Paolo Fusar-Poli

Summary

Country: Italy

Publications

  1. ncbi request reprint Roger Keith "Syd" Barrett (1946-2006)
    Paolo Fusar-Poli
    Neuroimaging Section, Division of Psychological Medicine PO67, Institute of Psychiatry, London SE5 8AF UK
    Am J Psychiatry 164:1028. 2007
  2. ncbi request reprint Effects of acute antipsychotic treatment on brain activation in first episode psychosis: an fMRI study
    P Fusar-Poli
    Division of Psychological Medicine Institute of Psychiatry, King s College London, De Crespigny Park, SE58AF, London, UK
    Eur Neuropsychopharmacol 17:492-500. 2007
  3. doi request reprint Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol
    Paolo Fusar-Poli
    Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Int J Neuropsychopharmacol 13:421-32. 2010
  4. pmc White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI-EEG study
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group, Institute of Psychiatry, King s Health Partners, King s College London, London, UK
    J Psychiatry Neurosci 36:239-48. 2011
  5. doi request reprint Neuroanatomy of vulnerability to psychosis: a voxel-based meta-analysis
    P Fusar-Poli
    University Psychiatric Unit, Brescia University School of Medicine and Brescia Spedali Civili, Brescia, Italy
    Neurosci Biobehav Rev 35:1175-85. 2011
  6. ncbi request reprint Attenuated psychosis syndrome: ready for DSM-5.1?
    P Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom email
    Annu Rev Clin Psychol 10:155-92. 2014
  7. pmc Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis
    Paolo Fusar-Poli
    To whom correspondence should be addressed Department of Psychosis Studies P063, King s College London, Institute of Psychiatry, De Crespigny Park, SE58AF London, UK tel 44 0 20 7848 0900, fax 44 0 20 7848 0976, E mail
    Schizophr Bull 40:120-31. 2014
  8. ncbi request reprint Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies
    P Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, United Kingdom Electronic address
    Neurosci Biobehav Rev 37:1680-91. 2013
  9. pmc White matter pathology--an endophenotype for bipolar disorder?
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland
    BMC Psychiatry 12:138. 2012
  10. pmc At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London and OASIS team, South London and the Maudsley NHS Foundation Trust, London, UK
    Schizophr Bull 39:923-32. 2013

Detail Information

Publications100

  1. ncbi request reprint Roger Keith "Syd" Barrett (1946-2006)
    Paolo Fusar-Poli
    Neuroimaging Section, Division of Psychological Medicine PO67, Institute of Psychiatry, London SE5 8AF UK
    Am J Psychiatry 164:1028. 2007
  2. ncbi request reprint Effects of acute antipsychotic treatment on brain activation in first episode psychosis: an fMRI study
    P Fusar-Poli
    Division of Psychological Medicine Institute of Psychiatry, King s College London, De Crespigny Park, SE58AF, London, UK
    Eur Neuropsychopharmacol 17:492-500. 2007
    ..These effects need to be considered when interpreting group differences in activation between medicated patients and controls...
  3. doi request reprint Modulation of effective connectivity during emotional processing by Delta 9-tetrahydrocannabinol and cannabidiol
    Paolo Fusar-Poli
    Neuroimaging Section, Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Int J Neuropsychopharmacol 13:421-32. 2010
    ..This is the first study to show that the disruption of prefrontal-subocritical connectivity by CBD may represent neurophysiological correlates of its anxiolytic properties...
  4. pmc White matter alterations related to P300 abnormalities in individuals at high risk for psychosis: an MRI-EEG study
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group, Institute of Psychiatry, King s Health Partners, King s College London, London, UK
    J Psychiatry Neurosci 36:239-48. 2011
    ..The relation between these factors in the development of illness is almost unknown. We studied the relation between white matter volumes and P300 in prodromal psychosis...
  5. doi request reprint Neuroanatomy of vulnerability to psychosis: a voxel-based meta-analysis
    P Fusar-Poli
    University Psychiatric Unit, Brescia University School of Medicine and Brescia Spedali Civili, Brescia, Italy
    Neurosci Biobehav Rev 35:1175-85. 2011
    ....
  6. ncbi request reprint Attenuated psychosis syndrome: ready for DSM-5.1?
    P Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London SE5 8AF, United Kingdom email
    Annu Rev Clin Psychol 10:155-92. 2014
    ..Areas of future research are identified, and a potential roadmap for inclusion in DSM-5.1 is traced. ..
  7. pmc Comorbid depressive and anxiety disorders in 509 individuals with an at-risk mental state: impact on psychopathology and transition to psychosis
    Paolo Fusar-Poli
    To whom correspondence should be addressed Department of Psychosis Studies P063, King s College London, Institute of Psychiatry, De Crespigny Park, SE58AF London, UK tel 44 0 20 7848 0900, fax 44 0 20 7848 0976, E mail
    Schizophr Bull 40:120-31. 2014
    ..Their impact on the presenting high-risk psychopathology, functioning, and transition outcomes has not been widely researched...
