Alberto Martini

Summary

Affiliation: G. Gaslini Institute
Country: Italy

Publications

  1. pmc Reviewer acknowledgement 2012
    Alberto Martini
    Ohio State University, Columbus, USA
    Pediatr Rheumatol Online J 11:8. 2013
  2. doi request reprint Systemic juvenile idiopathic arthritis
    Alberto Martini
    Dipartimento di Pediatria, Universita di Genova, Pediatria II e Reumatologia, Istituto G Gaslini, Genova, Italy
    Autoimmun Rev 12:56-9. 2012
  3. doi request reprint It is time to rethink juvenile idiopathic arthritis classification and nomenclature
    Alberto Martini
    University of Genoa, Pediatria II, Istituto G Gaslini, Largo Gaslini 5, Genova 16147, Italy
    Ann Rheum Dis 71:1437-9. 2012
  4. doi request reprint JIA in 2011: New takes on categorization and treatment
    Alberto Martini
    University of Genoa, Pediatria II e Reumatologia, Istituto G Gaslini, Largo G Gaslini 5, 16147 Genoa, Italy
    Nat Rev Rheumatol 8:67-8. 2012
  5. doi request reprint Juvenile idiopathic arthritis: state of the art and future perspectives
    Alberto Martini
    Dipartimento di Pediatria, Universita di Genova, Pediatria II Reumatologia, IRCCS G Gaslini, Largo Gaslini 5, 16147 Genova, Italy
    Ann Rheum Dis 69:1260-3. 2010
  6. ncbi request reprint Proxy-reported health-related quality of life of patients with juvenile idiopathic arthritis: the Pediatric Rheumatology International Trials Organization multinational quality of life cohort study
    Sheila Oliveira
    IRCCS G Gaslini, Pediatria II, Reumatologia, Pediatric Rheumatology International Trials Organization, Genoa, Italy
    Arthritis Rheum 57:35-43. 2007
  7. ncbi request reprint Course of joint disease in patients with antinuclear antibody-positive juvenile idiopathic arthritis
    Enrico Felici
    Dipartimento di Pediatria, Universita di Genova, Unita Operativa Pediatria II, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genova, Italy
    J Rheumatol 32:1805-10. 2005
  8. ncbi request reprint Agreement between multi-dimensional and renal-specific response criteria in patients with juvenile systemic lupus erythematosus and renal disease
    Nicolino Ruperto
    IRCCS G Gaslini, Pediatria II, Reumatologia, Paediatric Rheumatology INternational Trials Organisation PRINTO, Genova, Italy
    Clin Exp Rheumatol 28:424-33. 2010
  9. pmc Long-term efficacy and safety of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis: findings from an open-label treatment extension
    Nicolino Ruperto
    IRCCS Istituto G Gaslini, Pediatria II PRINTO, Largo Gaslini 5, EULAR Centre of Excellence in Rheumatology 2008 13, Genoa, Italy
    Ann Rheum Dis 69:718-22. 2010
  10. pmc Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
    Anna Corcione
    Laboratory of Oncology, IRCCS G Gaslini, Largo G Gaslini 5, Genoa, 16148, Italy
    Arthritis Res Ther 11:R150. 2009

Detail Information

Publications90

  1. pmc Reviewer acknowledgement 2012
    Alberto Martini
    Ohio State University, Columbus, USA
    Pediatr Rheumatol Online J 11:8. 2013
    ..CONTRIBUTING REVIEWERS: The Editors of Pediatric Rheumatology would like to thank all our reviewers who have contributed to the journal in Volume 10 (2012)...
  2. doi request reprint Systemic juvenile idiopathic arthritis
    Alberto Martini
    Dipartimento di Pediatria, Universita di Genova, Pediatria II e Reumatologia, Istituto G Gaslini, Genova, Italy
    Autoimmun Rev 12:56-9. 2012
    ..The specific inhibition of these two cytokines is going to change not only the therapeutic approach to the disease but also, presumably, its long term prognosis...
  3. doi request reprint It is time to rethink juvenile idiopathic arthritis classification and nomenclature
    Alberto Martini
    University of Genoa, Pediatria II, Istituto G Gaslini, Largo Gaslini 5, Genova 16147, Italy
    Ann Rheum Dis 71:1437-9. 2012
    ..Recent advances have shown that while some JIA categories identify quite definite disease entities, others still include heterogeneous conditions. Some aspects of JIA classification and nomenclature need therefore to be reconsidered...
  4. doi request reprint JIA in 2011: New takes on categorization and treatment
    Alberto Martini
    University of Genoa, Pediatria II e Reumatologia, Istituto G Gaslini, Largo G Gaslini 5, 16147 Genoa, Italy
    Nat Rev Rheumatol 8:67-8. 2012
    ..These advances hold promise for improved management of JIA in 2012 and beyond...
  5. doi request reprint Juvenile idiopathic arthritis: state of the art and future perspectives
    Alberto Martini
    Dipartimento di Pediatria, Universita di Genova, Pediatria II Reumatologia, IRCCS G Gaslini, Largo Gaslini 5, 16147 Genova, Italy
    Ann Rheum Dis 69:1260-3. 2010
    ..However, despite a dramatic advance in the understanding of JIA categories, pathobiology and treatments, much remains to be done...
