Lorenzo Moretta

Summary

Affiliation: G. Gaslini Institute
Country: Italy

Publications

  1. ncbi request reprint The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity
    Claudia Cantoni
    Dipartimento di Medicina Sperimentale, Universita di Genova, Via L B Alberti 1, 16132 Genova, Italy
    Structure 11:725-34. 2003
  2. doi request reprint Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ lymphocytopenia associated with novel immunophenotypic and molecular features
    Ignazia Prigione
    G Gaslini Scientific Institute, Genova, Italy
    Pediatr Infect Dis J 28:161-3. 2009
  3. doi request reprint Alloreactive natural killer cells in targeting high-risk leukaemias
    L Moretta
    Department of Experimental Medicine, University of Genova, Genova, Italy
    Ann Rheum Dis 67:iii39-43. 2008
  4. doi request reprint Human NK cells: from HLA class I-specific killer Ig-like receptors to the therapy of acute leukemias
    Alessandro Moretta
    Department of Experimental Medicine, University of Genova, Genova, Italy
    Immunol Rev 224:58-69. 2008
  5. ncbi request reprint NK cell-mediated immune response against cancer
    Lorenzo Moretta
    Department of Experimental Medicine, Giannina Gaslini Institute, University of Genova, Center of Excellence for Biomedical Research, Genova, Italy
    Surg Oncol 16:S3-5. 2007
  6. pmc The emerging role of HLA-E-restricted CD8+ T lymphocytes in the adaptive immune response to pathogens and tumors
    Gabriella Pietra
    Dipartimento di Medicina Sperimentale and Centro di Eccellenza per le Ricerche Biomediche, Universita degli Studi di Genova, 16132 Genova, Italy
    J Biomed Biotechnol 2010:907092. 2010
  7. ncbi request reprint Stromal cells from human decidua exert a strong inhibitory effect on NK cell function and dendritic cell differentiation
    Daniele Croxatto
    Department of Experimental Medicine, University of Genoa, Genoa, Italy
    PLoS ONE 9:e89006. 2014
  8. pmc Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells
    Franco Locatelli
    Department of Pediatric Hematology Oncology, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Pediatrico Bambino Gesù Rome, Italy Università di Pavia Pavia, Italy
    Front Immunol 4:15. 2013
  9. doi request reprint In vivo generation of decidual natural killer cells from resident hematopoietic progenitors
    Laura Chiossone
    Haematologica 99:448-57. 2014
  10. doi request reprint At the Bench: Preclinical rationale for exploiting NK cells and γδ T lymphocytes for the treatment of high-risk leukemias
    Håkan Norell
    1 Via G Gaslini 5, 16147 Genoa, Italy
    J Leukoc Biol 94:1123-39. 2013

Detail Information

Publications102 found, 100 shown here

  1. ncbi request reprint The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity
    Claudia Cantoni
    Dipartimento di Medicina Sperimentale, Universita di Genova, Via L B Alberti 1, 16132 Genova, Italy
    Structure 11:725-34. 2003
    ..The data presented are a first step toward understanding the molecular basis for ligand recognition by natural cytotoxicity receptors, whose key role in the immune system is established, but whose cellular ligands are still elusive...
  2. doi request reprint Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ lymphocytopenia associated with novel immunophenotypic and molecular features
    Ignazia Prigione
    G Gaslini Scientific Institute, Genova, Italy
    Pediatr Infect Dis J 28:161-3. 2009
    ..This novel form of idiopathic CD4 lymphocytopenia may predispose to multiple visceral leishmaniasis relapses...
  3. doi request reprint Alloreactive natural killer cells in targeting high-risk leukaemias
    L Moretta
    Department of Experimental Medicine, University of Genova, Genova, Italy
    Ann Rheum Dis 67:iii39-43. 2008
    ..Since alloreactive NK cells seem to play a key role also in preventing graft rejection and graft-vs-host disease, they may be an ideal tool to treat high-risk leukaemias in the haematopoietic stem cell transplantation setting...
  4. doi request reprint Human NK cells: from HLA class I-specific killer Ig-like receptors to the therapy of acute leukemias
    Alessandro Moretta
    Department of Experimental Medicine, University of Genova, Genova, Italy
    Immunol Rev 224:58-69. 2008
    ..The key role played also in preventing graft rejection and graft versus host disease renders alloreactive NK cells an ideal tool for successful haploidentical hematopoietic stem cell transplantation...
  5. ncbi request reprint NK cell-mediated immune response against cancer
    Lorenzo Moretta
    Department of Experimental Medicine, Giannina Gaslini Institute, University of Genova, Center of Excellence for Biomedical Research, Genova, Italy
    Surg Oncol 16:S3-5. 2007
    ..Thus, it is now possible to search for appropriate HLA class I mismatches to set NK cells in action to cure high risk leukemias...