  8. ncbi request reprint Progressive brain changes in schizophrenia related to antipsychotic treatment? A meta-analysis of longitudinal MRI studies
    P Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, United Kingdom Electronic address
    Neurosci Biobehav Rev 37:1680-91. 2013
    ..Antipsychotic treatment is the first-line treatment option for schizophrenia. Individual studies suggested they can significantly affect brain structure and account for progressive brain changes observed during the illness...
  9. pmc White matter pathology--an endophenotype for bipolar disorder?
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland
    BMC Psychiatry 12:138. 2012
    ..They are not confounded by the presence of illness duration or previous treatment with medication and may ultimately inform evaluation of risk for subsequent development of BD and subsequent therapeutic intervention...
  10. pmc At risk for schizophrenic or affective psychoses? A meta-analysis of DSM/ICD diagnostic outcomes in individuals at high clinical risk
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London and OASIS team, South London and the Maudsley NHS Foundation Trust, London, UK
    Schizophr Bull 39:923-32. 2013
    ..However, the extent to which different diagnostic types of illness develop remains unclear...
  11. doi request reprint Outreach and support in south London (OASIS), 2001-2011: ten years of early diagnosis and treatment for young individuals at high clinical risk for psychosis
    P Fusar-Poli
    Department of Psychosis Studies P063, King s College London, Institute of Psychiatry, De Crespigny Park, SE58AF London
    Eur Psychiatry 28:315-26. 2013
    ..The OASIS team has become an established model where clinical practice and research are fully integrated in the field of preventative interventions in psychosis...
  12. doi request reprint Efficacy and safety of second-generation long-acting injections in schizophrenia: a meta-analysis of randomized-controlled trials
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Int Clin Psychopharmacol 28:57-66. 2013
    ..These data suggest that SGLAI lack an advantage in reducing psychotic symptoms over oral medications. Their potential effects on relapse prevention should be better addressed by future randomized-controlled trials...
  13. doi request reprint The psychosis high-risk state: a comprehensive state-of-the-art review
    Paolo Fusar-Poli
    Department of Psychosis Studies, King s College London, London, UK
    JAMA Psychiatry 70:107-20. 2013
    ..The importance of this HR state has been increasingly recognized to such an extent that a new syndrome is being considered as a diagnostic category in the DSM-5...
  14. pmc Striatal presynaptic dopamine in schizophrenia, Part I: meta-analysis of dopamine active transporter (DAT) density
    Paolo Fusar-Poli
    Section of Psychiatry, Department of Health Sciences, University of Pavia, Pavia, Italy
    Schizophr Bull 39:22-32. 2013
    ..However, the currently available results using this approach in schizophrenia are inconsistent...
  15. pmc Striatal presynaptic dopamine in schizophrenia, part II: meta-analysis of [(18)F/(11)C]-DOPA PET studies
    Paolo Fusar-Poli
    Section of Psychiatry, DepartmentofHealth Sciences, University of Pavia, Pavia, Italy
    Schizophr Bull 39:33-42. 2013
    ..Although the functional integrity of the presynaptic system can be assessed by measuring striatal dopamine synthesis capacity (DSC), no quantitative meta-analysis is available...
  16. pmc Neuroanatomical maps of psychosis onset: voxel-wise meta-analysis of antipsychotic-naive VBM studies
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group, Department of Psychosis Studies, Institute of Psychiatry, King s College London, 16 De Crespigny Park, London SE58AF, UK
    Schizophr Bull 38:1297-307. 2012
    ..Available structural imaging literature in the field is undermined by several methodological caveats and a number of confounders such as exposure to antipsychotic treatment...
  17. doi request reprint Cognitive functioning in prodromal psychosis: a meta-analysis
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, England, UK
    Arch Gen Psychiatry 69:562-71. 2012
    ..Cognitive deficits may predate the onset of psychosis and may be useful as markers of increased vulnerability to illness...
  18. pmc Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies
    Paolo Fusar-Poli
    Institute of Psychiatry, Department of Psychosis Studies, King s College London, London, United Kingdom
    J Psychiatry Neurosci 37:170-84. 2012
    ..Although early interventions in individuals with bipolar disorder may reduce the associated personal and economic burden, the neurobiologic markers of enhanced risk are unknown...
  19. doi request reprint Mapping prodromal psychosis: a critical review of neuroimaging studies
    P Fusar-Poli
    Institute of Psychiatry, Department of Psychosis Studies, London, UK
    Eur Psychiatry 27:181-91. 2012
    ..To conclude, multimodal neuroimaging may ultimately clarify the neurobiology of the prodromal phases by the integration of functional, structural and neurochemical findings...
