M Gattorno

Summary

Affiliation: G. Gaslini Institute
Country: Italy

Publications

  1. ncbi request reprint Serum and synovial fluid concentration of vascular endothelial growth factor in juvenile idiopathic arthritides
    S Vignola
    Second Division of Paediatrics Rheumatology Unit, G Gaslini Scientific Institute for Children, Genoa, Italy
    Rheumatology (Oxford) 41:691-6. 2002
  2. ncbi request reprint Synovial expression of osteopontin correlates with angiogenesis in juvenile idiopathic arthritis
    M Gattorno
    Second Division of Pediatrics, Rheumatology Unit, G Gaslini Scientific Institute for Children, Largo G Gaslini 5, 16147, Genoa, Italy
    Rheumatology (Oxford) 43:1091-6. 2004
  3. doi request reprint Differentiating PFAPA syndrome from monogenic periodic fevers
    Marco Gattorno
    UO Pediatria II, G Gaslini Institute, Largo G Gaslini 5, 16146, Genova, Italy
    Pediatrics 124:e721-8. 2009
  4. pmc Long-term clinical profile of children with the low-penetrance R92Q mutation of the TNFRSF1A gene
    M A Pelagatti
    Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 63:1141-50. 2011
  5. pmc Clinical presentation and pathogenesis of cold-induced autoinflammatory disease in a family with recurrence of an NLRP12 mutation
    S Borghini
    Istituto G Gaslini and University of Genoa, Genoa, Italy
    Arthritis Rheum 63:830-9. 2011
  6. pmc Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients
    Denise Lasiglié
    Rheumatology Unit, Second Division of Pediatrics G Gaslini Institute, Genoa, Italy
    PLoS ONE 6:e20014. 2011
  7. doi request reprint Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review
    Nienke Ter Haar
    Department of Paediatrics, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 72:678-85. 2013
  8. doi request reprint Clinical impact of MEFV mutations in children with periodic fever in a prevalent western European Caucasian population
    Silvia Federici
    UO Pediatria II Reumatologia, Istituto G Gaslini, Genova, Italy
    Ann Rheum Dis 71:1961-5. 2012
  9. pmc Periodic fever syndromes in Eastern and Central European countries: results of a pediatric multinational survey
    Natasa Toplak
    Department of Allergology, Rheumatology and Clinical Immunology, University Children s Hospital, University Medical Centre Ljubljana, Slovenia
    Pediatr Rheumatol Online J 8:29. 2010
  10. doi request reprint Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome
    M Gattorno
    Istituto Giannina Gaslini, Genoa, Italy
    Arthritis Rheum 58:1516-20. 2008

Detail Information

Publications51

  1. ncbi request reprint Serum and synovial fluid concentration of vascular endothelial growth factor in juvenile idiopathic arthritides
    S Vignola
    Second Division of Paediatrics Rheumatology Unit, G Gaslini Scientific Institute for Children, Genoa, Italy
    Rheumatology (Oxford) 41:691-6. 2002
    ..To evaluate the role of vascular endothelial growth factor (VEGF) in the pathogenesis of local joint inflammation in juvenile idiopathic arthritis (JIA)...
  2. ncbi request reprint Synovial expression of osteopontin correlates with angiogenesis in juvenile idiopathic arthritis
    M Gattorno
    Second Division of Pediatrics, Rheumatology Unit, G Gaslini Scientific Institute for Children, Largo G Gaslini 5, 16147, Genoa, Italy
    Rheumatology (Oxford) 43:1091-6. 2004
    ..To evaluate the synovial expression of osteopontin (OPN) and its possible correlation with the degree of synovial angiogenesis in human chronic idiopathic arthritis...
  3. doi request reprint Differentiating PFAPA syndrome from monogenic periodic fevers
    Marco Gattorno
    UO Pediatria II, G Gaslini Institute, Largo G Gaslini 5, 16146, Genova, Italy
    Pediatrics 124:e721-8. 2009
    ....
