A Giustina

Summary

Country: Italy

Publications

  1. ncbi request reprint Cardiac and metabolic effects of chronic growth hormone and insulin-like growth factor I excess in young adults with pituitary gigantism
    Marta Bondanelli
    Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy
    Metabolism 54:1174-80. 2005
  2. pmc Treatment of Cushing disease: overview and recent findings
    Tatiana Mancini
    Department of Internal Medicine and Medical Specialties, San Marino Hospital, San Marino, Republic of San Marino
    Ther Clin Risk Manag 6:505-16. 2010
  3. pmc Meta-analysis on the effects of octreotide on tumor mass in acromegaly
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Montichiari Hospital, Brescia, Italy
    PLoS ONE 7:e36411. 2012
  4. doi request reprint A consensus on criteria for cure of acromegaly
    A Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Endocrine Service, Montichiari Hospital, Via Ciotti 154, 25018 Montichiari, Italy
    J Clin Endocrinol Metab 95:3141-8. 2010
  5. ncbi request reprint Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults
    A Giustina
    Department of Internal Medicine, University of Brescia, Brescia, Italy
    J Endocrinol Invest 31:820-38. 2008
  6. ncbi request reprint Assessment of the awareness and management of cardiovascular complications of acromegaly in Italy. The COM.E.T.A. (COMorbidities Evaluation and Treatment in Acromegaly) Study
    A Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    J Endocrinol Invest 31:731-8. 2008
  7. ncbi request reprint Effect of gonadal status on bone mineral density and radiological spinal deformities in adult patients with growth hormone deficiency
    Gherardo Mazziotti
    Endocrine Section, Department of Internal Medicine, University of Brescia, 2 Medicina Spedali Civili, Brescia 25125, Italy
    Pituitary 11:55-61. 2008
  8. doi request reprint High-dose intramuscular octreotide in patients with acromegaly inadequately controlled on conventional somatostatin analogue therapy: a randomised controlled trial
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, 25123 Brescia, Italy
    Eur J Endocrinol 161:331-8. 2009
  9. pmc Growth hormone, insulin-like growth factors, and the skeleton
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Endocr Rev 29:535-59. 2008
  10. ncbi request reprint Pituitary testing: a reappraisal
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Pituitary 11:113-4. 2008

Detail Information

Publications89

  1. ncbi request reprint Cardiac and metabolic effects of chronic growth hormone and insulin-like growth factor I excess in young adults with pituitary gigantism
    Marta Bondanelli
    Section of Endocrinology, Department of Biomedical Sciences and Advanced Therapies, University of Ferrara, 44100 Ferrara, Italy
    Metabolism 54:1174-80. 2005
    ....
  2. pmc Treatment of Cushing disease: overview and recent findings
    Tatiana Mancini
    Department of Internal Medicine and Medical Specialties, San Marino Hospital, San Marino, Republic of San Marino
    Ther Clin Risk Manag 6:505-16. 2010
    ..The aim of this review is to analyze the results and experiences with old and new medical treatments of CD and to reevaluate medical therapies for complications of CD and hypopituitarism in patients with cured CD...
  3. pmc Meta-analysis on the effects of octreotide on tumor mass in acromegaly
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Montichiari Hospital, Brescia, Italy
    PLoS ONE 7:e36411. 2012
    ..The long-acting somatostatin analogue octreotide is used either as an adjuvant or primary therapy to lower growth hormone (GH) levels in patients with acromegaly and may also induce pituitary tumor shrinkage...
  4. doi request reprint A consensus on criteria for cure of acromegaly
    A Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Endocrine Service, Montichiari Hospital, Via Ciotti 154, 25018 Montichiari, Italy
    J Clin Endocrinol Metab 95:3141-8. 2010
    ..The Acromegaly Consensus Group met in April 2009 to revisit the guidelines on criteria for cure as defined in 2000...
  5. ncbi request reprint Guidelines for the treatment of growth hormone excess and growth hormone deficiency in adults
    A Giustina
    Department of Internal Medicine, University of Brescia, Brescia, Italy
    J Endocrinol Invest 31:820-38. 2008
    ..The meeting was comprised of 66 delegates representing 13 different countries...
  6. ncbi request reprint Assessment of the awareness and management of cardiovascular complications of acromegaly in Italy. The COM.E.T.A. (COMorbidities Evaluation and Treatment in Acromegaly) Study
    A Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    J Endocrinol Invest 31:731-8. 2008
    ..However, as for other guidelines previously issued in the field, no data are available on their clinical application...
