V Pistoia

Summary

Affiliation: G. Gaslini Institute
Country: Italy

Publications

  1. ncbi request reprint Lymphoproliferative disorders and chemokines
    V Pistoia
    Laboratory of Oncology, G Gaslini Institute, Genova, Italy
    Curr Drug Targets 7:81-90. 2006
  2. doi request reprint Role of BAFF in Opsoclonus-Myoclonus syndrome, a bridge between cancer and autoimmunity
    Lizzia Raffaghello
    Laboratories of Oncology, Istituto Giannina Gaslini, Genoa, Italy
    J Leukoc Biol 94:183-91. 2013
  3. doi request reprint Targeting acute myeloid leukemia cells with cytokines
    Elisa Ferretti
    Laboratory of Oncology, Department of Experimental and Laboratory Medicine, Istituto Giannina Gaslini, Genova, Italy
    J Leukoc Biol 92:567-75. 2012
  4. ncbi request reprint Immunosuppressive treatments in acute myocardial infarction and stroke
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Largo Gerolamo Gaslini 5, 16145 Genoa, Italy
    Curr Pharm Biotechnol 13:59-67. 2012
  5. pmc Not proper ROC curves as new tool for the analysis of differentially expressed genes in microarray experiments
    Stefano Parodi
    Epidemiology and Biostatistics Section, Scientific Directorate, G Gaslini Children s Hospital, Genoa, Italy
    BMC Bioinformatics 9:410. 2008
  6. pmc Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    Alan Tyndall
    Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
    Arthritis Res Ther 9:301. 2007
  7. pmc Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
    Anna Corcione
    Laboratory of Oncology, IRCCS G Gaslini, Largo G Gaslini 5, Genoa, 16148, Italy
    Arthritis Res Ther 11:R150. 2009
  8. doi request reprint Cytokines in neuroblastoma: from pathogenesis to treatment
    Vito Pistoia
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Immunotherapy 3:895-907. 2011
  9. doi request reprint Interleukin-12 receptor beta2: from cytokine receptor to gatekeeper gene in human B-cell malignancies
    Vito Pistoia
    Laboratory of Oncology, Department of Experimental and Laboratory Medicine, G Gaslini Institute, 16147 Genova, Italy
    J Clin Oncol 27:4809-16. 2009
  10. doi request reprint IL-21: a new player in the control of isotype switch in Peyer's patches
    Vito Pistoia
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini, 5, 16147 Genoa, Italy
    J Leukoc Biol 85:739-43. 2009

Detail Information

Publications96

  1. ncbi request reprint Lymphoproliferative disorders and chemokines
    V Pistoia
    Laboratory of Oncology, G Gaslini Institute, Genova, Italy
    Curr Drug Targets 7:81-90. 2006
    ..In this respect, small antagonistic peptides are being produced by pharmaceutical companies and hold great promise for clinical application...
  2. doi request reprint Role of BAFF in Opsoclonus-Myoclonus syndrome, a bridge between cancer and autoimmunity
    Lizzia Raffaghello
    Laboratories of Oncology, Istituto Giannina Gaslini, Genoa, Italy
    J Leukoc Biol 94:183-91. 2013
    ..This study provides new insights in the mechanisms driving the neogenesis of lymphoid follicles and in the functional interactions between tumor and immune cells in OMS-associated NB. ..
  3. doi request reprint Targeting acute myeloid leukemia cells with cytokines
    Elisa Ferretti
    Laboratory of Oncology, Department of Experimental and Laboratory Medicine, Istituto Giannina Gaslini, Genova, Italy
    J Leukoc Biol 92:567-75. 2012
    ..Here, we review the current knowledge about the antileukemic effects of cytokines, documented in preclinical and clinical studies, discussing their potential clinical application...
  4. ncbi request reprint Immunosuppressive treatments in acute myocardial infarction and stroke
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Largo Gerolamo Gaslini 5, 16145 Genoa, Italy
    Curr Pharm Biotechnol 13:59-67. 2012
    ....
  5. pmc Not proper ROC curves as new tool for the analysis of differentially expressed genes in microarray experiments
    Stefano Parodi
    Epidemiology and Biostatistics Section, Scientific Directorate, G Gaslini Children s Hospital, Genoa, Italy
    BMC Bioinformatics 9:410. 2008
    ..e., concave) and not proper ROC curves (NPRC). In particular, NPRC may correspond to those genes that tend to escape standard selection methods...
  6. pmc Immunomodulatory properties of mesenchymal stem cells: a review based on an interdisciplinary meeting held at the Kennedy Institute of Rheumatology Division, London, UK, 31 October 2005
    Alan Tyndall
    Rheumatology, University Hospital Basel, Felix Platter Spital, Burgfelderstrasse 101, Basel, CH 4012, Switzerland
    Arthritis Res Ther 9:301. 2007
    ..This review summarizes the findings of a 1-day meeting devoted to the subject with the aim of coordinating efforts...
  7. pmc Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
    Anna Corcione
    Laboratory of Oncology, IRCCS G Gaslini, Largo G Gaslini 5, Genoa, 16148, Italy
    Arthritis Res Ther 11:R150. 2009
    ..Here, we have characterized synovial fluid and tissue B-cell subsets in patients with oligoarticular juvenile idiopathic arthritis (JIA), an issue not addressed before in detail...