  4. pmc Long-term clinical profile of children with the low-penetrance R92Q mutation of the TNFRSF1A gene
    M A Pelagatti
    Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 63:1141-50. 2011
    ....
  5. pmc Clinical presentation and pathogenesis of cold-induced autoinflammatory disease in a family with recurrence of an NLRP12 mutation
    S Borghini
    Istituto G Gaslini and University of Genoa, Genoa, Italy
    Arthritis Rheum 63:830-9. 2011
    ..D294E, affecting a protein sequence crucial for ATP binding, which was identified in a Caucasian family with familial cold-induced autoinflammatory syndrome in some family members...
  6. pmc Role of IL-1 beta in the development of human T(H)17 cells: lesson from NLPR3 mutated patients
    Denise Lasiglié
    Rheumatology Unit, Second Division of Pediatrics G Gaslini Institute, Genoa, Italy
    PLoS ONE 6:e20014. 2011
    ..In this work we asked whether the deregulated secretion of IL-1β secondary to mutations characterizing these patients could affect the IL-23/IL-17 axis...
  7. doi request reprint Treatment of autoinflammatory diseases: results from the Eurofever Registry and a literature review
    Nienke Ter Haar
    Department of Paediatrics, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 72:678-85. 2013
    ..To evaluate the response to treatment of autoinflammatory diseases from an international registry and an up-to-date literature review...
  8. doi request reprint Clinical impact of MEFV mutations in children with periodic fever in a prevalent western European Caucasian population
    Silvia Federici
    UO Pediatria II Reumatologia, Istituto G Gaslini, Genova, Italy
    Ann Rheum Dis 71:1961-5. 2012
    ..To evaluate the actual impact of MEFV mutations on clinical manifestations associated with fever attacks in Caucasian children with periodic fever...
  9. pmc Periodic fever syndromes in Eastern and Central European countries: results of a pediatric multinational survey
    Natasa Toplak
    Department of Allergology, Rheumatology and Clinical Immunology, University Children s Hospital, University Medical Centre Ljubljana, Slovenia
    Pediatr Rheumatol Online J 8:29. 2010
    ..abstract:..
  10. doi request reprint Persistent efficacy of anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome
    M Gattorno
    Istituto Giannina Gaslini, Genoa, Italy
    Arthritis Rheum 58:1516-20. 2008
    ..To evaluate the efficacy and safety of treatment with the interleukin-1 receptor antagonist anakinra in patients with tumor necrosis factor receptor-associated periodic syndrome (TRAPS) requiring high cumulative doses of steroids...
  11. ncbi request reprint Distinct expression pattern of IFN-alpha and TNF-alpha in juvenile idiopathic arthritis synovial tissue
    M Gattorno
    Second Division of Pediatrics, G Gaslini Institute and University of Genoa, Largo G Gaslini 5, 16147, Genoa, Italy
    Rheumatology (Oxford) 46:657-65. 2007
    ..We here investigated the presence and characteristics of natural type I IFN-producing cells (IPCs), as well as IFN-alpha and TNF-alpha expression at sites of inflammation in juvenile idiopathic arthritis (JIA)...
  12. ncbi request reprint Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations
    Marco Gattorno
    Second Division of Pediatrics, IRCCS, Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 56:3138-48. 2007
    ....
  13. doi request reprint Diagnosis and management of autoinflammatory diseases in childhood
    Marco Gattorno
    2nd Division of Pediatrics, G Gaslini Scientific Institute, Largo G Gaslini 5, 16147, Genova, Italy
    J Clin Immunol 28:S73-83. 2008
    ..Autoinflammatory diseases are a group monogenic inflammatory conditions characterized by an early onset during childhood...
