U Grohmann

Summary

Country: Italy

Publications

  1. ncbi request reprint Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, Italy
    J Immunol 174:6582-6. 2005
  2. ncbi request reprint Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Eur J Immunol 35:3111-8. 2005
  3. ncbi request reprint CTLA-4-Ig regulates tryptophan catabolism in vivo
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 3:1097-101. 2002
  4. pmc A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    J Exp Med 198:153-60. 2003
  5. ncbi request reprint The immunosuppressive activity of proinflammatory cytokines in experimental models: potential for therapeutic intervention in autoimmunity
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Curr Drug Targets Inflamm Allergy 1:77-87. 2002
  6. ncbi request reprint Tryptophan catabolism in nonobese diabetic mice
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, Italy
    Adv Exp Med Biol 527:47-54. 2003
  7. ncbi request reprint CTLA-4, T helper lymphocytes and dendritic cells: an internal perspective of T-cell homeostasis
    Ursula Grohmann
    Department of Experimental Medicine, Via del Giochetto, University of Perugia, 06126 Perugia, Italy
    Trends Mol Med 9:133-5. 2003
  8. ncbi request reprint Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma
    U Grohmann
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 167:221-7. 2001
  9. ncbi request reprint T cell apoptosis by tryptophan catabolism
    F Fallarino
    Department of Experimental Medicine, University of Perugia, Italy
    Cell Death Differ 9:1069-77. 2002
  10. ncbi request reprint IL-9 protects mice from Gram-negative bacterial shock: suppression of TNF-alpha, IL-12, and IFN-gamma, and induction of IL-10
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 164:4197-203. 2000

