Bruno Frediani

Summary

Country: Italy

Publications

  1. ncbi Improved efficacy of intramuscular weekly administration of clodronate 200 mg (100 mg twice weekly) compared with 100 mg (once weekly) for increasing bone mineral density in postmenopausal osteoporosis
    Bruno Frediani
    Rheumatology Department, Osteoporosis and Osteoarticular Instrumental Diagnosis Centre, University of Siena, Siena, Italy
    Clin Drug Investig 33:193-8. 2013
  2. ncbi Effects of two administration schemes of intramuscular clodronic acid on bone mineral density: a randomized, open-label, parallel-group study
    Bruno Frediani
    Osteoporosis and Osteo Articolar Instrumental Diagnosis Center, Rheumatology Department, University of Siena, Siena, Italy
    Clin Drug Investig 31:43-50. 2011
  3. ncbi Calcaneus ultrasonometry and dual-energy X-ray absorptiometry for the evaluation of vertebral fracture risk
    B Frediani
    Department of Clinical Medicine and Immunological Sciences, Rheumatology Unit, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    Calcif Tissue Int 79:223-9. 2006
  4. ncbi [Study of vitamin D status of rheumatoid arthritis patients. Rationale and design of a cross-sectional study by the osteoporosis and metabolic bone diseases study group of the Italian Society of Rheumatology (SIR)]
    B Frediani
    Istituto di Reumatologia, Universita di Siena, Ospedale Le Scotte, Siena, Italia
    Reumatismo 58:314-8. 2006
  5. ncbi Effects of high dose methylprednisolone pulse therapy on bone mass and biochemical markers of bone metabolism in patients with active rheumatoid arthritis: a 12-month randomized prospective controlled study
    Bruno Frediani
    Department of Clinical Medicine and Immunological Sciences, Division of Rheumatology, University of Siena, Siena, Italy
    J Rheumatol 31:1083-7. 2004
  6. ncbi Physical activity and bone turnover markers: a cross-sectional and a longitudinal study
    Silvano Adami
    Rheumatology Unit, Ospedale di Valeggio, University of Verona, 37067, Valeggio, Verona, Italy
    Calcif Tissue Int 83:388-92. 2008
  7. ncbi A proteomic study on human osteoblastic cells proliferation and differentiation
    Adriano Spreafico
    Dipartimento di Medicina Clinica e Scienze Immunologiche, Policlinico Le Scotte, , Italy
    Proteomics 6:3520-32. 2006
  8. ncbi Osteogenic growth peptide effects on primary human osteoblast cultures: potential relevance for the treatment of glucocorticoid-induced osteoporosis
    Adriano Spreafico
    Rheumatology Unit, Department of Clinical Medicine and Immunological Sciences, University of Siena, 53100 Siena, Italy
    J Cell Biochem 98:1007-20. 2006
  9. ncbi Tumour necrosis factor receptor-associated periodic syndrome (TRAPS): state of the art and future perspectives
    Luca Cantarini
    Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Siena, Italy
    Autoimmun Rev 12:38-43. 2012
  10. ncbi Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes
    Adriano Spreafico
    Sezione di Reumatologia, Dipartimento di Medicina Clinica e Scienze Immunologiche, Universita di Siena, Policlinico Le Scotte, Siena, Italy
    J Cell Biochem 108:1153-65. 2009

