Elio Castagnola

Summary

Affiliation: G. Gaslini Institute
Country: Italy

Publications

  1. ncbi request reprint Role of acute graft-versus-host disease in the risk of bacteremia and invasive fungal disease after allogeneic hemopoietic stem cell transplantation in children. Results from a single-center observational study
    Elio Castagnola
    Infectious Disease Unit, Istituto Giannina Gaslini, Genoa, Italy Electronic address
    Biol Blood Marrow Transplant 20:1068-73. 2014
  2. pmc Guidelines for the management of bacterial and fungal infections during chemotherapy for pediatric acute leukemia or solid tumors: what is available in 2010?
    Elio Castagnola
    Infectious Diseases Unit, Oncohematology Department, G Gaslini Children s Hospital, Genoa
    Pediatr Rep 3:e7. 2011
  3. doi request reprint Susceptibility to antibiotics of aerobic bacteria isolated from community acquired secondary peritonitis in children: therapeutic guidelines might not always fit with and everyday experience
    Elio Castagnola
    Infectious Diseases Unit, Hospital Infection Control Team
    J Chemother 25:213-6. 2013
  4. doi request reprint Current research in empirical therapy for febrile neutropenia in cancer patients: what should be necessary and what is going on
    Elio Castagnola
    Infectious Diseases Unit, Istituto Giannina Gaslini, Largo G Gaslini, 5, 16147, Genoa, Italy
    Expert Opin Emerg Drugs 18:263-78. 2013
  5. doi request reprint Rescue therapy of difficult-to-treat indwelling central venous catheter-related bacteremias in cancer patients: a review for practical purposes
    Elio Castagnola
    Infectious Diseases Unit, Istituto Giannina Gaslini, Genova, Italy
    Expert Rev Anti Infect Ther 11:179-86. 2013
  6. pmc Safety and efficacy of a caspofungin-based combination therapy for treatment of proven or probable aspergillosis in pediatric hematological patients
    Simone Cesaro
    Pediatric Hematology Oncology, Department of Pediatrics, University of Padua, Italy
    BMC Infect Dis 7:28. 2007
  7. ncbi request reprint Incidence of bacteremias and invasive mycoses in children with high risk neuroblastoma
    Elio Castagnola
    Infectious Diseases Unit, G Gaslini Children Hospital, Genoa, Italy
    Pediatr Blood Cancer 49:672-7. 2007
  8. ncbi request reprint Prevention of life-threatening infections due to encapsulated bacteria in children with hyposplenia or asplenia: a brief review of current recommendations for practical purposes
    Elio Castagnola
    Infectious Disease Unit, G Gaslini Children s Hospital, Genoa, Italy
    Eur J Haematol 71:319-26. 2003
  9. doi request reprint Bacteremias in children receiving hemopoietic SCT
    E Castagnola
    Infectious Diseases Unit, Department of Hematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Bone Marrow Transplant 41:S104-6. 2008
  10. ncbi request reprint Caspofungin associated with liposomal amphotericin B or voriconazole for treatment of refractory fungal pneumonia in children with acute leukaemia or undergoing allogeneic bone marrow transplant
    E Castagnola
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genoa, Italy
    Clin Microbiol Infect 10:255-7. 2004

Detail Information

Publications93

  1. ncbi request reprint Role of acute graft-versus-host disease in the risk of bacteremia and invasive fungal disease after allogeneic hemopoietic stem cell transplantation in children. Results from a single-center observational study
    Elio Castagnola
    Infectious Disease Unit, Istituto Giannina Gaslini, Genoa, Italy Electronic address
    Biol Blood Marrow Transplant 20:1068-73. 2014
    ..These data may be important to design management strategies of infections in pediatric allogeneic HSCT. ..
  2. pmc Guidelines for the management of bacterial and fungal infections during chemotherapy for pediatric acute leukemia or solid tumors: what is available in 2010?
    Elio Castagnola
    Infectious Diseases Unit, Oncohematology Department, G Gaslini Children s Hospital, Genoa
    Pediatr Rep 3:e7. 2011
    ..The paper summarizes guidelines provided for the management of infectious complications in adults with cancer by different international and will comment on how much they may be translated in the management of pediatric patients...
  3. doi request reprint Susceptibility to antibiotics of aerobic bacteria isolated from community acquired secondary peritonitis in children: therapeutic guidelines might not always fit with and everyday experience
    Elio Castagnola
    Infectious Diseases Unit, Hospital Infection Control Team
    J Chemother 25:213-6. 2013
    ..On the contrary, monotherapy with piperacillin-tazobactam or meropenem is highly effective. ..
  4. doi request reprint Current research in empirical therapy for febrile neutropenia in cancer patients: what should be necessary and what is going on
    Elio Castagnola
    Infectious Diseases Unit, Istituto Giannina Gaslini, Largo G Gaslini, 5, 16147, Genoa, Italy
    Expert Opin Emerg Drugs 18:263-78. 2013
    ..Emergence of infections due to resistant bacteria, especially Gram-negatives, and usefulness of empirical antifungal therapy represent the major concerns in this field...