  6. pmc The emerging role of HLA-E-restricted CD8+ T lymphocytes in the adaptive immune response to pathogens and tumors
    Gabriella Pietra
    Dipartimento di Medicina Sperimentale and Centro di Eccellenza per le Ricerche Biomediche, Universita degli Studi di Genova, 16132 Genova, Italy
    J Biomed Biotechnol 2010:907092. 2010
    ..Because HLA-E displays binding specificity for innate CD94/NKG2 receptors, as well as all the features of an antigen-presenting molecule, its role in both natural and acquired immune responses has recently been re-evaluated...
  7. ncbi request reprint Stromal cells from human decidua exert a strong inhibitory effect on NK cell function and dendritic cell differentiation
    Daniele Croxatto
    Department of Experimental Medicine, University of Genoa, Genoa, Italy
    PLoS ONE 9:e89006. 2014
    ..Our results strongly suggest an important role of DSCs in preventing potentially dangerous immune response, thus contributing to maintenance of pregnancy. ..
  8. pmc Cellular and molecular basis of haploidentical hematopoietic stem cell transplantation in the successful treatment of high-risk leukemias: role of alloreactive NK cells
    Franco Locatelli
    Department of Pediatric Hematology Oncology, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Pediatrico Bambino Gesù Rome, Italy Università di Pavia Pavia, Italy
    Front Immunol 4:15. 2013
    ..Novel approaches are in progress to further improve the clinical outcome based on the infusion of donor alloreactive NK cells either as a component of the transplanted cell population or as in vitro expanded NK cells...
  9. doi request reprint In vivo generation of decidual natural killer cells from resident hematopoietic progenitors
    Laura Chiossone
    Haematologica 99:448-57. 2014
    ....
  10. doi request reprint At the Bench: Preclinical rationale for exploiting NK cells and γδ T lymphocytes for the treatment of high-risk leukemias
    Håkan Norell
    1 Via G Gaslini 5, 16147 Genoa, Italy
    J Leukoc Biol 94:1123-39. 2013
    ..The clinical aspects of using NK cells and γδ T lymphocytes against hematological malignancies, including the allo-HSCT context, are reviewed in the related side-by-side paper by Locatelli and colleagues [1]. ..
  11. pmc Transplantation and innate immunity: the lesson of natural killer cells
    Alice Bertaina
    Paediatric Haematology Oncology, University of Pavia, Foundation IRCCS Policlinico San Matteo, Pavia, Italy
    Ital J Pediatr 35:44. 2009
    ..This study represents a major breakthrough in the cure of otherwise fatal leukemias, providing information on the best criteria for choosing the optimal donor...
  12. pmc Unravelling natural killer cell function: triggering and inhibitory human NK receptors
    Lorenzo Moretta
    Istituto Giannina Gaslini, Genova Quarto, Italy
    EMBO J 23:255-9. 2004
    ..Thus, the ability of NK cells to lyse target cells requires both the lack of surface MHC class I molecules and the expression of appropriate ligands that trigger NK receptors...
  13. ncbi request reprint Killer immunoglobulin-like receptors
    Lorenzo Moretta
    Istituto Giannina Gaslini, L go G Gaslini, 5 16147 Genova Quarto, Italy
    Curr Opin Immunol 16:626-33. 2004
    ..As recently shown, the HLA class I regulated control of NK cell function can be exploited in an allogeneic bone marrow transplantation setting to eradicate acute myeloid leukaemias...
  14. ncbi request reprint Different checkpoints in human NK-cell activation
    Lorenzo Moretta
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
    Trends Immunol 25:670-6. 2004
    ..Thus, it appears that the activation of NK cells and their potentially harmful effector functions are under the control of different checkpoints...
  15. ncbi request reprint Human natural killer cells: Molecular mechanisms controlling NK cell activation and tumor cell lysis
    Lorenzo Moretta
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
    Immunol Lett 100:7-13. 2005
    ..This clearly implies that activation of NK cells and of their potent effector mechanism are under the control of different checkpoints...
  16. doi request reprint Human NK receptors: from the molecules to the therapy of high risk leukemias
    Lorenzo Moretta
    Giannina Gaslini Institute, Genova Quarto, Italy
    FEBS Lett 585:1563-7. 2011
    ..These NK-mediated effects result in a sharp improvement of the estimated 5 years survival...
  17. doi request reprint Killer Ig-like receptor-mediated control of natural killer cell alloreactivity in haploidentical hematopoietic stem cell transplantation
    Lorenzo Moretta
    Giannina Gaslini Institute, Genova Quarto, Italy
    Blood 117:764-71. 2011
    ....
  18. ncbi request reprint Surface NK receptors and their ligands on tumor cells
    Lorenzo Moretta
    Istituto Giannina Gaslini, L go G Gaslini, Genova, Italy
    Semin Immunol 18:151-8. 2006
    ..Here we briefly illustrate the main NK receptors and their cellular ligands and we delineate the major receptor/ligands interactions leading to NK cell activation and tumor cell lysis...
  19. ncbi request reprint Effector and regulatory events during natural killer-dendritic cell interactions
    Lorenzo Moretta
    Direzione Scientifica, Istituto Giannina Gaslini, Largo G Gaslini, Genova Quarto, Italy
    Immunol Rev 214:219-28. 2006
    ..These interactions also determine the quality and strength of the subsequent adaptive responses. Remarkably, NK cells appear to play a key role in this complex network...