Detail Information

Publications48

  1. ncbi Improved efficacy of intramuscular weekly administration of clodronate 200 mg (100 mg twice weekly) compared with 100 mg (once weekly) for increasing bone mineral density in postmenopausal osteoporosis
    Bruno Frediani
    Rheumatology Department, Osteoporosis and Osteoarticular Instrumental Diagnosis Centre, University of Siena, Siena, Italy
    Clin Drug Investig 33:193-8. 2013
    ..However, to the best of our knowledge, this has never been proved...
  2. ncbi Effects of two administration schemes of intramuscular clodronic acid on bone mineral density: a randomized, open-label, parallel-group study
    Bruno Frediani
    Osteoporosis and Osteo Articolar Instrumental Diagnosis Center, Rheumatology Department, University of Siena, Siena, Italy
    Clin Drug Investig 31:43-50. 2011
    ..However, to our knowledge, a direct comparison of the effects of intramuscular clodronic acid 100 mg once weekly with a regimen consisting of a higher dose and a longer interval between two consecutive administrations is still lacking...
  3. ncbi Calcaneus ultrasonometry and dual-energy X-ray absorptiometry for the evaluation of vertebral fracture risk
    B Frediani
    Department of Clinical Medicine and Immunological Sciences, Rheumatology Unit, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    Calcif Tissue Int 79:223-9. 2006
    ..The combination of QUS and BMD did not improve the diagnostic ability of either individual technique. We found different diagnostic thresholds for QUS and DXA...
  4. ncbi [Study of vitamin D status of rheumatoid arthritis patients. Rationale and design of a cross-sectional study by the osteoporosis and metabolic bone diseases study group of the Italian Society of Rheumatology (SIR)]
    B Frediani
    Istituto di Reumatologia, Universita di Siena, Ospedale Le Scotte, Siena, Italia
    Reumatismo 58:314-8. 2006
    ..Patient enrollment will start on February 2007 and will last 4 months. By the end of 2007 the study will be concluded and results will be published...
  5. ncbi Effects of high dose methylprednisolone pulse therapy on bone mass and biochemical markers of bone metabolism in patients with active rheumatoid arthritis: a 12-month randomized prospective controlled study
    Bruno Frediani
    Department of Clinical Medicine and Immunological Sciences, Division of Rheumatology, University of Siena, Siena, Italy
    J Rheumatol 31:1083-7. 2004
    ....
  6. ncbi Physical activity and bone turnover markers: a cross-sectional and a longitudinal study
    Silvano Adami
    Rheumatology Unit, Ospedale di Valeggio, University of Verona, 37067, Valeggio, Verona, Italy
    Calcif Tissue Int 83:388-92. 2008
    ..In conclusion, both the cross-sectional and the longitudinal parts of our study demonstrate that even minor changes in physical activity are associated with a clear effect on bone formation markers...
  7. ncbi A proteomic study on human osteoblastic cells proliferation and differentiation
    Adriano Spreafico
    Dipartimento di Medicina Clinica e Scienze Immunologiche, Policlinico Le Scotte, , Italy
    Proteomics 6:3520-32. 2006
    ..Our findings confirmed the differences between cell lines and primary human cell cultures and suggested caution on the use of osteosarcoma to study anti-osteoporotic drugs in humans...
  8. ncbi Osteogenic growth peptide effects on primary human osteoblast cultures: potential relevance for the treatment of glucocorticoid-induced osteoporosis
    Adriano Spreafico
    Rheumatology Unit, Department of Clinical Medicine and Immunological Sciences, University of Siena, 53100 Siena, Italy
    J Cell Biochem 98:1007-20. 2006
    ..Our results support the employment of OGP (10-14) in clinical trials addressed to the treatment of different bone remodeling alterations including the GC-induced osteoporosis...
  9. ncbi Tumour necrosis factor receptor-associated periodic syndrome (TRAPS): state of the art and future perspectives
    Luca Cantarini
    Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Siena, Italy
    Autoimmun Rev 12:38-43. 2012
    ..In fact, the IL-1 receptor antagonist anakinra has recently been shown to prevent disease relapses both in the short- and in the long-term, and to induce a prompt and stable disease remission...
  10. ncbi Biochemical investigation of the effects of human platelet releasates on human articular chondrocytes
    Adriano Spreafico
    Sezione di Reumatologia, Dipartimento di Medicina Clinica e Scienze Immunologiche, Universita di Siena, Policlinico Le Scotte, Siena, Italy
    J Cell Biochem 108:1153-65. 2009
    ..We found that PRP treatment actually induced in chondrocytes the expression of proteins (some of which novel) involved in differentiation...
  11. ncbi Intramuscular neridronate in postmenopausal women with low bone mineral density
    Silvano Adami
    Rheumatology Unit, Ospedale di Valeggio, University of Verona, 37067, Valeggio, Verona, Italy
    Calcif Tissue Int 83:301-7. 2008
    ..The results of this study indicate that IM neridronate might be of value for patients intolerant to oral bisphosphonates and unwilling or unable to undergo intravenous infusion of bisphosphonates...
  12. ncbi Long-term clinical course of patients carrying the Q703K mutation in the NLRP3 gene: a case series
    Antonio Vitale
    Interdepartmental Research Centre of Systemic Autoimmune and Autoinflammatory Diseases, Unit of Rheumatology, Policlinico Le Scotte, University of Siena, Siena, Italy
    Clin Exp Rheumatol 30:943-6. 2012
    ..The Q703K allele is a variant of unknown pathogenetic significance, and has been considered to be both a clinically unremarkable polymorphism and a low- penetrance mutation...
  13. ncbi Determinants of bone turnover markers in healthy premenopausal women
    Silvano Adami
    Rheumatology Unit, University of Verona, Ospedale di Valeggio, Valeggio, Verona, Italy
    Calcif Tissue Int 82:341-7. 2008
    ..New normative ranges for serum OC, CTX, and P1NP were identified; and our findings in general impose a redefinition of the criteria for establishing the normal ranges for BTMs...
  14. ncbi Ultrasonographic study of Achilles tendon and plantar fascia in chondrocalcinosis
    Paolo Falsetti
    Department of Clinical Medicine and Immunological Sciences, Section of Rheumatology, University of Siena, Siena, