M Gambacciani

Summary

Country: Italy

Publications

  1. ncbi A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in early postmenopausal women
    M Gambacciani
    Department of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Gynecol Endocrinol 18:9-16. 2004
  2. ncbi Hormone replacement therapy: the benefits in tailoring the regimen and dose
    M Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 40:195-201. 2001
  3. ncbi Hormone replacement therapy and endometrial, ovarian and colorectal cancer
    M Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, Via Roma 35, Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 17:139-47. 2003
  4. ncbi Homocysteine, menopause and cardiovascular disease
    Marco Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynaecology, University of Pisa, Via Roma 57, 56100 Pisa, Italy
    Menopause Int 13:23-6. 2007
  5. ncbi Postmenopausal femur bone loss: effects of a low dose hormone replacement therapy
    Marco Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 45:175-83. 2003
  6. ncbi Longitudinal evaluation of perimenopausal bone loss: effects of different low dose oral contraceptive preparations on bone mineral density
    Marco Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 54:176-80. 2006
  7. ncbi Efficacy on climacteric symptoms of a continuous combined regimen of 1 mg 17beta-estradiol and trimegestone versus two regimens combining 1 or 2 mg 17beta-estradiol and norethisterone acetate
    M Gambacciani
    Dept of Obstetrics and Gynecology, Piero Fioretti University of Pisa, Via Roma 67, I 56100 Pisa, Italy
    Gynecol Endocrinol 21:65-73. 2005
  8. ncbi Quantitative ultrasound (QUS) of bone in the management of postmenopausal women
    Marco Gambacciani
    Department of Obstetrics and Gynaecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 47:139-49. 2004
  9. ncbi Effects of oral contraceptives on bone mineral density
    Marco Gambacciani
    Department of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Pisa, Italy
    Treat Endocrinol 3:191-6. 2004
  10. ncbi Postmenopausal osteoporosis and hormone replacement therapy
    M Gambacciani
    Department of Obstetrics and Gynecology, Pisa University Hospital, Pisa, Italy
    Minerva Med 95:507-20. 2004

Collaborators

Detail Information

Publications54

  1. ncbi A longitudinal evaluation of the effect of two doses of tibolone on bone density and metabolism in early postmenopausal women
    M Gambacciani
    Department of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Gynecol Endocrinol 18:9-16. 2004
    ..It is concluded that tibolone is effective, even at lower doses, in relieving climacteric symptoms and preventing a decrease in spine and femur BMD in early postmenopausal women...
  2. ncbi Hormone replacement therapy: the benefits in tailoring the regimen and dose
    M Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 40:195-201. 2001
    ..Low dose regimens should be considered as a starting dose to minimize the occurrence of side effects, improving compliance and, therefore, HRT effects on the prevention of long-term consequences of estrogen deprivation...
  3. ncbi Hormone replacement therapy and endometrial, ovarian and colorectal cancer
    M Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, Via Roma 35, Pisa, Italy
    Best Pract Res Clin Endocrinol Metab 17:139-47. 2003
    ..The future of HRT in post-menopausal women lies in the individualization of the therapy based upon personal risk factors and characteristics...
  4. ncbi Homocysteine, menopause and cardiovascular disease
    Marco Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynaecology, University of Pisa, Via Roma 57, 56100 Pisa, Italy
    Menopause Int 13:23-6. 2007
    ..Also, the benefits of reducing homocysteine levels with folic acid and vitamin B6 and B12 supplements are highly debated...
  5. ncbi Postmenopausal femur bone loss: effects of a low dose hormone replacement therapy
    Marco Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 45:175-83. 2003
    ..Previous studies indicate that low-dose hormone replacement therapy (LD-HRT) can relieve vasomotor symptoms and prevent spine bone loss...