  20. doi request reprint Natural killer alloeffector responses in haploidentical hemopoietic stem cell transplantation to treat high-risk leukemias
    L Moretta
    Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genova, Genova, Italy
    Tissue Antigens 75:103-9. 2010
    ..Because alloreactive NK cells play a central role also in preventing graft rejection and graft-vs-host disease, they may represent an ideal tool to treat patients affected by acute high-risk leukemias...
  21. ncbi request reprint Surface receptors and functional interactions of human natural killer cells: from bench to the clinic
    L Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti 2, 16132 Genova, Italy
    Cell Mol Life Sci 60:2139-46. 2003
    ..Alloreactive' NK cells derived from donor hematopoietic precursors not only prevented leukemic relapses, but also prevented graft rejection and graft-versus-host disease...
  22. ncbi request reprint Update on natural killer cells: cross-talk with dendritic cells and role in the cure of acute myeloid leukemias
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti 2 16132 Genova, Italy
    Cancer J 9:232-7. 2003
  23. ncbi request reprint Human natural killer cell function and their interactions with dendritic cells
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    Vaccine 21:S38-42. 2003
    ..Thus, two important players of the innate immunity may be involved in a coordinated regulation of critical events occurring at the interface between innate and adaptive immunity...
  24. ncbi request reprint Human natural killer cells: their origin, receptors and function
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 32:1205-11. 2002
    ..As a consequence, NK cells lyse target cells that have lost (or express insufficient amounts of) MHC class I molecules, as frequently occurs in tumors and in cells infected by certain viruses...
  25. ncbi request reprint Natural killer cells: a mystery no more
    L Moretta
    Istituto Giannina Gaslini, Genova
    Scand J Immunol 55:229-32. 2002
    ..Here, we describe the identification and characterization of such receptors and discuss the emerging implications of these findings in different diseases...
  26. ncbi request reprint Cellular and molecular basis of natural killer and natural killer-like activity
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti no 2, 16132 Genova, Italy
    Immunol Lett 88:89-93. 2003
    ....
  27. ncbi request reprint Human NK cells and their receptors
    Lorenzo Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Microbes Infect 4:1539-44. 2002
    ..host disease. This may lead to a true revolution in bone marrow transplantation, based on the exploitation of appropriate HLA-Cl I mismatches that can put NK cells in action...
  28. ncbi request reprint Human natural killer cell function and receptors
    L Moretta
    Istituto Giannina Gaslini, Genova, Italy
    Curr Opin Pharmacol 1:387-91. 2001
    ..It has also become clear that viruses such as cytomegalovirus have evolved strategies to interfere with NK-cell function to protect themselves from NK-mediated attack...
  29. ncbi request reprint NK-CTLs, a novel HLA-E-restricted T-cell subset
    Lorenzo Moretta
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, 16147 Genova Quarto, Italy
    Trends Immunol 24:136-43. 2003
  30. ncbi request reprint PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Mol Immunol 42:463-9. 2005
    ..Importantly, the specific interaction between DNAM-1 (in NK cells) and PVR or Nectin-2 (in target cells) enhanced the NK-mediated lysis of tumor cells that was downregulated by mAb-mediated masking of the receptor or its ligands...
  31. ncbi request reprint Expression of the DNAM-1 ligands, Nectin-2 (CD112) and poliovirus receptor (CD155), on dendritic cells: relevance for natural killer-dendritic cell interaction
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 107:2030-6. 2006
    ....
  32. ncbi request reprint HLA-E-restricted recognition of human cytomegalovirus by a subset of cytolytic T lymphocytes
    Chiara Romagnani
    Dipartimento di Medicinia Sperimentale, Centro di Eccellenza per Ricerche Biomediche, Universita degli Studi di Genova, Genova, Italy
    Hum Immunol 65:437-45. 2004
    ..This broad ability to recognize and kill allogeneic cells may pose serious problems in transplantation...
  33. ncbi request reprint Combined genotypic and phenotypic killer cell Ig-like receptor analyses reveal KIR2DL3 alleles displaying unexpected monoclonal antibody reactivity: identification of the amino acid residues critical for staining
    Michela Falco
    Istituto Giannina Gaslini, Italy
    J Immunol 185:433-41. 2010
    ..Our present data represent a substantial progress in the characterization of the NK cell repertoire and an improved phenotypic/functional definition of given KIR(+) subsets...
  34. ncbi request reprint Identification of effector-memory CMV-specific T lymphocytes that kill CMV-infected target cells in an HLA-E-restricted fashion
    Paola Mazzarino
    Dipartimento di Oncologia, Biologia e Genetica, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 35:3240-7. 2005
    ..Our data suggest that HLA-E-restricted CTL may represent an additional effector cell type involved in defenses against HCMV, a virus which escapes the control exerted by conventional CTL or NK cells...