  7. ncbi request reprint Effect of gonadal status on bone mineral density and radiological spinal deformities in adult patients with growth hormone deficiency
    Gherardo Mazziotti
    Endocrine Section, Department of Internal Medicine, University of Brescia, 2 Medicina Spedali Civili, Brescia 25125, Italy
    Pituitary 11:55-61. 2008
    ..Conversely, rhGH replacement treatment seems to be the only factor influencing the risk to develop vertebral deformities in adult GHD patients...
  8. doi request reprint High-dose intramuscular octreotide in patients with acromegaly inadequately controlled on conventional somatostatin analogue therapy: a randomised controlled trial
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, 25123 Brescia, Italy
    Eur J Endocrinol 161:331-8. 2009
    ..Response may be improved by increasing SSA frequency or dose. This study evaluated the biochemical efficacy and safety of high-dose octreotide in patients with acromegaly...
  9. pmc Growth hormone, insulin-like growth factors, and the skeleton
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Endocr Rev 29:535-59. 2008
    ..GH and IGF-I secretion are decreased in aging individuals, and abnormalities in the GH/IGF-I axis play a role in the pathogenesis of the osteoporosis of anorexia nervosa and after glucocorticoid exposure...
  10. ncbi request reprint Pituitary testing: a reappraisal
    Andrea Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Pituitary 11:113-4. 2008
    ..Drug effects on different axes are discussed since pharmacologic treatments may influence testing outcome...
  11. ncbi request reprint The negative role of subclinical thyrotoxicosis on the outcome of hospitalized geriatric patients
    S Bossoni
    University of Brescia, Brescia, Italy
    J Endocrinol Invest 25:64-5. 2002
  12. ncbi request reprint Does growth hormone replacement therapy improve cardiac function?
    Andrea Giustina
    University of Brescia, Italy
    Nat Clin Pract Endocrinol Metab 3:614-5. 2007
  13. doi request reprint Current management practices for acromegaly: an international survey
    A Giustina
    Department of Medical and Surgical Sciences, University of Brescia, Endocrine Service, Montichiari Hospital, Via Ciotti 154, 25018 Montichiari, Italy
    Pituitary 14:125-33. 2011
    ..The observation that most centers followed consensus statement recommendations encourages the future utility of these workshops aimed to create uniform management standards for acromegaly...
  14. doi request reprint Glucocorticoid replacement therapy and vertebral fractures in hypopituitary adult males with GH deficiency
    G Mazziotti
    Department of Medical and Surgical Sciences, Montichiari Hospital, University of Brescia, Via Ciotti 154, 25018 Montichiari, Italy
    Eur J Endocrinol 163:15-20. 2010
    ..We aimed to evaluate whether the prevalence of vertebral fractures may be influenced by glucocorticoid over-replacement in hypopituitary males with GHD...
  15. ncbi request reprint Association between l-thyroxine treatment, GH deficiency, and radiological vertebral fractures in patients with adult-onset hypopituitarism
    G Mazziotti
    Chair of EndocrinologyUniversity of Brescia, A O Spedali Civili di Brescia, 25123 Brescia, ItalyPituitary UnitDepartment of Endocrinology, Catholic University of Rome, 00168 Rome, Italy
    Eur J Endocrinol 170:893-9. 2014
    ..In this study, we aimed at evaluating the association between radiological vertebral fractures and levo-thyroxine (l-T4) replacement doses in adult patients with hypopituitarism...
  16. doi request reprint Biochemical evaluation of patients with active acromegaly and type 2 diabetes mellitus: efficacy and safety of the galanin test
    G Mazziotti
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Neuroendocrinology 88:299-304. 2008
    ..The results of our study provide evidence that the galanin test may be of value for the diagnosis of acromegaly in patients with type 2 diabetes mellitus...
  17. ncbi request reprint [Growth hormone secretion in heart failure]
    A Giustina
    Dipartimento di Scienze Mediche e Chirurgiche, Universita degli Studi di Brescia, Brescia, Italy
    Minerva Endocrinol 28:1-11. 2003
    ..Particularly attention should be given to those patients that present a peripheric GH resistance. On the other hand, those patients with a reduced pituitary GH reserve are supposed to have very beneficial effects from GH treatment...
  18. ncbi request reprint Resistance to somatostatin analogs in acromegaly: an evolving concept?
    M Gola
    Department of Internal Medicine, University of Brescia, Brescia, Italy
    J Endocrinol Invest 29:86-93. 2006
    ....
  19. ncbi request reprint Incidence of subclinical hypothyroidism and its influence on cognitive performance and on metabolic aspects in an hospitalized geriatric population
    S Bossoni
    University of Brescia, Brescia, Italy
    J Endocrinol Invest 25:75-6. 2002
  20. ncbi request reprint Differential inhibition of growth hormone secretion by analogs selective for somatostatin receptor subtypes 2 and 5 in human growth-hormone-secreting adenoma cells in vitro
    G Tulipano
    Endocrine Section, Department of Internal Medicine, University of Brescia, Italy
    Neuroendocrinology 73:344-51. 2001
    ..We conclude that the availability of somatostatin analogs selective for SSTR5 will enhance the treatment potency and spectrum in acromegaly...