  5. doi request reprint Rescue therapy of difficult-to-treat indwelling central venous catheter-related bacteremias in cancer patients: a review for practical purposes
    Elio Castagnola
    Infectious Diseases Unit, Istituto Giannina Gaslini, Genova, Italy
    Expert Rev Anti Infect Ther 11:179-86. 2013
    ..In the present review, the authors summarize these possible therapeutic options. The aim of the report is not to perform a systematic review of the literature, but to give an 'easy to read' text for everyday practice...
  6. pmc Safety and efficacy of a caspofungin-based combination therapy for treatment of proven or probable aspergillosis in pediatric hematological patients
    Simone Cesaro
    Pediatric Hematology Oncology, Department of Pediatrics, University of Padua, Italy
    BMC Infect Dis 7:28. 2007
    ..The recent development of new antifungal drugs gives the clinician the possibility to assess the combination of antifungal drugs with in-vitro or in animal-model synergistic effect...
  7. ncbi request reprint Incidence of bacteremias and invasive mycoses in children with high risk neuroblastoma
    Elio Castagnola
    Infectious Diseases Unit, G Gaslini Children Hospital, Genoa, Italy
    Pediatr Blood Cancer 49:672-7. 2007
    ..Information on the incidence of infectious complications during for treatment for high risk neuroblastoma (HR-NB) is limited. Bacteremias and invasive mycoses may be considered surrogate markers of the infection burden...
  8. ncbi request reprint Prevention of life-threatening infections due to encapsulated bacteria in children with hyposplenia or asplenia: a brief review of current recommendations for practical purposes
    Elio Castagnola
    Infectious Disease Unit, G Gaslini Children s Hospital, Genoa, Italy
    Eur J Haematol 71:319-26. 2003
    ....
  9. doi request reprint Bacteremias in children receiving hemopoietic SCT
    E Castagnola
    Infectious Diseases Unit, Department of Hematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Bone Marrow Transplant 41:S104-6. 2008
    ..Knowledge of epidemiology (incidence and etiology) of bacteremias following HSCT is pivotal for planning management strategies (prevention, diagnosis and therapy) that must be distinct in the different post-transplant period...
  10. ncbi request reprint Caspofungin associated with liposomal amphotericin B or voriconazole for treatment of refractory fungal pneumonia in children with acute leukaemia or undergoing allogeneic bone marrow transplant
    E Castagnola
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genoa, Italy
    Clin Microbiol Infect 10:255-7. 2004
    ..A combination antifungal therapy including caspofungin could represent an effective therapy for children with invasive mycoses refractory to single-agent antifungal therapy...
  11. doi request reprint Rare viral infections in children receiving hemopoietic stem cell transplant
    E Castagnola
    Infectious Diseases Unit, Department of Hematology and Oncology, G Gaslini Children Hospital, Genoa, Italy
    Bone Marrow Transplant 41:S100-3. 2008
    ..This fact may be at least partially due to an improvement in diagnostic facilities, but the increasing number of transplant procedures and the more severe immunosuppression may also have played an important role...
  12. ncbi request reprint Bloodstream infections and invasive mycoses in children undergoing acute leukaemia treatment: a 13-year experience at a single Italian institution
    Elio Castagnola
    Infectious Diseases Unit, Department of Hematology Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Eur J Cancer 41:1439-45. 2005
    ..001) and 0.274 in AnLL (P = 0.001). IR was 0.021 in ALL and 0.048 in AnLL (P = 0.034) for IM. In conclusion, there is a correlation between intensity of chemotherapy and rate of infections in paediatric acute leukaemias...
  13. ncbi request reprint Incidence of bacteremias and invasive mycoses in children undergoing allogeneic hematopoietic stem cell transplantation: a single center experience
    E Castagnola
    Infectious Diseases Unit, Department of Hematology and Oncology, G Gaslini Children Hospital, Genoa, Italy
    Bone Marrow Transplant 41:339-47. 2008
    ..46 in the late post-engraftment period (P<0.001) compared to MRD-HSCT. Only after 1 year did the epidemiology become similar. The epidemiology of invasive mycoses did not differ significantly between the two types of transplant...
  14. ncbi request reprint A prospective study on the epidemiology of febrile episodes during chemotherapy-induced neutropenia in children with cancer or after hemopoietic stem cell transplantation
    Elio Castagnola
    Infectious Diseases Unit, G Gaslini Children Hospital, Genoa, Italy
    Clin Infect Dis 45:1296-304. 2007
    ..The purpose of our study was to evaluate the incidence and clinical characteristics of febrile episodes during neutropenia following chemotherapy in children with cancer...
  15. doi request reprint Invasive mould infections in newborns and children
    Elio Castagnola
    G Gaslini Children s Hospital, Genova, Italy
    Early Hum Dev 87:S67-9. 2011
    ....
  16. ncbi request reprint Nebulized liposomal amphotericin B and combined systemic antifungal therapy for the treatment of severe pulmonary aspergillosis after allogeneic hematopoietic stem cell transplant for a fatal mitochondrial disorder
    E Castagnola
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genoa, Italy
    J Chemother 19:339-42. 2007
    ..Pulmonary aspergillosis responded well to 45 days of combined intravenous antifungal therapies which were maintained for 2 years with secondary prophylaxis, because of persistent immunosuppressive treatment...