  35. ncbi request reprint Molecular and functional characterization of NKG2D, NKp80, and NKG2C triggering NK cell receptors in rhesus and cynomolgus macaques: monitoring of NK cell function during simian HIV infection
    Roberto Biassoni
    Istituto Giannina Gaslini, Genova, Italy
    J Immunol 174:5695-705. 2005
    ....
  36. doi request reprint Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction
    Emanuela Marcenaro
    Dipartimento di Medicina Sperimentale and Centro di Eccellenza per le Ricerche Biomediche, Universita degli Studi di Genova, Genova, Italy
    Blood 114:4108-16. 2009
    ....
  37. ncbi request reprint Natural killer cells kill human melanoma cells with characteristics of cancer stem cells
    Gabriella Pietra
    Dipartimento di Medicina Sperimentale and Centro di Eccellenza per la Ricerca Biomedica, Universita degli Studi di Genova, Genova, Italy
    Int Immunol 21:793-801. 2009
    ..Since CSC have been reported to be both drug resistant and radioresistant, our present data suggest that NK-based adoptive immunotherapy could represent a novel therapeutic approach to possibly eradicate metastatic melanoma...
  38. ncbi request reprint The corticosteroid-induced inhibitory effect on NK cell function reflects down-regulation and/or dysfunction of triggering receptors involved in natural cytotoxicity
    Chiara Vitale
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 34:3028-38. 2004
    ..A similar inhibitory effect occurred in the expression of activating NK receptors. In addition, a sharp impairment of NK cytotoxicity against different tumor target cell lines or immature DC was detected...
  39. ncbi request reprint Both CD133+ and CD133- medulloblastoma cell lines express ligands for triggering NK receptors and are susceptible to NK-mediated cytotoxicity
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 37:3190-6. 2007
    ..In particular, B7 homolog 3 (B7-H3) was expressed by all the medulloblastoma cell lines analyzed, while the presence of GD(2) and NB84 was restricted to given cell lines and/or marked a defined tumor cell subset...
  40. ncbi request reprint Analysis of the receptor-ligand interactions in the natural killer-mediated lysis of freshly isolated myeloid or lymphoblastic leukemias: evidence for the involvement of the Poliovirus receptor (CD155) and Nectin-2 (CD112)
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, L go R Benzi 10, 16132 Genova, Italy
    Blood 105:2066-73. 2005
    ..In most leukemias, both CD48 and NTBA were down-regulated. The correlation found between marker expression and susceptibility to lysis may reveal useful information for NK-based immunotherapy...
  41. pmc Transforming growth factor beta 1 inhibits expression of NKp30 and NKG2D receptors: consequences for the NK-mediated killing of dendritic cells
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti 1, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 100:4120-5. 2003
    ..Our present data suggest a possible mechanism by which TGFbeta1-producing dendritic cells may acquire resistance to the NK-mediated attack...
  42. ncbi request reprint NK-dependent DC maturation is mediated by TNFalpha and IFNgamma released upon engagement of the NKp30 triggering receptor
    Massimo Vitale
    Istituto Scientifico per la Ricerca sul Cancro IST, Genova, Italy
    Blood 106:566-71. 2005
    ..Finally, the analysis of perforin-deficient NK cells allowed the dissection of the 2 NKp30-mediated NK-cell functions, since NKp30 could induce cytokine-dependent DC maturation in the absence of NK-mediated DC killing...
  43. pmc Identification of 4Ig-B7-H3 as a neuroblastoma-associated molecule that exerts a protective role from an NK cell-mediated lysis
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Via L B Alberti 2, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 101:12640-5. 2004
    ..These data suggest that 4Ig-B7-H3 molecules expressed at the tumor cell surface can exert a protective role from natural killer-mediated lysis by interacting with a still undefined inhibitory receptor expressed on natural killer cells...
  44. ncbi request reprint The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function
    Mariella Della Chiesa
    DIMS Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Blood 108:4118-25. 2006
    ..The effect of l-kynurenine, which is effective at both the transcriptional and the protein level, can be reverted, since NK cells were found to recover their functional competence after washing...
  45. doi request reprint IFN-alpha-mediated increase in cytolytic activity of maturing NK cell upon exposure to HSV-infected myelomonocytes
    Paola Costa
    Istituto Giannina Gaslini, Genova, Italy
    Eur J Immunol 39:147-58. 2009
    ..Thus, NK-cell precursors may be involved in the immune response to dsDNA viruses and possibly contribute to efficient control of virus infection...
  46. doi request reprint A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2
    Simona Sivori
    Dipartimento di Medicina Sperimentale and Centro di Eccellenza per Ricerca Biomedica, Universita di Genova, Genova, Italy
    Blood 116:1637-47. 2010
    ..This novel KIR-associated function emphasizes the antimicrobial role of NK cells in the course of infection...
  47. ncbi request reprint MSCs inhibit monocyte-derived DC maturation and function by selectively interfering with the generation of immature DCs: central role of MSC-derived prostaglandin E2
    Grazia Maria Spaggiari
    Istituto Giannina Gaslini, Largo Gerolamo Gaslini 5, Genoa, Italy
    Blood 113:6576-83. 2009
    ..These data emphasize the role of MSCs in inhibiting early DC maturation and identifying the molecular mechanisms responsible for the inhibitory effect...