  6. ncbi Longitudinal evaluation of perimenopausal bone loss: effects of different low dose oral contraceptive preparations on bone mineral density
    Marco Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 54:176-80. 2006
    ..To evaluate the pattern of mineral density in eumenorrhoic and oligomenorrhoic perimenopausal women, and assess the effects of different low dose oral contraceptives (OC) on bone metabolism and spine bone density...
  7. ncbi Efficacy on climacteric symptoms of a continuous combined regimen of 1 mg 17beta-estradiol and trimegestone versus two regimens combining 1 or 2 mg 17beta-estradiol and norethisterone acetate
    M Gambacciani
    Dept of Obstetrics and Gynecology, Piero Fioretti University of Pisa, Via Roma 67, I 56100 Pisa, Italy
    Gynecol Endocrinol 21:65-73. 2005
    ..125 mg trimegestone (TMG) with two continuous combined 17beta-E2/norethisterone acetate (NETA) combinations in the relief of climacteric symptoms in postmenopausal women...
  8. ncbi Quantitative ultrasound (QUS) of bone in the management of postmenopausal women
    Marco Gambacciani
    Department of Obstetrics and Gynaecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 47:139-49. 2004
    ..The gynaecologist plays an important role in establishing a "biological zero" in each perimenopausal patient, and controlling the rate of bone loss during postmenopausal period...
  9. ncbi Effects of oral contraceptives on bone mineral density
    Marco Gambacciani
    Department of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Pisa, Italy
    Treat Endocrinol 3:191-6. 2004
    ..In conclusion, the protective role of oral contraceptives on bone density is biologically plausible, since this treatment represents a replacement therapy with continuous exposure to exogenous estrogens...
  10. ncbi Postmenopausal osteoporosis and hormone replacement therapy
    M Gambacciani
    Department of Obstetrics and Gynecology, Pisa University Hospital, Pisa, Italy
    Minerva Med 95:507-20. 2004
    ..LD-HRT may enhance patient acceptability and continuation, ensuring adequate bone protection and menopausal symptoms control, and given physicians the possibility to personalize the doses on the basis of each individual patient's needs...
  11. ncbi Clinical usefulness of endometrial screening by ultrasound in asymptomatic postmenopausal women
    M Gambacciani
    Department of Obstetrics and Gynecology Piero Fioretti, University Pisa, Via Roma 67, Pisa 56126, Italy
    Maturitas 48:421-4. 2004
    ..The aim of the present study was to evaluate the clinical usefulness of routine use of endometrial ultrasound in asymptomatic, bleeding-free postmenopausal women...
  12. ncbi Effects of low-dose, continuous combined hormone replacement therapy on sleep in symptomatic postmenopausal women
    Marco Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 50:91-7. 2005
    ..Low-dose estrogen associated with low-dose micronized progesterone may especially benefit women who complain of disturbed sleep...
  13. ncbi Effects of low-dose, continuous combined estradiol and noretisterone acetate on menopausal quality of life in early postmenopausal women
    Marco Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100, Pisa, Italy
    Maturitas 44:157-63. 2003
    ....
  14. ncbi Ultra low-dose hormone replacement therapy and bone protection in postmenopausal women
    Marco Gambacciani
    Department of Obstetrics and Gynecology, Pisa University Hospital, Via Roma 67, Pisa, Italy
    Maturitas 59:2-6. 2008
    ..The aim of the present study was to evaluate the effects of low doses of hormone replacement therapy (HRT) in normal young postmenopausal women...
  15. ncbi New HRT options for the treatment of menopausal symptoms and the maintenance of quality of life in postmenopausal women
    Marco Gambacciani
    Department of Obstetrics and Gynecology, Menopause Unit, Pisa University Hospital, Via Roma 67, 56100 Pisa, Italy
    Endocrine 24:231-8. 2004
    ..The choice of lower estrogen doses may at least in part reduce the potential risks of postmenopausal hormone use, while maintaining the benefits of conventional HRT...
  16. ncbi Menopause and related problems
    M Gambacciani
    Department of Obstetrics and Gynecology, Pisa University Hospital, Pisa, Italy
    Minerva Med 98:191-201. 2007
    ....
