing radiation exposure and chromosomal DNA damage in interventional cardiologists
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, National Research Council, Pisa, Italy
    Mutat Res 666:57-63. 2009
    ..3, p=0.02). XRCC3 241Met alleles, particularly in combination with multiple risk alleles of DNA repair genes, contribute to chromosomal DNA damage levels in interventional cardiologists...
  12. ncbi request reprint Factor V Leiden, prothrombin G20210A substitution and hormone therapy: indications for molecular screening
    Maria Grazia Andreassi
    Laboratory of Cellular Biology and Genetics, CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Clin Chem Lab Med 44:514-21. 2006
    ..The purpose of this article is to discuss the usefulness and practical applications of thrombotic genetic testing to identify which women should be tested to improve both the safety and efficacy of individualized estrogen therapy...
  13. doi request reprint The association of micronucleus frequency with obesity, diabetes and cardiovascular disease
    Maria Grazia Andreassi
    GENETICS RESEARCH UNIT, Institute of Clinical Physiology, Italian National Research Council, Via Moruzzi 1, 56126 Pisa, Italy
    Mutagenesis 26:77-83. 2011
    ..Large population-based cohorts are needed in order to compare the MN frequencies as well as to better define whether MN is a biomarker or a mediator of cardiometabolic diseases...
  14. ncbi request reprint DNA damage as a new emerging risk factor in atherosclerosis
    Maria Grazia Andreassi
    Laboratory of Cellular Biology, CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Trends Cardiovasc Med 13:270-5. 2003
    ..It follows that the study of DNA damage may provide new insights into the pathogenesis of atherosclerosis and lead to the development of novel therapeutic approaches...
  15. ncbi request reprint Acute chromosomal DNA damage in human lymphocytes after radiation exposure in invasive cardiovascular procedures
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Eur Heart J 28:2195-9. 2007
    ..We evaluated whether radiation exposure during interventional cardiovascular procedures can induce damage to deoxyribonucleic acid (DNA)...
  16. ncbi request reprint Deoxyribonucleic acid damage in human lymphocytes after percutaneous transluminal coronary angioplasty
    Maria Grazia Andreassi
    Laboratory of Cellular Biology, CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    J Am Coll Cardiol 40:862-8. 2002
    ..BACKGROUND; Although it has recognized that ischemia-reperfusion can induce oxidative DNA damage, its occurrence in patients undergoing PTCA has not yet been demonstrated...
  17. doi request reprint Metabolic syndrome, diabetes and atherosclerosis: influence of gene-environment interaction
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud, Massa, Italy
    Mutat Res 667:35-43. 2009
    ..Such knowledge may be particularly relevant for improving cardiovascular risk stratification and conceiving the development of "personalized intervention program"...
  18. ncbi request reprint Genetic polymorphisms in folate and homocysteine metabolism as risk factors for DNA damage
    Nicoletta Botto
    CNR, Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Eur J Hum Genet 11:671-8. 2003
    ..2+/-3.6 vs 13.8+/-4.0 and 10.3+/-1.7, respectively; P=NS). Our results indicate that genetic instability may be associated with increased risk for multiple Hcy-related diseases...
  19. ncbi request reprint GSTM1, GSTT1 and CYP1A1 detoxification gene polymorphisms and susceptibility to smoking-related coronary artery disease: a case-only study
    Samantha Manfredi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Mutat Res 621:106-12. 2007
    ..Exploring gene-smoking effect provides an excellent model in order to understand gene-environment toxicants interaction and its implications to cardiovascular disease...
  20. ncbi request reprint Interactive effect of the glutathione S-transferase genes and cigarette smoking on occurrence and severity of coronary artery risk
    Serena Masetti
    Sant Anna School, Pisa, Italy
    J Mol Med (Berl) 81:488-94. 2003
    ..These observations suggest that GST-null genotypes strengthen the effect of smoking on CAD risk by modulating the detoxification of genotoxic atherogens...
  21. doi request reprint Cumulative patient effective dose and acute radiation-induced chromosomal DNA damage in children with congenital heart disease
    Lamia Ait-Ali
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Heart 96:269-74. 2010
    ..The seventh Committee on "Biological Effects of Ionizing Radiation" (BEIR VII, 2006) underlines "the need of studies of infants who are exposed to diagnostic radiation because catheters have been placed in their hearts"...