Collaborators

Detail Information

Publications46

  1. ncbi request reprint Cutting edge: silencing suppressor of cytokine signaling 3 expression in dendritic cells turns CD28-Ig from immune adjuvant to suppressant
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, Italy
    J Immunol 174:6582-6. 2005
    ..Thus, in the absence of SOCS3, CD28-Ig becomes immunosuppressive and mimics the action of CTLA-4-Ig on tryptophan catabolism...
  2. ncbi request reprint Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Eur J Immunol 35:3111-8. 2005
    ..Increased resistance to experimental encephalomyelitis is observed in DAP12 knockin mice, which is dependent on IDO expression. Therefore, DAP12-related receptors act as negative regulators of IDO-mediated tolerance in vivo...
  3. ncbi request reprint CTLA-4-Ig regulates tryptophan catabolism in vivo
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 3:1097-101. 2002
    ..These data suggest that modulation of tryptophan catabolism is a means by which CTLA-4 functions in vivo and that CTLA-4 acts as a ligand for B7 receptor molecules that transduce intracellular signals...
  4. pmc A defect in tryptophan catabolism impairs tolerance in nonobese diabetic mice
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    J Exp Med 198:153-60. 2003
    ..This is the first report of an experimental autoimmune disease in which defective tolerance is causally linked to impaired tryptophan catabolism...
  5. ncbi request reprint The immunosuppressive activity of proinflammatory cytokines in experimental models: potential for therapeutic intervention in autoimmunity
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    Curr Drug Targets Inflamm Allergy 1:77-87. 2002
    ....
  6. ncbi request reprint Tryptophan catabolism in nonobese diabetic mice
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, Italy
    Adv Exp Med Biol 527:47-54. 2003
    ..This finding correlates with a low expression of IDO activity, thus suggesting that poor expression of IDO by dendritic cells may play a role in the development of diabetes...
  7. ncbi request reprint CTLA-4, T helper lymphocytes and dendritic cells: an internal perspective of T-cell homeostasis
    Ursula Grohmann
    Department of Experimental Medicine, Via del Giochetto, University of Perugia, 06126 Perugia, Italy
    Trends Mol Med 9:133-5. 2003
    ....
  8. ncbi request reprint Positive regulatory role of IL-12 in macrophages and modulation by IFN-gamma
    U Grohmann
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 167:221-7. 2001
    ..Therefore, our findings suggest a general and critical role of IL-12 in potentiating the accessory function of myeloid APC...
  9. ncbi request reprint T cell apoptosis by tryptophan catabolism
    F Fallarino
    Department of Experimental Medicine, University of Perugia, Italy
    Cell Death Differ 9:1069-77. 2002
    ..These data suggest that the selective deletion of T lymphocytes may be a major mechanism whereby tryptophan metabolism affects immunity under physiopathologic conditions...
  10. ncbi request reprint IL-9 protects mice from Gram-negative bacterial shock: suppression of TNF-alpha, IL-12, and IFN-gamma, and induction of IL-10
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 164:4197-203. 2000
    ..aeruginosa infection. Therefore, IL-9 may be protective in septic shock via a rather unique mechanism involving a complex modulation of inflammatory and anti-inflammatory mediators...
  11. ncbi request reprint Immunogenicity of tumor peptides: importance of peptide length and stability of peptide/MHC class II complex
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Giochetto, Italy
    Cancer Immunol Immunother 48:195-203. 1999
    ....
  12. ncbi request reprint IL-6 inhibits the tolerogenic function of CD8 alpha+ dendritic cells expressing indoleamine 2,3-dioxygenase
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, I 06122 Perugia, Italy
    J Immunol 167:708-14. 2001
    ..The activity of IL-6 includes down-regulation of IFN-gammaR expression in the CD8(+) DC subset and correlates to a reduced ability of these cells to metabolize tryptophan and initiate T cell apoptosis in vitro...
  13. ncbi request reprint The combined effects of tryptophan starvation and tryptophan catabolites down-regulate T cell receptor zeta-chain and induce a regulatory phenotype in naive T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 176:6752-61. 2006
    ....
  14. ncbi request reprint IL-12 induces SDS-stable class II alphabeta dimers in murine dendritic cells
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Italy
    Cytokine 12:401-4. 2000
    ..This effect was accompanied by a striking increase in the overall proportion of SDS-stable heterodimers...
  15. ncbi request reprint Kynurenine pathway enzymes in dendritic cells initiate tolerogenesis in the absence of functional IDO
    Maria L Belladonna
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    J Immunol 177:130-7. 2006
    ..The paracrine production of kynurenines might be one mechanism used by IDO-competent cells to convert DCs lacking functional IDO to a tolerogenic phenotype within an IFN-gamma-rich environment...
  16. ncbi request reprint Functional plasticity of dendritic cell subsets as mediated by CD40 versus B7 activation
    Ursula Grohmann
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    J Immunol 171:2581-7. 2003
    ..Thus, environmental conditioning by T cell ligands may alter the default function of DC subsets to meet the needs of flexibility and redundancy...