  48. ncbi request reprint Expression and crystallographic characterization of the extracellular domain of human natural killer cell triggering receptor NKp46
    Marco Ponassi
    Laboratorio di Biologia Strutturale, Istituto Scientifico Tumori, Largo R Benzi 10, 16132 Genova, Italy
    Acta Crystallogr D Biol Crystallogr 59:2259-61. 2003
    ..Crystals of the NKp46 extracellular region belong to the hexagonal space group P6(1) (or P6(5)), with unit-cell parameters a = b = 85.48, c = 59.91 A, gamma = 120 degrees; the asymmetric unit contains one protein chain (197 amino acids)...
  49. ncbi request reprint Human natural killer cells exposed to IL-2, IL-12, IL-18, or IL-4 differently modulate priming of naive T cells by monocyte-derived dendritic cells
    Sophie Agaugué
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    Blood 112:1776-83. 2008
    ..Thus, the prevalence of IL-12, IL-2, IL-18, or IL-4 at inflammatory sites may differentially modulate the NK-cell interaction with DCs, leading to different outcomes in naive T-cell polarization...
  50. pmc Crosstalk between decidual NK and CD14+ myelomonocytic cells results in induction of Tregs and immunosuppression
    Paola Vacca
    Giannina Gaslini Institute, 16147 Genoa, Italy
    Proc Natl Acad Sci U S A 107:11918-23. 2010
    ..Along this line, it is conceivable that an impaired function of these cells may result in pregnancy failure...
  51. ncbi request reprint Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses
    Mariella Della Chiesa
    Dipartimento di Medicina Sperimentale, Sezione di Istologia, Via G B Marsano 10, 16132 Genova, Italy
    Blood 108:3851-8. 2006
    ....
  52. pmc Susceptibility of human melanoma cells to autologous natural killer (NK) cell killing: HLA-related effector mechanisms and role of unlicensed NK cells
    Paolo Carrega
    Istituto Giannina Gaslini, Genoa, Italy
    PLoS ONE 4:e8132. 2009
    ....
  53. doi request reprint Evidence that the KIR2DS5 gene codes for a surface receptor triggering natural killer cell function
    Mariella Della Chiesa
    Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Eur J Immunol 38:2284-9. 2008
    ..Finally, soluble KIR2DS5-Fc fusion protein does not bind to cell transfectants expressing different HLA-C alleles, suggesting that, if KIR2DS5 does recognize HLA-C molecules, this may only occur in the presence of certain peptides...
  54. pmc CpG and double-stranded RNA trigger human NK cells by Toll-like receptors: induction of cytokine release and cytotoxicity against tumors and dendritic cells
    Simona Sivori
    Dipartimento di Medicina Sperimentale, Universita di Genova, Via Leon Battista Alberti 2, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 101:10116-21. 2004
    ....
  55. pmc Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation
    Simona Sivori
    Dipartimento di Medicina Sperimentale, Universita di Genova, Via L B Alberti 2, 16132 Genoa, Italy
    Proc Natl Acad Sci U S A 99:4526-31. 2002
    ....
  56. ncbi request reprint IL-12 or IL-4 prime human NK cells to mediate functionally divergent interactions with dendritic cells or tumors
    Emanuela Marcenaro
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    J Immunol 174:3992-8. 2005
    ..On the contrary, NK cells exposed to IL-4 do not exert DC selection, may impair efficient Th1 priming, and favor either tolerogenic or Th2-type responses...
  57. ncbi request reprint Major histocompatibility complex class I-related chain A and UL16-binding protein expression on tumor cell lines of different histotypes: analysis of tumor susceptibility to NKG2D-dependent natural killer cell cytotoxicity
    Daniela Pende
    Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    Cancer Res 62:6178-86. 2002
    ..Our data suggest that the involvement of NKG2D in natural killer cell-mediated cytotoxicity strictly correlates with the expression and the surface density of MICA and ULBP on target cell tumors of different histotypes...
  58. ncbi request reprint Functional characterization of natural killer cells in type I leukocyte adhesion deficiency
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Istituto Giannina Gaslini, University of Genoa, Largo G Gaslini 5, 16147 Genoa, Italy
    Blood 109:4873-81. 2007
    ....
  59. pmc CD34+ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells
    Paola Vacca
    Giannina Gaslini Institute, 16147 Genova, Italy
    Proc Natl Acad Sci U S A 108:2402-7. 2011
    ..Our findings strongly suggest that decidual NK cells may directly derive from CD34(+) cell precursors present in the decidua upon specific cellular interactions with components of the decidual microenvironment...
  60. ncbi request reprint NK cells recognize and kill human glioblastoma cells with stem cell-like properties
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    J Immunol 182:3530-9. 2009
    ..Importantly, glioblastoma stem cells expressed high levels of PVR and Nectin-2, the ligands of DNAM-1-activating NK receptor...