  22. ncbi request reprint Methylenetetrahydrofolate reductase gene C677T polymorphism, homocysteine, vitamin B12, and DNA damage in coronary artery disease
    Maria Grazia Andreassi
    Laboratory of Cellular Biology, CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Hum Genet 112:171-7. 2003
    ..429, P=0.005). These data indicate that the MN index is associated with the severity of CAD and is related to the MTHFR polymorphism, suggesting an interesting link between coronary atherosclerosis and genetic instability in humans...
  23. doi request reprint Maternal environmental exposure, infant GSTP1 polymorphism, and risk of isolated congenital heart disease
    Monica Cresci
    Unità di Ricerca Genetica, G Pasquinucci Hospital, CNR Istituto di Fisiologia Clinica, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Pediatr Cardiol 34:281-5. 2013
    ..Maternal exposure to toxicants increased the risk of children with CHD. However, fetal GSTP1 Ile105Val polymorphism did not increase the risk of CHD...
  24. ncbi request reprint C677T polymorphism of the methylenetetrahydrofolate reductase gene is a risk factor of adverse events after coronary revascularization
    Nicoletta Botto
    CNR, Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe 54100, Massa, Italy
    Int J Cardiol 96:341-5. 2004
    ..The aim of this study was to investigate whether C677T polymorphism can be a predictor of major adverse cardiac events after myocardial revascularization...
  25. doi request reprint Maternal and paternal environmental risk factors, metabolizing GSTM1 and GSTT1 polymorphisms, and congenital heart disease
    Monica Cresci
    National Research Council Institute of Clinical Physiology, Massa, Italy
    Am J Cardiol 108:1625-31. 2011
    ..In conclusion, paternal smoking and exposure to toxicants for both parents affect the risk of children with CHD. Polymorphisms in GST genes can modify a person's risk of toxicant exposure-induced disease...
  26. doi request reprint Glutathione S-transferase T1- and M1-null genotypes and coronary artery disease risk in patients with Type 2 diabetes mellitus
    Samantha Manfredi
    National Research Council, Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Pharmacogenomics 10:29-34. 2009
    ..We assessed the potential glutathione S-transferase (GST) gene-gene (GSTM1(null)-GSTT1(null)) and gene-smoking interactions on the development of CAD in patients with Type 2 diabetes...
  27. ncbi request reprint Endothelial nitric oxide synthase gene polymorphisms and risk of coronary artery disease
    Maria Giovanna Colombo
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Clin Chem 49:389-95. 2003
    ..This study investigated the relationship of the eNOS Glu(298)-->Asp and T(786)-->C polymorphisms with the presence and severity of CAD in the Italian population...
  28. pmc T(-786)→C polymorphism of the endothelial nitric oxide synthase gene is associated with insulin resistance in patients with ischemic or non ischemic cardiomyopathy
    Cecilia Vecoli
    CNR, Institute of Clinical Physiology, Pisa, Italy
    BMC Med Genet 13:92. 2012
    ..Aim of the study was to assess the reciprocal relationships between T(-786)→C eNOS polymorphism and IR in ischemic and non-ischemic cardiomyopathy...
  29. pmc Sequencing of NOTCH1, GATA5, TGFBR1 and TGFBR2 genes in familial cases of bicuspid aortic valve
    Ilenia Foffa
    CNR Istituto di Fisiologia Clinica, Via Moruzzi 1, Pisa 56124, Italy
    BMC Med Genet 14:44. 2013
    ..The purpose of our study was to investigate the potential contribution of germline mutations in NOTCH1, GATA5 and TGFBR1 and TGFBR2 genes in a cohort of Italian patients with familial Bicuspid Aortic Valve (BAV)...