  20. doi request reprint Striatal dopamine transporter alterations in ADHD: pathophysiology or adaptation to psychostimulants? A meta-analysis
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, USA
    Am J Psychiatry 169:264-72. 2012
    ..However, individual studies using single photon emission tomography (SPECT) or positron emission tomography (PET) have yielded inconsistent results, i.e., both high and low striatal dopamine transporter levels...
  21. doi request reprint Eicosapentaenoic acid interventions in schizophrenia: meta-analysis of randomized, placebo-controlled studies
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group, Institute of Psychiatry, King s College London, London, United Kingdom
    J Clin Psychopharmacol 32:179-85. 2012
    ..Published results are conflicting, and the antipsychotic efficacy of such augmentation strategies is not well established...
  22. doi request reprint Predicting psychosis: meta-analysis of transition outcomes in individuals at high clinical risk
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    Arch Gen Psychiatry 69:220-9. 2012
    ..However, the risk of transition to psychosis varies between centers, and some recent work suggests that the risk of transition may be declining...
  23. ncbi request reprint Reliability and validity of the Comprehensive Assessment of the At Risk Mental State, Italian version (CAARMS-I)
    P Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London UK
    Curr Pharm Des 18:386-91. 2012
    ..We found that the CAARMS-I demonstrates adequate validity and reliability and appears to be helpful in the diagnosis of the ARMS and prediction of psychosis transition...
  24. doi request reprint Distinct effects of {delta}9-tetrahydrocannabinol and cannabidiol on neural activation during emotional processing
    Paolo Fusar-Poli
    Neuroimaging Section, Division of Psychological Medicine, PO67, Institute of Psychiatry, London SE58AF, England
    Arch Gen Psychiatry 66:95-105. 2009
    ..Cannabis use can both increase and reduce anxiety in humans. The neurophysiological substrates of these effects are unknown...
  25. doi request reprint Duration of untreated prodromal symptoms and 12-month functional outcome of individuals at risk of psychosis
    P Fusar-Poli
    OASIS, South London and Maudsley NHS Trust, and Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 194:181-2. 2009
    ..375, P=0.008). This effect was independent of age and gender and may have implications for the improvement of treatment strategies in pre-psychotic phases...
  26. doi request reprint Neurophysiological response to emotional faces with increasing intensity of fear: a skin conductance response study
    P Fusar-Poli
    Department of Psychobehavioural Health Sciences, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    J Clin Neurosci 16:981-2. 2009
    ....
  27. pmc Functional atlas of emotional faces processing: a voxel-based meta-analysis of 105 functional magnetic resonance imaging studies
    Paolo Fusar-Poli
    Fusar Poli, Carletti, Allen, McGuire Section of Neuroimaging, Department of Psychological Medicine, Institute of Psychiatry, King s College London, United Kingdom
    J Psychiatry Neurosci 34:418-32. 2009
    ..Furthermore, such emotional processes are thought to be aberrant in a range of clinical disorders, including psychosis and depression. However, the exact neurofunctional maps underlying emotional facial processing are not well defined...
  28. doi request reprint Laterality effect on emotional faces processing: ALE meta-analysis of evidence
    P Fusar-Poli
    Department of Psychological Medicine, Institute of Psychiatry, King s College London, United Kingdom
    Neurosci Lett 452:262-7. 2009
    ..001). Significant interactions between the approach and avoidance dimensions and prefrontal response were observed (p=0.001)...
  29. doi request reprint Lifestyles and cardiovascular risk in individuals with functional psychoses
    Paolo Fusar-Poli
    Department of Psychobehavioural Health Sciences, University of Pavia, Pavia, Italy
    Perspect Psychiatr Care 45:87-99. 2009
    ..This study aims to examine known determinants of cardiovascular risk in Italian patients with functional psychoses...
  30. doi request reprint Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis
    P Fusar-Poli
    Department of Psychological Medicine, Neuroimaging Section, Institute of Psychiatry, King s College London, London, UK
    Mol Psychiatry 16:67-75. 2011
    ..These changes reflect an increased vulnerability to psychosis and predate the first episode of frank psychosis...
  31. doi request reprint Effect of image analysis software on neurofunctional activation during processing of emotional human faces
    P Fusar-Poli
    Neuroimaging Section, Division of Psychological Medicine, PO67, Institute of Psychiatry, King s College London, De Crespigny Park 103, Denmark Hill, London SE5 8AF, UK
    J Clin Neurosci 17:311-4. 2010
    ..Overall, SPM and XBAM analyses revealed comparable whole-group brain responses. Further studies are needed to explore the between-group compatibility of the different imaging packages in other cognitive and emotional processing domains...