  17. ncbi Postmenopausal osteoporosis management
    M Gambacciani
    Department of Reproductive Medicine and Child Development, Piero Fioretti, University of Pisa, Italy
    Curr Opin Obstet Gynecol 12:189-97. 2000
    ..Tibolone as well as raloxifene prevent bone loss and solid data demonstrate a reduction of vertebral fractures after raloxifene administration...
  18. ncbi Longitudinal evaluation of perimenopausal femoral bone loss: effects of a low-dose oral contraceptive preparation on bone mineral density and metabolism
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Italy
    Osteoporos Int 11:544-8. 2000
    ..05) increase in femoral bone density. It is concluded that perimenopausal OC administration can avoid the increase in bone turnover and the decrease in femoral bone density due to the perimenopausal impairment of ovarian function...
  19. ncbi Prospective evaluation of body weight and body fat distribution in early postmenopausal women with and without hormonal replacement therapy
    M Gambacciani
    Department of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Maturitas 39:125-32. 2001
    ....
  20. ncbi Effects of low-dose continuous combined conjugated estrogens and medroxyprogesterone acetate on menopausal symptoms, body weight, bone density, and metabolism in postmenopausal women
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Italy
    Am J Obstet Gynecol 185:1180-5. 2001
    ....
  21. ncbi Assessment of the QoL in Italian menopausal women: comparison between HRT users and non-users
    A R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Via Roma 35, 56100 Pisa, Italy
    Maturitas 42:267-80. 2002
    ....
  22. ncbi Clinical and metabolic effects of drospirenone-estradiol in menopausal women: a prospective study
    M Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology Piero Fioretti, Pisa University Hospital, University of Pisa, Via Roma 67, Pisa, Italy
    Climacteric 14:18-24. 2011
    ..To describe the effects of low-dose hormonal replacement therapy (HRT) on quality of life, metabolic parameters and blood pressure in postmenopausal women...
  23. ncbi Postmenopausal osteoporosis: therapeutic options
    A R Genazzani
    Department of Gynecology and Obstetrics, University of Pisa, Italy
    Climacteric 8:99-109. 2005
  24. ncbi Effects of combined low dose of the isoflavone derivative ipriflavone and estrogen replacement on bone mineral density and metabolism in postmenopausal women
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Italy
    Maturitas 28:75-81. 1997
    ..To assess the pattern of biochemical markers of bone metabolism and vertebral bone mineral density in early postmenopausal women treated with combined ipriflavone and low dose conjugated estrogens...
  25. ncbi Menopause and aging, quality of life and sexuality
    A R Genazzani
    Department of Reproductive Medicine and Child Development, University of Pisa, Pisa, Italy
    Climacteric 10:88-96. 2007
  26. ncbi Vasomotor symptoms and cardiovascular risk
    M Gambacciani
    Department of Obstetrics and Gynecology, Menopause and Osteoporosis Center, Pisa University Hospital, Pisa, Italy
    Climacteric 12:32-5. 2009
    ..This point may explain, at least in part, the negative/null effects of HRT on cardiovascular disease observed in the trials where HRT was given to largely asymptomatic, elderly women...
  27. ncbi The relative contributions of menopause and aging to postmenopausal reduction in intervertebral disk height
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Climacteric 10:298-305. 2007
    ....
  28. ncbi Low-dose hormone replacement therapy: effects on bone
    M Gambacciani
    Department of Obstetrics and Gynecology Piero Fioretti, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Climacteric 5:135-9. 2002
    ..In older women, these may minimize the occurrence of side-effects and improve compliance, while preventing the long-term consequences of estrogen deprivation...
  29. ncbi Adrenal function under long-term raloxifene administration
    A R Genazzani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 17:159-68. 2003
    ....