  17. ncbi request reprint Differences in the proportions of fluoroquinolone-resistant Gram-negative bacteria isolated from bacteraemic children with cancer in two Italian centres
    E Castagnola
    Infectious Diseases Unit, Department of Hematology and Oncology, G Gaslini Teaching Hospital, Genoa, Italy
    Clin Microbiol Infect 11:505-7. 2005
    ..001). Ciprofloxacin resistance was more frequent in children who shared an environment with adults who were receiving ciprofloxacin prophylaxis...
  18. doi request reprint Incidence of bacteremias and invasive mycoses in children with acute non-lymphoblastic leukemia: results from a multi-center Italian study
    Elio Castagnola
    Department of Hematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Pediatr Blood Cancer 55:1103-7. 2010
    ..Data on the epidemiology of bacteremias and invasive fungal diseases (IFD) in children with acute myeloid leukemia (AML) are scarce...
  19. doi request reprint Epidemiology of febrile neutropenia in children with central nervous system tumor: results from a single center prospective study
    Elio Castagnola
    Infectious Diseases Unit, G Gaslini Children Hospital, Genoa, Italy
    J Pediatr Hematol Oncol 33:e310-5. 2011
    ..standard and PBSCT) and the thresholds of granulocyte count at neutropenia onset (999-501/cmm and 500-101/cmm vs. ≤100/cmm) were the only factors significantly associated with the development of febrile neutropenia...
  20. ncbi request reprint Conditions associated with infections of indwelling central venous catheters in cancer patients: a summary
    Elio Castagnola
    Infectious Diseases Unit and Department of Paediatric Haematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Br J Haematol 121:233-9. 2003
  21. doi request reprint Invasive mycoses in children receiving hemopoietic SCT
    E Castagnola
    Infectious Diseases Unit, Department of Hematology and Oncology, G Gaslini Children Hospital, Genoa, Italy
    Bone Marrow Transplant 41:S107-11. 2008
    ..Mortality due to invasive mycoses after HSCT in children is high...
  22. ncbi request reprint Temporary interruption of ceftazidime continuous infusion without reduction of activity: a computer-assisted simulation
    E Castagnola
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genoa, Italy
    J Chemother 13:395-401. 2001
    ....
  23. doi request reprint Performance of the galactomannan antigen detection test in the diagnosis of invasive aspergillosis in children with cancer or undergoing haemopoietic stem cell transplantation
    E Castagnola
    Unit of Infectious Diseases, Department of Haematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Clin Microbiol Infect 16:1197-203. 2010
    ..The GM assay is useful for identifying periods of IA in children undergoing aggressive chemotherapy or allogeneic HSCT...
  24. doi request reprint Management of bacteremia in patients undergoing hematopoietic stem cell transplantation
    Elio Castagnola
    Infectious Diseases Unit, Department of Hematology and Oncology, G Gaslini Children Hospital, Largo G Gaslini 5, Genoa, Italy
    Expert Rev Anti Infect Ther 7:607-21. 2009
    ..g., Gram-negative rods)...
  25. ncbi request reprint Bacillus sphaericus bacteraemia in children with cancer: case reports and literature review
    E Castagnola
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genoa, Italy
    J Hosp Infect 48:142-5. 2001
    ..Ciprofloxacin was the only drug active against all the isolated strains.Bacillus sphaericus represents a new cause of infection in the immunocompromised host, with low aggressiveness, but a peculiar pattern of antibiotic susceptibility...
  26. ncbi request reprint The desire to be fashionable. Should we consider it a risk factor for infection in adolescents with acute leukaemia?
    E Castagnola
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genoa, Italy
    Support Care Cancer 9:207-8. 2001
    ....
  27. ncbi request reprint Clinical and laboratory features predicting a favorable outcome and allowing early discharge in cancer patients with low-risk febrile neutropenia: a literature review
    E Castagnola
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genova, Italy
    J Hematother Stem Cell Res 9:645-9. 2000
    ....
  28. doi request reprint Clostridium difficile-associated disease in children with solid tumors
    Elio Castagnola
    Infectious Diseases Unit, G Gaslini Children Hospital, Largo G Gaslini, 5, 16147 Genoa, Italy
    Support Care Cancer 17:321-4. 2009
    ..The goal of this study was to describe the incidence of Clostridium difficile-associated disease (CDAD) in children with solid tumours...
  29. doi request reprint Clinical aspects of invasive candidiasis in paediatric patients
    Elio Castagnola
    Infectious Diseases Unit, Department of Hematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Drugs 69:45-50. 2009
    ....
  30. ncbi request reprint Correlation between "malfunctioning events" and catheter-related infections in pediatric cancer patients bearing tunneled indwelling central venous catheter: results of a prospective observational study
    Elio Castagnola
    Infectious Diseases Unit, Department of Hematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Support Care Cancer 13:757-9. 2005
    ..To evaluate the possible link between malfunctioning events and catheter related infections in indwelling central venous devices in children with cancer...