  8. doi request reprint Cytokines in neuroblastoma: from pathogenesis to treatment
    Vito Pistoia
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Immunotherapy 3:895-907. 2011
    ..These recent results raise hope for more efficacious treatment of this ominous pediatric malignancy...
  9. doi request reprint Interleukin-12 receptor beta2: from cytokine receptor to gatekeeper gene in human B-cell malignancies
    Vito Pistoia
    Laboratory of Oncology, Department of Experimental and Laboratory Medicine, G Gaslini Institute, 16147 Genova, Italy
    J Clin Oncol 27:4809-16. 2009
    ..We will delineate three paradigms reflecting the differential expression of IL-12Rbeta2 in different groups of malignant B cells and discuss the therapeutic perspectives stemming from these studies...
  10. doi request reprint IL-21: a new player in the control of isotype switch in Peyer's patches
    Vito Pistoia
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini, 5, 16147 Genoa, Italy
    J Leukoc Biol 85:739-43. 2009
    ..In this JLB issue, IL-21 is reported to dampen TGF-beta1-induced IgG2b but not IgA production by mouse B cells, possibly explaining why IgA(+) B cells predominate in PP...
  11. doi request reprint Damage-associated molecular patterns (DAMPs) and mesenchymal stem cells: a matter of attraction and excitement
    Vito Pistoia
    Laboratory of Oncology, G Departmental of Experimental and Laboratory Medicine, Gaslini Institute, Genoa, Italy
    Eur J Immunol 41:1828-31. 2011
    ..Importantly, the hypoxic conditions of the tumor microenvironment may protect DAMPs from oxidation and thereby preserve their functionality...
  12. ncbi request reprint Potential of mesenchymal stem cells for the therapy of autoimmune diseases
    Vito Pistoia
    Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148 Genova, Italy
    Expert Rev Clin Immunol 6:211-8. 2010
    ..Although these results pave the way toward the design of clinical trials with MSCs in AD patients, studies published so far are few in number. However, it appears from these studies that administration of MSCs is safe and feasible...
  13. pmc Soluble HLA-G: Are they clinically relevant?
    Vito Pistoia
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Semin Cancer Biol 17:469-79. 2007
    ..Finally, the potential clinical relevance of sHLA-G serum levels is discussed...
  14. ncbi request reprint Stromal cell-derived factor-1 as a chemoattractant for follicular center lymphoma B cells
    A Corcione
    Laboratory of Oncology, G Gaslini Institute, Genoa, Italy
    J Natl Cancer Inst 92:628-35. 2000
    ..e., germinal center B cells) and 2) whether the same cells express SDF-1 transcripts...
  15. pmc Low-dose interferon-gamma-producing human neuroblastoma cells show reduced proliferation and delayed tumorigenicity
    I Airoldi
    Laboratory of Oncology, Gaslini Institute, Largo Gaslini 5, 16148 Genoa, Italy
    Br J Cancer 90:2210-8. 2004
    ..This effect adds to the immunoregulatory and antiangiogenic activities operated by IFN-gamma in syngeneic tumour-bearing hosts...
  16. ncbi request reprint Lack of HLA-class I antigens in human neuroblastoma cells: analysis of its relationship to TAP and tapasin expression
    M V Corrias
    Laboratorio di Oncologia, Istituto Scientifico G. Gaslini, Genoa, Italy
    Tissue Antigens 57:110-7. 2001
    ..These data indicate that multiple mechanisms play a role in the HLA class I antigen-deficient phenotype of human neuroblastoma...
  17. ncbi request reprint Cytokine gene expression in neoplastic B cells from human mantle cell, follicular, and marginal zone lymphomas and in their postulated normal counterparts
    I Airoldi
    Laboratory of Oncology, G. Gaslini Institut, Genova, Italy
    Cancer Res 61:1285-90. 2001
    ..Different "hole" combinations were identified consistently in mantle cell lymphoma, follicular lymphoma, and marginal zone lymphoma, thus representing molecular fingerprints of each individual lymphoma entity...
  18. ncbi request reprint Expression and function of IL-12 and IL-18 receptors on human tonsillar B cells
    I Airoldi
    Laboratory of Oncology, G Gaslini Institute, Genoa, Italy
    J Immunol 165:6880-8. 2000
    ..Finally, naive but not germinal center or memory, tonsillar B cells were identified as the exclusive IL-12 targets in terms of induction of NF-kappaB activation and of IFN-gamma production...
  19. doi request reprint Absence of IL-12Rβ2 in CD33(+)CD38(+) pediatric acute myeloid leukemia cells favours progression in NOD/SCID/IL2RγC-deficient mice
    E Ferretti
    Laboratory of Oncology, G Gaslini Institute, Genova, Italy
    Leukemia 26:225-35. 2012
    ..Our data indicate that the absence of IL-12Rβ2 in pediatric AML cells favours leukemia progression in NOD/SCID/IL2Rγc-deficient mice...
  20. ncbi request reprint Cytokines as anti-angiogenic agents in haematological malignancies
    C Cocco
    A I R C Laboratory of Immunology and Tumors, G Gaslini Institute, Genova, Italy
    Curr Cancer Drug Targets 11:997-1004. 2011
    ..In this review we will summarize the current knowledge about the role of cytokines as anti-angiogenic agents in cancer, focusing our attention on the anti-angiogenic activity of IL-12 family members in haematological malignancies...