  17. ncbi request reprint Modulation of tryptophan catabolism by regulatory T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 4:1206-12. 2003
    ..Thus, regulation of immunosuppressive tryptophan catabolism in dendritic cells might represent a major mechanism of action of T(R) cells...
  18. ncbi request reprint Tryptophan catabolism in IDO+ plasmacytoid dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, Section of Pharmacology, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    Curr Drug Metab 8:209-16. 2007
    ....
  19. ncbi request reprint CD40 ligand and CTLA-4 are reciprocally regulated in the Th1 cell proliferative response sustained by CD8(+) dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 169:1182-8. 2002
    ..In addition, they suggest that reciprocal regulation of CD40 ligand and CTLA-4 expression occurs in Th1 cells exposed to CD8(+) DCs...
  20. ncbi request reprint CD40 ligation prevents onset of tolerogenic properties in human dendritic cells treated with CTLA-4-Ig
    Carmine Vacca
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Italy
    Microbes Infect 7:1040-8. 2005
    ..However, it is unable to induce suppressive properties in DC matured by CD40 engagement. Thus, CD40-driven events may physiologically set human DC free from restraint by regulatory cells expressing surface CTLA-4...
  21. ncbi request reprint Circulating levels of IL-10 are critically related to growth and rejection patterns of murine mastocytoma cells
    U Grohmann
    Department of Experimental Medicine, University of Perugia, Italy
    Cell Immunol 181:109-19. 1997
    ....
  22. pmc CTLA-4-Ig activates forkhead transcription factors and protects dendritic cells from oxidative stress in nonobese diabetic mice
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia 06126, Italy
    J Exp Med 200:1051-62. 2004
    ....
  23. ncbi request reprint Murine plasmacytoid dendritic cells initiate the immunosuppressive pathway of tryptophan catabolism in response to CD200 receptor engagement
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 173:3748-54. 2004
    ..These data prospect novel functions for both pDCs and the CD200-CD200R pair in the mouse. At the same time, these data underscore the possible unifying role of the IDO mechanism in immune tolerance...
  24. pmc SOCS3 drives proteasomal degradation of indoleamine 2,3-dioxygenase (IDO) and antagonizes IDO-dependent tolerogenesis
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Proc Natl Acad Sci U S A 105:20828-33. 2008
    ..In addition to identifying SOCS3 as a candidate signature for mouse DC subsets programmed to direct immunity, this study demonstrates that IDO undergoes regulatory proteolysis in response to immunogenic stimuli...
  25. ncbi request reprint Toward the identification of a tolerogenic signature in IDO-competent dendritic cells
    Ciriana Orabona
    Section of Pharmacology, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Blood 107:2846-54. 2006
    ..Overall, these studies reveal the occurrence of a simple and evolutionarily conserved code in the control of tolerance by an ancestral metabolic enzyme...
  26. ncbi request reprint CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86
    Ciriana Orabona
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nat Immunol 5:1134-42. 2004
    ..Thus, different ligands of B7 can signal dendritic cells to express functionally distinct effector responses...
  27. doi request reprint IDO mediates TLR9-driven protection from experimental autoimmune diabetes
    Francesca Fallarino
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    J Immunol 183:6303-12. 2009
    ..Thus, our data suggest that the TLR9-IDO axis may represent a valuable target in the prevention/therapy of type 1 diabetes...
  28. doi request reprint Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous disease
    Luigina Romani
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Nature 451:211-5. 2008
    ..Yet, this condition can be reverted by reactivating the pathway downstream of the superoxide-dependent step...
  29. ncbi request reprint Tolerance, DCs and tryptophan: much ado about IDO
    Ursula Grohmann
    Department of Experimental Medicine, Via del Giochetto, University of Perugia, 06126 Perugia, Italy
    Trends Immunol 24:242-8. 2003
  30. ncbi request reprint IL-23 neutralization protects mice from Gram-negative endotoxic shock
    Maria Laura Belladonna
    Department of Experimental Medicine and Biochemical Sciences, Section of Pharmacology, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    Cytokine 34:161-9. 2006
    ..aeruginosa-challenged mice was associated with a dramatic decrease in circulating levels of the pathogenetic cytokines, TNF-alpha and IFN-gamma. Hence, IL-23 may represent a new therapeutic target in Gram-negative endotoxic shock...
  31. ncbi request reprint Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, Section of Pharmacology, University of Perugia, 06126 Perugia, Italy
    Int Immunol 17:1429-38. 2005
    ..Therefore, although pDCs do not mediate IDO-dependent tolerance constitutively, multiple ligands and cytokines will contribute to the expression of a tolerogenic phenotype by pDCs in the mouse...
  32. ncbi request reprint Cutting edge: Autocrine TGF-beta sustains default tolerogenesis by IDO-competent dendritic cells
    Maria L Belladonna
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 181:5194-8. 2008
    ..These data are the first to link TGF-beta signaling with IDO in controlling spontaneous tolerogenesis by DCs...
  33. ncbi request reprint Functional expression of indoleamine 2,3-dioxygenase by murine CD8 alpha(+) dendritic cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06122, Italy
    Int Immunol 14:65-8. 2002
    ..Therefore, in the mouse, CD8 alpha(+) DC may be unique APC capable of fully expressing the IDO mechanism functionally...
  34. ncbi request reprint IDO and regulatory T cells: a role for reverse signalling and non-canonical NF-kappaB activation
    Paolo Puccetti
    Paolo Puccetti and Ursula Grohmann are at the Department of Experimental Medicine, Section of Pharmacology, University of Perugia, Perugia 06126, Italy
    Nat Rev Immunol 7:817-23. 2007
    ..This mechanism may also underlie the protective function of glucocorticoids in pathological conditions...
  35. ncbi request reprint Immunosuppression via tryptophan catabolism: the role of kynurenine pathway enzymes
    Maria Laura Belladonna
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Transplantation 84:S17-20. 2007
    ....
  36. ncbi request reprint IL-23 and IL-12 have overlapping, but distinct, effects on murine dendritic cells
    Maria Laura Belladonna
    Department of Experimental Medicine, University of Perugia, Perugia, Italy
    J Immunol 168:5448-54. 2002
    ..In addition, the in vitro effects of IL-23-Ig did not appear to require IL-12Rbeta2 or to be mediated by the production of IL-12. These data may establish IL-23 as a novel cytokine with major effects on APC...
  37. ncbi request reprint T cell apoptosis by kynurenines
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Italy
    Adv Exp Med Biol 527:183-90. 2003
    ..These data may represent the first experimental evidence for the involvement of tryptophan catabolism in the regulation of T cell apoptosis and maintenance of peripheral T cell tolerance...
  38. ncbi request reprint Tryptophan catabolism generates autoimmune-preventive regulatory T cells
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, 06126 Perugia, Italy
    Transpl Immunol 17:58-60. 2006
    ..These cells are capable of effective control of diabetogenic T cells in vivo...
  39. ncbi request reprint Effects of IL-12 and IL-23 on antigen-presenting cells at the interface between innate and adaptive immunity
    Paolo Puccetti
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, 06126 Perugia, Italy
    Crit Rev Immunol 22:373-90. 2002
    ..This review summarizes recent data on the actions of IL-12 and IL-23 on dendritic cells and macrophages at the interface between innate and adaptive immunity...
  40. ncbi request reprint Using an ancient tool for igniting and propagating immune tolerance: IDO as an inducer and amplifier of regulatory T cell functions
    F Fallarino
    Department of Experimental Medicine and Biochemical Sciences, Via del Giochetto, Perugia, Italy
    Curr Med Chem 18:2215-21. 2011
    ..Thus, in the periphery, tolerogenic immune responses mediated by T(reg) cells can be induced and amplified by IDO, a tryptophan catabolizing enzyme that also contributes to the plasticity of the T(reg) cell lineage...
  41. pmc Therapy of experimental type 1 diabetes by isolated Sertoli cell xenografts alone
    Francesca Fallarino
    Department of Experimental Medicine, University of Perugia, Perugia 06126, Italy
    J Exp Med 206:2511-26. 2009
    ....
  42. doi request reprint TGF-beta and kynurenines as the key to infectious tolerance
    Maria L Belladonna
    Department of Experimental Medicine, University of Perugia, Via del Giochetto, Perugia 06126, Italy
    Trends Mol Med 15:41-9. 2009
    ..Current molecular insights suggest a synergistic potential for TGF-beta and IDO in physiologically or therapeutically opposing human pathologies sustained by over-reacting immune responses...
  43. ncbi request reprint Reverse signaling through GITR ligand enables dexamethasone to activate IDO in allergy
    Ursula Grohmann
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, 06126 Perugia, Italy
    Nat Med 13:579-86. 2007
    ..Induction of IDO could be an important mechanism underlying the anti-inflammatory action of corticosteroids...
  44. doi request reprint Metabotropic glutamate receptor-4 modulates adaptive immunity and restrains neuroinflammation
    Francesca Fallarino
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Nat Med 16:897-902. 2010
    ..The high amounts of glutamate in neuroinflammation might reflect a counterregulatory mechanism that is protective in nature and might be harnessed therapeutically for restricting immunopathology in multiple sclerosis...
  45. doi request reprint Control of immune response by amino acid metabolism
    Ursula Grohmann
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Perugia, Italy
    Immunol Rev 236:243-64. 2010
    ..In this review, we analyze the evidence supporting a critical role for the metabolism of various amino acids in regulating different steps of both innate and adaptive immunity...
  46. doi request reprint Ctla-4 blockade confers lymphocyte resistance to regulatory T-cells in advanced melanoma: surrogate marker of efficacy of tremelimumab?
    Cedric Menard
    Center of Clinical Investigations, CBT507, Institut Gustave Roussy, Villejuif, France
    Clin Cancer Res 14:5242-9. 2008
    ..However, mechanisms of action and surrogate immunologic markers of efficacy have not been reported thus far...