  21. ncbi request reprint Effects of calcitonin on GH response to pyridostigmine in combination with hGHRH (1-29) NH2 in normal adult subjects
    A Giustina
    Cattedra di Clinica Medica, University of Brescia, Italy
    Clin Endocrinol (Oxf) 33:375-80. 1990
    ..We conclude that sCT is able to inhibit GHRH-stimulated GH secretion in man without influencing the hypothalamic somatostatinergic tone...
  22. ncbi request reprint Low T3 syndrome and outcome in elderly hospitalized geriatric patients
    S Bossoni
    University of Brescia, Brescia, Italy
    J Endocrinol Invest 25:73-4. 2002
  23. doi request reprint Vertebral fractures in patients with acromegaly: a 3-year prospective study
    G Mazziotti
    Chair of Endocrinology, University of Brescia, Endocrine Service, Spedali Civili, 25125 Brescia, Italy
    J Clin Endocrinol Metab 98:3402-10. 2013
    ..Cross-sectional studies showed an elevated prevalence of vertebral fractures in acromegaly. However, no data are available on incident vertebral fractures in this clinical setting...
  24. ncbi request reprint Glucocorticoid-induced osteoporosis and parathyroid hormone
    R Carpinteri
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    J Endocrinol Invest 33:16-21. 2010
    ..Teriparatide (1-34PTH) has been studied in patients with GIO with effects on bone mineral density and on fracture risk which were shown to be superior to those obtained with alendronate...
  25. ncbi request reprint Growth hormone in glucocorticoid-induced osteoporosis
    F Manelli
    Endocrine Section, Department of Internal Medicine, University of Brescia, Italy
    Front Horm Res 30:174-83. 2002
  26. ncbi request reprint Assessment of the awareness and management of sleep apnea syndrome in acromegaly. The COM.E.TA (Comorbidities Evaluation and Treatment in Acromegaly) Italian Study Group
    E De Menis
    Department of Internal Medicine, General Hospital, v Monte Grappa 30, 31044 Montebelluna, Italy
    J Endocrinol Invest 34:60-4. 2011
    ..Continuous positive airway pressure is the cornerstone of therapy, but patients' acceptance may be critical. Control of GH/IGF-I secretion is important to improve SAS. Management of SAS requires cooperation between specialists...
  27. ncbi request reprint Effects of intranasal calcitonin administration on pituitary GH response to hGHRH (1-29)NH2 in normal adult subjects
    A Giustina
    Cattedra di Patologia Speciale Medica and Cattedra di Chimica, University of Brescia, Italy
    Clin Endocrinol (Oxf) 30:699-704. 1989
    ..n. sCT 551 +/- 116 micrograms 120 min/l. P less than 0.001; or vs GHRH plus i.m. sCT 700 +/- 167 micrograms 120 min/l, P less than 0.001. We conclude that sCT is able to inhibit GHRH-stimulated GH secretion in man...
  28. doi request reprint New understanding and treatments for osteoporosis
    G Mazziotti
    Department of Medical and Surgical Sciences, University of Brescia, Brescia, Italy
    Endocrine 41:58-69. 2012
    ..Future research is needed to address the efficacy of anti-osteoporotic drugs in these more recently recognized conditions of skeletal fragility. Osteoporosis continues to be an important field of biomedical research...
  29. ncbi request reprint GH deficiency in the adult and bone
    M Doga
    Endocrine Section, Department of Internal Medicine, University of Brescia, Brescia, Italy
    J Endocrinol Invest 28:18-23. 2005
    ..To understand if these BMD changes may result in a reduction of fracture risk, it is necessary to carry out a longitudinal follow-up of large cohorts of GHD adults on GH replacement therapy...
  30. ncbi request reprint Relationship between instrumental activities of daily living and blood glucose control in elderly subjects with type 2 diabetes
    S Bossoni
    Department of Internal Medicine, University of Brescia, Italy
    Age Ageing 37:222-5. 2008
  31. ncbi request reprint Effects of the selective estrogen receptor modulator LY117018 on growth hormone secretion: In vitro studies
    G Tulipano
    Endocrine Section, Department of Intternal Medicine, University of Brescia, Brescia, Italy
    Metabolism 53:563-70. 2004
    ..LY117018 also showed an estrogen-like activity, inducing the proliferation of rat pituitary GH-secreting adenomatous cells (GH1)...