  31. ncbi request reprint Incidence of catheter-related infections within 30 days from insertion of Hickman-Broviac catheters
    Elio Castagnola
    Department of Hematology and Oncology, Infectious Diseases Unit, G Gaslini Children s Hospital, Genoa, Italy
    Pediatr Blood Cancer 48:35-8. 2007
    ..To evaluate the incidence of surgical site infections and bacteremias occurring within 30 days from insertion of partially implanted central venous catheters...
  32. ncbi request reprint Helicobacter pylori as cause of gastrointestinal disease in children with hemato-oncologic diseases
    Elio Castagnola
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genoa, Italy
    Pediatr Blood Cancer 47:89-91. 2006
    ..pylori faecal antigen. All patients recovered with appropriate therapy. H. pylori may represent a cause of severe gastrointestinal complications in children with cancer or following bone marrow transplant...
  33. ncbi request reprint Fungal infections in children with cancer: a prospective, multicenter surveillance study
    Elio Castagnola
    G Gaslini Children Hospital, Genova, Italy
    Pediatr Infect Dis J 25:634-9. 2006
    ..Data on epidemiology and survival after fungal infections in patients with cancer are primarily based on studies in adults, whereas few data are available on children...
  34. doi request reprint Acute graft-versus-host disease in pediatric allogeneic hematopoietic stem cell transplantation. Single-center experience during 10 yr
    Maura Faraci
    Hematopoietic Stem Cell Transplantation Unit, Haematology Oncology Department, G Gaslini Children s Research Institute, Genova, Italy
    Pediatr Transplant 16:887-93. 2012
    ..Myeloablation and malignant disease represented the only risk factors for classic a-GvHD. Our results highlight the need for a better prevention of this complication in the non-malignant setting...
  35. ncbi request reprint Mycobacterium tuberculosis pneumonia and bacteremia after allogeneic hematopoietic stem cell transplant: report of an instructive pediatric case
    Erika Biral
    Hematology Oncology Department, G Gaslini Children s Research Institute, Genova, Italy
    New Microbiol 35:353-7. 2012
    ..We describe an interesting pediatric case of miliary lung tuberculosis after HSCT, which was successfully treated after administering the appropriate therapy...
  36. ncbi request reprint Gram-negative urinary tract infections and increasing isolation of ESBL-producing or ceftazidime-resistant strains in children: results from a single-centre survey
    Stefano Giardino
    Stem Cell Transplant Unit, Department of Hematology and Oncology, Istituto Giannina Gaslini, Genoa, Italy
    Infez Med 21:29-33. 2013
    ..This phenomenon gives cause for concern and should be monitored carefully to avoid the risk of selecting resistant bacteria that have no therapeutic options...
  37. doi request reprint Risk of repeated febrile episodes during chemotherapy-induced granulocytopenia in children with cancer: a prospective single center study
    Francesca Bagnasco
    Epidemiology and Biostatistics Section, Scientific Directorate, G Gaslini Children s Hospital, Genoa, Italy
    J Chemother 24:155-60. 2012
    ..Febrile neutropenia (FN) is a possible complication of antineoplastic chemotherapy. Aim of the study was to estimate the risk of developing fever at the beginning of any neutropenic period based on the previous history of FN...
  38. ncbi request reprint A multicenter, randomized, double blind placebo-controlled trial of amoxicillin/clavulanate for the prophylaxis of fever and infection in neutropenic children with cancer
    Elio Castagnola
    Infectious Disease Unit, National Institute for Cancer Research, Largo Rosanna Benzi 10, 16132 Genoa, Italy
    Pediatr Infect Dis J 22:359-65. 2003
    ..To evaluate the effectiveness of oral amoxicillin/clavulanate (25 mg/kg every 12 h) for prevention of fever and/or infection in neutropenic children with cancer...
  39. doi request reprint Role of management strategies in reducing mortality from invasive fungal disease in children with cancer or receiving hemopoietic stem cell transplant: a single center 30-year experience
    Elio Castagnola
    From the Infectious Diseases Unit Epidemiology and Biostatistics Unit Oncology Unit Hemopoietic Stem Cell Transplant Unit Hematology Unit Laboratory of Analysis Service of Radiology Surgery Unit and Intensive Care Unit, Istituto Giannina Gaslini, Genova, Italy
    Pediatr Infect Dis J 33:233-7. 2014
    ..Few data are available on their impact on mortality in children...
  40. pmc High Levels of beta-D-glucan in immunocompromised children with proven invasive fungal disease
    Alessandra Mularoni
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genova, Italy
    Clin Vaccine Immunol 17:882-3. 2010
    ..The BDG test may be useful for identification of IFD in pediatrics...
  41. ncbi request reprint Treatment of febrile neutropenia: what is new?
    Claudio Viscoli
    Infectious Disease Unit, National Institute for Cancer Research, University of Genoa, Italy
    Curr Opin Infect Dis 15:377-82. 2002
    ....
