Gian M Ghiggeri

Summary

Affiliation: G. Gaslini Institute
Country: Italy

Publications

  1. ncbi request reprint Discordant evolution of nephrotic syndrome in mono- and dizygotic twins
    Gian Marco Ghiggeri
    Nephrology Unit, G Gaslini Children s Hospital, Genoa, Italy
    Pediatr Nephrol 21:419-22. 2006
  2. pmc Genetic approaches to human renal agenesis/hypoplasia and dysplasia
    Simone Sanna-Cherchi
    Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Pediatr Nephrol 22:1675-84. 2007
  3. pmc Teaching molecular genetics: chapter 4-positional cloning of genetic disorders
    Aldamaria Puliti
    Laboratory of Molecular Genetics, Istituto G Gaslini, Genoa, Italy
    Pediatr Nephrol 22:2023-9. 2007
  4. pmc The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait
    Francesco P Schena
    Renal Unit, University of Bari, Italy
    BMC Nephrol 6:14. 2005
  5. doi request reprint Post-transplant proteinuria associated with everolimus: Definition of main features with proteomics
    Gian Marco Ghiggeri
    Division of Nephrology and Laboratory on Pathophysiology of Uremia, G Gaslini Children Hospital, Genoa, Italy
    Proteomics Clin Appl 2:1327-37. 2008
  6. ncbi request reprint Recurrent lymphomatoid papulosis associated with nephrotic syndrome. An occurrence of uncertain origin
    Gian Marco Ghiggeri
    Laboratory on Pathophysiology of Uremia, G Gaslini Children Hospital, Largo G Gaslini 5, 16148, Genova, Italy
    Pediatr Nephrol 24:189-92. 2009
  7. ncbi request reprint Depletion of clusterin in renal diseases causing nephrotic syndrome
    Gian Marco Ghiggeri
    Laboratory on Pathophysiology of Uremia and Unit of Nephrology, Istituto Giannina Gaslini, Genova, Italy
    Kidney Int 62:2184-94. 2002
  8. ncbi request reprint Protracted remission of proteinuria after combined therapy with plasmapheresis and anti-CD20 antibodies/cyclophosphamide in a child with oligoclonal IgM and glomerulosclerosis
    Gian Marco Ghiggeri
    Department of Nephrology, G Gaslini Children s Hospital, Genoa, Italy
    Pediatr Nephrol 22:1953-6. 2007
  9. ncbi request reprint Posttransplant recurrence of proteinuria in a case of focal segmental glomerulosclerosis associated with WT1 mutation
    G M Ghiggeri
    Laboratory on Pathophysiology of Uremia, Department of Nephrology, G Gaslini Children s Hospital, Genoa, and Department of Biomedical Sciences Nephrology Section, University of Foggia, Italy
    Am J Transplant 6:2208-11. 2006
  10. ncbi request reprint Cyclosporine in patients with steroid-resistant nephrotic syndrome: an open-label, nonrandomized, retrospective study
    Gian Marco Ghiggeri
    Department of Nephrology, G Gaslini Children s Hospital, Genova, Italy
    Clin Ther 26:1411-8. 2004