  30. ncbi request reprint Evidence for enhanced 8-isoprostane plasma levels, as index of oxidative stress in vivo, in patients with coronary artery disease
    Cristina Vassalle
    CNR Institute of Clinical Physiology, Via Moruzzi 1, I 56100 Pisa, Italy
    Coron Artery Dis 14:213-8. 2003
    ..In particular, 8-isoprostane (8-epiPGF(2alpha)) has been indicated as a marker of antioxidant deficiency and oxidative stress of potential relevance to assess human vascular diseases...
  31. ncbi request reprint Hormone replacement therapy: one-year follow up of DNA damage
    Marta Casella
    Institute of Clinical Physiology, CNR CREAS, Via Moruzzi 1, 56124 Pisa, Italy
    Mutat Res 585:14-20. 2005
    ..This study shows the absence of any significant increase of MN frequencies in women undergoing oral and/or transdermal HRT, sequentially monitored for up to 12 months of therapy...
  32. ncbi request reprint Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease
    Nicoletta Botto
    CNR, Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Mutat Res 570:81-8. 2005
    ..The obtained results may suggest that the increase of oxidative stress in cardiovascular disease may be responsible for the accumulation of mtDNA damage in coronary artery disease patients...
  33. doi request reprint Lack of association of the 3'-UTR polymorphism (rs1017) in the ISL1 gene and risk of congenital heart disease in the white population
    Monica Cresci
    National Research Council Institute of Clinical Physiology, Via Aurelia Sud, 54100, Massa, Italy
    Pediatr Cardiol 34:938-41. 2013
    ..7) nor stratifying the population by sex and CHD classification. In conclusion, ISL1 common variant rs1017 is not associated with increased genetic risk of CHD in the white population...
  34. ncbi request reprint An increased platelet-leukocytes interaction at the culprit site of coronary artery occlusion in acute myocardial infarction: a pathogenic role for "no-reflow" phenomenon?
    Nicoletta Botto
    CNR, Institute of Clinical Physiology G Pasquinucci Hospital, 54100, Massa, Italy
    Int J Cardiol 117:123-30. 2007
    ..So far, it has not been well clarified which mechanism is mainly involved in distal coronary protection...
  35. pmc A novel LMNA mutation (R189W) in familial dilated cardiomyopathy: evidence for a 'hot spot' region at exon 3: a case report
    Nicoletta Botto
    GENETICS RESEARCH UNIT, Fondazione G Monasterio CNR Regione Toscana, Via Aurelia Sud, Massa, Italy
    Cardiovasc Ultrasound 8:9. 2010
    ..Genetic screening of lamin A/C gene revealed in proband the presence of a novel missense mutation (R189W), near the most prevalent lamin A/C mutation (R190W), suggesting a "hot spot" region at exon 3...
  36. ncbi request reprint P53 codon 72 polymorphism in coronary artery disease: no evidence for association with increased risk or micronucleus frequency
    Samantha Manfredi
    Laboratory of Cellular Biology, CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Environ Mol Mutagen 40:110-5. 2002
    ..Although there appears to be an association between CAD and MN frequency, our results indicate that the Arg72Pro polymorphism does not have a significant impact on CAD or MN frequencies...
  37. doi request reprint Relation of increased chromosomal damage to future adverse cardiac events in patients with known coronary artery disease
    Chiara Federici
    CNR, Institute of Clinical Physiology, Gabriele Monasterio Foundation, Massa, Italy
    Am J Cardiol 102:1296-300. 2008
    ..2, 95% confidence interval 1.1 to 4.7, p = 0.03). In conclusion, levels of peripheral chromosomal DNA damage may be a new sensitive biomarker of prognostic stratification in patients with known CAD...
  38. doi request reprint Germline hereditary, somatic mutations and microRNAs targeting-SNPs in congenital heart defects
    Saverio Sabina
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Mol Cell Cardiol 60:84-9. 2013
    ..3-0.9, p=0.03), likely due to the relatively low binding of the miRNA and high levels of protein. These results suggest that common SNPs in the 3'UTR of GATA4 alter miRNA gene regulation contributing to the pathogenesis of CHDs...
  39. doi request reprint Cellular adaptive response to chronic radiation exposure in interventional cardiologists
    Gian Luigi Russo
    Institute of Food Sciences, National Research Council, Via Roma 64, Avellino, Italy
    Eur Heart J 33:408-14. 2012
    ....
