F Pastorino

Summary

Affiliation: G. Gaslini Institute
Country: Italy

Publications

  1. pmc Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells
    Marina Pisano
    Istituto di Chimica Biomolecolare, CNR, Sassari, Italy
    Mol Cancer 9:137. 2010
  2. ncbi request reprint Recent advances in targeted anti-vasculature therapy: the neuroblastoma model
    F Pastorino
    Experimental Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148 Genoa, Italy
    Curr Drug Targets 10:1021-7. 2009
  3. doi request reprint Enhanced antitumor efficacy of clinical-grade vasculature-targeted liposomal doxorubicin
    Fabio Pastorino
    Experimental Therapies Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Clin Cancer Res 14:7320-9. 2008
  4. doi request reprint Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor
    Fabio Pastorino
    G Gaslini Children s Hospital, National Cancer Institute, Genoa, Italy
    Clin Cancer Res 16:4809-21. 2010
  5. doi request reprint Increase of therapeutic effects by treating melanoma with targeted combinations of c-myc antisense and doxorubicin
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, 16148 Genoa, Italy
    J Control Release 126:85-94. 2008
  6. ncbi request reprint Anti-GD2 monoclonal antibody immunotherapy: a promising strategy in the prevention of neuroblastoma relapse
    L Raffaghello
    Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148 Genoa, Italy
    Cancer Lett 197:205-9. 2003
  7. ncbi request reprint Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: therapeutic implications
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148, Genoa, Italy
    Ann N Y Acad Sci 1028:90-103. 2004
  8. ncbi request reprint Immune cell-mediated antitumor activities of GD2-targeted liposomal c-myb antisense oligonucleotides containing CpG motifs
    Chiara Brignole
    Laboratory of Oncology, Gaslini Children s Hospital, Genoa, Italy
    J Natl Cancer Inst 96:1171-80. 2004
  9. ncbi request reprint Ligand-targeted liposomal therapies of neuroblastoma
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Curr Med Chem 14:3070-8. 2007
  10. ncbi request reprint Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, 16148 Genoa, Italy
    Clin Cancer Res 9:4595-605. 2003