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Discordant evolution of nephrotic syndrome in mono- and dizygotic twins
    Gian Marco Ghiggeri
    Nephrology Unit, G Gaslini Children s Hospital, Genoa, Italy
    Pediatr Nephrol 21:419-22. 2006
    ..Discordant outcomes indicate a major influence of environmental and/or epigenetic multifactorial mechanisms on persistence and evolution of the disease to focal-segmental glomerulosclerosis...
  2. pmc Genetic approaches to human renal agenesis/hypoplasia and dysplasia
    Simone Sanna-Cherchi
    Department of Medicine, Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Pediatr Nephrol 22:1675-84. 2007
    ..The goal appears to be feasible with the large multicentric collaborative groups that share the same objectives and resources...
  3. pmc Teaching molecular genetics: chapter 4-positional cloning of genetic disorders
    Aldamaria Puliti
    Laboratory of Molecular Genetics, Istituto G Gaslini, Genoa, Italy
    Pediatr Nephrol 22:2023-9. 2007
    ..Altogether, positional cloning has represented a fundamental step in the research on genetic renal disorders, leading to the definition of several disease mechanisms and allowing a proper diagnostic approach to many conditions...
  4. pmc The IgA nephropathy Biobank. An important starting point for the genetic dissection of a complex trait
    Francesco P Schena
    Renal Unit, University of Bari, Italy
    BMC Nephrol 6:14. 2005
    ..The organization of a multi-centre Biobank for the collection of biological samples and clinical data from IgAN patients and relatives is an important starting point for the identification of the disease susceptibility genes...
  5. doi request reprint Post-transplant proteinuria associated with everolimus: Definition of main features with proteomics
    Gian Marco Ghiggeri
    Division of Nephrology and Laboratory on Pathophysiology of Uremia, G Gaslini Children Hospital, Genoa, Italy
    Proteomics Clin Appl 2:1327-37. 2008
    ..Specific urinary markers reflect renal alterations related to the transplant or specific alterations associated with the drug...
  6. ncbi request reprint Recurrent lymphomatoid papulosis associated with nephrotic syndrome. An occurrence of uncertain origin
    Gian Marco Ghiggeri
    Laboratory on Pathophysiology of Uremia, G Gaslini Children Hospital, Largo G Gaslini 5, 16148, Genova, Italy
    Pediatr Nephrol 24:189-92. 2009
    ..Even though the etiology of LYP is, in this case, uncertain, it should be considered as a clinical association of nephrotic syndrome in children and also included among potential triggers of the disease...
  7. ncbi request reprint Depletion of clusterin in renal diseases causing nephrotic syndrome
    Gian Marco Ghiggeri
    Laboratory on Pathophysiology of Uremia and Unit of Nephrology, Istituto Giannina Gaslini, Genova, Italy
    Kidney Int 62:2184-94. 2002
    ..In focal segmental glomerulosclerosis (FSGS), it inhibits permeability plasma factor activity and could influence proteinuria. Moreover, with aging, knockout mice for clusterin develop a progressive glomerulopathy with sclerosis...
  8. ncbi request reprint Protracted remission of proteinuria after combined therapy with plasmapheresis and anti-CD20 antibodies/cyclophosphamide in a child with oligoclonal IgM and glomerulosclerosis
    Gian Marco Ghiggeri
    Department of Nephrology, G Gaslini Children s Hospital, Genoa, Italy
    Pediatr Nephrol 22:1953-6. 2007
    ..Long term efficacy and safety of the association are still to be determined...
  9. ncbi request reprint Posttransplant recurrence of proteinuria in a case of focal segmental glomerulosclerosis associated with WT1 mutation
    G M Ghiggeri
    Laboratory on Pathophysiology of Uremia, Department of Nephrology, G Gaslini Children s Hospital, Genoa, and Department of Biomedical Sciences Nephrology Section, University of Foggia, Italy
    Am J Transplant 6:2208-11. 2006
    ..This observation confirms the concept that recurrence of proteinuria may occur in inherited forms of FSGS so far reported only for patients carrying NPHS2 mutations and reinforces the idea on multifactorial origin of the disease...
  10. ncbi request reprint Cyclosporine in patients with steroid-resistant nephrotic syndrome: an open-label, nonrandomized, retrospective study
    Gian Marco Ghiggeri
    Department of Nephrology, G Gaslini Children s Hospital, Genova, Italy