  21. ncbi request reprint Cytokine gene expression and T-cell proliferative responses in lymph node mononuclear cells from children with early stage human immunodeficiency virus infection
    I Airoldi
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Haematologica 85:1237-47. 2000
    ..The aim of this study was to investigate cytokine gene expression and proliferative responses in lymph node (LN) biopsies from five children with early stage HIV infection, in the context of LN morphology and viral load...
  22. ncbi request reprint Involvement of the hypothalamic-pituitary-adrenal axis in children with oligoarticular-onset idiopathic arthritis
    P Picco
    Department of Pediatric Rheumatology, G Gaslini Institute, Genova, Italy
    Ann N Y Acad Sci 966:369-72. 2002
    ..Our study suggests the presence of a partial resistance to ACTH with a dysregulated pattern of secretion also in inactive o-JIA patients. These preliminary data need further confirmation in larger pediatric studies...
  23. ncbi request reprint Levels of soluble CD27 in sera and synovial fluid and its expression on memory T cells in patients with juvenile idiopathic arthritides
    M Gattorno
    2nd Department of Pediatrics, G Gaslini Scientific Institute for Children and University of Genoa, Largo G Gaslini 5, 16147, Genoa, Italy
    Clin Exp Rheumatol 20:863-6. 2002
    ..The aim of the present study was to evaluate the levels of soluble CD27 in sera and synovial fluids, together with its expression on circulating and synovial fluid (SF) memory T cells, in children with JIA...
  24. doi request reprint Long-term follow-up of neuroblastoma-associated opsoclonus-myoclonus-ataxia syndrome
    E De Grandis
    Department of Child Neuropsychiatry, G Gaslini Institute, University of Genoa, Genoa, Italy
    Neuropediatrics 40:103-11. 2009
    ....
  25. pmc ICF syndrome with variable expression in sibs
    G Gimelli
    Laboratorio di Citogenetica, Istituto G Gaslini, Genova, Italy
    J Med Genet 30:429-32. 1993
    ..These cases indicate the autosomal recessive mode of inheritance and the variable expressivity of the ICF syndrome...
  26. ncbi request reprint Growth factors increase retroviral transduction but decrease clonogenic potential of umbilical cord blood CD34+ cells
    M V Corrias
    Laboratory of Oncology, G Gaslini Institute, Genoa, Italy
    Haematologica 83:580-6. 1998
    ....
  27. ncbi request reprint Interferon gamma and tumour necrosis factor alpha are overexpressed in bone marrow T lymphocytes from paediatric patients with aplastic anaemia
    C Dufour
    Department of Paediatric Haematology Oncology, Scientific Directorate, G Gaslini Children s Hospital, Largo G Gaslini 5, 16147 Genoa, Italy
    Br J Haematol 115:1023-31. 2001
    ....
  28. doi request reprint ATP/P2X7 axis modulates myeloid-derived suppressor cell functions in neuroblastoma microenvironment
    G Bianchi
    Laboratory of Oncology, Istituto Giannina Gaslini, Genoa, Italy
    Cell Death Dis 5:e1135. 2014
    ..This study describes a novel scenario in which MDSC immunosuppressive functions are modulated by the ATP-enriched tumor microenvironment. ..
  29. doi request reprint A novel role of the CX3CR1/CX3CL1 system in the cross-talk between chronic lymphocytic leukemia cells and tumor microenvironment
    E Ferretti
    Laboratory of Oncology, IRCCS G Gaslini, Genova, Italy
    Leukemia 25:1268-77. 2011
    ....
  30. doi request reprint Interferon-gamma and IL-10 may protect from allergic polysensitization in children: preliminary evidence
    I Prigione
    Laboratory of Oncology, DIMI, University of Genoa Azienda Ospedaliera Universitaria San Martino, Viale Benedetto XV 6, Genoa, Italy
    Allergy 65:740-2. 2010
    ..A functional defect of T regulatory cells (Treg) has been proposed as pathogenic mechanism of allergic reaction. Polysensitization is a common feature of allergic patients...
  31. pmc Expression of costimulatory molecules in human neuroblastoma. Evidence that CD40+ neuroblastoma cells undergo apoptosis following interaction with CD40L
    I Airoldi
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini, 16148 Genova, Italy
    Br J Cancer 88:1527-36. 2003
    ..Interferon-gamma gene-transfected NB cells expressed constitutively surface CD40 and were induced into apoptosis by incubation with rCD40L through a caspase-8-dependent mechanism. CD40 may represent a novel therapeutic target in NB...
  32. ncbi request reprint Catastrophic relapse of Evans syndrome five years after allogeneic BMT notwithstanding full donor chimerism. Terminal hemolytic-uremic syndrome
    A M Marmont
    Division of Hematology and Stem Cell Transplantation Center, Istituto G Gaslini, Genova, Italy
    Autoimmunity 39:505-11. 2006
    ..The postulated graft-versus-autoimmunity (GVA) effect was apparently not sufficient to eradicate autoimmunity in this patient...
  33. ncbi request reprint Analysis of stepwise genetic changes in an AIDS-related Burkitt's lymphoma
    F Fais
    Clinical Immunology Division, National Cancer Institute, Genoa, Italy
    Int J Cancer 88:744-50. 2000
    ..These events occurred prior to or during the germinal center (GC) phase of B-cell maturation. Thereafter, possibly upon exit of the cells from the GC, EBV infection occurred, further promoting lymphomagenesis...