  32. doi request reprint Effects of recombinant follicle-stimulating hormone on bone turnover markers in infertile women undergoing in vitro fertilization procedure
    U Omodei
    University of Brescia, 25121 Brescia, Italy
    J Clin Endocrinol Metab 98:330-6. 2013
    ..There is experimental but limited clinical evidence that FSH may have direct effects on bone...
  33. doi request reprint Effect of inhaled glucocorticoids and beta(2) agonists on vertebral fracture risk in COPD patients: the EOLO study
    S Gonnelli
    Department of Internal Medicine, Endocrine Metabolic Science, and Biochemistry, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100 Siena, Italy
    Calcif Tissue Int 87:137-43. 2010
    ..28, and OR = 1.40, CI 1.06-1.82, respectively). In conclusion, in COPD patients high doses of inhaled GCs, but not beta(2) agonists, are associated with an increased risk of vertebral fractures and a reduction of QUS at the calcaneus...
  34. ncbi request reprint Cardiopulmonary adaptation to exercise after acute weight loss in severely obese subjects
    E Boni
    Dept of Internal Medicine, University of Brescia, Italy
    Monaldi Arch Chest Dis 50:264-8. 1995
    ..Moreover, this acute weight loss is able to partially reverse all of the cardiopulmonary alterations seen in obese patients both at baseline and during exercise...
  35. ncbi request reprint Development of acromegaly in a patient with anorexia nervosa: pathogenetic and diagnostic implications
    E De Menis
    Internal Medicine, Treviso Hospital, Brescia, Italy
    J Endocrinol Invest 29:821-5. 2006
    ..In this clinical report, we describe the development of acromegaly in a patient affected by AN and we discuss pathogenetic and diagnostic implications...
  36. ncbi request reprint Pituitary tumours: inflammatory and granulomatous expansive lesions of the pituitary
    R Carpinteri
    Department of Medical and Surgical Sciences, University of Brescia, Endocrine Service, Montichiari Hospital, Via Ciotti 154, 25018 Montichiari, Italy
    Best Pract Res Clin Endocrinol Metab 23:639-50. 2009
    ....
  37. ncbi request reprint Development of a meningioma in a patient with acromegaly during octreotide treatment: are there any causal relationships?
    E De Menis
    Department of Internal Medicine, Hospital of Treviso, Brescia, Italy
    J Endocrinol Invest 26:359-63. 2003
    ..These results suggest that somatostatin-mediated proliferative effect on meningioma cells is not mediated by the subtype 2 of the somatostatin receptor...
  38. ncbi request reprint Diagnosis and treatment of acromegaly and its complications: consensus guidelines
    S Bonadonna
    Department of Internal Medicine, Endocrine Section, University of Brescia, Italy
    J Endocrinol Invest 28:43-7. 2005
    ..This review paper summarizes the main points of the three consensus statements published following these three workshops...
  39. ncbi request reprint Maturation of the regulation of growth hormone secretion in young males with hypogonadotropic hypogonadism pharmacologically exposed to progressive increments in serum testosterone
    A Giustina
    Department of Internal Medicine, University of Brescia, Italy
    J Clin Endocrinol Metab 82:1210-9. 1997
    ..e. directly at the pituitary level, and also at hypothalamic loci, possibly increasing both GHRH and somatostatin release...
  40. ncbi request reprint Cardiovascular risk in aging and obesity: is there a role for GH
    M Gola
    Endocrine Section, Department of Internal Medicine, University of Brescia, Brescia, Italy
    J Endocrinol Invest 28:759-67. 2005
    ....
  41. ncbi request reprint Effects of metoclopramide on the growth hormone response to galanin in normal man
    A Giustina
    Cattedra di Clinica Medica, University of Brescia, Italy
    Horm Metab Res 25:489-92. 1993
    ..4 +/- 1.6 micrograms/l). During MCP infusion no significant differences in the GH response to galanin with respect to saline were observed both when absolute GH levels and GH AUC were examined.(ABSTRACT TRUNCATED AT 250 WORDS)..
  42. ncbi request reprint Hexarelin, a novel GHRP-6 analog, stimulates growth hormone (GH) release in a GH-secreting rat cell line (GH1) insensitive to GH-releasing hormone
    A Giustina
    Department of Internal Medicine, Brescia, Italy
    Regul Pept 70:49-54. 1997
    ..Moreover, the observation that cells not sensitive to GHRH can be significantly stimulated by hexarelin strongly suggests that GHRPs and GHRH have two distinct sites and modes of action at the pituitary level...
  43. ncbi request reprint Prevention and treatment of glucocorticoid-induced osteoporosis
    M Doga
    Department of Internal Medicine, University of Brescia, Brescia, Italy
    J Endocrinol Invest 31:53-8. 2008
    ..Anabolic therapeutic strategies are under investigation. Teriparatide seems to be also efficacious for the treatment of patients with GIO...