Collaborators

Detail Information

Publications32

  1. pmc Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells
    Marina Pisano
    Istituto di Chimica Biomolecolare, CNR, Sassari, Italy
    Mol Cancer 9:137. 2010
    ..Recently, we have synthesized and tested in vitro various curcumin-related compounds in order to select new anti-tumor agents displaying stronger and selective growth inhibition activity on neuroectodermal tumors...
  2. ncbi request reprint Recent advances in targeted anti-vasculature therapy: the neuroblastoma model
    F Pastorino
    Experimental Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148 Genoa, Italy
    Curr Drug Targets 10:1021-7. 2009
    ..Here, we present an overview of the most recent advances in anti-vasculature therapy of neuroblastoma, and describe some preclinical results as well as future perspectives...
  3. doi request reprint Enhanced antitumor efficacy of clinical-grade vasculature-targeted liposomal doxorubicin
    Fabio Pastorino
    Experimental Therapies Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Clin Cancer Res 14:7320-9. 2008
    ....
  4. doi request reprint Tumor regression and curability of preclinical neuroblastoma models by PEGylated SN38 (EZN-2208), a novel topoisomerase I inhibitor
    Fabio Pastorino
    G Gaslini Children s Hospital, National Cancer Institute, Genoa, Italy
    Clin Cancer Res 16:4809-21. 2010
    ..The antitumor activity of a water soluble pegylated SN38 drug conjugate, EZN-2208, was compared with CPT-11 (a prodrug for SN38) in preclinical models of human neuroblastoma...
  5. doi request reprint Increase of therapeutic effects by treating melanoma with targeted combinations of c-myc antisense and doxorubicin
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, 16148 Genoa, Italy
    J Control Release 126:85-94. 2008
    ..Our data indicate the increasing cell sensitivity to DXR by c-myc-asODNs as a promising basis for developing novel anti-tumor strategy against advanced melanoma...
  6. ncbi request reprint Anti-GD2 monoclonal antibody immunotherapy: a promising strategy in the prevention of neuroblastoma relapse
    L Raffaghello
    Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148 Genoa, Italy
    Cancer Lett 197:205-9. 2003
    ..Whatever the effecting mechanism(s) involved, these results strongly support the clinical use of anti-GD2 mAbs after first-line induction regimens...
  7. ncbi request reprint Targeted delivery of oncogene-selective antisense oligonucleotides in neuroectodermal tumors: therapeutic implications
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148, Genoa, Italy
    Ann N Y Acad Sci 1028:90-103. 2004
    ..These results suggest that inhibition of c-myc or c-myb proto-oncogenes by GD2-targeted antisense therapy could provide an effective approach for the treatment of neuroectodermal tumors in an adjuvant setting...
  8. ncbi request reprint Immune cell-mediated antitumor activities of GD2-targeted liposomal c-myb antisense oligonucleotides containing CpG motifs
    Chiara Brignole
    Laboratory of Oncology, Gaslini Children s Hospital, Genoa, Italy
    J Natl Cancer Inst 96:1171-80. 2004
    ..Because antisense oligonucleotides containing CpG motifs can stimulate immune responses, we evaluated the effect of CpG-containing c-myb antisense oligonucleotides encapsulated within targeted liposomes...
  9. ncbi request reprint Ligand-targeted liposomal therapies of neuroblastoma
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Curr Med Chem 14:3070-8. 2007
    ..This review will focus on the description of the most clinically relevant animal models established to test the efficacy of targeted liposomal anti-tumour formulations for the treatment of Neuroblastoma...
  10. ncbi request reprint Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, 16148 Genoa, Italy
    Clin Cancer Res 9:4595-605. 2003
    ....
  11. doi request reprint Liposome-mediated therapy of neuroblastoma
    Daniela Di Paolo
    Experimental Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Methods Enzymol 465:225-49. 2009
    ..Here, we describe the methodology used in these studies, as well as the antitumor results obtained by the use of several "anticancer drugs," encapsulated into antibody- and peptide-targeted liposomal formulations, against NB...
  12. ncbi request reprint Combined targeting of perivascular and endothelial tumor cells enhances anti-tumor efficacy of liposomal chemotherapy in neuroblastoma
    Monica Loi
    G Gaslini Children s Hospital, Genoa, Italy
    J Control Release 145:66-73. 2010
    ..The availability of novel ligands binding to additional tumor vasculature-associated antigens will allow the design of sophisticated combinations of ligand-targeted liposomal anti-cancer drugs...
  13. ncbi request reprint Targeted delivery system for antisense oligonucleotides: a novel experimental strategy for neuroblastoma treatment
    Chiara Brignole
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148 Genoa, Italy
    Cancer Lett 197:231-5. 2003
    ..Future studies will be performed to evaluate the antitumour efficacy of the above formulations in animal models...
  14. ncbi request reprint Development of Fab' fragments of anti-GD(2) immunoliposomes entrapping doxorubicin for experimental therapy of human neuroblastoma
    Chiara Brignole
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, Genoa 16148, Italy
    Cancer Lett 197:199-204. 2003
    ..0001). Fab'-SIL[DXR] prevented the establishment and the metastatic growth of the tumor cells in all organs examined. In conclusion, Fab'-SIL[DXR] formulations should receive clinical evaluation as adjuvant therapy of neuroblastoma...
  15. ncbi request reprint Doxorubicin-loaded Fab' fragments of anti-disialoganglioside immunoliposomes selectively inhibit the growth and dissemination of human neuroblastoma in nude mice
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy 16148
    Cancer Res 63:86-92. 2003
    ..In conclusion, Fab'-SIL[DXR] formulations led to the total inhibition of metastatic growth of human NB in a nude mouse metastatic model. This formulation should receive clinical evaluation as adjuvant therapy of NB...
  16. ncbi request reprint Targeting liposomal chemotherapy via both tumor cell-specific and tumor vasculature-specific ligands potentiates therapeutic efficacy
    Fabio Pastorino
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Cancer Res 66:10073-82. 2006