  6. ncbi request reprint Proxy-reported health-related quality of life of patients with juvenile idiopathic arthritis: the Pediatric Rheumatology International Trials Organization multinational quality of life cohort study
    Sheila Oliveira
    IRCCS G Gaslini, Pediatria II, Reumatologia, Pediatric Rheumatology International Trials Organization, Genoa, Italy
    Arthritis Rheum 57:35-43. 2007
    ..To investigate the proxy-reported health-related quality of life (HRQOL) and its determinants in patients with juvenile idiopathic arthritis (JIA)...
  7. ncbi request reprint Course of joint disease in patients with antinuclear antibody-positive juvenile idiopathic arthritis
    Enrico Felici
    Dipartimento di Pediatria, Universita di Genova, Unita Operativa Pediatria II, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genova, Italy
    J Rheumatol 32:1805-10. 2005
    ..To describe the patterns and time course of arthritis in patients with antinuclear antibody (ANA)-positive juvenile idiopathic arthritis (JIA)...
  8. ncbi request reprint Agreement between multi-dimensional and renal-specific response criteria in patients with juvenile systemic lupus erythematosus and renal disease
    Nicolino Ruperto
    IRCCS G Gaslini, Pediatria II, Reumatologia, Paediatric Rheumatology INternational Trials Organisation PRINTO, Genova, Italy
    Clin Exp Rheumatol 28:424-33. 2010
    ..To evaluate change over time and level of agreement of renal-specific and multi-dimensional measures in juvenile systemic lupus erythematosus (SLE) with renal disease...
  9. pmc Long-term efficacy and safety of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis: findings from an open-label treatment extension
    Nicolino Ruperto
    IRCCS Istituto G Gaslini, Pediatria II PRINTO, Largo Gaslini 5, EULAR Centre of Excellence in Rheumatology 2008 13, Genoa, Italy
    Ann Rheum Dis 69:718-22. 2010
    ..To assess the long-term efficacy and safety of infliximab plus methotrexate in juvenile rheumatoid arthritis (JRA)...
  10. pmc Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
    Anna Corcione
    Laboratory of Oncology, IRCCS G Gaslini, Largo G Gaslini 5, Genoa, 16148, Italy
    Arthritis Res Ther 11:R150. 2009
    ..Here, we have characterized synovial fluid and tissue B-cell subsets in patients with oligoarticular juvenile idiopathic arthritis (JIA), an issue not addressed before in detail...
  11. doi request reprint Development and testing of reduced joint counts in juvenile idiopathic arthritis
    Anna Bazso
    Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    J Rheumatol 36:183-90. 2009
    ..To develop and test reduced joint counts in children with juvenile idiopathic arthritis (JIA)...
  12. doi request reprint Validation of the Childhood Health Assessment Questionnaire in active juvenile systemic lupus erythematosus
    Silvia Meiorin
    IRCCS G Gaslini, Pediatria II, Reumatologia and Paediatric Rheumatology International Trials Organisation, Universita di Genova, Largo Gaslini 5, Genoa, Italy
    Arthritis Rheum 59:1112-9. 2008
    ..To validate the Childhood Health Assessment Questionnaire (C-HAQ) as a measure of disability in patients with active juvenile systemic lupus erythematosus (SLE)...
  13. doi request reprint Development and preliminary validation of a paediatric-targeted MRI scoring system for the assessment of disease activity and damage in juvenile idiopathic arthritis
    Clara Malattia
    Correspondence to Dr Clara Malattia, Pediatria II, IRCCS G Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    Ann Rheum Dis 70:440-6. 2011
    ..To compare the paediatric MRI score with the adult-designed. Outcome Measures in Rheumatology Clinical Trials-Rheumatoid Arthritis MRI Score (RAMRIS), whose suitability for assessing growing joints was tested...
  14. doi request reprint Development and initial validation of a radiographic scoring system for the hip in juvenile idiopathic arthritis
    Marta Bertamino
    Universita degli Studi di Genova, Genova, Italy
    J Rheumatol 37:432-9. 2010
    ..To develop and validate a radiographic scoring system for the assessment of radiographic damage in the hip joint in patients with juvenile idiopathic arthritis (JIA)...
  15. doi request reprint Dynamic contrast-enhanced magnetic resonance imaging in the assessment of disease activity in patients with juvenile idiopathic arthritis
    Clara Malattia
    Pediatria II, IRCCS G Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    Rheumatology (Oxford) 49:178-85. 2010
    ..To determine the capability and reliability of dynamic contrast-enhanced MRI (DCE-MRI) in the assessment of disease activity in juvenile idiopathic arthritis (JIA)...
  16. doi request reprint Evaluation of 21-numbered circle and 10-centimeter horizontal line visual analog scales for physician and parent subjective ratings in juvenile idiopathic arthritis
    Giovanni Filocamo
    Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genova, Italy
    J Rheumatol 37:1534-41. 2010
    ..To evaluate the measurement properties of 21-numbered circle visual analog scales (VAS) and traditional 10-cm horizontal line VAS for physician and parent subjective ratings in children with juvenile idiopathic arthritis (JIA)...