  44. ncbi request reprint Ectopic secretion of growth hormone-releasing hormone (GHRH) in neuroendocrine tumors: relevant clinical aspects
    M Doga
    Department of Internal Medicine, University of Brescia, Italy
    Ann Oncol 12:S89-94. 2001
    ..Finally, the advent of these antagonists has allowed significant progress in the understanding of the role of the central and tissue GHRH-GH-IGFs system in the pathogenesis of tumors...
  45. ncbi request reprint Role of growth hormone in chronic heart failure. Therapeutic implications
    M Volterrani
    Fondazione S Maugeri, Cardiology Department, Gussago Medical Centre, Brescia, Italy
    Drugs 60:711-9. 2000
    ..Whether GH treatment will finally find a place, and with which modalities, in the treatment of heart failure remains to be established...
  46. ncbi request reprint Diagnosis and treatment of acromegaly complications
    A Giustina
    University of Brescia, Brescia, Italy
    J Endocrinol Invest 26:1242-7. 2003
    ..Effective management of co-morbid acromegaly complications will lead to improved morbidity and mortality in acromegaly...
  47. doi request reprint Prevalence of thoracic vertebral fractures in hospitalized elderly patients with heart failure
    G Mazziotti
    Endocrinology, University of Brescia, Brescia, Italy
    Eur J Endocrinol 167:865-72. 2012
    ..Indeed, most literature data on fractures were based on an historical and clinical approach focused on the identification of peripheral fractures, whereas the risk of vertebral fractures in this clinical setting is still unclear...
  48. ncbi request reprint Baseline and stimulated catecholamine secretion in normotensive patients with active acromegaly: acute effects of continuous octreotide infusion
    G D Rio
    Department of Internal Medicine, Section of Endocrinology and Metabolism, University of Modena, Italy
    Eur J Endocrinol 142:179-86. 2000
    ..Since few data are available on the catecholamine secretory dynamics in active acromegaly and no evidence exists on catecholamine variations during GH decrease, we studied acromegalic patients before and during octreotide administration...
  49. ncbi request reprint Long-term treatment with the dual antithromboxane agent picotamide decreases microalbuminuria in normotensive type 2 diabetic patients
    A Giustina
    Department of Internal Medicine, University of Brescia, Italy
    Diabetes 47:423-30. 1998
    ....
  50. ncbi request reprint Effect of pyridostigmine on the hydrocortisone-mediated decrease of circulating growth hormone levels in acromegaly
    A Giustina
    Cattedra di Clinica Medica, University of Brescia, Italy
    Horm Metab Res 26:288-92. 1994
    ..abstract truncated at 250 words)..
  51. ncbi request reprint Role of bone mineral density in predicting morphometric vertebral fractures in patients with HIV infection
    T Porcelli
    Chair of Endocrinology, University of Brescia, Brescia, Italy
    Osteoporos Int 25:2263-9. 2014
    ..This study investigated the bone of HIV patients both in terms of quantity and quality. It was found that HIV-infected patients did fracture independently of the degree of bone demineralization as in other forms of secondary osteoporosis...
  52. ncbi request reprint Diagnostic and therapeutic consensus on acromegaly
    M Doga
    Endocrine Section, Department of Internal Medicine, University of Brescia, Brescia, Italy
    J Endocrinol Invest 28:56-60. 2005
    ..This review paper summarizes the main points of the two consensus statements published following these two workshops...
  53. ncbi request reprint Comparative effect of clonidine and growth hormone (GH)-releasing hormone on GH secretion in adult patients on chronic glucocorticoid therapy
    A Giustina
    Cattedra di Clinica Medica, University of Brescia, Italy
    Horm Metab Res 24:240-3. 1992
    ..Clonidine is not able to enhance GH secretion similar to GHRH in patients chronically treated with steroids. It can be hypothesized that clonidine does not elicit GH secretion decreasing hypothalamic somatostatin tone...
  54. ncbi request reprint A single dose of aztreonam in the prevention of urinary tract infections in elderly catheterized patients
    G Romanelli
    Cattedra di Patologia Speciale Medica, University of Brescia, Italy
    J Chemother 2:178-81. 1990
    ..3%) had negative urine without clinical signs of UTI. In conclusion, our data suggest that a single 2g i.m. dose of aztreonam is effective in preventing UTI in elderly patients needing indwelling urethral catheterization...
  55. ncbi request reprint Bacteriological and clinical evaluation of cefotetan in the treatment of severe infections in hospitalized patients
    G Romanelli
    Department of Internal Medicine, University of Brescia, Italy
    Drugs Exp Clin Res 14:411-7. 1988
    ..In conclusion, cefotetan appears to be safe and highly effective for the treatment of severe infections in hospitalized patients...