  14. doi request reprint The pattern of response to anti-interleukin-1 treatment distinguishes two subsets of patients with systemic-onset juvenile idiopathic arthritis
    Marco Gattorno
    G Gaslini Institute, Genoa, Italy
    Arthritis Rheum 58:1505-15. 2008
    ..To assess the clinical response to interleukin-1 (IL-1) blockade and in vitro IL-1beta and IL-18 secretion in patients with systemic-onset juvenile idiopathic arthritis (JIA)...
  15. ncbi request reprint An update on autoinflammatory diseases. New concepts for new and old diseases
    M Gattorno
    U O Pediatria 2, IRCCS G Gaslini and Department of Pediatrics, University of Genoa, Italy
    Clin Exp Rheumatol 27:354-65. 2009
    ..Thus, the aim of the present article is to report the main highlights from the above-mentioned meeting and to give a general update of the more recent advances in this field...
  16. pmc Phenotypic and functional characterisation of CCR7+ and CCR7- CD4+ memory T cells homing to the joints in juvenile idiopathic arthritis
    Marco Gattorno
    II Division of Pediatrics, University of Genoa, Genoa, Italy
    Arthritis Res Ther 7:R256-67. 2005
    ..Moreover, discrete patterns of chemokine receptor expression are detected in the synovial tissue...
  17. ncbi request reprint Neonatal lupus and a seronegative mother
    M Gattorno
    2nd Division of Paediatrics, Department of Paediatrics, University of Genoa, G Gaslini Institute, Genoa, Italy
    Lancet 363:1038. 2004
  18. ncbi request reprint Levels of soluble CD27 in sera and synovial fluid and its expression on memory T cells in patients with juvenile idiopathic arthritides
    M Gattorno
    2nd Department of Pediatrics, G Gaslini Scientific Institute for Children and University of Genoa, Largo G Gaslini 5, 16147, Genoa, Italy
    Clin Exp Rheumatol 20:863-6. 2002
    ..The aim of the present study was to evaluate the levels of soluble CD27 in sera and synovial fluids, together with its expression on circulating and synovial fluid (SF) memory T cells, in children with JIA...
  19. ncbi request reprint Outcome of primary antiphospholipid syndrome in childhood
    M Gattorno
    Dipartimento di Pediatria, Universita di Genova, Pediatria II, Istituto G Gaslini, Italy
    Lupus 12:449-53. 2003
    ..In conclusion; our analysis suggests that some children who present with the features of primary APS may progress to develop SLE or lupus-like syndrome...
  20. ncbi request reprint Serum and synovial fluid concentrations of matrix metalloproteinases 3 and its tissue inhibitor 1 in juvenile idiopathic arthritides
    Marco Gattorno
    2nd Division of Pediatrics, G Gaslini Institute for Children, Genoa, Italy
    J Rheumatol 29:826-31. 2002
    ..We investigated serum and synovial fluid (SF) concentrations of MMP-3 and its tissue inhibitor (TIMP-1) in juvenile idiopathic arthritides (JIA)...
  21. ncbi request reprint Synovial membrane expression of matrix metalloproteinases and tissue inhibitor 1 in juvenile idiopathic arthritides
    Marco Gattorno
    Department of Pathology, G Gaslini Institute for Children, Genoa, Italy
    J Rheumatol 29:1774-9. 2002
    ..We investigated synovial tissue expression of the main proteolytic enzymes (MMP-1, MMP-3, and MMP-13) and tissue inhibitor of metalloprotease 1 (TIMP-1) in juvenile idiopathic arthritides (JIA)...
  22. ncbi request reprint A diagnostic score for molecular analysis of hereditary autoinflammatory syndromes with periodic fever in children
    M Gattorno
    Giannina Gaslini Institute, Genoa, Italy
    Arthritis Rheum 58:1823-32. 2008
    ..To identify a set of clinical parameters that can predict the probability of carrying mutations in one of the genes associated with hereditary autoinflammatory syndromes...
