Research Topics
| Gian Luigi GigliSummaryCountry: Italy Publications
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Detail Information
Publications
Epidemiology and clinical features of sleep disorders in extrapyramidal diseaseStefania Brotini
Department of Neurosciences, Neurology Neurophysiopathology Unit, Sleep Disorders Center, S Maria della Misericordia General Hospital, Piazzale S Maria della Misericordia, 15, 33100 Udine, Italy
Sleep Med 5:169-79. 2004..There are no data available at present as to the role of gender in sleep disturbances. Finally, the benefit of sleep on extrapyramidal diseases will be addressed, taking into account that the above causes may modify the effects of sleep...
Restless legs syndrome in end-stage renal diseaseGian Luigi Gigli
Neurologia Neurofisiopatologia, Department of Neurosciences, Center for Sleep Medicine, Azienda Ospedaliera S Maria della Misericordia, Piazzale S Maria della Misericordia, 15 33100 Udine, Italy
Sleep Med 5:309-15. 2004..Moreover, some data were collected prior to the recent improvements in dialysis techniques, pharmacological therapies and to the establishment of internationally recognised diagnostic criteria for RLS...
The withdrawal of nutrition and hydration in the vegetative state patient: societal dimension and issues at stake for the medical professionGian Luigi Gigli
Department of Neurosciences, Ospedale Santa Maria della Misericordia, Udine, Italy
NeuroRehabilitation 19:315-28. 2004..In the second part, the authors outline the changes that this attitude can provoke in the integrity and the juridical status of the medical and nursing professions, and its potential impact on the society at large...
Incidence of transient ischemic attack and early stroke risk: validation of the ABCD2 score in an Italian population-based studyIacopo Cancelli
Department of Neurosciences, S Maria della Misericordia University Hospital, and Department of Experimental and Clinical Medicine, University of Udine Medical School, Piazza Santa Maria della Misericordia, 33100 Udine, Italy
Stroke 42:2751-7. 2011..However, population-based studies are still needed. We aimed to provide data on TIA incidence and to evaluate the ABCD2 predictive ability for early recurrent stroke in a population-based study...
Gabapentin enacarbil in restless legs syndromeGiovanni Merlino
Sleep Disorders Center, Dept of Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy
Drugs Today (Barc) 46:3-11. 2010..Further studies are required to confirm the long term efficacy and safety of gabapentin enacarbil on the symptoms of RLS...
Drugs with anticholinergic properties as a risk factor for cognitive impairment in elderly people: a population-based studyIacopo Cancelli
Department of Neurology, S Maria della Misericordia University Hospital, University of Udine Medical School, Udine, Italy
J Clin Psychopharmacol 28:654-9. 2008..30; 95% confidence interval, 1.19-4.45). Our data suggest that ACH drug intake should be regarded a potentially modifiable risk factor for cognitive impairment in the elderly...
A case-control study on restless legs syndrome in nondialyzed patients with chronic renal failureGiovanni Merlino
Department of Neurosciences, Sleep Disorders Center, Santa Maria della Misericordia University Hospital, Udine, Italy
Mov Disord 25:1019-25. 2010..Nephrologists should investigate and treat RLS in their nondialyzed patients with CRF. In particular, physicians should carefully investigate women and patients with iron deficiency in the presence of RLS symptoms...
Restless legs syndrome in dialysis patients: a comparison between hemodialysis and continuous ambulatory peritoneal dialysisGiovanni Merlino
Department of Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy
Neurol Sci 33:1311-8. 2012..Dialysis schedule was associated with RLS in HD patients, while female sex was related to RLS in CAPD patients. Awareness concerning RLS identification and treatment in HD and CAPD patients is recommended...
Clinical experience with pramipexole in the treatment of restless legs syndromeGiovanni Merlino
Santa Maria della Misericordia University Hospital, Sleep Disorder Center, Neurology and Clinical Neurophysiology, Udine, Italy
Expert Opin Drug Metab Toxicol 4:225-35. 2008..Augmentation, the most common side effect of levodopa, is less prevalent after treatment with pramipexole. In addition, the recurrence of unpleasant symptoms due to pramipexole is uncommon...
Association of restless legs syndrome in type 2 diabetes: a case-control studyGiovanni Merlino
Sleep Disorder Center Neurology and Clinical Neurophysiology, Santa Maria della Misericordia University Hospital, Udine, Italy
Sleep 30:866-71. 2007....
Gabapentin enacarbil, a gabapentin prodrug for the treatment of the neurological symptoms associated with disorders such as restless legs syndromeGiovanni Merlino
Sleep Disorder Center, Santa Maria della Misericordia University Hospital, Piazzale S Maria della Misericordia, Udine, Italy
Curr Opin Investig Drugs 10:91-102. 2009..The author concludes that additional studies are required in order to better assess the efficacy and safety of gabapentin enacarbil on RLS...
Association of body rolling, leg rolling, and rhythmic feet movements in a young adult: A video-polysomnographic study performed before and after one night of clonazepamGiovanni Merlino
Sleep Disorder Center, Neurology and Clinical Neurophysiology, Santa Maria della Misericordia University Hospital, Udine, Italy
Mov Disord 23:602-7. 2008..We discuss the characteristics of the RMD and the response to the first administration of pharmacological treatment, observed in our patient...
Drugs with anticholinergic properties: cognitive and neuropsychiatric side-effects in elderly patientsIacopo Cancelli
Department of Neurology, Santa Maria della Misericordia University Hospital, Udine, Italy
Neurol Sci 30:87-92. 2009..The threat of developing cognitive impairment, psychosis and delirium will be particularly analyzed...