  34. ncbi request reprint MICA gene polymorphisms in an Italian paediatric series of juvenile Behçet disease
    P Picco
    Department of Paediatrics, G Gaslini Institute, Genoa, Italy
    Int J Mol Med 10:575-8. 2002
    ..This finding sheds light on the role of a receptor for MICA, named NKG2D, presented by natural killer cells, and CD8+, alphabetaT cells and gammadeltaT cells, usually localised in gut mucosa...
  35. pmc CD10 is a marker for cycling cells with propensity to apoptosis in childhood ALL
    G Cutrona
    Servizi di Immunologia Clinica, Istituto Nazionale per la Ricerca sul Cancro, IST, Genoa, Italy, and Dipartimento di Oncologia, Biologia e Genetica, Universita di Genova, Genoa, Italy
    Br J Cancer 86:1776-85. 2002
    ....
  36. ncbi request reprint Spontaneous production of granulocyte colony-stimulating factor in vitro by human B-lineage lymphocytes is a distinctive marker of germinal center cells
    A Corcione
    Laboratory of Oncology, Giannina Gaslini Scientific Institute, Genoa, Italy
    J Immunol 153:2868-77. 1994
    ..This autocrine loop of production and response to G-CSF by GC B cells may be activated by stimuli such as those delivered via the surface CD40 molecule, that participate in the rescue of GC B cells from apoptosis...
  37. ncbi request reprint Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis
    Chiara Brignole
    Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16147 Genoa, Italy
    J Natl Cancer Inst 98:1142-57. 2006
    ..No data are available on bortezomib activity against human pediatric neuroblastoma...
  38. pmc Endogenous IL-12 triggers an antiangiogenic program in melanoma cells
    Irma Airoldi
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genoa, Italy
    Proc Natl Acad Sci U S A 104:3996-4001. 2007
    ..A previously undescribed mechanism of the IL-12 antitumor activity has been here identified and characterized...
  39. ncbi request reprint Tumor origin of endothelial cells in human neuroblastoma
    Annalisa Pezzolo
    Laboratories of Oncology and Pathology, G Gaslini Institute, Genova, Italy
    J Clin Oncol 25:376-83. 2007
    ..Tumor endothelial microvessels attract interest as therapeutic targets, but their genetic instability would curtail such approach. Here, we have investigated the tumor origin of endothelial microvessels in human neuroblastoma (NB)...
  40. ncbi request reprint Chromosomal imbalances in pediatric Burkitt-like lymphoma and review of the literature in relation to other germinal center derived B-cell tumors
    Annalisa Pezzolo
    Laboratory of Oncology, Giannina Gaslini Institute, Genoa, Italy
    Leuk Lymphoma 47:2359-64. 2006
    ..In view of the paucity of pediatric BLL cases published, this report adds novel, relevant information on the molecular cytogenetic features of this rare tumor...
  41. pmc Tumor mRNA-transfected dendritic cells stimulate the generation of CTL that recognize neuroblastoma-associated antigens and kill tumor cells: immunotherapeutic implications
    Fabio Morandi
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Neoplasia 8:833-42. 2006
    ..This study demonstrates that DC transfected with NB mRNA induce the generation of patients' CTL specific for different NB-associated antigens, supporting the feasibility of NB T-cell immunotherapy...
  42. ncbi request reprint Peripheral blood stem cell tumor cell contamination and survival of neuroblastoma patients
    Maria Valeria Corrias
    Laboratory of Oncology, Gaslini Institute, Largo Gaslini 5, 16147 Genoa, Italy
    Clin Cancer Res 12:5680-5. 2006
    ..Contribution of peripheral blood stem cell (PBSC) contaminating tumor cells to subsequent relapse and overall survival of neuroblastoma patients remains controversial...
  43. ncbi request reprint Immunoregulatory function of mesenchymal stem cells
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
    Eur J Immunol 36:2566-73. 2006
    ..Thus, it is likely that MSC effects on the immune system may be deeply influenced not only by cell-to-cell interactions, but also by environmental factors shaping their phenotype and functions...
  44. ncbi request reprint Human mesenchymal stem cells promote survival of T cells in a quiescent state
    Federica Benvenuto
    Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Via De Toni 5, 16132 Genoa, Italy
    Stem Cells 25:1753-60. 2007
    ..Disclosure of potential conflicts of interest is found at the end of this article...
  45. ncbi request reprint Mesenchymal stem cells: a new strategy for immunosuppression?
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
    Trends Immunol 28:219-26. 2007
    ..In immune-mediated diseases, the protective effects might function in concert with the immunosuppressive and anti-inflammatory activities...
  46. ncbi request reprint Human NK cell infusions prolong survival of metastatic human neuroblastoma-bearing NOD/scid mice
    Roberta Castriconi
    Department of Experimental Medicine, University of Genoa, Genoa, Italy
    Cancer Immunol Immunother 56:1733-42. 2007
    ..However, homing properties, safety and therapeutic efficacy of NK cell infusions need to be evaluated in a suitable preclinical murine NB model...