  30. ncbi Hormone replacement therapy in climacteric and aging brain. International Menopause Society Expert Workshop, 15-18 March 2003, Pisa, Italy
    A R Genazzani
    Department of Gynecology and Obstetrics, University of Pisa, Via Roma 35, 56126 Italy
    Climacteric 6:188-203. 2003
  31. ncbi Controversial issues in climacteric medicine II. Hormone replacement therapy and cancer. International Menopause Society Expert Workshop. 9-12 June 2001, Opera del Duomo, Pisa, Italy
    A R Genazzani
    Department of Gynecology and Obstetrics, University of Pisa, Via Roma 35, 56126 Italy
    Climacteric 4:181-93. 2001
    ..This issue is considered as an important area for future evaluation and research. The International Menopause Society is in the process of drawing up specific recommendations for further research in the field of HRT and cancer...
  32. ncbi Effect of climacteric transition and hormone replacement therapy on body weight and body fat distribution
    Andrea Riccardo Genazzani
    Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Gynecol Endocrinol 22:145-50. 2006
    ..Perimenopausal and postmenopausal women show a shift to a central, android fat distribution that can be counteracted by HRT...
  33. ncbi The HRT misuse and osteoporosis epidemic: a possible future scenario
    M Gambacciani
    Department of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Climacteric 10:273-5. 2007
    ....
  34. ncbi Comparison of effects of 3 mg drospirenone plus 20 μg ethinyl estradiol alone or combined with metformin or cyproterone acetate on classic metabolic cardiovascular risk factors in nonobese women with polycystic ovary syndrome
    Franca Fruzzetti
    Department of Obstetrics and Gynecology, Ospedale S Chiara, University of Pisa, Pisa, Italy
    Fertil Steril 94:1793-8. 2010
    ....
  35. ncbi Risk identification of osteoporosis in postmenopausal women by a simple algorithm based on ultrasound densitometry and body mass index
    Umberto Omodei
    Obstetric and Gynaecologic Clinic, University of Brescia, Brescia, Italy
    J Clin Densitom 11:412-6. 2008
    ..The diagnostic work up proposed appears effective to be indicated for extensive clinical employment, thanks also to its simplicity...
  36. ncbi Effect of an oral contraceptive containing 30 microg ethinylestradiol plus 3 mg drospirenone on body composition of young women affected by premenstrual syndrome with symptoms of water retention
    Franca Fruzzetti
    Department of Obstetrics and Gynecology, University of Pisa, Via Roma 67, 56100 Pisa, Italy
    Contraception 76:190-4. 2007
    ....
  37. ncbi HRT misuse and the osteoporosis epidemic
    M Gambacciani
    Department of Obstetrics and Gynecology, Pisa University Hospital, Pisa, Italy
    Climacteric 15:10-1. 2012
    ..In view of the dramatic decline in the number of hormone users all around the world, this mini-review discusses the 'neglected' skeletal outcomes of such global trends...
  38. ncbi Validation of Italian version of the Women's Health Questionnaire: assessment of quality of life of women from the general population and those attending menopause centers
    A R Genazzani
    Department of Reproductive Medicine and Child Development, Section of Obstetrics and Gynecology, University of Pisa, Via Roma n. 67, 56126 Pisa, Italy
    Climacteric 5:70-7. 2002
    ..CONCLUSION: The Italian version of the WHO is valid and reproducible. The subjective perception of the menopause and its related problems is similar in geographically and culturally different populations...
  39. ncbi Dydrogesterone does not reverse the effects of estradiol on endothelium-dependant vasodilation in postmenopausal women: a randomised clinical trial
    Marco Gambacciani
    Department of Reproductive Medicine and Child Development, Division of Obstetrics and Gynecology, University of Pisa, Pisa, Italy
    Maturitas 43:117-23. 2002
    ..CONCLUSIONS: Hormone replacement therapy with estradiol and dydrogesterone improves endothelial function and reduces plasma levels of endothelin-1 in PMW at risk for coronary artery disease...