  40. pmc Ascending aortic aneurysm in a patient with bicuspid aortic valve, positive history of systemic autoimmune diseases and common genetic factors: a case report
    Ilenia Foffa
    Institute of Clinical Physiology, Massa, Italy
    Cardiovasc Ultrasound 7:34. 2009
    ..Gene-environmental interactions may represent an additional pathogenetic dimension in the still challenging management of the abnormalities of the aortic wall, including dilatation, aneurysm and dissection...
  41. pmc Clinical utility of genetic tests for inherited hypertrophic and dilated cardiomyopathies
    Maria Giovanna Colombo
    Genetics Research Unit G, Monasterio Foundation, CNR Regione Toscana, CNR Institute of Clinical Physiology, Massa, Italy
    Cardiovasc Ultrasound 6:62. 2008
    ..This paper provides a concise overview of the genetic etiology as well as the clinical utilities and limitations of genetic testing for the heritable cardiomyopathies...
  42. doi request reprint Cancer risk from professional exposure in staff working in cardiac catheterization laboratory: insights from the National Research Council's Biological Effects of Ionizing Radiation VII Report
    Lucia Venneri
    CNR, Institute of Clinical Physiology and Fondazione Gabriele Monasterio, Pisa, Italy
    Am Heart J 157:118-24. 2009
    ..The aim of the present study was to evaluate the order of magnitude of cancer risk caused by professional radiation exposure in modern invasive cardiology practice...
  43. ncbi request reprint Prothrombotic mutations as risk factors for cryptogenic ischemic cerebrovascular events in young subjects with patent foramen ovale
    Nicoletta Botto
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Stroke 38:2070-3. 2007
    ..We evaluated the prevalence of the 2 most common genetic risk factors for thromboembolism, factor V Leiden (G1691A) and prothrombin G20210A, in young PFO patients who were referred for percutaneous transcatheter closure of their PFO...
  44. doi request reprint Angiotensin-converting enzyme insertion/deletion polymorphism is a risk factor for thoracic aortic aneurysm in patients with bicuspid or tricuspid aortic valves
    Ilenia Foffa
    CNR Institute of Clinical Physiology, Pisa, Italy
    J Thorac Cardiovasc Surg 144:390-5. 2012
    ..The aim of the present study was to examine the role of ACE insertion/deletion polymorphism on the risk of TAA in patients with bicuspid aortic valves or tricuspid aortic valves...
  45. ncbi request reprint Imaging and laboratory biomarkers in cardiovascular disease
    Maria Grazia Andreassi
    CNR, Institute of Clinical Physiology, Pisa, Italy
    Curr Pharm Des 15:1131-41. 2009
    ..In general, a targeted approach tailored on the individual patient should be preferred to a carpet diagnostic bombing, which will lead to an exorbitant multiplier of costs, risks and inappropriate testing...
  46. pmc Health risk and biological effects of cardiac ionising imaging: from epidemiology to genes
    Ilenia Foffa
    Institute of Clinical Physiology, CNR, Pisa, Italy
    Int J Environ Res Public Health 6:1882-93. 2009
    ..We also discuss the perspectives offered by the use of molecular biomarkers in order to better assess the long-term development of health effects...
  47. doi request reprint Congenital anomalies among live births in a high environmental risk area--a case-control study in Brindisi (southern Italy)
    Emilio Antonio Luca Gianicolo
    National Research Council, Institute of Clinical Physiology, Lecce, Italy der Johannes Gutenberg Universität Mainz, Institut fur Medizinische Biometrie, Epidemiologie und Informatik, Mainz, Germany Electronic address
    Environ Res 128:9-14. 2014
    ..01) and VSDs (p for trend <0.05). Findings for TSP were less consistent. In conclusion, in the studied area, maternal exposure to sulfur dioxide increased risk of CHD. ..
  48. pmc Congenital anomalies among live births in a polluted area. A ten-year retrospective study
    Emilio Antonio Luca Gianicolo
    National Research Council, Institute of Clinical Physiology, Lecce, Italy
    BMC Pregnancy Childbirth 12:165. 2012
    ..Congenital anomalies and their primary prevention are a crucial public health issue. This work aimed to estimate the prevalence of congenital anomalies in Brindisi, a city in southeastern Italy at high risk of environmental crisis...