  47. ncbi request reprint Serum and synovial fluid concentrations of matrix metalloproteinases 3 and its tissue inhibitor 1 in juvenile idiopathic arthritides
    Marco Gattorno
    2nd Division of Pediatrics, G Gaslini Institute for Children, Genoa, Italy
    J Rheumatol 29:826-31. 2002
    ..We investigated serum and synovial fluid (SF) concentrations of MMP-3 and its tissue inhibitor (TIMP-1) in juvenile idiopathic arthritides (JIA)...
  48. doi request reprint Constitutive expression of IL-12R beta 2 on human multiple myeloma cells delineates a novel therapeutic target
    Irma Airoldi
    Department of Experimental and Laboratory Medicine, G Gaslini Institute, Genova, Italy
    Blood 112:750-9. 2008
    ..Thus, IL-12R beta 2 directly restrains MM cell growth, and targeting of IL-12 to tumor cells holds promise as new therapeutic strategy...
  49. doi request reprint Immunotherapy of neuroblastoma by an Interleukin-21-secreting cell vaccine involves survivin as antigen
    Michela Croce
    Laboratory of Immunological Therapy, Istituto Nazionale per la Ricerca sul Cancro, Largo Benzi 10, 16132 Genoa, Italy
    Cancer Immunol Immunother 57:1625-34. 2008
    ..IL-21 is the most recently identified member of the IL-2 cytokine family. Here we studied the therapeutic efficacy of IL-21-gene-modified cells (Neuro2a/IL-21) in a syngeneic metastatic neuroblastoma (NB) model...
  50. pmc Immunogenicity of human mesenchymal stem cells in HLA-class I-restricted T-cell responses against viral or tumor-associated antigens
    Fabio Morandi
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Stem Cells 26:1275-87. 2008
    ..However, they are protected from CTL-mediated lysis through a mechanism that is partly sHLA-G-dependent...
  51. doi request reprint Identification of novel chromosomal abnormalities and prognostic cytogenetics markers in intracranial pediatric ependymoma
    Annalisa Pezzolo
    Laboratory of Oncology, Department of Laboratory and Experimental Medicine, Giannina Gaslini Institute, Genoa, Italy
    Cancer Lett 261:235-43. 2008
    ..3 gain, (iii) 3q23-qter losses, (iv) 18q22.2 loss, and (v) 19p13.1-p13.3 gain. The combined presence of 6p22-pter and 13q14.3-qter losses predicted significantly reduced survival. Larger studies are warranted to validate these findings...
  52. ncbi request reprint Mechanisms of BSO (L-buthionine-S,R-sulfoximine)-induced cytotoxic effects in neuroblastoma
    Barbara Marengo
    Giannina Gaslini Institute, Genoa, Italy
    Free Radic Biol Med 44:474-82. 2008
    ....
  53. ncbi request reprint Human mesenchymal stem cells inhibit neutrophil apoptosis: a model for neutrophil preservation in the bone marrow niche
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Genova 15145, Italy
    Stem Cells 26:151-62. 2008
    ....
  54. ncbi request reprint Human neuroblastoma cells trigger an immunosuppressive program in monocytes by stimulating soluble HLA-G release
    Fabio Morandi
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Cancer Res 67:6433-41. 2007
    ....
  55. ncbi request reprint CXCR5 may be involved in the attraction of human metastatic neuroblastoma cells to the bone marrow
    Irma Airoldi
    Department of Experimental and Laboratory Medicine, G Gaslini Institute, Largo G Gaslini 5, 16147, Genova, Italy
    Cancer Immunol Immunother 57:541-8. 2008
    ..Up-regulation of some chemokine receptors on tumor cells is associated with increased metastatic potential. In this respect, limited information is available on chemokine receptor in human neuroblastoma (NB)...
  56. ncbi request reprint Expression and functional analysis of human leukocyte antigen class I antigen-processing machinery in medulloblastoma
    Lizzia Raffaghello
    Laboratories of Oncology, G Gaslini Institute, Genoa, Italy
    Cancer Res 67:5471-8. 2007
    ..In conclusion, these results can contribute to optimize T cell-based immunotherapeutic strategies for Mb treatment...
  57. ncbi request reprint Molecularly guided therapy of neuroblastoma: a review of different approaches
    Gian Paolo Tonini
    Unit of Translational Pediatric Oncology, National Institute for Cancer Research IST, L go R Benzi, 10 16132 Genoa, Italy
    Curr Pharm Des 12:2303-17. 2006
    ....
  58. ncbi request reprint Immunotherapy of neuroblastoma: present, past and future
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Largo Gerolamo Gaslini 5, 16147 Genova, Italy
    Expert Rev Neurother 6:509-18. 2006
    ..Among the new, innovative approaches, immunotherapy has attracted much interest. However, until recently, little information was available about the immunogenicity of human neuroblastoma...
  59. pmc Downregulation and/or release of NKG2D ligands as immune evasion strategy of human neuroblastoma
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Genova, Italy
    Neoplasia 6:558-68. 2004
    ..ULBP-3 was expressed in 5 of 9 cell lines, ULBP-2 in 2 of 9, whereas ULBP-1 was never detected. These studies delineate novel potential pathways of tumor escape and immunodeficiency in NB...
  60. ncbi request reprint Cytokine flexibility of early and differentiated memory T helper cells in juvenile idiopathic arthritis
    Sabrina Chiesa
    2nd Division of Pediatrics, G Gaslini Scientific Institute for Children, Genoa, Italy
    J Rheumatol 31:2048-54. 2004
    ....