  40. ncbi The sound of an International anti-HRT herald
    Andrea R Genazzani
    Department of Obstetrics and Gynaecology, University of Pisa, Italy
    Maturitas 46:105-6. 2003
  41. ncbi Hormonal influence on the central nervous system
    Andrea R Genazzani
    Department of Obstetrics and Gynecology, University of Pisa Via Roma 35, 56100 Pisa, Italy
    Maturitas 43:S11-7. 2002
    ..Further studies are required in order to explain the specific role of endogenous and exogenous sex steroids on the CNS...
  42. ncbi "Controversial issues in climacteric medicine" series 3rd Pisa workshop "HRT in climacteric and aging brain". Pisa, Italy, 15-18 March 2003
    Andrea R Genazzani
    Department of Reproductive Medicine and Child Development, University of Pisa, Italy
    Maturitas 46:7-26. 2003
  43. ncbi Clinical relevance of the HERS trial
    Marco Gambacciani
    Lancet 360:641. 2002
  44. ncbi Different effect of hormone replacement therapy, DHEAS and tibolone on endothelial function in postmenopausal women with increased cardiovascular risk
    Antonello Silvestri
    Department of Medical Sciences, Cardiovascular Research Unit, San Raffaele--Roma, Tosinvest Sanita, via della Pisana 235, 00163 Roma, Italy
    Maturitas 50:305-11. 2005
    ..In conclusion, HRT, but neither T nor DHEAS, improves endothelial function and reduces plasma levels of endothelin-1 in PMW at risk of CAD...
  45. ncbi Positive effects on cardiovascular and breast metabolic markers of oral estradiol and dydrogesterone in comparison with transdermal estradiol and norethisterone acetate
    Carlo Campagnoli
    Unit of Endocrinological Gynaecology, Azienda Ospedaliera O.I.R.M./Sant'Anna, C.so Spezia, 60-10127 Torino, Italy
    Maturitas 41:299-311. 2002
    ..These effects were significantly different from those obtained with a transdermal estradiol associated to an androgenic progestogen...
  46. ncbi From the challenge to the reassessment of the Women's Health Initiative: a personal initiative for women's health
    Marco Gambacciani
    Gynecol Endocrinol 22:115-6. 2006
  47. ncbi The Xmas present for women's health: a strike to osteoporosis prevention
    Marco Gambacciani
    Maturitas 48:9-11. 2004
  48. ncbi The osteoporosis dilemma
    Marco Gambacciani
    Gynecol Endocrinol 18:59-61. 2004
  49. ncbi Practical recommendations for hormone replacement therapy in the peri- and postmenopause
    Henry Burger
    Climacteric 7:210-6. 2004
  50. ncbi [Management of cardiovascular risk in the peri-menopausal woman--a consensus statement of European cardiologists and gynaecologists]
    Peter Collins
    NHLI, Imperial College London, Royal Brompton Hospital, London, Wielka Brytania
    Kardiol Pol 65:1331-46; discussion 1347-49. 2007
  51. ncbi IMS updated recommendations on postmenopausal hormone therapy
    Amos Pines
    Department of Internal Medicine T, Ichilov Hospital, Tel Aviv, Israel
    Climacteric 10:181-94. 2007
  52. ncbi Hormone therapy
    Marco Gambacciani
    Menopause 10:266-7; author reply 267. 2003
  53. ncbi Management of cardiovascular risk in the peri-menopausal woman: a consensus statement of European cardiologists and gynaecologists
    Peter Collins
    NHLI, Imperial College London, Royal Brompton Hospital, Dovehouse Street, London SW3 6LY, UK
    Eur Heart J 28:2028-40. 2007
    ....
  54. ncbi The latest elaboration of the Women's Health Initiative data on hormone replacement therapy and cardiovascular disease in postmenopausal women
    Andrea R Genazzani
    Gynecol Endocrinol 23:183-5. 2007