  17. doi request reprint Remission, minimal disease activity, and acceptable symptom state in juvenile idiopathic arthritis: defining criteria based on the juvenile arthritis disease activity score
    Alessandro Consolaro
    Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 64:2366-74. 2012
    ..To determine cutoff values for defining remission, minimal disease activity, and parent and child acceptable symptom state in juvenile idiopathic arthritis (JIA) using the Juvenile Arthritis Disease Activity Score (JADAS)...
  18. doi request reprint The PRINTO criteria for clinically inactive disease in juvenile dermatomyositis
    Dragana Lazarevic
    Pediatria II, Reumatologia, Istituto Giannina Gaslini, Genova, Italy
    Ann Rheum Dis 72:686-93. 2013
    ..To develop data-driven criteria for clinically inactive disease on and off therapy for juvenile dermatomyositis (JDM)...
  19. ncbi request reprint Physicians' and parents' ratings of inactive disease are frequently discordant in juvenile idiopathic arthritis
    Alessandro Consolaro
    Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genova, Italy
    J Rheumatol 34:1773-6. 2007
    ..To investigate discrepancies between physicians' and parents' ratings of inactive disease in children with juvenile idiopathic arthritis (JIA) and the determinants of the discrepancy...
  20. ncbi request reprint Possible discontinuation of therapies after clinical remission in juvenile idiopathic arthritis
    Sara Verazza
    Istituto Giannina Gaslini, Genova, Italy
    Clin Exp Rheumatol 31:S98-101; quiz S102-7. 2013
    ..In addition, the optimal policy for discontinuation of other biologic medications used in children with JIA, such as anakinra, abatacept, tocilizumab, and canakinumab, should be established. ..
  21. doi request reprint A new short and simple health-related quality of life measurement for paediatric rheumatic diseases: initial validation in juvenile idiopathic arthritis
    Giovanni Filocamo
    Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genova, Italy
    Rheumatology (Oxford) 49:1272-80. 2010
    ..To develop and validate a new short and simple measure of health-related quality of life (HRQL) in children with juvenile idiopathic arthritis (JIA)...
  22. doi request reprint Parent and child acceptable symptom state in juvenile idiopathic arthritis
    Giovanni Filocamo
    Pediatria II, Istituto G Gaslini, Largo G Gaslini 5, 16147 Genoa, Italy
    J Rheumatol 39:856-63. 2012
    ..To explore the parent and child acceptable symptom state in juvenile arthritis (JA-PASS and JA-CASS, respectively) and estimate the JA-PASS and JA-CASS cutoff values for outcome measures...
  23. doi request reprint Clinical impact of MEFV mutations in children with periodic fever in a prevalent western European Caucasian population
    Silvia Federici
    UO Pediatria II Reumatologia, Istituto G Gaslini, Genova, Italy
    Ann Rheum Dis 71:1961-5. 2012
    ..To evaluate the actual impact of MEFV mutations on clinical manifestations associated with fever attacks in Caucasian children with periodic fever...
  24. doi request reprint Achievement of a state of inactive disease at least once in the first 5 years predicts better outcome of patients with polyarticular juvenile idiopathic arthritis
    Alessandra Magnani
    Istituto G Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    J Rheumatol 36:628-34. 2009
    ..To investigate whether the achievement of inactive disease in the first 5 years predicts a more favorable outcome of children with juvenile idiopathic arthritis (JIA)...
  25. doi request reprint Criteria to define response to therapy in paediatric rheumatic diseases
    Nicolino Ruperto
    IRCCS G Gaslini, Pediatria II, Reumatologia, Pædiatric Rheumatology International Trials Organisation PRINTO, Genoa, Italy
    Eur J Clin Pharmacol 67:125-31. 2011
    ....
  26. doi request reprint Periodic fever, apthous stomatitis, pharyngitis and adenitis syndrome
    Roberta Caorsi
    UO Pediatria II, G Gaslini Institute and Department of Pediatrics, University of Genoa, Genoa, Italy
    Curr Opin Rheumatol 22:579-84. 2010
    ..We report on the findings coming from the analysis of large cohorts of PFAPA patients and the possible implication for the differential diagnosis. An update on the efficacy of possible prophylactic treatments and tonsillectomy is given...
  27. doi request reprint Differentiating PFAPA syndrome from monogenic periodic fevers
    Marco Gattorno
    UO Pediatria II, G Gaslini Institute, Largo G Gaslini 5, 16146, Genova, Italy
    Pediatrics 124:e721-8. 2009
    ....
  28. ncbi request reprint The Pediatric Rheumatology International Trials Organization/American College of Rheumatology provisional criteria for the evaluation of response to therapy in juvenile systemic lupus erythematosus: prospective validation of the definition of improvement
    Nicolino Ruperto
    Pediatric Rheumatology International Trials Organization, IRCCS G Gaslini, Università di Genova Pediatria II Reumatologia, 5 Largo Gaslini, 16147 Genoa, Italy
    Arthritis Rheum 55:355-63. 2006
    ....