  23. ncbi request reprint Lymphoid neogenesis in juvenile idiopathic arthritis correlates with ANA positivity and plasma cells infiltration
    A Gregorio
    2nd Division of Pediatrics, G Gaslini Institute, Genoa, Italy
    Rheumatology (Oxford) 46:308-13. 2007
    ..The aim of the study was to evaluate the pattern of the lymphoid organization in the synovial tissue of patients affected with juvenile idiopathic arthritis (JIA)...
  24. pmc A polymorphic variant inside the osteopontin gene shows association with disease course in oligoarticular juvenile idiopathic arthritis
    R Marciano
    Laboratory of Molecular Genetics, G Gaslini Institute, Largo G Gaslini 5, 16147 Genova, Italy
    Ann Rheum Dis 65:662-5. 2006
    ..In some patients the disease remains confined to a few joints (persistent oligoarticular) while in others it extends to affect more joints (oligoarticular extended). Osteopontin is thought to play a role in the pathogenesis...
  25. ncbi request reprint Clinical and genetic characterization of Italian patients affected by CINCA syndrome
    F Caroli
    Department of Molecular Genetics, IRCCS G Gaslini, Genoa, Italy
    Rheumatology (Oxford) 46:473-8. 2007
    ..The clinical and genetic features of 12 unrelated Italian patients with CINCA syndrome are described, focusing on the possible influence of the presence of CIAS1/cryopyrin mutations on the phenotype of the disease and on its prognosis...
  26. ncbi request reprint Involvement of the hypothalamic-pituitary-adrenal axis in children with oligoarticular-onset idiopathic arthritis
    P Picco
    Department of Pediatric Rheumatology, G Gaslini Institute, Genova, Italy
    Ann N Y Acad Sci 966:369-72. 2002
    ..Our study suggests the presence of a partial resistance to ACTH with a dysregulated pattern of secretion also in inactive o-JIA patients. These preliminary data need further confirmation in larger pediatric studies...
  27. ncbi request reprint Recurrent antiphospholipid-related deep vein thrombosis as presenting manifestation of systemic lupus erythematosus
    M Gattorno
    2nd Division of Pediatrics Pediatric Rheumatology Unit, G Gaslini Scientific Institute for Children, Largo G Gaslini 5, 16147 Genoa, Italy
    Eur J Pediatr 159:211-4. 2000
    ..This issue was definitively confirmed in a subsequent follow-up...
  28. ncbi request reprint MICA gene polymorphisms in an Italian paediatric series of juvenile Behçet disease
    P Picco
    Department of Paediatrics, G Gaslini Institute, Genoa, Italy
    Int J Mol Med 10:575-8. 2002
    ..This finding sheds light on the role of a receptor for MICA, named NKG2D, presented by natural killer cells, and CD8+, alphabetaT cells and gammadeltaT cells, usually localised in gut mucosa...
  29. ncbi request reprint Periodic fever, apthous stomatitis, pharyngitis and adenitis syndrome
    Roberta Caorsi
    UO Pediatria II, G Gaslini Institute and Department of Pediatrics, University of Genoa, Genoa, Italy
    Curr Opin Rheumatol 22:579-84. 2010
    ..We report on the findings coming from the analysis of large cohorts of PFAPA patients and the possible implication for the differential diagnosis. An update on the efficacy of possible prophylactic treatments and tonsillectomy is given...
  30. ncbi request reprint Brain perfusion spect in juvenile neuro-Behçet's disease
    S Vignola
    II Division of Pediatrics, Giannina Gaslini Institute, University of Genoa, Italy
    J Nucl Med 42:1151-7. 2001
    ....
  31. doi request reprint Dynamic contrast-enhanced magnetic resonance imaging in the assessment of disease activity in patients with juvenile idiopathic arthritis
    Clara Malattia
    Pediatria II, IRCCS G Gaslini, Largo G Gaslini 5, 16147 Genova, Italy
    Rheumatology (Oxford) 49:178-85. 2010
    ..To determine the capability and reliability of dynamic contrast-enhanced MRI (DCE-MRI) in the assessment of disease activity in juvenile idiopathic arthritis (JIA)...