  32. doi request reprint Social dysfunction predicts two years clinical outcome in people at ultra high risk for psychosis
    P Fusar-Poli
    Psychosis Clinical Academic Group, Institute of Psychiatry, King s Health Partners, King s College London, UK
    J Psychiatr Res 44:294-301. 2010
    ..Unemployment at the first contact with the prodromal service may be a risk factor for the development of a psychotic episode...
  33. doi request reprint Altered brain function directly related to structural abnormalities in people at ultra high risk of psychosis: longitudinal VBM-fMRI study
    P Fusar-Poli
    Department of Psychosis Studies, King s College London, King s Health Partners, Institute of Psychiatry, UK
    J Psychiatr Res 45:190-8. 2011
    ..However, the longitudinal course of these abnormalities, and how they relate to subsequent clinical and functional outcome is relatively unclear...
  34. pmc Prefrontal function at presentation directly related to clinical outcome in people at ultrahigh risk of psychosis
    P Fusar-Poli
    Section of Psychiatry, Department of Health Sciences, University of Pavia, Pavia, Italy
    Schizophr Bull 37:189-98. 2011
    ..The prodromal phase of psychosis is characterized by impaired executive function and altered prefrontal activation. The extent to which the severity of these deficits at presentation predicts subsequent clinical outcomes is unclear...
  35. doi request reprint Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group PO67, Institute of Psychiatry, De Crespigny Park, London SE58AF, England
    Arch Gen Psychiatry 67:683-91. 2010
    ..Alterations in dopaminergic neurotransmission and function of the prefrontal cortex are thought to be central to the pathophysiology of schizophrenia, but the relationship between these factors in the development of psychosis is unclear...
  36. doi request reprint Spatial working memory in individuals at high risk for psychosis: longitudinal fMRI study
    P Fusar-Poli
    Institute of Psychiatry, King s Health Partners, King s College London, UK
    Schizophr Res 123:45-52. 2010
    ..The longitudinal dynamic course of the neurofunctional abnormalities underlying liability to psychosis and their relation to clinical outcomes is unknown...
  37. doi request reprint Gray matter alterations related to P300 abnormalities in subjects at high risk for psychosis: longitudinal MRI-EEG study
    Paolo Fusar-Poli
    Psychosis Clinical Academic Group, Institute of Psychiatry, King s College London, London, UK
    Neuroimage 55:320-8. 2011
    ..Psychotic disorders are characterized by gray matter and volumetric and electrophysiological abnormalities. The relationship between these factors in the onset of psychotic illness is unclear...
  38. doi request reprint Paul Eugen Bleuler and the birth of schizophrenia (1908)
    Paolo Fusar-Poli
    Department of Applied and Psychobehavioral Health Sciences, University of Pavia, Pavia, Italy
    Am J Psychiatry 165:1407. 2008
  39. ncbi request reprint Modulation of neural response to happy and sad faces by acute tryptophan depletion
    Paolo Fusar-Poli
    Department of Applied and Psychobehavioural Health Sciences, University of Pavia, via Bassi 21, 27100, Pavia, Italy
    Psychopharmacology (Berl) 193:31-44. 2007
    ..We used functional neuroimaging (fMRI) to investigate the effects of experimental manipulation of central 5HT levels on the regional neural response to happy and sad facial expressions...
  40. ncbi request reprint Can antidepressants prevent psychosis?
    Paolo Fusar-Poli
    Outreach and Support in South London OASIS, South London and Maudsley NHS Trust, London, UK
    Lancet 370:1746-8. 2007
  41. pmc Socioeconomic provisions for specialist training in Italy and the UK: integrating the differences
    Paolo Fusar-Poli
    Department of Applied and Psychobehavioural Sciences, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    Postgrad Med J 82:810-2. 2006
    ....
  42. ncbi request reprint Depression after lung transplantation: causes and treatment
    P Fusar-Poli
    Department of Applied and Psychobehavioural Health Sciences, University of Pavia, via Bassi 21, 27100, Pavia, Italy
    Lung 185:55-65. 2007
    ..Additional well-conducted randomized controlled trials are needed to clarify the epidemiologic course of depression following lung transplantation and to tailor effective pharmacologic or psychological interventions accordingly...
  43. ncbi request reprint Neuroimaging and electrophysiological studies of the effects of acute tryptophan depletion: a systematic review of the literature
    Paolo Fusar-Poli
    Department of Applied and Psychobehavioral Health Sciences, University of Pavia, via Bassi 21, 27100, Pavia, Italy
    Psychopharmacology (Berl) 188:131-43. 2006
    ..To date, no systematic review has been undertaken assessing the neurophysiological effects following this acute central 5-HT manipulation...