    Clin Ther 26:1411-8. 2004
    ..In the past decade, immunosuppressive drugs such as cyclosporine (CsA) and cyclophosphamide have been introduced for the treatment of SRNS, but data on long-term clinical outcome (over years) are lacking...
  11. ncbi request reprint Glomerular albumin permeability as an in vitro model for characterizing the mechanism of focal glomerulosclerosis and predicting post-transplant recurrence
    Gian Marco Ghiggeri
    Unit of Nephrology, G Gaslini Children s Hospital, 16148 Genoa, Italy
    Pediatr Transplant 8:339-43. 2004
    ..Only the definitive characterization and quantification in vivo of the different molecules that play a role in FSGS may furnish adequate answer...
  12. ncbi request reprint Genetics, clinical and pathological features of glomerulonephritis associated with mutations of nonmuscle myosin IIA (Fechtner syndrome)
    Gian Marco Ghiggeri
    Laboratory on Pathophysiology of Uremia and Laboratory of Molecular Genetics, Istituto di Ricerca e Cura a Carattere Scientifico G Gaslini, Genova, Italy
    Am J Kidney Dis 41:95-104. 2003
    ..Although it recently was shown that FTNS derives from mutation of MYH9, the gene for the heavy chain of nonmuscle myosin IIA (NMMHC-IIA), its pathophysiological characteristics remain unknown...
  13. doi request reprint Exome sequencing identified MYO1E and NEIL1 as candidate genes for human autosomal recessive steroid-resistant nephrotic syndrome
    Simone Sanna-Cherchi
    Division of Nephrology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Kidney Int 80:389-96. 2011
    ..Our findings demonstrate the utility of exome sequencing for rapidly identifying candidate genes for human SRNS...
  14. doi request reprint Combinatorial peptide ligand libraries for the analysis of low-expression proteins: Validation for normal urine and definition of a first protein MAP
    Laura Santucci
    G Gaslini Children Hospital, Laboratory of Pathophysiology of Uremia, Genoa, Italy
    Proteomics 12:509-15. 2012
    ..This map will be completed in a near future; in the meantime this would represent the basic reference sample for newly developed studies on human diseases...
  15. doi request reprint High-resolution 2-DE for resolving proteins, protein adducts and complexes in plasma
    Giovanni Candiano
    Laboratory on Pathophysiology of Uremia, G Gaslini Children Hospital, Largo G Gaslini, Genova, Italy
    Electrophoresis 29:682-94. 2008
    ..Our system provides therefore new tools for resolving proteins, protein aggregates and complexes and amplifies the potentiality of traditional electrophoretic analysis...
  16. pmc Circulating suPAR in two cohorts of primary FSGS
    Changli Wei
    Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA
    J Am Soc Nephrol 23:2051-9. 2012
    ..The associations between a change in circulating suPAR with different therapeutic regimens and with remission support the role of suPAR in the pathogenesis of FSGS...
  17. doi request reprint Pregnancy and progression of IgA nephropathy: results of an Italian multicenter study
    Monica Limardo
    Department of Nephrology, Dialysis and Transplantation, A Manzoni Hospital, Lecco, Italy
    Am J Kidney Dis 56:506-12. 2010
    ..This study aims to compare the long-term outcome of kidney disease in women with IgA nephropathy and preserved kidney function who did and did not become pregnant...
  18. pmc Clinical features and long-term outcome of nephrotic syndrome associated with heterozygous NPHS1 and NPHS2 mutations
    Gianluca Caridi
    Division of Nephrology and Laboratory on Pathophysiology of Uremia Istituto Giannina Gaslini, Genova, Italy
    Clin J Am Soc Nephrol 4:1065-72. 2009
    ..Mutations in nephrin (NPHS1) and podocin (NPHS2) genes represent a major cause of idiopathic nephrotic syndrome (NS) in children. It is not yet clear whether the presence of a single mutation acts as a modifier of the clinical course of NS...
  19. pmc Autoimmunity in membranous nephropathy targets aldose reductase and SOD2
    Marco Prunotto
    Division of Nephrology and Laboratory on Pathophysiology of Uremia, G Gaslini Children Hospital, Genova, Italy
    J Am Soc Nephrol 21:507-19. 2010
    ..In conclusion, our data support AR and SOD2 as renal antigens of human MN and suggest that oxidative stress may drive glomerular SOD2 expression...