  32. doi request reprint HLA-G and HLA-E in patients with juvenile idiopathic arthritis
    Ignazia Prigione
    Laboratory of Oncology, G Gaslini Scientific Institute, Largo G Gaslini 5, 16148 Genova, Italy
    Rheumatology (Oxford) 50:966-72. 2011
    ..To investigate the expression and release of HLA-G and HLA-E in JIA...
  33. pmc Phenotypic and functional characterization of switch memory B cells from patients with oligoarticular juvenile idiopathic arthritis
    Anna Corcione
    Laboratory of Oncology, IRCCS G Gaslini, Largo G Gaslini 5, Genoa, 16148, Italy
    Arthritis Res Ther 11:R150. 2009
    ..Here, we have characterized synovial fluid and tissue B-cell subsets in patients with oligoarticular juvenile idiopathic arthritis (JIA), an issue not addressed before in detail...
  34. ncbi request reprint Childhood-onset lupus nephritis: a single-center experience of pulse intravenous cyclophosphamide therapy
    Giancarlo Barbano
    Nephrology Department, G Gaslini Children s Hospital, Genoa, Italy
    J Nephrol 15:123-9. 2002
    ..Medical records of 33 LN children were retrospectively analysed in order to assess the effect of treatment with pCy and corticosteroids (Cs) on renal survival and child growth...
  35. doi request reprint The hypoxic synovial environment regulates expression of vascular endothelial growth factor and osteopontin in juvenile idiopathic arthritis
    Maria Carla Bosco
    Laboratory of Molecular Biology, Department of Pediatrics, G Gaslini Institute, Genova, Italy
    J Rheumatol 36:1318-29. 2009
    ..We characterized the contribution of the local hypoxic environment to VEGF and OPN production by monocytic cells recruited to the synovium in JIA...
  36. doi request reprint Successful treatment of idiopathic recurrent pericarditis in children with interleukin-1beta receptor antagonist (anakinra): an unrecognized autoinflammatory disease?
    Paolo Picco
    G Gaslini Institute, University of Genoa, Genoa, Italy
    Arthritis Rheum 60:264-8. 2009
    ..The findings in these patients suggest that idiopathic recurrent pericarditis may be a previously unrecognized autoinflammatory disease...
  37. ncbi request reprint Cytokine flexibility of early and differentiated memory T helper cells in juvenile idiopathic arthritis
    Sabrina Chiesa
    2nd Division of Pediatrics, G Gaslini Scientific Institute for Children, Genoa, Italy
    J Rheumatol 31:2048-54. 2004
    ....
  38. doi request reprint Invasive mould infections in newborns and children
    Elio Castagnola
    G Gaslini Children s Hospital, Genova, Italy
    Early Hum Dev 87:S67-9. 2011
    ....
  39. ncbi request reprint Chemokine receptor CCR7 is expressed in muscle fibers in juvenile dermatomyositis
    Carlo Minetti
    Neuromuscular Disease Unit, University of Genova and G Gaslini Institute, Genoa, Italy
    Biochem Biophys Res Commun 333:540-3. 2005
    ..The selective expression of CCR7 in JDM may open new perspectives in the understanding of the pathogenesis of inflammatory myopathies, offering a new tool for the differential diagnosis of these disorders...
  40. ncbi request reprint Severe hypoalbuminaemia in a systemic lupus erythematosus-like patient
    Marco Gattorno
    2nd Division of Paediatrics, G Gaslini Institute for Children, Genoa, Italy
    Eur J Pediatr 161:84-6. 2002
    ..Colonoscopy revealed the presence of diffuse purpuric lesions at the level of the submucosa. Aggressive immunosuppressive treatment completely resolved the clinical picture...