  44. doi request reprint Determinants of quality of life in Marfan syndrome
    Paolo Fusar-Poli
    DSSAeP, Sezione di Psichiatria, Universita di Pavia, Pavia, Italy
    Psychosomatics 49:243-8. 2008
    ..Marfan syndrome (MFS) is a rare, heritable disorder that affects connective tissue. Men and women are equally affected. Clinical manifestations involve multiple sites, especially bones and ligaments and heart and blood vessels...
  45. ncbi request reprint Anti-depressive therapies after heart transplantation
    Paolo Fusar-Poli
    Department of Applied and Psychobehavioural Sciences, University of Pavia, Pavia, Italy
    J Heart Lung Transplant 25:785-93. 2006
    ..To date, no review has explored the efficacy and safety of pharmacologic or psychologic interventions in this patient group...
  46. doi request reprint Medicine and the arts. Brain Damage by Pink Floyd (1973). Commentary
    Paolo Fusar-Poli
    Neuroimaging Section, Institute of Psychiatry, King s College London, London, UK
    Acad Med 83:742-3. 2008
  47. doi request reprint Thalamic glutamate levels as a predictor of cortical response during executive functioning in subjects at high risk for psychosis
    P Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, England
    Arch Gen Psychiatry 68:881-90. 2011
    ..Alterations in glutamatergic neurotransmission and cerebral cortical dysfunction are thought to be central to the pathophysiology of psychosis, but the relationship between these 2 factors is unclear...
  48. ncbi request reprint Depression and quality of life in patients living 10 to 18 years beyond heart transplantation
    Paolo Fusar-Poli
    DSSAeP, Sezione di Psichiatria, Università di Pavia and Servizio Psichiatrico di Diagnosi e Cura San Matteo, Pavia, Italy
    J Heart Lung Transplant 24:2269-78. 2005
    ..The purpose of this study was to advance current understanding of factors that influence long-term quality-of-life (QoL) outcomes after heart transplantation, by addressing the influence of depression on perceived health status...
  49. ncbi request reprint Neurofunctional correlates of vulnerability to psychosis: a systematic review and meta-analysis
    Paolo Fusar-Poli
    Department of Applied and Psychobehavioural Health Sciences, University of Pavia, Italy
    Neurosci Biobehav Rev 31:465-84. 2007
    ..These abnormalities have mainly been described in the prefrontal and anterior cingulated cortex, the basal ganglia, hippocampus and cerebellum...
  50. doi request reprint Neural basis of Delta-9-tetrahydrocannabinol and cannabidiol: effects during response inhibition
    Stefan J Borgwardt
    Section of Neuroimaging, Institute of Psychiatry, King s College London, United Kingdom
    Biol Psychiatry 64:966-73. 2008
    ..This study examined the effect of Delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) on brain activation during a motor inhibition task...
  51. pmc Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosis
    Paul Allen
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, UK
    Schizophr Bull 38:1040-9. 2012
    ....
  52. pmc Altered prefrontal and hippocampal function during verbal encoding and recognition in people with prodromal symptoms of psychosis
    Paul Allen
    Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, London, UK
    Schizophr Bull 37:746-56. 2011
    ..These neurofunctional differences were associated with diminished recognition performance and may reflect the greatly increased risk of psychosis associated with the ARMS...
  53. ncbi request reprint Effect of acute tryptophan depletion on pre-frontal engagement
    Paul P Allen
    Division of Psychological Medicine P067, Institute of Psychiatry, De Crespigny Park, London, UK
    Psychopharmacology (Berl) 187:486-97. 2006
    ..We tested the hypothesis that acute tryptophan depletion (ATD) would attenuate pre-frontal activation during both tasks...
  54. doi request reprint Modulation of mediotemporal and ventrostriatal function in humans by Delta9-tetrahydrocannabinol: a neural basis for the effects of Cannabis sativa on learning and psychosis
    Sagnik Bhattacharyya
    Section of Neuroimaging, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, Box P067, De Crespigny Park, London SE5 8AF, England
    Arch Gen Psychiatry 66:442-51. 2009
    ..Cannabis sativa use can impair verbal learning, provoke acute psychosis, and increase the risk of schizophrenia. It is unclear where C. sativa acts in the human brain to modulate verbal learning and to induce psychotic symptoms...
  55. pmc Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals
    Paul Allen
    Department of Psychosis Studies, Institute of Psychiatry, King s College, London, UK
    Schizophr Bull 38:1268-76. 2012
    ..We investigated whether functional magnetic resonance imaging (fMRI) in conjunction with a phonological fluency task at presentation could distinguish subjects who subsequently developed psychosis from those who did not...