  42. doi request reprint Low dosage cidofovir without probenecid as treatment for BK virus hamorrhagic cystitis after hemopoietic stem cell transplant
    Maura Faraci
    Department of Haematology and Oncology, G Gaslini Children Hospital, Genoa, Italy
    Pediatr Infect Dis J 28:55-7. 2009
    ..Clinical improvement was observed in all cases, without adverse events, although significant reduction of urinary viral load was observed 2 weeks after the end of cidofovir in 5 out of 6 patients who completed the treatment...
  43. doi request reprint HHV-8-related visceral Kaposi's sarcoma following allogeneic HSCT: report of a pediatric case and literature review
    Ilaria Sala
    Department of Hematology Oncology, Infectious Diseases Unit, G Gaslini Children s Research Institute, Genova, Italy
    Pediatr Transplant 15:E8-11. 2011
    ..However, our observation suggests that HHV-8-related KS should be taken into consideration in the differential diagnosis of late post-HSCT complications...
  44. ncbi request reprint Prospective study of indwelling central venous catheter-related complications in children with broviac or clampless valved catheters
    Giuseppe Fratino
    Department of Pediatric Surgery, G Gaslini Children s Institute, Largo G Gaslini, 5 I 16147 Genoa, Italy
    J Pediatr Hematol Oncol 24:657-61. 2002
    ..To compare two types of central venous catheters (Broviac and valved clampless) for the incidence and severity of catheter-related complications in children...
  45. ncbi request reprint A single institution observational study of early mechanical complications in central venous catheters (valved and open-ended) in children with cancer
    Giuseppe Fratino
    Department of Pediatric Surgery, G Gaslini Children s Hospital, Largo G Gaslini 5, 16147 Genoa, Italy
    Pediatr Surg Int 20:704-7. 2004
    ..We conclude that catheter type correlates with the risk of early mechanical complications and removal...
  46. ncbi request reprint Urokinase for restoring patency of malfunctioning or blocked central venous catheters in children with hemato-oncological diseases
    Angelo Claudio Molinari
    Section of Thrombosis and Haemostasis, Department of Pediatric Hematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Support Care Cancer 12:840-3. 2004
    ....
  47. doi request reprint Pegfilgrastim in children with severe congenital neutropenia
    Francesca Fioredda
    Haematology Unit, Giannina Gaslini Childrens Hospital, Genoa, Italy
    Pediatr Blood Cancer 54:465-7. 2010
    ..These data suggest that pegfilgrastim may be beneficial in SCN patients with an exposure of hematopoietic cells to G-CSF similar to that on filgrastim...
  48. doi request reprint Catheter-related bacteremia caused by methicillin-resistant coagulase negative staphylococci with elevated minimal inhibitory concentration for vancomycin
    Elio Castagnola
    Infectious Diseases Unit, Department of Hematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Pediatr Infect Dis J 29:1047-8. 2010
    ..There are few data supporting efficacy and safety of antibiotic catheter lock or use of daptomycin or linezolid for this indication in children...
  49. ncbi request reprint Uneventful outcome of unrelated hematopoietic stem cell transplantation in a patient with leukemic transformation of Kostmann syndrome and long-lasting invasive pulmonary mycosis
    Sandro Dallorso
    Department of Hematology Oncology, Surgical Emergency Unit, Infectious Diseases Unit, G Gaslini Children s Hospital, Genova, Italy
    Eur J Haematol 70:322-5. 2003
    ..In spite of these poor prognostic characteristics, outcome was uneventful and the patient is alive and well in continuous complete remission with no signs of fungal infection...
  50. pmc Case report of the reliability 1,3-β-D-glucan monitoring during treatment of peritoneal candidiasis in a child receiving continuous peritoneal dialysis
    Francesca Ginocchio
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genoa, Italy
    Clin Vaccine Immunol 19:626-7. 2012
    ..This case report shows the utility of 1,3-β-D-glucan monitoring in management of Candida peritonitis in a child undergoing continuous peritoneal dialysis...
  51. doi request reprint Infectious complications in children with severe congenital, autoimmune or idiopathic neutropenia: a retrospective study from the Italian Neutropenia Registry
    Francesca Fioredda
    Haematology Unit, Giannina Gaslini Children s Hospital, Genova, Italy
    Pediatr Infect Dis J 32:410-2. 2013
    ..Infections are an important clinical issue in the management of neutropenic patients, even in those considered at lower risk...
  52. ncbi request reprint Re-immunisation schedule in leukaemic children after intensive chemotherapy: a possible strategy
    Francesca Fioredda
    Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, Scientific Directorate, G Gaslini Children s Hospital, Genova, Italy
    Eur J Haematol 74:20-3. 2005
    ..Larger studies are needed to confirm these observations...
  53. ncbi request reprint Surgery for acute graft-versus-host disease of the bowel: description of a pediatric case
    Maura Faraci
    Department of Pediatric Hematology Oncology Bone Marrow Transplant Unit Infectious Diseases, G Gaslini Children s Research Institute, Genova, Italy
    J Pediatr Hematol Oncol 26:441-3. 2004
    ..This experience suggests that surgery can be performed on children with severe, unresponsive GI-aGvHD...