  41. ncbi request reprint MVK mutations and associated clinical features in Italian patients affected with autoinflammatory disorders and recurrent fever
    Andrea D'Osualdo
    Divisione Pediatria II Clinica Pediatrica, Genova, Italy
    Eur J Hum Genet 13:314-20. 2005
    ..Our study demonstrates that MKD is a common cause of recurrent fever also in the Italian population, where it is associated with both a wide spectrum of previously unreported MVK mutations and peculiar phenotypic features...
  42. ncbi request reprint Bone marrow-derived mesenchymal stem cells induce both polyclonal expansion and differentiation of B cells isolated from healthy donors and systemic lupus erythematosus patients
    Elisabetta Traggiai
    Second Division of Pediatrics, IRCCS, Institute G Gaslini, Genova, Italy
    Stem Cells 26:562-9. 2008
    ..This study casts important questions on bone marrow mesenchymal stem cells as a therapeutic tool in autoimmune diseases in which B-cell activation is crucially implicated in the pathogenesis of the disease...
  43. ncbi request reprint Hypoxic synovial environment and expression of macrophage inflammatory protein 3gamma/CCL20 in juvenile idiopathic arthritis
    Maria Carla Bosco
    G Gaslini Institute, Genoa, Italy
    Arthritis Rheum 58:1833-8. 2008
    ....
  44. ncbi request reprint Neutrophils from patients with TNFRSF1A mutations display resistance to tumor necrosis factor-induced apoptosis: pathogenetic and clinical implications
    Andrea D'Osualdo
    Istituto G Gaslini, Genoa, Italy
    Arthritis Rheum 54:998-1008. 2006
    ..To explore tumor necrosis factor (TNF)-induced apoptosis in neutrophils from patients with TNF receptor-associated periodic syndrome (TRAPS) and to correlate the results with the different kinds of TNFRSF1A mutations...
  45. pmc Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia
    Claudia R Ruprecht
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    J Exp Med 201:1793-803. 2005
    ....
  46. ncbi request reprint Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, Type 2)
    Marina Sironi
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    J Leukoc Biol 80:342-9. 2006
    ..Thus, CCL1 is a CC chemokine with a unique pattern of regulation associated with a distinct form of M2 (Type 2, M2b) monocyte activation, which participates in macrophage-dependent regulatory circuits of innate and adaptive immunity...
  47. ncbi request reprint Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    Eva V Acosta-Rodriguez
    Institute for Research in Biomedicine, CH 6500 Bellinzona, Switzerland
    Nat Immunol 8:639-46. 2007
    ..Our results demonstrate that human T(H)-17 cells have distinct migratory capacity and antigenic specificities and establish a link between microbial products, T helper cell differentiation and homing in response to fungal antigens...
  48. ncbi request reprint Diagnostic challenge of hyper-IgD syndrome in four children with inflammatory gastrointestinal complaints
    Chiara Oretti
    Children s Hospital IRCCS Burlo Garofolo, Department of Sciences of Reproduction and Development, University of Trieste, Trieste, Italy
    Scand J Gastroenterol 41:430-6. 2006
    ..The levels of IgD were measured in a series of patients with CD to evaluate the specificity of this assay in the differential diagnosis between the two conditions...
  49. ncbi request reprint Clinical features, long-term follow-up and outcome of a large cohort of patients with Chronic Granulomatous Disease: an Italian multicenter study
    Baldassarre Martire
    Dipartimento di Biomedicina dell Eta Evolutiva, Universita di Bari, Italy
    Clin Immunol 126:155-64. 2008
    ..No evidence justifying long-term prophylaxis with IFNgamma was obtained...
  50. ncbi request reprint Cerebrovascular disease and varicella in children
    Giuseppe Losurdo
    Infectious Diseases Unit, G Gaslini Children s Hospital, Largo G Gaslini 5, 16147 Genoa, Italy
    Brain Dev 28:366-70. 2006
    ..On the basis of our experience and of literature data on varicella-associated stroke, we recommend that VZV infection be taken into account in every episode of stroke in children...