    ..Long-term survivors were obtained only in animals treated with the combined tumor- and vascular-targeted formulations, confirming the pivotal role of combination therapies in treating aggressive metastatic neuroblastoma...
  17. ncbi request reprint Immunoliposomal fenretinide: a novel antitumoral drug for human neuroblastoma
    L Raffaghello
    Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148 Genoa, Italy
    Cancer Lett 197:151-5. 2003
    ..0001). Anti-GD2 liposomal HPR should receive clinical evaluation as adjuvant therapy of neuroblastoma...
  18. ncbi request reprint Effect of bortezomib on human neuroblastoma cell growth, apoptosis, and angiogenesis
    Chiara Brignole
    Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16147 Genoa, Italy
    J Natl Cancer Inst 98:1142-57. 2006
    ..No data are available on bortezomib activity against human pediatric neuroblastoma...
  19. ncbi request reprint Vascular damage and anti-angiogenic effects of tumor vessel-targeted liposomal chemotherapy
    Fabio Pastorino
    Differentiation Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Largo G Gaslini 5, 16148 Genoa, Italy
    Cancer Res 63:7400-9. 2003
    ..This combined strategy has the potential to overcome some major limitations of conventional chemotherapy...
  20. ncbi request reprint Neuroblastoma targeting by c-myb-selective antisense oligonucleotides entrapped in anti-GD2 immunoliposome: immune cell-mediated anti-tumor activities
    Chiara Brignole
    Laboratory of Oncology, Giannina Gaslini Children s Hospital, Largo Gerolamo Gaslini, 5, 16148 Genova, Italy
    Cancer Lett 228:181-6. 2005
    ..Here, we will describe a novel experimental therapeutic approach for neuroblastoma based on anti-GD2 liposomal c-myb-selective antisense oligonucleotides...
  21. ncbi request reprint Drug delivery systems: application of liposomal anti-tumor agents to neuroectodermal cancer treatment
    Daniela Di Paolo
    Experimental Therapies Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Tumori 94:246-53. 2008
    ..The most multifunctional targeted liposomes are herein described, with primary attention on testing their efficacy in clinically relevant animal models for the treatment of neuroblastoma and melanoma...
  22. doi request reprint Therapeutic targeting of TLR9 inhibits cell growth and induces apoptosis in neuroblastoma
    Chiara Brignole
    Experimental Therapy Unit, Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Cancer Res 70:9816-26. 2010
    ..TLR9 expression in primary human NB specimens was found to correlate inversely with disease stage. Our findings establish functional expression of TLR9 in NB and suggest that TLR9 may represent a novel theranostic target in this disease...
  23. ncbi request reprint In vitro and in vivo antitumor activity of liposomal Fenretinide targeted to human neuroblastoma
    Lizzia Raffaghello
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Int J Cancer 104:559-67. 2003
    ..0001). Anti-GD2 liposomal HPR should receive clinical evaluation as adjuvant therapy of neuroblastoma...
  24. ncbi request reprint Anti-IL-10R antibody improves the therapeutic efficacy of targeted liposomal oligonucleotides
    Chiara Brignole
    Laboratory of Oncology, G Gaslini Children s Hospital, 16147 Genoa, Italy
    J Control Release 138:122-7. 2009
    ..These results support the feasibility of a clinical trial with TL-asCpG and aIL-10R in advanced NB patients...
  25. doi request reprint The combined therapeutic effects of bortezomib and fenretinide on neuroblastoma cells involve endoplasmic reticulum stress response
    Gabriella Pagnan
    Laboratory of Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Clin Cancer Res 15:1199-209. 2009
    ..Here we have investigated the antitumor activity of bortezomib in combination with fenretinide, a synthetic retinoid, against neuroblastoma cells...
  26. ncbi request reprint Combined therapeutic effects of vinblastine and rapamycin on human neuroblastoma growth, apoptosis, and angiogenesis
    Danilo Marimpietri
    Laboratory of Oncology, G Gaslini Children s Hospital, Italian Neuroblastoma Foundation c o National Institute for Cancer Research, Genoa, Italy
    Clin Cancer Res 13:3977-88. 2007
    ..Vinblastine and rapamycin displayed synergistic inhibition of human neuroblastoma-related angiogenesis. Here, we studied the antitumor activity of vinblastine and rapamycin against human neuroblastoma...
  27. ncbi request reprint Chemopreventive N-(4-hydroxyphenyl)retinamide (fenretinide) targets deregulated NF-{kappa}B and Mat1A genes in the early stages of rat liver carcinogenesis
    Maria M Simile
    Department of Biomedical Sciences, Division of Experimental Pathology and Oncology, University of Sassari, Italy
    Carcinogenesis 26:417-27. 2005
    ..Moreover, they demonstrate a partially new mechanism of HPR chemopreventive effect and indicate the potential clinical relevance of this compound for prevention of hepatocellular carcinoma...
  28. ncbi request reprint Proteomic analysis of an orthotopic neuroblastoma xenograft animal model
    Natascia Campostrini
    Department of Agricultural and Industrial Biotechnologies, University of Verona, Strada Le Grazie 15, 37134 Verona, Italy
    J Chromatogr B Analyt Technol Biomed Life Sci 808:279-86. 2004
    ..Moreover new proteins, which were absent in control samples, were expressed in tumour samples, such as nucleophosmin (NPM) and stathmin (oncoprotein 18)...
  29. ncbi request reprint Angiogenesis in neuroblastoma
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari Medical School, Piazza Giulio Cesare, 11, Policlinico, I 70124 Bari, Italy
    Ann N Y Acad Sci 1028:133-42. 2004
    ..A major goal is the determination of whether inhibition of angiogenesis is a realistic way of inhibiting tumor cell dissemination and formation of metastasis in neuroblastoma...
  30. ncbi request reprint Spot overlapping in two-dimensional maps: a serious problem ignored for much too long
    Natascia Campostrini
    Department of Agricultural and Industrial Biotechnologies, University of Verona, Verona, Italy
    Proteomics 5:2385-95. 2005
    ..Ways and means for minimizing spot overlap and visualising a greater number of spots in a two-dimensional map are discussed...
  31. ncbi request reprint In vivo angiogenic activity of neuroblastoma correlates with MYCN oncogene overexpression
    Domenico Ribatti
    Department of Human Anatomy and Histology, University of Bari, Policlinico, Bari, Italy
    Int J Cancer 102:351-4. 2002
    ....