  56. doi request reprint Induction of psychosis by Δ9-tetrahydrocannabinol reflects modulation of prefrontal and striatal function during attentional salience processing
    Sagnik Bhattacharyya
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, London, England
    Arch Gen Psychiatry 69:27-36. 2012
    ..Cannabis can induce acute psychotic symptoms, and its chronic use may increase the risk of schizophrenia. We investigated whether its psychotic effects are mediated through an influence on attentional salience processing...
  57. pmc Modulation of auditory and visual processing by delta-9-tetrahydrocannabinol and cannabidiol: an FMRI study
    Toby T Winton-Brown
    Department of Psychosis Studies, Institute of Psychiatry, King s Health Partners, London, UK
    Neuropsychopharmacology 36:1340-8. 2011
    ..Single doses of THC and CBD differently modulate brain function in areas that process auditory and visual stimuli and relate to induced psychotic symptoms...
  58. pmc Opposite effects of delta-9-tetrahydrocannabinol and cannabidiol on human brain function and psychopathology
    Sagnik Bhattacharyya
    Section of Neuroimaging, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, London, UK
    Neuropsychopharmacology 35:764-74. 2010
    ..Delta-9-THC and CBD can have opposite effects on regional brain function, which may underlie their different symptomatic and behavioral effects, and CBD's ability to block the psychotogenic effects of Delta-9-THC...
  59. doi request reprint Altered medial temporal activation related to local glutamate levels in subjects with prodromal signs of psychosis
    Isabel Valli
    Department of Psychosis Studies, King s College London, London, United Kingdom
    Biol Psychiatry 69:97-9. 2011
    ..However, although animal models of psychosis suggest that these two abnormalities are interrelated, their relationship in humans has yet to be investigated...
  60. doi request reprint Neural correlates of executive function and working memory in the 'at-risk mental state'
    Matthew R Broome
    Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 194:25-33. 2009
    ..People with prodromal symptoms have a very high risk of developing psychosis...
  61. ncbi request reprint Getting old with a new heart: impact of age on depression and quality of life in long-term heart transplant recipients
    Valentina Martinelli
    DSSAeP, Section of Psychiatry, University of Pavia, Pavia, Italy
    J Heart Lung Transplant 26:544-8. 2007
    ..The aim of the present study was to investigate the role of age on depression and quality of life in a sample of long-term heart transplant recipients...
  62. doi request reprint Superior temporal lobe dysfunction and frontotemporal dysconnectivity in subjects at risk of psychosis and in first-episode psychosis
    Nicolas A Crossley
    Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, United Kingdom
    Hum Brain Mapp 30:4129-37. 2009
    ..However, the stage of the disorder at which these functional alterations occur is unclear. We addressed this issue by using functional MRI (fMRI) to study subjects in the prodromal and first episode phases of schizophrenia...
  63. doi request reprint Genetic vulnerability to affective psychopathology in childhood: a combined voxel-based morphometry and functional magnetic resonance imaging study
    Andrea Mechelli
    Department of Psychology, Institute of Psychiatry, PO Box 67, Division of Psychological Medicine and Psychiatry, King s College London, 103 Denmark Hill, London SE5 8AF, United Kingdom
    Biol Psychiatry 66:231-7. 2009
    ....
  64. doi request reprint Reduced mismatch negativity predates the onset of psychosis
    Madiha Shaikh
    PO63, NIHR Biomedical Research Centre for Mental Health at the Institute of Psychiatry, King s College London and The South London and Maudsley NHS Foundation Trust, London, SE5 8AF, UK
    Schizophr Res 134:42-8. 2012
    ..We examined whether mismatch negativity (MMN) could help to identify those who are particularly likely to make a transition to psychosis...
  65. doi request reprint Glutamate dysfunction in people with prodromal symptoms of psychosis: relationship to gray matter volume
    James M Stone
    Institute of Psychiatry, King s College London, University College London, United Kingdom
    Biol Psychiatry 66:533-9. 2009
    ..Here we determine whether changes in brain glutamate are present in subjects at ultra high risk of developing psychosis and whether these changes are related to reductions in cortical gray matter volume...
  66. ncbi request reprint Cognitive remediation in the early course of schizophrenia: a critical review
    Stefano Barlati
    Department of Psychiatry, Spedali Civili Hospital, Brescia, Italy
    Curr Pharm Des 18:534-41. 2012
    ....
  67. ncbi request reprint Genetic vulnerability to psychosis and cortical function: epistatic effects between DAAO and G72
    Andrea Mechelli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF UK
    Curr Pharm Des 18:510-7. 2012
    ..Future studies could explore the effects of DAAO and G72 in individuals with prodromal symptoms of psychosis, in order to elucidate glutamate dysfunction in this critical phase of the disorder...