  29. doi request reprint Abatacept in children with juvenile idiopathic arthritis: a randomised, double-blind, placebo-controlled withdrawal trial
    Nicolino Ruperto
    IRCCS G Gaslini, PRINTO, Genoa, Italy
    Lancet 372:383-91. 2008
    ..We aimed to assess the safety and efficacy of abatacept, a selective T-cell costimulation modulator, in children with juvenile idiopathic arthritis who had failed previous treatments...
  30. ncbi request reprint Toward a treat-to-target approach in the management of juvenile idiopathic arthritis
    Alessandro Consolaro
    Istituto di Ricovero e Cura a Carattere Scientifico Giannina Gaslini, Genova, Italy
    Clin Exp Rheumatol 30:S157-62. 2012
    ..Future studies will clarify whether the addition of an imaging assessment to the management of children with JIA will improve the prediction of clinical outcomes...
  31. doi request reprint Therapeutic approaches in the treatment of juvenile dermatomyositis in patients with recent-onset disease and in those experiencing disease flare: an international multicenter PRINTO study
    Rachana Hasija
    IRCCS G Gaslini, Genoa, Italy
    Arthritis Rheum 63:3142-52. 2011
    ..To evaluate response to therapy over a 24-month period in a large prospective international cohort of patients with juvenile dermatomyositis (DM)...
  32. doi request reprint An international consensus survey of diagnostic criteria for macrophage activation syndrome in systemic juvenile idiopathic arthritis
    Sergio Davì
    Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genova, Italy
    J Rheumatol 38:764-8. 2011
    ..To identify candidate diagnostic criteria for macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (sJIA) using international consensus formation through a Delphi questionnaire survey...
  33. ncbi request reprint Comparison of clinical features and drug therapies among European and Latin American patients with juvenile dermatomyositis
    Dinara Guseinova
    Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genova, Italy
    Clin Exp Rheumatol 29:117-24. 2011
    ..To compare the demographic features, presenting manifestations, diagnostic investigations, disease course, and drug therapies of children with juvenile dermatomyositis (JDM) followed in Europe and Latin America...
  34. doi request reprint The hypoxic synovial environment regulates expression of vascular endothelial growth factor and osteopontin in juvenile idiopathic arthritis
    Maria Carla Bosco
    Laboratory of Molecular Biology, Department of Pediatrics, G Gaslini Institute, Genova, Italy
    J Rheumatol 36:1318-29. 2009
    ..We characterized the contribution of the local hypoxic environment to VEGF and OPN production by monocytic cells recruited to the synovium in JIA...
  35. doi request reprint Frequency of radiographic damage and progression in individual joints in children with juvenile idiopathic arthritis
    Gabriella Giancane
    Istituto Giannina Gaslini, Genova, Italy
    Arthritis Care Res (Hoboken) 66:27-33. 2014
    ....
  36. ncbi request reprint Adapted versions of the Sharp/van der Heijde score are reliable and valid for assessment of radiographic progression in juvenile idiopathic arthritis
    Angelo Ravelli
    Università degli Studi di Genoa, and IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3087-95. 2007
    ..To develop adapted versions of the Sharp/van der Heijde radiographic scoring system for use in juvenile idiopathic arthritis (JIA), and to investigate their validity in JIA patients with polyarticular disease...
  37. ncbi request reprint The Pediatric Rheumatology International Trials Organization criteria for the evaluation of response to therapy in juvenile systemic lupus erythematosus: prospective validation of the disease activity core set
    Nicolino Ruperto
    Pediatric Rheumatology International Trials Organization PRINTO, IRCCS G Gaslini, Universita di Genova, Pediatria II Reumatologia, Largo Gaslini, Genoa, Italy
    Arthritis Rheum 52:2854-64. 2005
    ..To validate and promulgate a core set of outcome measures for the evaluation of response to treatment in patients with juvenile systemic lupus erythematosus (SLE)...
  38. ncbi request reprint Development and validation of a clinical index for assessment of long-term damage in juvenile idiopathic arthritis
    Stefania Viola
    Universita di Genova, IRCCS G Gaslini, Genoa, Italy
    Arthritis Rheum 52:2092-102. 2005
    ..To develop and validate a clinical measure of articular and extraarticular damage in patients with juvenile idiopathic arthritis (JIA)...
  39. doi request reprint A new approach to clinical care of juvenile idiopathic arthritis: the Juvenile Arthritis Multidimensional Assessment Report
    Giovanni Filocamo
    Pediatria II, Istituto G Gaslini, Largo G Gaslini 5, Genoa, Italy
    J Rheumatol 38:938-53. 2011
    ..To develop and test a new multidimensional questionnaire for assessment of children with juvenile idiopathic arthritis (JIA) in standard clinical care...
  40. doi request reprint EULAR/PRINTO/PRES criteria for Henoch-Schönlein purpura, childhood polyarteritis nodosa, childhood Wegener granulomatosis and childhood Takayasu arteritis: Ankara 2008. Part I: Overall methodology and clinical characterisation
    Nicolino Ruperto
    Paediatric Rheumatology INternational Trials Organisation PRINTO, IRCCS G Gaslini, Universita di Genova, Pediatria II Reumatologia, EULAR Centre of Excellence in Rheumatology 2008 2013, Largo Gaslini, 5, Genova 16147, Italy
    Ann Rheum Dis 69:790-7. 2010
    ....