  49. doi request reprint Development of a new multiplex quantitative real-time PCR assay for the detection of the mtDNA(4977) deletion in coronary artery disease patients: a link with telomere shortening
    Laura Sabatino
    Institute of Clinical Physiology, National Research Council C N R, 56124 Pisa, Italy
    Environ Mol Mutagen 54:299-307. 2013
    ..02 and P = 0.006, respectively). In conclusion, the present study suggests that mtDNA(4977) deletion and telomere shortening may represent additional and synergic major risk factors for the pathogenesis of CAD and its complications...
  50. doi request reprint Maternal and sex dependency of insulin resistance: longitudinal PET and echocardiography study from the healthy fetus to the adult minipig
    Letizia Guiducci
    Institute of Clinical Physiology, National Research Council, Pisa, Italy
    J Nucl Med 52:1993-2000. 2011
    ....
  51. ncbi request reprint Coronary atherosclerosis and somatic mutations: an overview of the contributive factors for oxidative DNA damage
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Mutat Res 543:67-86. 2003
    ....
  52. doi request reprint Adenosine A2(A) receptor gene polymorphism (1976C>T) affects coronary flow reserve response during vasodilator stress testing in patients with non ischemic-dilated cardiomyopathy
    Maria Grazia Andreassi
    CNR, Institute of Clinical Physiology, Pisa, Italy
    Pharmacogenet Genomics 21:469-75. 2011
    ..The aim of this study was to assess whether genetic polymorphisms (263C>T and 1976C>T) of the A2(A) receptor gene affect CFR response in patients with DCM...
  53. ncbi request reprint Genetic instability, DNA damage and atherosclerosis
    Maria Grazia Andreassi
    CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Via Aurelia Sud Montepepe, 54100 Massa, Italy
    Cell Cycle 2:224-7. 2003
    ..We review the role of somatic mutations and genetic instability in the pathogenesis of atherosclerosis, suggesting novel therapeutic approaches...
  54. ncbi request reprint Genomic medicine and thrombotic risk: who, when, how and why?
    Chiara Federici
    Laboratory of Cellular Biology and Genetics, CNR Institute of Clinical Physiology, G Pasquinucci Hospital, Massa, Italy
    Int J Cardiol 106:3-9. 2006
    ....
  55. doi request reprint Genetic polymorphisms of the natriuretic peptide system in the pathogenesis of cardiovascular disease: what lies on the horizon?
    Cristina Vassalle
    Fondazione G Monasterio and Institute of Clinical Physiology, Italian National Research Council, Pisa, Italy
    Clin Chem 55:878-87. 2009
    ..Accordingly, these molecules are widely recognized as key clinical biomarkers in the diagnosis and monitoring of heart failure, hypertension, and coronary heart disease...
  56. ncbi request reprint Smoking and congenital heart disease: the epidemiological and biological link
    Emilio Antonio Luca Gianicolo
    CNR, Institute of Clinical Physiology, Lecce, Italy
    Curr Pharm Des 16:2572-7. 2010
    ..Further research is needed to better define the relationship between parental smoking and the risk of heart defects as well as to assess parental-fetal gene-smoking interactions...
  57. ncbi request reprint [Patent foramen ovale: "les liaisons dangereuses" between anatomy and genetics]
    Nicoletta Botto
    Istituto di Fisiologia Clinica, Consiglio Nazionale delle Ricerche, Pisa
    Recenti Prog Med 100:356-60. 2009
    ..3 +/- 3.9 micromol/L). These findings strongly confirm and emphasize the importance of the genetic screening for thrombotic mutations in young patients with PFO-related ischemic events in order to improve secondary prevention strategies...
  58. ncbi request reprint [A novel lamin A/C mutation in a family with dilated cardiomyopathy and a strong history of sudden cardiac death]
    Maria Grazia Andreassi
    UO Ricerca Genetica, Istituto di Fisiologia Clinica CNR e Fondazione G Monasterio, Regione Toscana, Pisa e Massa
    Recenti Prog Med 101:127-30. 2010
    ..Here we present a family with a strong positive history of sudden cardiac death in presence of idiopathic dilated cardiomyopathy and cardiac conduction abnormalities, related to a novel lamin A/C mutation in exon 3...