  56. ncbi request reprint Dehydroepiandrosterone sulfate enhances natural killer cell cytotoxicity in humans via locally generated immunoreactive insulin-like growth factor I
    S B Solerte
    Department of Internal Medicine, Geriatrics and Gerontologic Clinic and School of Endocrinology and Metabolism, University of Pavia, Italy
    J Clin Endocrinol Metab 84:3260-7. 1999
    ..The higher NKCC response to DHEAS found in old subjects than in younger might counterbalance the age-dependent decline in circulating DHEAS, thus contributing to maintain the pattern of NK immunity during aging...
  57. ncbi request reprint Preliminary observations on the effects of acute infusion of growth hormone on coronary vasculature and on myocardial function and energetics of an isolated and blood-perfused heart
    R Lorusso
    Experimental Cardiac Surgery Unit, Ospedale Civile, Brescia, Italy
    J Endocrinol Invest 26:RC1-4. 2003
    ....
  58. ncbi request reprint Diagnosis and complications of Cushing's syndrome: a consensus statement
    G Arnaldi
    Department of Internal Medicine, University of Ancona, 60100 Ancona, Italy
    J Clin Endocrinol Metab 88:5593-602. 2003
    ..The consensus statement on diagnostic criteria and the diagnosis and treatment of complications of this syndrome reached at the workshop is hereby summarized...
  59. ncbi request reprint Characterization of new selective somatostatin receptor subtype-2 (sst2) antagonists, BIM-23627 and BIM-23454. Effects of BIM-23627 on GH release in anesthetized male rats after short-term high-dose dexamethasone treatment
    G Tulipano
    Department of Biomedical Sciences and Biotechnology, University of Brescia, 25125 Brescia, Italy
    Endocrinology 143:1218-24. 2002
    ..Based on prior reports that sst2 tonically suppresses glucagon secretion, the antagonist most likely increased glucagon secretion from the pancreatic alpha-cells, with resultant increases in plasma glucose and then insulin...
  60. doi request reprint Prognostic significance of the Ki-67 labeling index in growth hormone-secreting pituitary adenomas
    A Fusco
    Section of Endocrinology, Department of Internal Medicine, Universita Cattolica del Sacro Cuore, Via Cassia 901, Rome, Italy
    J Clin Endocrinol Metab 93:2746-50. 2008
    ..Ki-67 is a marker of proliferation activity associated with invasiveness and prognosis in human tumors...
  61. ncbi request reprint Bisphosphonates in the treatment of glucocorticoid-induced osteoporosis
    M Doga
    Endocrine Section, Department of Internal Medicine, University of Brescia, Italy
    Front Horm Res 30:150-64. 2002
  62. ncbi request reprint Does growth hormone play a role in chronic heart failure?
    Maurizio Volterrani
    Cardiology Department, Gussago Medical Center, Brescia, Italy
    Heart Fail Monit 3:60-4. 2002
    ..Due to the small number of patients examined to date, larger, randomized, controlled studies are needed...
  63. ncbi request reprint Clinical review: Growth hormone and cardiovascular risk factors
    Monica Gola
    Endocrine Section, Department of Internal Medicine, University of Brescia, 2 Medicina Spedali Civili, 25125 Brescia, Italy
    J Clin Endocrinol Metab 90:1864-70. 2005
    ..Moreover, enough evidence from GHD studies has been produced to suggest a physiological role for the GH/IGF-I axis in the control and regulation of several metabolic cardiovascular risk factors...
  64. ncbi request reprint Efficacy and safety of the new 60-mg formulation of the long-acting somatostatin analog lanreotide in the treatment of acromegaly
    Maria Rosaria Ambrosio
    Department of Biomedical Sciences and Advanced Therapies, Section of Endocrinology, University of Ferrara, Italy
    Metabolism 51:387-93. 2002
    ..The first injections of SR-LAN 60 are very helpful in predicting the optimal long-term injection frequency. Patients on SR-LAN 30 can be safely and effectively shifted to SR-LAN 60...
  65. ncbi request reprint Current guidelines for adult GH replacement
    Mauro Doga
    Ospedale Carlo Poma Mantova, Italy
    Rev Endocr Metab Disord 6:63-70. 2005
  66. ncbi request reprint Primary empty sella
    Laura De Marinis
    Departments of Endocrinology, Catholic University of Rome, 00168 Rome, Italy
    J Clin Endocrinol Metab 90:5471-7. 2005
    ..The term primary empty sella (PES) refers to a number of endocrine and/or neurological disturbances that may be caused by the herniation of subarachnoid space within the sella...