  41. doi request reprint Treatment of Takayasu's arteritis with tumor necrosis factor antagonists
    Giovanni Filocamo
    Pediatria II IRCCS G Gaslini e Dipartimento di Pediatria, Universita di Genova, Italy
    J Pediatr 153:432-4. 2008
    ..Two patients went into remission; in the other 2, the response was partial. Anti-tumor necrosis factor agents can have a role in the treatment of Takayasu's arteritis; further controlled studies are required...
  42. ncbi request reprint Consensus procedures and their role in pediatric rheumatology
    Nicolino Ruperto
    IRCCS G Gaslini, Pediatria II PRINTO, University of Genoa, Largo Gaslini, 5, 16147 Genova, Italy
    Curr Rheumatol Rep 10:142-6. 2008
    ....
  43. doi request reprint Predictors of poor response to methotrexate in polyarticular-course juvenile idiopathic arthritis: analysis of the PRINTO methotrexate trial
    Iris Vilca
    IRCCS G Gaslini, Pediatria II, Reumatologia, PRINTO, Genova, Italy
    Ann Rheum Dis 69:1479-83. 2010
    ..To determine whether baseline demographic, clinical, articular and laboratory variables predict methotrexate (MTX) poor response in polyarticular-course juvenile idiopathic arthritis...
  44. doi request reprint Abatacept improves health-related quality of life, pain, sleep quality, and daily participation in subjects with juvenile idiopathic arthritis
    Nicolino Ruperto
    Universita di Genova, Genoa, Italy
    Arthritis Care Res (Hoboken) 62:1542-51. 2010
    ..To assess health-related quality of life (HRQOL) in abatacept-treated children/adolescents with juvenile idiopathic arthritis (JIA)...
  45. ncbi request reprint A proposal for a pediatric version of the Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index based on the analysis of 1,015 patients with juvenile-onset systemic lupus erythematosus
    Raul Gutiérrez-Suárez
    IRCCS G Gaslini, Genoa, Italy
    Arthritis Rheum 54:2989-96. 2006
    ....
  46. ncbi request reprint Performance of Birmingham Vasculitis Activity Score and disease extent index in childhood vasculitides
    Erkan Demirkaya
    IRCCS G Gaslini, Pediatria II, Reumatologia, PRINTO, Genova, Italy
    Clin Exp Rheumatol 30:S162-8. 2012
    ..To evaluate the performance of the Birmingham Vasculitis Activity Score (BVAS) v3 and the Disease Extent Index (DEI) for the assessment of disease activity in 4 primary childhood (c-) systemic vasculitides...
  47. pmc Agreement between physicians and parents in rating functional ability of children with juvenile idiopathic arthritis
    Elena Palmisani
    Pediatria II, Istituto di Ricovero e Cura a Carattere Scientifico G, Gaslini, Genova, Italy
    Pediatr Rheumatol Online J 5:23. 2007
    ..To investigate concordance between physicians and parents in rating the degree of functional ability of children with juvenile idiopathic arthritis (JIA)...
  48. ncbi request reprint A randomized, placebo-controlled trial of infliximab plus methotrexate for the treatment of polyarticular-course juvenile rheumatoid arthritis
    Nicolino Ruperto
    IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3096-106. 2007
    ..To evaluate the safety and efficacy of infliximab in the treatment of juvenile rheumatoid arthritis (JRA)...
  49. ncbi request reprint Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
    Marco Gattorno
    Second Division of Pediatrics, IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3138-48. 2007
    ....
  50. doi request reprint Candidate genes in patients with autoinflammatory syndrome resembling tumor necrosis factor receptor-associated periodic syndrome without mutations in the TNFRSF1A gene
    Silvia Borghini
    Laboratorio di Genetica Molecolare, Istituto G Gaslini, Genova, Italy
    J Rheumatol 38:1378-84. 2011
    ..Patients display different mutations of the TNF receptor superfamily 1A gene (TNFRSF1A), coding for a nearly ubiquitous TNF receptor (TNFR1). No TNFRSF1A mutation has been identified in a proportion of patients with TRAPS-like phenotype...
  51. doi request reprint A phase II, multicenter, open-label study evaluating dosing and preliminary safety and efficacy of canakinumab in systemic juvenile idiopathic arthritis with active systemic features
    Nicolino Ruperto
    IRCCS G Gaslini, Genoa, Italy
    Arthritis Rheum 64:557-67. 2012
    ..To assess dosing, preliminary safety, and efficacy of canakinumab, a fully human anti-interleukin-1β (anti-IL-1β) antibody, in children with systemic juvenile idiopathic arthritis (JIA) and active systemic features...
  52. doi request reprint Network in pediatric rheumatology: the example of the Pediatric Rheumatology International Trials Organization
    Nicolino Ruperto
    IRCCS Istituto G Gaslini, Pediatria II, Reumatologia, Genoa, Italy
    World J Pediatr 4:186-91. 2008
    ..The research aimed at studying new therapeutic approaches is difficult because of logistic, methodological and ethical problems...