  61. ncbi request reprint Immune cell-mediated antitumor activities of GD2-targeted liposomal c-myb antisense oligonucleotides containing CpG motifs
    Chiara Brignole
    Laboratory of Oncology, Gaslini Children s Hospital, Genoa, Italy
    J Natl Cancer Inst 96:1171-80. 2004
    ..Because antisense oligonucleotides containing CpG motifs can stimulate immune responses, we evaluated the effect of CpG-containing c-myb antisense oligonucleotides encapsulated within targeted liposomes...
  62. ncbi request reprint Generation and characterization of dimeric small immunoproteins specific for neuroblastoma associated antigen GD2
    Marzia Occhino
    International Centre for Genetic Engineering and Biotechnology, 34012 Trieste, Italy
    Int J Mol Med 14:383-8. 2004
    ..Both mini-antibodies were successfully produced and shown to retain binding specificity as well as an affinity similar to that of the original antibody...
  63. pmc Recapitulation of B cell differentiation in the central nervous system of patients with multiple sclerosis
    Anna Corcione
    Laboratory of Oncology, Scientific Direction, G Gaslini Institute, 16148 Genoa, Italy
    Proc Natl Acad Sci U S A 101:11064-9. 2004
    ..The presence of lymphotoxin-alpha, CXCL12, and CXCL13 in the CNS may provide favorable microenvironmental conditions for these events...
  64. pmc The IL-12Rbeta2 gene functions as a tumor suppressor in human B cell malignancies
    Irma Airoldi
    Laboratory of Oncology, G Gaslini Institute, Genoa, Italy
    J Clin Invest 113:1651-9. 2004
    ..The IL-12Rbeta2 gene acts as tumor suppressor in chronic B cell malignancies, and IL-12 exerts direct antitumor effects on IL-12Rbeta2-expressing neoplastic B cells...
  65. ncbi request reprint CCL19 and CXCL12 trigger in vitro chemotaxis of human mantle cell lymphoma B cells
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genoa, Italy
    Clin Cancer Res 10:964-71. 2004
    ..Information on these issues may allow us to identify novel mechanisms of chemokine-driven tumor cell migration...
  66. ncbi request reprint Heterogeneous expression of interleukin-18 and its receptor in B-cell lymphoproliferative disorders deriving from naive, germinal center, and memory B lymphocytes
    Irma Airoldi
    Laboratories of Oncology and Pathology, G Gaslini Institute, Genoa, Italy, and Laboratory of Pathology, St Andrea Hospital, La Spezia, Italy
    Clin Cancer Res 10:144-54. 2004
    ..Moreover, IL-18Ralpha and beta expression was investigated in the same cells by reverse transcription-PCR, flow cytometry, and immunohistochemistry...
  67. ncbi request reprint Different levels of control prevent interferon-gamma-inducible HLA-class II expression in human neuroblastoma cells
    Michela Croce
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genoa, Italy
    Oncogene 22:7848-57. 2003
    ..Altogether, these data point to multiple mechanisms preventing HLA class II expression in the neuroblastoma, either involving CIITA promoter-IV silencing, or acting at the CIITA post-transcriptional level...
  68. ncbi request reprint Recombinant antibodies in the immunotherapy of neuroblastoma: perspectives of new developments
    Marco Bestagno
    International Centre for Genetic Engineering and Biotechnology, Area Science Park, Padriciano 99, 34012 Trieste, Italy
    Cancer Lett 197:193-8. 2003
    ..The current status of mAb therapy for NB is discussed together with our preliminary results on the generation of novel anti-GD2 molecules using the SIP technique...
  69. ncbi request reprint TNF-alpha and IFN-gamma are overexpressed in the bone marrow of Fanconi anemia patients and TNF-alpha suppresses erythropoiesis in vitro
    Carlo Dufour
    Hematology Unit, Department of Pediatric Hematology Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16147 Genoa, Italy
    Blood 102:2053-9. 2003
    ..This indicates that FA subjects have a marrow TNF-alpha activity that inhibits erythropoiesis in vitro. TNF-alpha has a relevant role in the pathogenesis of erythroid failure in FA patients...
  70. ncbi request reprint Neuroblastic tumors associated with opsoclonus-myoclonus syndrome: histological, immunohistochemical and molecular features of 15 Italian cases
    Claudio Gambini
    Service of Pathology, Giannina Gaslini Children s Hospital, Largo Gerolamo Gaslini 5, 16148, Genova, Italy
    Virchows Arch 442:555-62. 2003
    ..In conclusion, ganglioneuroblastoma, intermixed subtype, lack of MYCN amplification, aneuploid DNA content and presence of lymphoid infiltrates may contribute to favorable prognosis in NTs associated with OMS...
  71. ncbi request reprint Expression of HER2/neu is uncommon in human neuroblastic tumors and is unrelated to tumor progression
    Claudio Gambini
    Pathology Department, Istituto G Gaslini, Largo Gaslini 5, 16148 Genoa, Italy
    Cancer Immunol Immunother 52:116-20. 2003
    ..These data suggest that HER2/neu should not be considered as a relevant prognostic factor in NT, and that HER2/neu-based immunotherapy may be feasible only in a minority of NT patients...