  68. ncbi request reprint Ten years of "extended" life: quality of life among heart transplantation survivors
    Pierluigi Politi
    DSSAeP, Sezione di Psichiatria, Università di Pavia and Servizio Psichiatrico di Diagnosi e Cura, IRCCS Policlinico San Matteo Pavia, 27100 Pavia, Italy
    Transplantation 78:257-63. 2004
    ..Long-term quality of life (QOL) outcome in heart transplant recipients still remains uncertain. This study evaluates the health status and QOL of survivors with associated predictors 10 years after heart transplantation...
  69. ncbi request reprint Episodic memory dysfunction in individuals at high-risk of psychosis: a systematic review of neuropsychological and neurofunctional studies
    Isabel Valli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, De Crespigny Park, SE5 8AF, London, UK
    Curr Pharm Des 18:443-58. 2012
    ....
  70. ncbi request reprint Neurophysiological alterations in the prepsychotic phases
    Nicolas A Crossley
    Department of Psychosis Studies Institute of Psychiatry, King s College London, SE58AF, UK
    Curr Pharm Des 18:479-85. 2012
    ..We particularly focus in the P300, Mismatch-Negativity (MMN) and P50 paradigms, discussing the main findings, but also the limitations and challenges in electrophysiological studies in this population...
  71. pmc Voxel-wise meta-analysis of fMRI studies in patients at clinical high risk for psychosis
    Paolo Fusar-Poli
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London, United Kingdom
    J Psychiatry Neurosci 37:106-12. 2012
    ..Reliable neurofunctional markers of increased vulnerability to psychosis are needed to improve the predictive value of psychosis risk syndrome and inform preventive interventions...
  72. doi request reprint Neuroimaging studies of the early stages of psychosis: a critical review
    Paolo Fusar-Poli
    Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, Kings College, London, UK
    Eur Psychiatry 23:237-44. 2008
    ....
  73. doi request reprint Egas Moniz (1875-1955), the father of psychosurgery
    Paolo Fusar-Poli
    Neuroimaging Section, Department of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Br J Psychiatry 193:50. 2008
  74. doi request reprint Functional neuroimaging in schizophrenia: diagnosis and drug discovery
    Philip McGuire
    Sections of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King s College, De Crespigny Park 16, London, UK
    Trends Pharmacol Sci 29:91-8. 2008
    ..Here, we focus on the potential for the use of these techniques in the diagnosis of schizophrenia and in the development of new drugs for its treatment...
  75. doi request reprint Franco Basaglia, 1924-1980
    Giovanni de Girolamo
    Department of Applied and Psychobehavioral Health Sciences, University of Pavia, via Bassi 21, 27100 Pavia, Italy
    Am J Psychiatry 165:968. 2008
  76. ncbi request reprint Anterior cingulate pathology in the prodromal stage of schizophrenia
    Stefan J Borgwardt
    Institute of Psychiatry, King s College London, UK
    Neuroimage 39:553-4. 2008
  77. ncbi request reprint Conceptual issues in psychiatric neuroimaging
    Paolo Fusar-Poli
    PO 67, Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, De Crespigny Park, London, UK
    Curr Opin Psychiatry 19:608-12. 2006
    ..Given the level of sophistication of the techniques and the importance of imaging in current academic psychiatry, it is timely to review its conceptual influence on psychopathology...
  78. ncbi request reprint Biochemical markers of impending psychosis
    Enzo Emanuele
    Department of Health Sciences, Section of Psychiatry, University of Pavia, Pavia, Italy
    Curr Pharm Des 18:505-9. 2012
    ..We will also examine the practical issues that seem to be limiting the effective integration of biomarkers into clinical development...
  79. ncbi request reprint Economic impact of early detection and early intervention of psychosis
    Lucia R Valmaggia
    King s College London, King s Health Partners, Institute of Psychiatry, Psychosis Clinical Academic Group, London, UK
    Curr Pharm Des 18:592-5. 2012
    ..Whilst there is a growing body of evidence relating to the effectiveness of early detection and early intervention services there have been relatively few studies which have provided information on whether they are cost-effective...
  80. doi request reprint Gray matters!--mapping the transition to psychosis
    Stefan Borgwardt
    Department of Psychiatry, University of Basel, Basel, Switzerland
    Schizophr Res 133:63-7. 2011
    ..Subjects at high risk of psychosis show qualitatively similar albeit less severe gray matter abnormalities as patients with psychosis...
  81. doi request reprint Neural correlates of movement generation in the 'at-risk mental state'
    Matthew R Broome
    Section of Neuroimaging, Division of Psychological Medicine, Institute of Psychiatry, King s College London, London, UK
    Acta Psychiatr Scand 122:295-301. 2010
    ..We examined the neurocognitive basis of this vulnerability by using functional MRI to study subjects with an at-risk mental state (ARMS) while they performed a random movement generation task...