  53. ncbi request reprint Preliminary diagnostic guidelines for macrophage activation syndrome complicating systemic juvenile idiopathic arthritis
    Angelo Ravelli
    Department of Pediatrics, Division of Pediatrics II, University of Genoa, Istituto G Gaslini, Largo G Gaslini 5, 16147 Genoa, Italy
    J Pediatr 146:598-604. 2005
    ..To develop diagnostic guidelines for macrophage activation syndrome (MAS) complicating systemic juvenile idiopathic arthritis (S-JIA)...
  54. doi request reprint Magnetic resonance imaging, ultrasonography, and conventional radiography in the assessment of bone erosions in juvenile idiopathic arthritis
    Clara Malattia
    Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 59:1764-72. 2008
    ....
  55. ncbi request reprint Level of agreement between children, parents, and physicians in rating pain intensity in juvenile idiopathic arthritis
    Pablo Garcia-Munitis
    Unita Operativa Pediatria II, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Universita di Genova, Largo G Gaslini 5, 16147 Genoa, Italy
    Arthritis Rheum 55:177-83. 2006
    ..To investigate the level of agreement between patients, mothers, fathers, and physicians in rating pain intensity in juvenile idiopathic arthritis (JIA), and to identify factors explaining discrepancies between raters...
  56. doi request reprint Networking in paediatrics: the example of the Paediatric Rheumatology International Trials Organisation (PRINTO)
    Nicolino Ruperto
    Pediatria II, Reumatologia, University of Genoa, EULAR Centre of Excellence in Rheumatology 2008 13, IRCCS G Gaslini, Largo G Gaslini 5, Genoa, Italy
    Arch Dis Child 96:596-601. 2011
    ..The PRINTO and PRCSG networks can be seen as a model for international co-operation in other paediatric subspecialties...
  57. ncbi request reprint Health-related quality of life in juvenile-onset systemic lupus erythematosus and its relationship to disease activity and damage
    Nicolino Ruperto
    Universita di Genova, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genoa, Italy
    Arthritis Rheum 51:458-64. 2004
    ..To assess the health-related quality of life (HRQL) of patients with juvenile-onset systemic lupus erythematosus (JSLE) and its relationship with disease activity and accumulated damage...
  58. doi request reprint Agreement among musculoskeletal pediatric specialists in the assessment of radiographic joint damage in juvenile idiopathic arthritis
    Ana Luisa Rodríguez-Lozano
    Istituto Giannina Gaslini, Genova, Italy
    Arthritis Care Res (Hoboken) 66:34-9. 2014
    ..To evaluate agreement among musculoskeletal pediatric specialists in assessing radiographic joint damage in juvenile idiopathic arthritis (JIA)...
  59. doi request reprint Recurrent pericarditis in Myhre syndrome
    Paolo Picco
    Pediatria II, G Gaslini Istitute, and University of Genoa, Genoa, Italy
    Am J Med Genet A 161:1164-6. 2013
    ....
  60. doi request reprint MRI of the wrist in juvenile idiopathic arthritis: proposal of a paediatric synovitis score by a consensus of an international working group. Results of a multicentre reliability study
    Maria Beatrice Damasio
    Department of Radiology, Ospedale Pediatrico Gaslini, Genova, Italy
    Pediatr Radiol 42:1047-55. 2012
    ..MRI is a sensitive tool for the evaluation of synovitis in juvenile idiopathic arthritis (JIA)...
  61. ncbi request reprint Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients
    Elisabetta Traggiai
    Second Division of Pediatrics, IRCCS, Institute G Gaslini, Genova, Italy
    Stem Cells 26:562-9. 2008
    ..This study casts important questions on bone marrow mesenchymal stem cells as a therapeutic tool in autoimmune diseases in which B-cell activation is crucially implicated in the pathogenesis of the disease...
  62. doi request reprint Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease?
    Paolo Picco
    G Gaslini Institute, University of Genoa, Genoa, Italy
    Arthritis Rheum 60:264-8. 2009
    ..The findings in these patients suggest that idiopathic recurrent pericarditis may be a previously unrecognized autoinflammatory disease...
  63. doi request reprint HLA-G and HLA-E in patients with juvenile idiopathic arthritis
    Ignazia Prigione
    Laboratory of Oncology, G Gaslini Scientific Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Rheumatology (Oxford) 50:966-72. 2011
    ..To investigate the expression and release of HLA-G and HLA-E in JIA...
  64. doi request reprint Synovial and inflammatory diseases in childhood: role of new imaging modalities in the assessment of patients with juvenile idiopathic arthritis
    Maria Beatrice Damasio
    Department of Diagnostic Imaging, G Gaslini Institute, Largo G Gaslini 5, Genoa 16148, Italy
    Pediatr Radiol 40:985-98. 2010
    ..In this era of advancing imaging technology, knowledge of the relative values of available imaging techniques is necessary to optimize the management of children with JIA...