  72. ncbi request reprint A novel syngeneic murine model for thoracic neuroblastoma obtained by intramediastinal injection of tumor cells
    Maria V Corrias
    Laboratory of Oncology, Istituto G Gaslini, L go Gaslini 5, Genova 16148, Italy
    Cancer Detect Prev 26:468-75. 2002
    ..This new model may be relevant for testing the efficacy of novel immunotherapeutic strategies for poor prognosis NB patients with localized disease...
  73. ncbi request reprint Synovial membrane expression of matrix metalloproteinases and tissue inhibitor 1 in juvenile idiopathic arthritides
    Marco Gattorno
    Department of Pathology, G Gaslini Institute for Children, Genoa, Italy
    J Rheumatol 29:1774-9. 2002
    ..We investigated synovial tissue expression of the main proteolytic enzymes (MMP-1, MMP-3, and MMP-13) and tissue inhibitor of metalloprotease 1 (TIMP-1) in juvenile idiopathic arthritides (JIA)...
  74. ncbi request reprint Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Int Immunol 14:883-92. 2002
    ..CCR1, CCR2 and CCR4 were detected by flow cytometry on non-GC (i.e. naive and memory) B cells, whereas they were absent (CCR1 and CCR2) or poorly expressed (CCR4) on GC B cells...
  75. ncbi request reprint The interleukin-12 and interleukin-12 receptor system in normal and transformed human B lymphocytes
    Irma Airoldi
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genoa, Italy
    Haematologica 87:434-42. 2002
    ..IL-12 also activates human B-cells through the IL-12 receptor (IL-12R) complex. Here we review the expression and function of IL-12 and IL-12R in human B-cells and in their malignant counterparts...
  76. ncbi request reprint CCL3 (MIP-1alpha) induces in vitro migration of GM-CSF-primed human neutrophils via CCR5-dependent activation of ERK 1/2
    Luciano Ottonello
    Laboratory of Phagocyte Physiopathology and Inflammation, Department of Internal Medicine, University of Genoa, G Gaslini Institute, Genoa, Italy
    Cell Signal 17:355-63. 2005
    ..This suggests that by activating ERK-1, GM-CSF renders neutrophils rapidly responsive to CCL3 stimulation throughout CCR5 which is constitutively expressed on the cell surface...
  77. ncbi request reprint Detection of neuroblastoma cells in bone marrow and peripheral blood by different techniques: accuracy and relationship with clinical features of patients
    Maria Valeria Corrias
    Laboratory of Oncology, Service of Epidemiology and Biostatistics, Department of Hematology Oncology, and Service of Pathology, Istituto Gaslini, L go Gaslini, 5, 16148 Genoa, Italy
    Clin Cancer Res 10:7978-85. 2004
    ....
  78. ncbi request reprint Immunogenicity of human neuroblastoma
    Ignazia Prigione
    Laboratory of Oncology, G Gaslini Scientific Institute, Genova, Italy
    Ann N Y Acad Sci 1028:69-80. 2004
    ..On the other hand, NB cells represent an excellent target for natural killer cells, the potential role of which in immunotherapy of NB is now being investigated...
  79. ncbi request reprint Methylation of the IL-12Rbeta2 gene as novel tumor escape mechanism for pediatric B-acute lymphoblastic leukemia cells
    Irma Airoldi
    Laboratory of Oncology, G Gaslini Institute, Genova, Italy
    Cancer Res 66:3978-80. 2006
    ..In conclusion, epigenetic silencing of the IL-12Rbeta2 gene represents a novel mechanism of tumor escape for B-ALL cells...
  80. ncbi request reprint Mechanisms of the adaptive immune response inside the central nervous system during inflammatory and autoimmune diseases
    Enrico Pedemonte
    Neuroimmunology Unit, Department of Neurosciences, Ophthalmology and Genetics, University of Genoa, Italy
    Pharmacol Ther 111:555-66. 2006
    ....
  81. ncbi request reprint The P2X7 receptor sustains the growth of human neuroblastoma cells through a substance P-dependent mechanism
    Lizzia Raffaghello
    Laboratory of Oncology, Giannina Gaslini Institute, Largo Gerolamo Gaslini 5, Genoa, Italy 16147
    Cancer Res 66:907-14. 2006
    ..Therefore, neuroblastoma cells seem to have molded P2X(7) function to their advantage in two ways (i.e., by silencing P2X(7) proapoptotic activity and by coupling P2X(7) stimulation to release of locally acting trophic factors)...
  82. ncbi request reprint CXCL12 does not attract CXCR4+ human metastatic neuroblastoma cells: clinical implications
    Irma Airoldi
    Laboratory of Oncology, Department of Experimental and Laboratory Medicine, G Gaslini Institute, Genoa, Italy
    Clin Cancer Res 12:77-82. 2006
    ..The aim of this study was to investigate the expression and chemotactic functionality of CXCR4 in human metastatic neuroblastoma cells isolated from the bone marrow and, for comparison, in a panel of neuroblastoma cell lines...
  83. ncbi request reprint T cell mediated immune responses to Toxoplasma gondii in pregnant women with primary toxoplasmosis
    Ignazia Prigione
    Laboratory of Oncology, Department of Experimental and Laboratory Medicine, G Gaslini Scientific Institute, Largo G Gaslini 5, 16148 Genoa, Italy
    Microbes Infect 8:552-60. 2006
    ..In conclusion, pregnant women with primary toxoplasmosis mounted in vitro Tg-specific Th1/Th0 responses whose impact on neonatal infection warrants further investigation...
  84. ncbi request reprint B-cell differentiation in the CNS of patients with multiple sclerosis
    Anna Corcione
    Laboratory of Oncology, Department of Experimental and Laboratory Medicine, Scientific G Gaslini Institute, Genoa, Italy
    Autoimmun Rev 4:549-54. 2005
    ..Thus, B cells are likely to expand and mature inside the CNS, giving rise to ASC, which may play an effector role in the pathogenesis of MS...
  85. ncbi request reprint Human mesenchymal stem cells modulate B-cell functions
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Blood 107:367-72. 2006
    ..These results further support the potential therapeutic use of hMSCs in immune-mediated disorders, including those in which B cells play a major role...
  86. ncbi request reprint Chemokine receptor expression and function in childhood acute lymphoblastic leukemia of B-lineage
    Anna Corcione
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Leuk Res 30:365-72. 2006
    ..Freshly isolated CCR7(+) early pre-B-ALL cells migrated to CCL19, whereas CCR7(+) pro-B- and pre-B-ALL cells were attracted by CCL19 only following culture with soluble recombinant CD40 ligand...
  87. ncbi request reprint Lack of Il12rb2 signaling predisposes to spontaneous autoimmunity and malignancy
    Irma Airoldi
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Blood 106:3846-53. 2005
    ..The development of autoimmunity, lymphoproliferation, and B-cell tumors in Il12rb2 knockout (KO) mice suggests that IL-12 functions physiologically to restrain aberrant B-cell activation...
  88. ncbi request reprint Anti-neuroblastoma effect of ch14.18 antibody produced in CHO cells is mediated by NK-cells in mice
    Yan Zeng
    Charite Children s Hospital, University Medicine, 13353 Berlin, Germany
    Mol Immunol 42:1311-9. 2005
    ..In vivo depletion of NK-cells completely abrogated this effect, suggesting that the mechanism involved in the ch14.18/CHO induced anti-neuroblastoma effect is mediated by NK-dependent ADCC...
  89. ncbi request reprint Neuroblastoma targeting by c-myb-selective antisense oligonucleotides entrapped in anti-GD2 immunoliposome: immune cell-mediated anti-tumor activities
    Chiara Brignole
    Laboratory of Oncology, Giannina Gaslini Children s Hospital, Largo Gerolamo Gaslini, 5, 16148 Genova, Italy
    Cancer Lett 228:181-6. 2005
    ..Here, we will describe a novel experimental therapeutic approach for neuroblastoma based on anti-GD2 liposomal c-myb-selective antisense oligonucleotides...
  90. ncbi request reprint Mechanisms of immune evasion of human neuroblastoma
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Genova, Italy
    Cancer Lett 228:155-61. 2005
    ..Additional mechanisms of immune evasion used by human NB cells are discussed...
  91. ncbi request reprint Opsoclonus myoclonus syndrome in neuroblastoma a report from a workshop on the dancing eyes syndrome at the advances in neuroblastoma meeting in Genoa, Italy, 2004
    Katherine K Matthay
    Department of Pediatrics, University of California, San Francisco, CA, USA
    Cancer Lett 228:275-82. 2005
    ....
  92. ncbi request reprint Multiple defects of the antigen-processing machinery components in human neuroblastoma: immunotherapeutic implications
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Institute, Largo G Gaslini, Genova, Italy
    Oncogene 24:4634-44. 2005
    ..HLA class I upregulation by interferon-gamma, although enhancing neuroblastoma cell recognition by cytotoxic T cells, dampens their susceptibility to NK cells...
  93. ncbi request reprint Unveiling the enigma of the CNS as a B-cell fostering environment
    Antonio Uccelli
    Neuroimmunology Unit, Department of Neurosciences, Centre of Excellence for Biomedical Research, University of Genoa, Italy
    Trends Immunol 26:254-9. 2005
    ....
  94. pmc Phenotypic and functional characterisation of CCR7+ and CCR7- CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis
    Marco Gattorno
    II Division of Pediatrics, University of Genoa, Genoa, Italy
    Arthritis Res Ther 7:R256-67. 2005
    ..Moreover, discrete patterns of chemokine receptor expression are detected in the synovial tissue...
  95. ncbi request reprint Sequential immunogene therapy with interleukin-12- and interleukin-15-engineered neuroblastoma cells cures metastatic disease in syngeneic mice
    Michela Croce
    Laboratory of Immunopharmacology, Istituto Nazionale per la Ricerca sul Cancro, Largo Benzi 10, 16132 Genoa, Italy
    Clin Cancer Res 11:735-42. 2005
    ..To investigate the potential synergistic effects of Neuro2a neuroblastoma cells engineered with IL-12 and/or IL-15 genes in improving survival of syngeneic mice bearing neuroblastoma metastatic disease...
  96. ncbi request reprint Dual effect of CD85/leukocyte Ig-like receptor-1/Ig-like transcript 2 and CD152 (CTLA-4) on cytokine production by antigen-stimulated human T cells
    Daniele Saverino
    Department of Experimental Medicine, Human Anatomy Section, University of Genoa, Via De Toni 14, 16132 Genoa, Italy
    J Immunol 168:207-15. 2002
    ..In contrast, cross-linking of this receptor down-regulates Ag-specific CD4+ T cell proliferation and increases IL-10 and TGF-beta production...