Sleep disturbances in dialysis patientsGiovanni Merlino
Sleep Disorder Center, Neurology and Clinical Neurophysiology, Santa Maria della Misericordia University Hospital, Piazza Santa Maria della Misericordia, Udine, Italy
J Nephrol 21:S66-70. 2008..However, literature and personal data suggest that undertreatment is common, calling to higher awareness of sleep disturbances among nephrologists...
Changes of cortical excitability after dopaminergic treatment in restless legs syndromeAnna Scalise
Department of Neurosciences, S Maria della Misericordia University Hospital, Udine, Italy
Sleep Med 11:75-81. 2010..The purpose of our study was to compare practice-dependent plasticity in RLS patients before and after a month of dopaminergic treatment...
ADMET considerations for restless leg syndrome drug treatmentsStefano de Biase
Department of Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy
Expert Opin Drug Metab Toxicol 8:1247-61. 2012..Concerning RLS due to iron deficiency, a head-to-head study comparing efficacy, safety and compliance of oral iron versus intravenous one seems to be needed...
The acute effect of a low dosage of pramipexole on severe idiopathic restless legs syndrome: an open-label trialGiovanni Merlino
Sleep Disorder Centre, Department of Neurology, Santa Maria della Misericordia University Hospital, Udine, Italy
Neuropsychobiology 54:195-200. 2006..CONCLUSIONS: Our results suggest that low doses of pramipexole are effective in reducing sensory symptoms and motor signs of RLS, even after the first administration...
Sleep-related movement disordersGiovanni Merlino
Department of Neurosciences, Santa Maria della Misericordia University Hospital, Udine, Italy
Neurol Sci 33:491-513. 2012..Patients reporting poor sleep due to these abnormal movements should undergo non-pharmacological or pharmacological treatments...
Drugs with anticholinergic properties: a potential risk factor for psychosis onset in Alzheimer's disease?Iacopo Cancelli
Santa Maria della Misericordia University Hospital, Department of Neurology, Udine, Italy
Expert Opin Drug Saf 8:549-57. 2009..This review focuses on biological and clinical data which suggest that anti-cholinergic drugs should be regarded as a potential risk factor for psychosis in Alzheimer's disease...
Sleep before and after temporal lobe epilepsy surgeryAnna Serafini
Epilepsy Unit, Hopital Gui de Chauliac, Montpellier, France
Seizure 21:260-5. 2012....
The accuracy of discharge diagnosis coding for Amyotrophic Lateral Sclerosis in a large teaching hospitalFederica Edith Pisa
Institute of Hygiene and Epidemiology, DPMSC, Azienda Ospedaliero Universitaria di Udine, Via Colugna 40, 33100, Udine, Italy
Eur J Epidemiol 24:635-40. 2009....
Nerve fibre layer analysis with GDx with a variable corneal compensator in patients with multiple sclerosisGiovanni Della Mea
Department of Ophthalmology, S Maria della Misericordia Hospital, Udine, Italy
Ophthalmologica 221:186-9. 2007..To evaluate the ability of GDx with variable corneal compensator (VCC) compared to visual-evoked potentials (VEPs) and standard automated perimetry (SAP) in the detection of early optic nerve damage in patients with multiple sclerosis (MS)...
Absence of postexercise and delayed facilitation of motor cortex excitability in restless legs syndrome: evidence of altered cortical plasticity?Anna Scalise
Department of Neurosciences, S Maria della Misericordia Hospital, Udine, Italy
Sleep 29:770-5. 2006..Previous studies have suggested alterations in motor cortex function in RLS. We aimed to compare motor cortex plasticity in subjects with RLS versus healthy controls...
Motor cortex excitability in restless legs syndromeAnna Scalise
Department of Neurosciences, S Maria della Misericordia Hospital, Piazzale S Maria della Misericordia 15, Udine, Italy
Sleep Med 5:393-6. 2004..In this study we used TMS to define motor cortical excitability in RLS subjects...
Increasing cortical excitability: a possible explanation for the proconvulsant role of sleep deprivationAnna Scalise
Department of Neurosciences, S Maria della Misericordia Hospital, Udine, Italy
Sleep 29:1595-8. 2006..In order to evaluate the effects of SD on cortical excitability, we studied the effects of sleep loss on healthy subjects by transcranial magnetic stimulation (TMS)...
Sleep disorders in patients with end-stage renal disease undergoing dialysis therapyGiovanni Merlino
Sleep Disorder Center, Neurology Unit, S. Maria della Misericordia Hospital and Udine University Hospital, 33100 Udine, Italy
Nephrol Dial Transplant 21:184-90. 2006..Our data might help nephrologists to deal with uraemic patients with possible sleep disorders. Concerning the high prevalence of possible narcolepsy, further studies using polysomnographic records are necessary to confirm our results...
Multicenter case-control study on restless legs syndrome in multiple sclerosis: the REMS studyMauro Manconi
Sleep Disorders Center, Scientific Institute and Ospedale San Raffaele, Via Stamira d Ancona 20, 20127 Milan, Italy
Sleep 31:944-52. 2008..To verify the existence of a symptomatic form of restless legs syndrome (RLS) secondary to multiple sclerosis (MS) and to identify possible associated risk factors...
ForewordGian Luigi Gigli
NeuroRehabilitation 19:271-2. 2004
Specific impairments of rule induction in different frontal lobe subgroupsCarlo Reverberi
International School for Advanced Studies, Trieste, Italy
Neuropsychologia 43:460-72. 2005....
Statement on euthanasia in childrenGian Luigi Gigli
Med Etika Bioet 11:22. 2004
Considerations on the scientific and ethical problems related to vegetative stateGian Luigi Gigli
Med Etika Bioet 11:20-1. 2004