  65. doi request reprint Emerging drugs to treat juvenile idiopathic arthritis
    Nicolino Ruperto
    IRCCS Istituto G Gaslini Pediatria II, Reumatologia, Genova, Italy
    Expert Opin Emerg Drugs 16:493-505. 2011
    ..Some of the new drugs that are under investigation for RA could also be suitable in the future for improving the treatment of JIA...
  66. doi request reprint Methotrexate therapy may prevent the onset of uveitis in juvenile idiopathic arthritis
    Charalampia Papadopoulou
    Istituto Giannina Gaslini, Genova, Italy
    J Pediatr 163:879-84. 2013
    ..To evaluate whether early treatment with methotrexate (MTX) prevents the onset of uveitis in children with juvenile idiopathic arthritis...
  67. pmc A randomized, double-blind, placebo-controlled trial of paracetamol and ketoprofren lysine salt for pain control in children with pharyngotonsillitis cared by family pediatricians
    Nicolino Ruperto
    IRCCS G Gaslini, Pediatria II, Reumatologia, PRINTO, Genoa, Italy
    Ital J Pediatr 37:48. 2011
    ..To evaluate the analgesic effect and tolerability of paracetamol syrup compared to placebo and ketoprofen lysine salt in children with pharyngotonsillitis cared by family pediatricians...
  68. doi request reprint Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis
    Nicolino Ruperto
    Istituto Giannina Gaslini, Pediatria II, Reumatologia, Paediatric Rheumatology International Trials Organisation PRINTO Coordinating Center, Genoa, Italy
    N Engl J Med 367:2396-406. 2012
    ..Interleukin-1 is pivotal in the pathogenesis of systemic juvenile idiopathic arthritis (JIA). We assessed the efficacy and safety of canakinumab, a selective, fully human, anti-interleukin-1β monoclonal antibody, in two trials...
  69. ncbi request reprint Clinical assessment in juvenile dermatomyositis
    Angelo Ravelli
    Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Universita di Genova, Dipartimento di Pediatria, Italy
    Autoimmunity 39:197-203. 2006
    ....
  70. ncbi request reprint Juvenile idiopathic arthritis
    Angelo Ravelli
    Department of Paediatrics, University of Genoa and Institute G Gaslini, Genoa, Italy
    Lancet 369:767-78. 2007
    ....
  71. ncbi request reprint Preliminary core sets of measures for disease activity and damage assessment in juvenile systemic lupus erythematosus and juvenile dermatomyositis
    Nicolino Ruperto
    IRCCS G Gasalini, Pediatria II, Genova, Italy
    Rheumatology (Oxford) 42:1452-9. 2003
    ..To identify preliminary core sets of outcome variables for disease activity and damage assessment in juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM)...
  72. pmc The Paediatric Rheumatology International Trials Organisation provisional criteria for the evaluation of response to therapy in juvenile dermatomyositis
    Nicolino Ruperto
    Paediatric Rheumatology International Trials Organisation, Genoa, Italy
    Arthritis Care Res (Hoboken) 62:1533-41. 2010
    ..To develop a provisional definition for the evaluation of response to therapy in juvenile dermatomyositis (DM) based on the Paediatric Rheumatology International Trials Organisation juvenile DM core set of variables...
  73. ncbi request reprint Increased expression of alpha(1,3)-fucosyltransferase-VII and P-selectin binding of synovial fluid T cells in juvenile idiopathic arthritis
    Fabrizio De Benedetti
    Pediatria Generale e Reumatologia, Dipartimento di Pediatria, IRCCS Policlinico San Matteo, Pavia, Italy
    J Rheumatol 30:1611-5. 2003
    ..Here, we focus on alpha(1,3)-fucosyltransferase-VII (FucT-VII), an enzyme responsible for the generation of functional P- and E-selectin ligands that is upregulated in Th1 cells...
  74. doi request reprint Antinuclear antibody-positive patients should be grouped as a separate category in the classification of juvenile idiopathic arthritis
    Angelo Ravelli
    IRCCS G Gaslini and Università degli Studi di Genova, Genoa, Italy
    Arthritis Rheum 63:267-75. 2011
    ....
  75. doi request reprint Long-term outcome and prognostic factors of juvenile dermatomyositis: a multinational, multicenter study of 490 patients
    Angelo Ravelli
    Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini and Università degli Studi di Genoa, Genoa, Italy
    Arthritis Care Res (Hoboken) 62:63-72. 2010
    ..To investigate the long-term outcome and prognostic factors of juvenile dermatomyositis (DM) through a multinational, multicenter study...
  76. doi request reprint Diagnosis and management of autoinflammatory diseases in childhood
    Marco Gattorno
    2nd Division of Pediatrics, G Gaslini Scientific Institute, Largo G Gaslini 5, 16147, Genova, Italy
    J Clin Immunol 28:S73-83. 2008
    ..Autoinflammatory diseases are a group monogenic inflammatory conditions characterized by an early onset during childhood...
  77. doi request reprint The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis
    Marco Gattorno
    G Gaslini Institute, Genoa, Italy
    Arthritis Rheum 58:1505-15. 2008
    ..To assess the clinical response to interleukin-1 (IL-1) blockade and in vitro IL-1beta and IL-18 secretion in patients with systemic-onset juvenile idiopathic arthritis (JIA)...