  61. ncbi request reprint Comparative analysis of NK- or NK-CTL-mediated lysis of immature or mature autologous dendritic cells
    Gabriella Pietra
    Istituto Giannina Gaslini, Genova, Italy
    Eur J Immunol 33:3427-32. 2003
    ..The capability of killing autologous DC, presenting a non-self, HLA-E-binding peptide, may represent a feedback mechanism by which NK-CTL down-regulate HLA-E-restricted responses to certain pathogens...
  62. doi request reprint Analysis of NK cell/DC interaction in NK-type lymphoproliferative disease of granular lymphocytes (LDGL): role of DNAM-1 and NKp30
    Mirna Balsamo
    DI ME S Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Exp Hematol 37:1167-75. 2009
    ..In this study, we analyze whether, in NK-lymphoproliferative disease of granular lymphocytes (LDGL) patients, this function could be altered and contribute to the persistence of the disease...
  63. ncbi request reprint IL-21 induces both rapid maturation of human CD34+ cell precursors towards NK cells and acquisition of surface killer Ig-like receptors
    Simona Sivori
    Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Eur J Immunol 33:3439-47. 2003
    ....
  64. ncbi request reprint Significant NK cell activation associated with decreased cytolytic function in peripheral blood of HIV-1-infected patients
    Manuela Fogli
    Dipartimanto di Medicina Interna, Universita degli Studi di Genova, Largo B Benzi 10, I 16132 Genoa, Italy
    Eur J Immunol 34:2313-21. 2004
    ..These results suggest a consistent continuous involvement of the innate immune response in the failure to control viral replication...
  65. ncbi request reprint CD59 is physically and functionally associated with natural cytotoxicity receptors and activates human NK cell-mediated cytotoxicity
    Emanuela Marcenaro
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Eur J Immunol 33:3367-76. 2003
    ..Thus, CD59-mediated costimulation of NK cells requires direct physical interaction of this GPI-linked protein with primary triggering NK receptors...
  66. ncbi request reprint Natural killer cell-mediated killing of freshly isolated neuroblastoma cells: critical role of DNAX accessory molecule-1-poliovirus receptor interaction
    Roberta Castriconi
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genoa, Italy
    Cancer Res 64:9180-4. 2004
    ..Thus, assessment of the PVR surface levels may represent a novel useful criterion to predict the susceptibility/resistance of neuroblastomas to NK-mediated killing...
  67. doi request reprint Methylprednisolone induces preferential and rapid differentiation of CD34+ cord blood precursors toward NK cells
    Chiara Vitale
    Dipartimento Medicina Sperimentale, Universita di Genova, Genova, Italy
    Int Immunol 20:565-75. 2008
    ..These effects should be further investigated in hemopoietic stem cell transplanted patients receiving steroids to treat GvHD...
  68. doi request reprint Human NK cells at early stages of differentiation produce CXCL8 and express CD161 molecule that functions as an activating receptor
    Elisa Montaldo
    Department of Experimental Medicine, University of Genova, Genoa, Italy
    Blood 119:3987-96. 2012
    ..Altogether, these data provide novel information that may offer clues to optimize NK cell maturation in hematopoietic stem cell transplantation...
  69. ncbi request reprint Heterogeneity of TLR3 mRNA transcripts and responsiveness to poly (I:C) in human NK cells derived from different donors
    Simona Sivori
    Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Int Immunol 19:1341-8. 2007
    ....
  70. ncbi request reprint Homophilic interaction of NTBA, a member of the CD2 molecular family: induction of cytotoxicity and cytokine release in human NK cells
    Michela Falco
    Istituto Giannina Gaslini, Genoa, Italy
    Eur J Immunol 34:1663-72. 2004
    ..Altogether our data indicate that NTBA is characterized by self recognition...
  71. ncbi request reprint The interaction between NK cells and dendritic cells in bacterial infections results in rapid induction of NK cell activation and in the lysis of uninfected dendritic cells
    Guido Ferlazzo
    Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 33:306-13. 2003
    ..Activated NK cells, by limiting the supply of immature DC, may then exert a control on subsequent innate and adaptive immune responses...
  72. ncbi request reprint The natural killer cell-mediated killing of autologous dendritic cells is confined to a cell subset expressing CD94/NKG2A, but lacking inhibitory killer Ig-like receptors
    Mariella Della Chiesa
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Italy
    Eur J Immunol 33:1657-66. 2003
    ..However, a small NK cell subset was capable of killing not only iDC but also mature DC...
  73. ncbi request reprint What is a natural killer cell?
    Alessandro Moretta
    Dipartimento di Medicina Sperimentale, Universita degli Studi di Genova, Genova, Italy
    Nat Immunol 3:6-8. 2002
  74. ncbi request reprint Cellular ligands of activating NK receptors
    Cristina Bottino
    Istituto Giannina Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    Trends Immunol 26:221-6. 2005
    ..However, although NK cells use different means to identify and fight target cells, target cells have various strategies to hide themselves, and disarm or even confuse the immune system...