  59. doi request reprint Ionizing radiation and atherosclerosis: current knowledge and future challenges
    Andrea Borghini
    CNR, Institute of Clinical Physiology, Pisa, Italy
    Atherosclerosis 230:40-7. 2013
    ....
  60. pmc Arsenic-induced genotoxicity and genetic susceptibility to arsenic-related pathologies
    Francesca Faita
    Institute of Clinical Physiology, CNR, Via Moruzzi 1, Pisa 56124, Italy
    Int J Environ Res Public Health 10:1527-46. 2013
    ....
  61. ncbi request reprint Influence of ScaI and natriuretic peptide (NP) clearance receptor polymorphisms of the NP System on NP concentration in chronic heart failure
    Cristina Vassalle
    Institute of Clinical Physiology, Consiglio Nazionale delle Ricerche, Pisa, Italy
    Clin Chem 53:1886-90. 2007
    ..Despite the importance of NPs in heart failure (HF), the role of these polymorphisms in HF has not been evaluated...
  62. pmc Nitrogen biobank for cardiovascular research
    Antonella Mercuri
    U O Biobank, CNR, Institute of Clinical Physiology, Pisa, Italy
    Curr Cardiol Rev 9:253-9. 2013
    ....
  63. doi request reprint Telomere shortening and ionizing radiation: a possible role in vascular dysfunction?
    Laura Sabatino
    Institute of Clinical Physiology, National Research Council C N R, Pisa, Italy
    Int J Radiat Biol 88:830-9. 2012
    ..There is also evidence supporting the crucial role of telomeres in the formation of chromosome and chromatid aberrations induced by ionizing radiation...
  64. doi request reprint Carcinoembryonic antigen concentrations in patients with acute coronary syndrome
    Cristina Vassalle
    Fondazione G Monasterio CNR Regione Toscana and Institute of Clinical Physiology CNR, Pisa, Italy
    Clin Chem Lab Med 48:1339-43. 2010
    ..The aim of our study was to evaluate whether CEA concentrations have a role in coronary artery disease (CAD)...
  65. doi request reprint DNA modifications in atherosclerosis: from the past to the future
    Andrea Borghini
    CNR Institute of Clinical Physiology, Via Moruzzi 1, 56124 Pisa, Italy Electronic address
    Atherosclerosis 230:202-9. 2013
    ..Unraveling these molecular mechanisms provide the rationale for the development of novel efficient therapies to combat the vascular aging process. ..
  66. pmc Next generation sequencing in cardiovascular diseases
    Francesca Faita
    Francesca Faita, Cecilia Vecoli, Ilenia Foffa, Maria Grazia Andreassi, CNR, Institute of Clinical Physiology, 54100 Massa, Italy
    World J Cardiol 4:288-95. 2012
    ..We also discuss the future utility and challenges related to NGS in studying the genetic basis of CVDs in order to improve diagnosis, prevention, and treatment...
  67. ncbi request reprint Chronic low-dose radiation exposure from interventional cardiology procedures induces chromosomal abnormalities in originally genetically identical twins
    Maria Grazia Andreassi
    Int J Cardiol 118:130-1. 2007
  68. ncbi request reprint 8-iso-prostaglandin F2alpha as a risk marker in patients with coronary heart disease
    Cristina Vassalle
    Circulation 110:e49-50. 2004
  69. ncbi request reprint Diagnostic and therapeutic radiation exposure in children: new evidence and perspectives from a biomarker approach
    Lamia Ait-Ali
    Pediatr Radiol 37:109-11. 2007
  70. ncbi request reprint Lack of radiological awareness among physicians working in a tertiary-care cardiological centre
    Maria Joao Correia
    Universitary Hospital of Pulido Valente, Lisbon, Portugal
    Int J Cardiol 103:307-11. 2005
    ..Medical irradiation is the most important artificial source of exposure to ionising radiations in Europe and implies biorisks...