  78. doi request reprint Long-term safety and efficacy of abatacept in children with juvenile idiopathic arthritis
    Nicolino Ruperto
    Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Genoa, Italy
    Arthritis Rheum 62:1792-802. 2010
    ..Here, we report results from the long-term extension (LTE) phase of that study...
  79. doi request reprint HRCT and pulmonary function tests in monitoring of lung involvement in juvenile systemic sclerosis
    Serena Panigada
    U O Pneumologia, IRCCS G Gaslini, Genova, Italy
    Pediatr Pulmonol 44:1226-34. 2009
    ..To investigate the role of high-resolution computed tomography (HRCT) and pulmonary function tests (PFTs) in staging pulmonary involvement in juvenile systemic sclerosis (JSS)...
  80. pmc Coxarthritis as the presenting symptom of Gaucher disease type 1
    Giacomo Brisca
    2nd Division of Paediatrics, G Gaslini Institute, Largo Gaslini 5, 16129 Genova, Italy
    Arthritis 2011:361279. 2011
    ..Herein, we report a patient in whom the osteoarticular involvement has been the only symptom of the disease stressing that this unusual presentation of GD has prompted a wide differential diagnosis with more common forms of coxitis...
  81. doi request reprint The provisional Paediatric Rheumatology International Trials Organisation/American College of Rheumatology/European League Against Rheumatism Disease activity core set for the evaluation of response to therapy in juvenile dermatomyositis: a prospective va
    Nicolino Ruperto
    IRCCS G Gaslini, Genoa, Italy
    Arthritis Rheum 59:4-13. 2008
    ..To validate a core set of outcome measures for the evaluation of response to treatment in patients with juvenile dermatomyositis (DM)...
  82. ncbi request reprint Outcome in juvenile onset systemic lupus erythematosus
    Angelo Ravelli
    Dipartimento di Pediatria, Universita di Genova, Unita Operativa Pediatria II, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Italy
    Curr Opin Rheumatol 17:568-73. 2005
    ..This review summarizes the recent advances in the investigation on survival, accumulated damage, and health-related quality of life in patients with juvenile-onset systemic lupus erythematosus...
  83. doi request reprint Treatment of autoinflammatory syndromes
    Marco Gattorno
    UO Pediatria II, G Gaslini Institute, Genova, Italy
    Curr Opin Pediatr 22:771-8. 2010
    ..In this review, we outline the more recent novelties in the treatment of autoinflammatory diseases and their possible implications for some multifactorial pediatric conditions...
  84. ncbi request reprint Antiphospholipid syndrome
    Angelo Ravelli
    Pediatria II, Istituto di Ricovero e Cura a Carattere Scientifico G Gaslini, Largo G Gaslini, 5, 16147, Genoa, Italy
    Pediatr Clin North Am 52:469-91, vi. 2005
    ....
  85. pmc Phenotypic and functional characterisation of CCR7+ and CCR7- CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis
    Marco Gattorno
    II Division of Pediatrics, University of Genoa, Genoa, Italy
    Arthritis Res Ther 7:R256-67. 2005
    ..Moreover, discrete patterns of chemokine receptor expression are detected in the synovial tissue...
  86. pmc Current medical treatments for juvenile idiopathic arthritis
    Nicolino Ruperto
    Pediatria II e Reumatologia, Istituto G Gaslini Genoa, University of Genoa Genoa, Italy
    Front Pharmacol 2:60. 2011
    ..This review will currently describe the methodological approach for performing clinical trials in JIA as well as the current available drug treatment...
  87. ncbi request reprint A randomized trial of parenteral methotrexate comparing an intermediate dose with a higher dose in children with juvenile idiopathic arthritis who failed to respond to standard doses of methotrexate
    Nicolino Ruperto
    IRCCS G Gaslini, University of Genoa, Genoa, Italy
    Arthritis Rheum 50:2191-201. 2004
    ..5 mg/m(2)/week)...
  88. ncbi request reprint International research networks in pediatric rheumatology: the PRINTO perspective
    Nicolino Ruperto
    IRCCS G Gaslini, Universita di Genova, Pediatria II Reumatologia, Genova, Italy
    Curr Opin Rheumatol 16:566-70. 2004
    ..The purpose of this review is to highlight the problems and possible solutions for the conduct of international collaborative research for pediatric rheumatic diseases...
  89. ncbi request reprint A randomized, double-blind clinical trial of two doses of meloxicam compared with naproxen in children with juvenile idiopathic arthritis: short- and long-term efficacy and safety results
    Nicolino Ruperto
    IRCCS G Gaslini, Pediatria II, Reumatologia, Genoa, Italy
    Arthritis Rheum 52:563-72. 2005
    ....
  90. ncbi request reprint Patients with antinuclear antibody-positive juvenile idiopathic arthritis constitute a homogeneous subgroup irrespective of the course of joint disease
    Angelo Ravelli
    IRCCS G Gaslini, Genoa, Italy
    Arthritis Rheum 52:826-32. 2005
    ....