  67. ncbi request reprint Glucocorticoid-induced osteoporosis: an update
    Gherardo Mazziotti
    Department of Internal Medicine, Spedali Civili, University of Brescia, 25125 Brescia, Italy
    Trends Endocrinol Metab 17:144-9. 2006
    ..Anabolic and alternative therapeutic strategies are currently under investigation in glucocorticoid-induced osteoporosis...
  68. ncbi request reprint Long-term effects of the combination of pegvisomant with somatostatin analogs (SSA) on glucose homeostasis in non-diabetic patients with active acromegaly partially resistant to SSA
    Laura De Marinis
    Endocrinology, Catholic University of Sacred Heart, Rome, Italy
    Pituitary 10:227-32. 2007
    ....
  69. ncbi request reprint Impact of somatostatin analogs on the heart in acromegaly: a metaanalysis
    Patrick Maison
    Service de Pharmacologie Clinique, Unite de recherche clinique, Assistance Publique Hopitaux de Paris, Hopital Henri Mondor, University of Paris 12, F 94010 Creteil, France
    J Clin Endocrinol Metab 92:1743-7. 2007
    ..Treatment with somatostatin analogs has been shown to improve some cardiac parameters, but most published clinical trials involved few patients and were not randomized or controlled. In addition, their results are rather variable...
  70. ncbi request reprint Chronic glucocorticoid treatment alters spontaneous pulsatile parathyroid hormone secretory dynamics in human subjects
    Stefania Bonadonna
    Department of Medical Sciences, University of Brescia, Brescia, Italy
    Eur J Endocrinol 152:199-205. 2005
    ..Spontaneous parathyroid hormone (PTH) secretory dynamics include tonic and pulsatile components. It is not known how glucocorticoids might alter these secretory dynamics...
  71. ncbi request reprint Glucocorticoid inhibition of growth in rats: partial reversal with the full-length ghrelin analog BIM-28125
    Giovanni Tulipano
    Department of Biomedical Sciences and Biotechnologies, University of Brescia, Brescia, Italy
    Pituitary 10:267-74. 2007
    ..These preclinical results leads to the conclusion that BIM-28125 may represent a good tool to reverse the catabolic effects induced by glucocorticoids...
  72. ncbi request reprint Bone ultrasonometric features and growth hormone secretion in asthmatic patients during chronic inhaled corticosteroid therapy
    Mario Malerba
    Department of Internal Medicine, University of Brescia, 1 Divisione di Medicina, Spedali Civili, Pzza Spedali Civili 1, 25100 Brescia, Italy
    Bone 38:119-24. 2006
    ..Therefore, the aim of this study was to evaluate the effects of long-term therapy with inhaled CSs (ICSs) on structural bone characteristics and their correlations with GH secretion and bone markers in asthmatic patients...
  73. ncbi request reprint Consensus Document on substitution therapy with DHEA in the elderly
    Giorgio Valenti
    Dipartimento di Medicina Interna e Scienze Biomediche, Sezione Geriatria, Universita degli Studi di Parma, Via Gramsci 14, 43100 Parma, Italy
    Aging Clin Exp Res 18:277-300. 2006
  74. ncbi request reprint Active acromegaly enhances spontaneous parathyroid hormone pulsatility
    Gherardo Mazziotti
    Department of Internal Medicine, University of Brescia, 25125 Brescia, Italy
    Metabolism 55:736-40. 2006
    ..Potentially negative bone effects of the modifications of PTH secretory pattern in acromegaly should be investigated...
  75. ncbi request reprint Long-term effects of lanreotide SR and octreotide LAR on tumour shrinkage and GH hypersecretion in patients with previously untreated acromegaly
    Giovanni Amato
    Endocrinology Institute Second University of Naples, Italy
    Clin Endocrinol (Oxf) 56:65-71. 2002
    ..We aimed to investigate the long-term effects of these drugs on tumour shrinkage and growth hormone (GH) hypersecretion without the confounding influences of previous therapy...
  76. ncbi request reprint Increased prevalence of radiological spinal deformities in active acromegaly: a cross-sectional study in postmenopausal women
    Stefania Bonadonna
    Endocrine Section, Department of Internal Medicine, University of Brescia, Brescia, Italy
    J Bone Miner Res 20:1837-44. 2005
    ..In patients with active acromegaly, vertebral fractures occur even in presence of normal BMD, whereas in patients with controlled acromegaly, vertebral fractures are always accompanied by a pathological BMD...