  82. doi request reprint Dysbindin modulates brain function during visual processing in children
    A Mechelli
    Department of Psychology, Institute of Psychiatry, King s College London, 103 Denmark Hill, London, UK
    Neuroimage 49:817-22. 2010
    ..These findings are consistent with the notion that the DTNBP1 gene influences brain development and can thereby modulate vulnerability to schizophrenia...
  83. doi request reprint Neuroimaging in cannabis use: a systematic review of the literature
    R Martin-Santos
    Section of Neuroimaging, PO67 Division of Psychological Medicine, Institute of Psychiatry, King s College London, UK
    Psychol Med 40:383-98. 2010
    ..We conducted a systematic review to assess the evidence for specific effects of cannabis on brain structure and function. The review focuses on the cognitive changes associated with acute and chronic use of the drug...
  84. ncbi request reprint Glutamate and psychosis risk
    Alice Egerton
    Department of Psychosis Studies, Institute of Psychiatry, King s Health Partners, King s College London, De Crespigny Park, Denmark Hill, London, UK
    Curr Pharm Des 18:466-78. 2012
    ..If glutamatergic abnormalities are present early in the disorder, this suggests that glutamatergic therapies may be useful in psychosis prevention...
  85. ncbi request reprint Cannabis abuse and vulnerability to psychosis: targeting preventive services
    Anna Kolliakou
    Department of Psychosis Studies, Institute of Psychiatry, King s College London, London
    Curr Pharm Des 18:542-9. 2012
    ....
  86. ncbi request reprint Medicine and the arts. Two allegories of love by Agnolo di Cosimo di Mariano "Bronzino" and Bartels, et al. Commentary
    Paolo Fusar-Poli
    Department of Psychological Medicine, Institute of Psychiatry, London, United Kingdom
    Acad Med 82:1108-9. 2007
  87. ncbi request reprint Imaging the neural effects of cannabinoids: current status and future opportunities for psychopharmacology
    S Bhattacharyya
    Section of Neuroimaging, Box PO67, Division of Psychological Medicine and Psychiatry, Institute of Psychiatry, King s College London, De Crespigny Park, London, UK
    Curr Pharm Des 15:2603-14. 2009
    ..Further, we also discuss how combining neuroimaging and pharmacological challenge with cannabinoids may open up newer avenues for target identification and validation in psychopharmacology...
  88. ncbi request reprint Anxiety and depression after lung transplantation: Mirtazapine as a first-choice agent?
    Paolo Fusar-Poli
    J Psychosom Res 62:101. 2007
  89. ncbi request reprint Linking autism, regression and Landau-Kleffner syndrome: integrative role of nerve growth factor
    Mariachiara Cortesi
    Med Hypotheses 68:1178-9. 2007
  90. ncbi request reprint Pooling of data in psychiatric neuroimaging: a bridge towards clinical neuroimaging?
    Paolo Fusar-Poli
    Eur Psychiatry 22:265. 2007
  91. ncbi request reprint Imaging Genomics - An integrative approach to understand the biological susceptibility for schizophrenia
    Stefan J Borgwardt
    Med Hypotheses 68:1426. 2007
  92. ncbi request reprint Can acute tryptophan depletion modulate brain function in absence of behavioural effects?
    Paolo Fusar-Poli
    Med Hypotheses 68:722. 2007
  93. ncbi request reprint Quetiapine as a first-choice agent in subjects at high-risk to psychosis?
    Ryan O'Connor
    Med Hypotheses 69:230. 2007
  94. ncbi request reprint Is a DNA sequence variation of the gene protocadherin Y a possible explanation for the sixfold higher risk to develop schizophrenia in Moroccan males?
    Murat Yildiz
    Med Hypotheses 69:694. 2007
  95. ncbi request reprint Can neuroimaging reduce social stigma in schizophrenia?
    Paolo Fusar-Poli
    Med Hypotheses 69:457. 2007
  96. doi request reprint 'Truman' signs and vulnerability to psychosis
    Paolo Fusar-Poli
    Br J Psychiatry 193:168. 2008
  97. doi request reprint Heterogeneity in the assessment of the at-risk mental state for psychosis
    Paolo Fusar-Poli
    Psychiatr Serv 59:813. 2008
  98. doi request reprint Insular pathology in the at-risk mental state
    Stefan J Borgwardt
    Eur Arch Psychiatry Clin Neurosci 258:254-5. 2008
  99. ncbi request reprint Differential diagnosis between the early onset of schizophrenia and bipolar disorder: potential role of neuroimaging
    Paolo Fusar-Poli
    CNS Spectr 13:363-4. 2008
  100. ncbi request reprint Memantine as a neuroprotective agent in early phases of psychosis
    Paolo Fusar-Poli
    Med Hypotheses 68:459-60. 2007