  54. doi request reprint Incidence of indwelling central venous catheter-related complications using the Sri Paran technique for device fixation in children with cancer
    G Fratino
    Pediatric Surgery Department, G Gaslini Children s Hospital, Largo G Gaslini 5, Genoa 16100, Italy
    Pediatr Surg Int 25:591-4. 2009
    ..Fixation procedures are, therefore, of primary importance. We prospectively evaluated the incidence of CVC-related mechanical and infectious complications observed in devices fixated with the Sri Paran technique...
  55. doi request reprint Daclizumab as useful treatment in refractory acute GVHD: a paediatric experience
    M Miano
    Department of Paediatric Haematology Oncology, G Gaslini Research Institute, Genoa, Italy
    Bone Marrow Transplant 43:423-7. 2009
    ..In our experience, daclizumab proved to be a useful and safe treatment for refractory and steroid-resistant/dependent aGVHD, in particular for cutaneous and low-moderate intestinal involvement...
  56. pmc The use of mannan antigen and anti-mannan antibodies in the diagnosis of invasive candidiasis: recommendations from the Third European Conference on Infections in Leukemia
    Malgorzata Mikulska
    Division of Infectious Diseases, San Martino University Hospital, L, go R, Benzi, 10, Genoa, Italy
    Crit Care 14:R222. 2010
    ..Mannan antigen (Mn) and anti-mannan antibodies (A-Mn) are present in patients with IC. On behalf of the Third European Conference on Infections in Leukemia, the performance of these tests was analysed and reviewed...
  57. ncbi request reprint Helicobacter pylori-associated large gastric ulcer during treatment for childhood leukemia
    Francesca Fioredda
    Department of Pediatric Hematology, Oncology and Bone Marrow Transplantation, G Gaslini Children s Hospital, Largo Gerolamo Gaslini 5, 16148 Genoa, Italy
    J Pediatr Hematol Oncol 24:759-62. 2002
    ..This case points to a possible role for H. pylori as a pathogen in children with leukemia who have either evident or occult gastrointestinal bleeding...
  58. doi request reprint Molecular characterization of hospital-acquired methicillin-resistant Staphylococcus aureus strains in pediatric outbreaks using variable tandem repeat analysis with spa and ClfB typing
    Elisabetta Ugolotti
    Molecular Medicine, Deparment of Experimental Medicine Istituto Giannina Gaslini, Largo G Gaslini 5, 16147 Genoa, Italy
    Diagn Microbiol Infect Dis 69:213-7. 2011
    ....
  59. ncbi request reprint Severe neurologic complications after hematopoietic stem cell transplantation in children
    M Faraci
    Department of Hematology Oncology, Bone Marrow Transplant Unit, G Gaslini Children s Research Institute, Genova, Italy
    Neurology 59:1895-904. 2002
    ..To describe and evaluate the incidence and risk factors of severe neurologic events (SNE) in pediatric recipients of allogeneic or autologous hematopoietic stem cell transplantation (HSCT) for hematologic or nonhematologic diseases...
  60. ncbi request reprint Strategies for cost-containment: once-daily ceftriaxone plus amikacin as empiric therapy for febrile granulocytopenic children with cancer
    E Castagnola
    Division of Infectious Diseases, G Gaslini Children s Hospital, Genoa, Italy
    J Chemother 11:54-60. 1999
    ....
  61. doi request reprint Viral-load and B-lymphocyte monitoring of EBV reactivation after allogeneic hemopoietic SCT in children
    M Faraci
    Hemopoietic Stem cell Transplant Unit, Hematology Oncology Department, G Gaslini Children s Research Institute, Genova, Italy
    Bone Marrow Transplant 45:1052-5. 2010
    ..Through this approach, we significantly reduced the number of patients treated with rituximab, and consequently the acute and chronic adverse events related to this treatment...
  62. ncbi request reprint Mechanical complications related to indwelling central venous catheter in pediatric hematology/oncology patients
    G Fratino
    Department of Paediatric Surgery, G Gaslini Institute, L go G Gaslini, 5 I 16147 Genoa, Italy
    Pediatr Hematol Oncol 18:317-24. 2001
    ..Moreover, the experience of administering a systemic low-dosage thrombolytic therapy demonstrates new prospects of reducing CVC replacement by restoring CVC viability...
  63. ncbi request reprint Thromboembolic complications related to indwelling central venous catheters in children with oncological/haematological diseases: a retrospective study of 362 catheters
    A C Molinari
    Department of Oncology and Haematology, Giannina Gaslini Institute, Genova, Italy
    Support Care Cancer 9:539-44. 2001
    ..A prospective study, which has already been started, should identify the exact role of thromboembolic complications in children with indwelling CVC for oncological/ haematological malignancies...
  64. ncbi request reprint Incidence of septicaemias and invasive mycoses in children undergoing treatment for solid tumours: a 12-year experience at a single Italian institution
    R Haupt
    Clinical Epidemiology and Biostatistics Section, Gaslini Children's Hospital, Genoa, Italy
    Eur J Cancer 37:2413-9. 2001
    ..4). This study demonstrates that the risk of bacteraemia increases in parallel with the treatment intensity, and that a considerable number of children with solid tumours develop bacteraemia in the absence of an identifiable risk factor...