  77. ncbi request reprint Consensus Document on substitution therapy with testosterone in hypoandrogenic elderly men
    Giorgio Valenti
    Dipartimento di Medicina Interna e Scienze Biomediche, University of Parma, Italy
    Aging Clin Exp Res 14:439-64. 2002
  78. ncbi request reprint Perspectives on glucocorticoid-induced osteoporosis
    Ernesto Canalis
    Saint Francis Hospital and Medical Center, Hartford, CT 06105, USA
    Bone 34:593-8. 2004
  79. ncbi request reprint Acromegaly consensus: the next steps
    Andrea Giustina
    J Clin Endocrinol Metab 88:1913-4. 2003
  80. ncbi request reprint Cushing's syndrome and bone
    Tatiana Mancini
    Division of Medicine, San Marino Hospital, Republic of San Marino
    Pituitary 7:249-52. 2004
    ..The decision to discontinue antiresorptive therapy should be based on clinical monitoring and DEXA measurements...
  81. doi request reprint Erectile dysfunction as a predictor of cardiovascular events and death in diabetic patients with angiographically proven asymptomatic coronary artery disease: a potential protective role for statins and 5-phosphodiesterase inhibitors
    Carmine Gazzaruso
    Cardio Metabolic Unit and the Centre for Applied Clinical Research Ce R C A Clinical Institute Beato Matteo, Hospital Group San Donato, Vigevano, Italy
    J Am Coll Cardiol 51:2040-4. 2008
    ....
  82. ncbi request reprint Nutritional supplements with oral amino acid mixtures increases whole-body lean mass and insulin sensitivity in elderly subjects with sarcopenia
    Sebastiano B Solerte
    Geriatric Clinic, Department of Internal Medicine, University of Pavia, Pavia, Italy
    Am J Cardiol 101:69E-77E. 2008
    ..The improvement in the amount of whole-body lean mass could be linked to increased insulin sensitivity and anabolic conditions related to IGF-1 availability...
  83. ncbi request reprint Growth hormone response to growth hormone-releasing hormone is reduced in adult asthmatic patients receiving long-term inhaled corticosteroid treatment
    Mario Malerba
    Department of Internal Medicine, University of Brescia, 1 Divisione di Medicina, Spedali Civili, Piazza Spedali Civili 1, 25100 Brescia, Italy
    Chest 127:515-21. 2005
    ..The aim of study was to investigate the effects of long-term therapy with inhaled CSs (ICSs) on the hypothalamic-pituitary-GH axis by the GH response to GH-releasing hormone (GHRH), as well as bone turnover, in adult asthmatic patients...
  84. ncbi request reprint Mechanisms of anabolic therapies for osteoporosis
    Ernesto Canalis
    Department of Research, Saint Francis Hospital and Medical Center, Hartford, CT 06105 1299, USA
    N Engl J Med 357:905-16. 2007
  85. ncbi request reprint The somatostatin subtype-2 receptor antagonist, BIM-23627, improves the catabolic effects induced by long-term glucocorticoid treatment in the rat
    Giovanni Tulipano
    Department of Biomedical Sciences and Biotechnology, University of Brescia, Italy
    Regul Pept 125:85-92. 2005
    ..Further studies are required in order to fully optimize the SSTR-2 antagonist-induced reversal of DEX-induced somatic growth inhibition...
  86. ncbi request reprint Leptin stimulates growth hormone secretion via a direct pituitary effect combined with a decreased somatostatin tone in a median eminence-pituitary perifusion study
    Roberta Saleri
    Department of Animal Production, Veterinary Biotechnology, Food Safety, University of Parma, Parma, Italy
    Neuroendocrinology 79:221-8. 2004
    ..These results support the hypothesis that leptin may be an interesting hormonal mediator of growth and related metabolic effects by acting directly on the hypothalamic-pituitary axis...
  87. ncbi request reprint Acromegalic patients show the presence of hypertrophic remodeling of subcutaneous small resistance arteries
    Damiano Rizzoni
    Department of Medical and Surgical Sciences, University of Brescia, Chair of Internal Medicine, Spedali Civili, 25100 Brescia, Italy
    Hypertension 43:561-5. 2004
    ..In conclusion, our data suggest the presence of hypertrophic remodeling of subcutaneous small resistance arteries of AP, probably as a consequence of growth-stimulator properties of IGF-1...
  88. ncbi request reprint Transformation of a MGUS to overt multiple myeloma: the possible role of a pituitary macroadenoma secreting high levels of insulin-like growth factor 1 (IGF-1)
    Alessandra Tucci
    Sezione di Ematologia, Spedali Civili, p le Spedali Civili 1, 25125 Brescia, Italy
    Leuk Lymphoma 44:543-5. 2003
    ....
  89. ncbi request reprint Increased prevalence of radiological spinal deformities in adult patients with GH deficiency: influence of GH replacement therapy
    Gherardo Mazziotti
    Endocrine Section, Department of Internal Medicine, University of Brescia, Brescia, Italy
    J Bone Miner Res 21:520-8. 2006
    ..Patients undergoing GH replacement treatment showed a significantly lower prevalence of vertebral deformities versus treated patients in the presence of similar BMD, as assessed by DXA...