  75. pmc Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells
    Guido Ferlazzo
    Laboratorio di Immunoterapia Cellulare, Unità di Immunologia, Istituto Nazionale per la Ricerca sul Cancro, 16132 Genova, Italy
    J Exp Med 195:343-51. 2002
    ..We suggest that DCs are able to control directly the expansion of NK cells and that the lysis of immature DCs can regulate the afferent limb of innate and adaptive immunity...
  76. ncbi request reprint Comparison of different CpG oligodeoxynucleotide classes for their capability to stimulate human NK cells
    Simona Sivori
    DI ME S Dipartimento di Medicina Sperimentale, Universita di Genova, Genova, Italy
    Eur J Immunol 36:961-7. 2006
    ..Remarkably, NK cells displaying poor responses to ODN A/B were efficiently stimulated by ODN C...
  77. ncbi request reprint Immunoregulatory function of mesenchymal stem cells
    Antonio Uccelli
    Department of Neurosciences, Ophthalmology and Genetics, University of Genova, Genova, Italy
    Eur J Immunol 36:2566-73. 2006
    ..Thus, it is likely that MSC effects on the immune system may be deeply influenced not only by cell-to-cell interactions, but also by environmental factors shaping their phenotype and functions...
  78. ncbi request reprint Increased natural cytotoxicity receptor expression and relevant IL-10 production in NK cells from chronically infected viremic HCV patients
    Andrea De Maria
    Department of Internal Medicine, University of Genova, Genova, Italy
    Eur J Immunol 37:445-55. 2007
    ....
  79. ncbi request reprint Analysis of the activating receptors and cytolytic function of human natural killer cells undergoing in vivo differentiation after allogeneic bone marrow transplantation
    Chiara Vitale
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Eur J Immunol 34:455-60. 2004
    ..Our present study allows a better understanding of the NK cell differentiation in vivo...
  80. ncbi request reprint Low expression of inhibitory natural killer receptors in CD8 cytotoxic T lymphocytes in long-term non-progressor HIV-1-infected patients
    Paola Costa
    Dipartimento di Medicina Interna, University of Genova, Genoa, Italy
    AIDS 17:257-60. 2003
    ..The lack of iNKR-mediated functional inhibition of HIV-1-specific cytotoxic T lymphocytes in vitro could provide an additional mechanism for the efficient control of virus spread in LTNP patients...
  81. ncbi request reprint Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells
    Massimo Vitale
    Istituto Nazionale per la Ricerca sul Cancro, Genova, Italy
    Blood 99:1723-9. 2002
    ..Another possibility would be that TAP2(-/-) NK cells are missing a still unidentified triggering receptor involved in NK cell-mediated killing of PHA blasts...
  82. pmc NKp44 expression, phylogenesis and function in non-human primate NK cells
    Andrea De Maria
    Centro di Eccellenza per la Ricerca Biomedica, Genova, Italy
    Int Immunol 21:245-55. 2009
    ..Thus, NKp44 may represent an NCR being only recently emerged during speciation, acquiring functional relevance only in non-human primates closest to H. sapiens...
  83. pmc HLA-E-restricted recognition of cytomegalovirus-derived peptides by human CD8+ cytolytic T lymphocytes
    Gabriella Pietra
    Istituto Giannina Gaslini, 16147 Genova, Italy
    Proc Natl Acad Sci U S A 100:10896-901. 2003
    ....
  84. doi request reprint Extending killer Ig-like receptor function: from HLA class I recognition to sensors of microbial products
    Simona Sivori
    Department of Experimental Medicine and Center of Excellence for Biomedical Research, University of Genova, Italy
    Trends Immunol 31:289-94. 2010
    ..This novel KIR-associated function offers clues to understanding the NK cell response to microbial infection, and extends the role played by KIRs in immune defence...
  85. ncbi request reprint Human cytolytic T lymphocytes expressing HLA class-I-specific inhibitory receptors
    Maria Cristina Mingari
    Istituto Nazionale per la Ricerca sul Cancro, L go Rosanna Benzi, 10, 16132 Genova, Italy
    Curr Opin Immunol 17:312-9. 2005
    ..The expression of iNKRs in T cells might contribute to the prevention of apoptotic cell death, thus allowing their survival and clonal expansion in vivo. In addition, iNKR(+) T cells might contribute to peripheral self-tolerance...
  86. ncbi request reprint Perturbations of natural killer cell regulatory functions in respiratory allergic diseases
    Francesca Scordamaglia
    Clinica Malattie dell Apparato Respiratorio e Allergologia, Dipartimento di Medicina Interna, Universita di Genova, Genoa, Italy
    J Allergy Clin Immunol 121:479-85. 2008
    ..Natural killer (NK) cells give rise to a complex NK/dendritic cell (DC) cross-talk that would help T(H)1 responses...
  87. ncbi request reprint NK cells: a lesson from mismatched hematopoietic transplantation
    Andrea Velardi
    Dipartimento di Medicina Clinica e Sperimentale, Sezione Di Ematologia e Immunologia Clinica, Universita degli Studi di Perugia, Italy
    Trends Immunol 23:438-44. 2002
    ..Thus, it might now be possible to search for appropriate HLA class I mismatches to set NK cells in action...