  65. doi request reprint Near-miss events are really missed! Reflections on incident reporting in a department of pediatric surgery
    Girolamo Mattioli
    Pediatric Surgery Department, Giannina Gaslini Institute, University of Genoa, Genoa, Italy
    Pediatr Surg Int 28:405-10. 2012
    ....
  66. doi request reprint Arthritis caused by group B Streptococcus: a case report
    Maddalena Perotti
    Department of Clinical Pathology and Microbiology, Genoa, Italy
    Pediatr Emerg Care 28:805-6. 2012
    ..We report a case of a monoarticular arthritis in a 6-month-old girl...
  67. doi request reprint Use of linezolid in infants and children: a retrospective multicentre study of the Italian Society for Paediatric Infectious Diseases
    Silvia Garazzino
    Department of Paediatrics, Infectious Diseases Unit, University of Turin, Regina Margherita Children s Hospital, Turin, Italy
    J Antimicrob Chemother 66:2393-7. 2011
    ..However, clinical experience in the paediatric population is still limited. We undertook a multicentre study to analyse the use of linezolid in children...
  68. doi request reprint Immunization after the elective end of antineoplastic chemotherapy in children
    Francesca Fioredda
    Haematology Unit, Department of Haematology and Oncology, G Gaslini Children Hospital, Genoa, Italy
    Pediatr Blood Cancer 52:165-8. 2009
    ..Efforts to find a common strategy of re-immunization should be directed towards setting up prospective studies on sufficient numbers of patients to obtain statistically relevant end points...
  69. ncbi request reprint Infections after stem cell transplantation in children: state of the art and recommendations
    G Dini
    Department of Hemato-Oncology and Bone Marrow Transplantation in children, Istituto Giannina Gaslini, Genoa, Italy
    Bone Marrow Transplant 28:S18-21. 2001
    ..No benefit is observed in children undergoing peripheral blood SCT. The routine use of G-CSF in the latter group of patients is not justified...
  70. ncbi request reprint Economic aspects of empiric antibiotic therapy for febrile neutropenia in children with cancer
    E Castagnola
    Infectious Disease Unit, G Gaslini Children s Hospital, Genova, Italy
    Support Care Cancer 6:524-8. 1998
    ..In general, the combination regimen with ceftriaxone plus aminoglycoside turned out to be less expensive than other regimens (including monotherapy with third-generation cephalosporins or carbapenems)...
  71. ncbi request reprint Association between antifungal prophylaxis and rate of documented bacteremia in febrile neutropenic cancer patients
    C Viscoli
    University of Genova and National Institute for Cancer Research, Genova, Italy
    Clin Infect Dis 32:1532-7. 2001
    ..88) for those who were receiving absorbable antifungal agents. Antifungal prophylaxis with absorbable agents might have an impact on the rate of documented bacteremia in febrile neutropenia. This effect should be confirmed prospectively...
  72. ncbi request reprint Broviac catheter-related bacteraemias due to unusual pathogens in children with cancer: case reports with literature review
    E Castagnola
    Department of Infectious Diseases, G Gaslini Children s Hospital, Genoa, Italy
    J Infect 34:215-8. 1997
    ..Susceptibility to different antibiotics of all strains are reported. In all cases catheter removal was required for culture negativization. All episodes were diagnosed in absence of granulocytopenia...
  73. ncbi request reprint Central venous catheter-related complications in children with oncological/hematological diseases: an observational study of 418 devices
    G Fratino
    Department of Pediatric Surgery, G Gaslini Children s Hospital, Genoa, Italy
    Ann Oncol 16:648-54. 2005
    ..We describe the experience of two tertiary care centers in Italy that prospectively followed up three types of CVC used at both institutions over a 30-month period...
  74. doi request reprint Quantification of micafungin in human plasma by liquid chromatography-tandem mass spectrometry
    Giuliana Cangemi
    Clinical Pathology Laboratory Unit, Giannina Gaslini Institute, The Pediatric Hospital of Genoa, Via G Gaslini 3 5, 16147, Genoa, Italy
    Anal Bioanal Chem 406:1795-8. 2014
    ..A simple and rapid LC-MS/MS method which provides high specificity, precision, and accuracy for quantification of MCF in plasma has been developed and validated. ..
  75. ncbi request reprint Cerebrovascular disease and varicella in children
    Giuseppe Losurdo
    Infectious Diseases Unit, G Gaslini Children s Hospital, Largo G Gaslini 5, 16147 Genoa, Italy
    Brain Dev 28:366-70. 2006
    ..On the basis of our experience and of literature data on varicella-associated stroke, we recommend that VZV infection be taken into account in every episode of stroke in children...
  76. doi request reprint Multiple relapses of visceral leishmaniasis in an adolescent with idiopathic CD4+ lymphocytopenia associated with novel immunophenotypic and molecular features
    Ignazia Prigione
    G Gaslini Scientific Institute, Genova, Italy
    Pediatr Infect Dis J 28:161-3. 2009
    ..This novel form of idiopathic CD4 lymphocytopenia may predispose to multiple visceral leishmaniasis relapses...
