U Grohmann

Summary

Country: Italy

Publications

  1. ncbi Immunogenicity of tumor peptides: importance of peptide length and stability of peptide/MHC class II complex
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Giochetto, Italy
    Cancer Immunol Immunother 48:195-203. 1999
  2. ncbi IL-9 protects mice from Gram-negative bacterial shock: suppression of TNF-alpha, IL-12, and IFN-gamma, and induction of IL-10
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 164:4197-203. 2000
  3. ncbi IL-12 induces SDS-stable class II alphabeta dimers in murine dendritic cells
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Italy
    Cytokine 12:401-4. 2000
  4. ncbi Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma
    U Grohmann
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 167:221-7. 2001
  5. ncbi Circulating levels of IL-10 are critically related to growth and rejection patterns of murine mastocytoma cells
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Italy
    Cell Immunol 181:109-19. 1997
  6. ncbi T cell apoptosis by tryptophan catabolism
    F Fallarino
    Department of Experimental Medicine, University of Perugia, Italy
    Cell Death Differ 9:1069-77. 2002
  7. ncbi IL-6 inhibits the tolerogenic function of CD8 alpha+ dendritic cells expressing indoleamine 2,3-dioxygenase
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, I 06122 Perugia, Italy
    J Immunol 167:708-14. 2001
  8. ncbi Tryptophan catabolism in IDO+ plasmacytoid dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, Section of Pharmacology, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    Curr Drug Metab 8:209-16. 2007
  9. ncbi The immunosuppressive activity of proinflammatory cytokines in experimental models: potential for therapeutic intervention in autoimmunity
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Curr Drug Targets Inflamm Allergy 1:77-87. 2002
  10. ncbi Using an ancient tool for igniting and propagating immune tolerance: IDO as an inducer and amplifier of regulatory T cell functions
    F Fallarino
    Department of Experimental Medicine and Biochemical Sciences, Via del Giochetto, Perugia, Italy
    Curr Med Chem 18:2215-21. 2011

Detail Information

Publications11

  1. ncbi Immunogenicity of tumor peptides: importance of peptide length and stability of peptide/MHC class II complex
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Giochetto, Italy
    Cancer Immunol Immunother 48:195-203. 1999
    ....
  2. ncbi IL-9 protects mice from Gram-negative bacterial shock: suppression of TNF-alpha, IL-12, and IFN-gamma, and induction of IL-10
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 164:4197-203. 2000
    ..aeruginosa infection. Therefore, IL-9 may be protective in septic shock via a rather unique mechanism involving a complex modulation of inflammatory and anti-inflammatory mediators...
  3. ncbi IL-12 induces SDS-stable class II alphabeta dimers in murine dendritic cells
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Italy
    Cytokine 12:401-4. 2000
    ..This effect was accompanied by a striking increase in the overall proportion of SDS-stable heterodimers...
  4. ncbi Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma
    U Grohmann
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 167:221-7. 2001
    ..Therefore, our findings suggest a general and critical role of IL-12 in potentiating the accessory function of myeloid APC...
  5. ncbi Circulating levels of IL-10 are critically related to growth and rejection patterns of murine mastocytoma cells
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Italy
    Cell Immunol 181:109-19. 1997
    ....
  6. ncbi T cell apoptosis by tryptophan catabolism
    F Fallarino
    Department of Experimental Medicine, University of Perugia, Italy
    Cell Death Differ 9:1069-77. 2002
    ..These data suggest that the selective deletion of T lymphocytes may be a major mechanism whereby tryptophan metabolism affects immunity under physiopathologic conditions...
  7. ncbi IL-6 inhibits the tolerogenic function of CD8 alpha+ dendritic cells expressing indoleamine 2,3-dioxygenase
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, I 06122 Perugia, Italy
    J Immunol 167:708-14. 2001
    ..The activity of IL-6 includes down-regulation of IFN-gammaR expression in the CD8(+) DC subset and correlates to a reduced ability of these cells to metabolize tryptophan and initiate T cell apoptosis in vitro...
  8. ncbi Tryptophan catabolism in IDO+ plasmacytoid dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, Section of Pharmacology, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    Curr Drug Metab 8:209-16. 2007
    ....
  9. ncbi The immunosuppressive activity of proinflammatory cytokines in experimental models: potential for therapeutic intervention in autoimmunity
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Curr Drug Targets Inflamm Allergy 1:77-87. 2002
    ....
  10. ncbi Using an ancient tool for igniting and propagating immune tolerance: IDO as an inducer and amplifier of regulatory T cell functions
    F Fallarino
    Department of Experimental Medicine and Biochemical Sciences, Via del Giochetto, Perugia, Italy
    Curr Med Chem 18:2215-21. 2011
    ..Thus, in the periphery, tolerogenic immune responses mediated by T(reg) cells can be induced and amplified by IDO, a tryptophan catabolizing enzyme that also contributes to the plasticity of the T(reg) cell lineage...
  11. ncbi O6-alkylguanine-DNA alkyltransferase attenuates triazene-induced cytotoxicity and tumor cell immunogenicity in murine L1210 leukemia
    G Graziani
    Department of Experimental Medicine and Biochemical Sciences, University of Rome Tor Vergata, Italy
    Cancer Res 55:6231-6. 1995
    ....