  88. ncbi request reprint The small subset of CD56brightCD16- natural killer cells is selectively responsible for both cell proliferation and interferon-gamma production upon interaction with dendritic cells
    Massimo Vitale
    Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
    Eur J Immunol 34:1715-22. 2004
    ..This implies that, in vivo, the interactions between DC undergoing maturation and CD56(bright) NK cells may occur in different tissues and have different functional implications...
  89. ncbi request reprint Learning how to discriminate between friends and enemies, a lesson from Natural Killer cells
    Cristina Bottino
    Istituto Giannina Gaslini, L go G Gaslini 5, Genova 16148, Italy
    Mol Immunol 41:569-75. 2004
    ..Finally, the ability of NK cells to interact with normal, non-transformed other cells such as dendritic cells (DC) appears to crucially contribute to the regulation of both innate and adaptive immune responses...
  90. pmc Increased expression of the natural killer cell inhibitory receptor CD85j/ILT2 on antigen-specific effector CD8 T cells and its impact on CD8 T-cell function
    M Nedim Ince
    CBR Institute for Biomedical Research and Department of Pediatrics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
    Immunology 112:531-42. 2004
    ..Thus, ILT2 expression, increased on antiviral CD8 cells in chronic infection, may interfere with protective CD8 T-cell function by suppressing IFN-gamma production...
  91. pmc Distinct roles of IL-12 and IL-15 in human natural killer cell activation by dendritic cells from secondary lymphoid organs
    Guido Ferlazzo
    Laboratory of Viral Immunobiology, The Rockefeller University, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 101:16606-11. 2004
    ..These results identify secondary lymphoid organs as a potential DC/NK cell interaction site and identify the distinct roles for DC-derived IL-12 and IL-15 in NK cell activation...
  92. ncbi request reprint Human natural killer cells undergoing in vivo differentiation after allogeneic bone marrow transplantation: analysis of the surface expression and function of activating NK receptors
    Chiara Vitale
    Istituto Nazionale per la Ricerca sul Cancro, CBA Centro Biotecnologie Avanzate, Largo Rosanna Benzi 10 16132 Genova, Italy
    Mol Immunol 42:405-11. 2005
    ..Our present study allows a better understanding of the NK cell differentiation in vivo...
  93. ncbi request reprint 2B4 (CD244) is expressed and functional on human eosinophils
    Ariel Munitz
    Department of Pharmacology, School of Pharmacy, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 91120, Israel
    J Immunol 174:110-8. 2005
    ..Furthermore, we showed that eosinophils express slam-associated protein. The demonstration that human eosinophils express a functional 2B4 receptor indicates a broader role for these cells in health and disease...
  94. ncbi request reprint A single amino acid change, A91V, leads to conformational changes that can impair processing to the active form of perforin
    Christina Trambas
    Sir William Dunn School of Pathology, South Parks Rd, Oxford OX1 3RE, United Kingdom
    Blood 106:932-7. 2005
    ..The conformational changes and impaired cleavage of A91V perforin are likely to explain the reduced cytotoxicity in CTLs and NK cells from this patient and are likely to contribute to the pathogenesis of HLH...
  95. ncbi request reprint Activation of human NK cells by plasmacytoid dendritic cells and its modulation by CD4+ T helper cells and CD4+ CD25hi T regulatory cells
    Chiara Romagnani
    German Rheumatism Research Centre, Clinical Immunology, Berlin, Germany
    Eur J Immunol 35:2452-8. 2005
    ..Our data show that TLR9-engaged pDC represent a critical stimulus for human NK cells and that CD4+ Th cells and CD4+ CD25hi Treg cells play an important role in modulating human NK cell responses...
  96. ncbi request reprint Analysis of natural killer cells isolated from human decidua: Evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function
    Paola Vacca
    Dipartamento di Oncologia, Biologia e Genetica, University of Genoa, Italy
    Blood 108:4078-85. 2006
    ..This might suggest that dNK cells, although potentially capable of killing, are inhibited in their function when interacting with cells expressing CD48...
  97. ncbi request reprint Molecular analysis of the methylprednisolone-mediated inhibition of NK-cell function: evidence for different susceptibility of IL-2- versus IL-15-activated NK cells
    Laura Chiossone
    Instituto Scientifico Giannina Gaslini, Genoa, Italy
    Blood 109:3767-75. 2007
    ..Our study suggests a different ability of IL-15-cultured NK cells to survive to steroid treatment, thus offering interesting clues for a correct NK-cell cytokine conditioning in adoptive immunotherapy...
  98. ncbi request reprint Differential NKp30 inducibility in chimpanzee NK cells and conserved NK cell phenotype and function in long-term HIV-1-infected animals
    Erik Rutjens
    Biomedical Primate Research Centre, Rijswijk, The Netherlands
    J Immunol 178:1702-12. 2007
    ..These data suggest that one of the keys to successful lentivirus control may reside in part in a different regulation of NK cell-triggering receptor expression...