  77. ncbi request reprint Antifungal prophylaxis with azole derivatives
    E Castagnola
    Infectious Diseases Unit and Department of Haematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Clin Microbiol Infect 10:86-95. 2004
    ....
  78. ncbi request reprint Nitazoxanide or CD3+/CD4+ lymphocytes for recovery from severe Cryptosporidium infection after allogeneic bone marrow transplant?
    M Faraci
    Bone Marrow Transplant Unit, Department of Hematology and Oncology, G Gaslini Children s Hospital, Genoa, Italy
    Pediatr Transplant 11:113-6. 2007
    ....
  79. doi request reprint Shifting from open surgical cut down to ultrasound-guided percutaneous central venous catheterization in children: learning curve and related complications
    S Avanzini
    Paediatric Surgery Department, G Gaslini Children Hospital, Genoa, Italy
    Pediatr Surg Int 26:819-24. 2010
    ....
  80. ncbi request reprint Anti-varicella-zoster vaccination in contacts of children receiving antineoplastic chemotherapy: a prospective pilot study
    A Timitilli
    Unit of Infectious Diseases, G Gaslini Childrens Hospital, Genoa, Italy
    Infez Med 16:144-7. 2008
    ..The attitude of paediatric oncologists and parental refusal currently represent the main challenges against the complete success of this strategy in countries where VZV vaccination is not inserted in the general vaccination programme...
  81. ncbi request reprint Varicella and its complications as cause of hospitalization
    G Losurdo
    Infectious Diseases Unit, G Gaslini Children s Hospital, Genova, Italy
    Infez Med 13:229-34. 2005
    ..Our retrospective data regarding a single tertiary care pediatric hospital shows that hospitalization due to varicella or its sequelae may present an important medical and indirect economic problem...
  82. ncbi request reprint Spleen and lung involvement by Acinetobacter calcoaceticus bacteremia mimicking deep fungal infection in a child with acute non-lymphoblastic leukemia
    Andrea Di Cataldo
    Centre of Paediatric Haematology and Oncology, University of Catania, Catania, Italy
    Pediatr Blood Cancer 46:266. 2006
  83. ncbi request reprint Broviac catheter-related candidemia
    Elio Castagnola
    Pediatr Infect Dis J 24:747. 2005
  84. ncbi request reprint Assessment of humoral immunity to poliomyelitis, tetanus, hepatitis B, measles, rubella, and mumps in children after chemotherapy
    Francesca Fioredda
    Cancer 103:1758-9; author reply 1760. 2005
  85. ncbi request reprint Cytomegalovirus infection after bone marrow transplantation in children
    Elio Castagnola
    Department of Clinical and Experimental Medicine, St Orsola Malpighi General Hospital, University of Bologna, Bologna, Italy
    Hum Immunol 65:416-22. 2004
    ..Specific studies on children are lacking, however, the clinical pictures and features seems to be similar both in children and adults...
  86. ncbi request reprint Possible role of toll-like receptor 9 polymorphism in chemotherapy-related invasive mold infections in children with hematological malignancies
    Marina Lanciotti
    Pediatr Blood Cancer 50:944. 2008
  87. pmc Maintenance of therapeutic concentrations of caspofungin after temporary treatment interruption (48 hours) in a child with invasive aspergillosis
    Elio Castagnola
    Antimicrob Agents Chemother 51:3775. 2007
  88. ncbi request reprint Results of a multicenter retrospective study of a combined medical and surgical approach to pulmonary aspergillosis in pediatric neutropenic patients
    Simone Cesaro
    Clinic of Pediatric Hematology Oncology, Department of Pediatrics, University of Padua, Padua, Italy
    Pediatr Blood Cancer 49:909-13. 2007
    ..Surgical resection has been reported to improve disease control and patient survival. There are few reports describing the role of surgery in children with pulmonary IA...
  89. ncbi request reprint High-dose oral ganciclovir for management of CMV-symptomatic infection in a child with acute lymphoblastic leukemia
    Elio Castagnola
    Med Pediatr Oncol 38:295-6. 2002
  90. ncbi request reprint Long-lasting hypogammaglobulinemia following rituximab administration for Epstein-Barr virus-related post-transplant lymphoproliferative disease preemptive therapy
    Elio Castagnola
    J Hematother Stem Cell Res 12:9-10. 2003
  91. ncbi request reprint Hyperglycaemia as a possible marker of invasive fungal infection in preterm neonates
    Paolo Manzoni
    Neonatology Unit and Hospital NICU, Ospedale S Anna, Turin, Italy
    Acta Paediatr 95:486-93. 2006
    ..We evaluated whether glucose intolerance could represent a possible surrogate marker predictor of invasive fungal infection in preterm neonates...
  92. pmc Catheter lock and systemic infusion of linezolid for treatment of persistent Broviac catheter-related staphylococcal bacteremia
    Elio Castagnola
    Antimicrob Agents Chemother 50:1120-1. 2006
  93. ncbi request reprint Decline in mortality with varicella vaccination
    Raffaella Giacchino
    N Engl J Med 352:1819. 2005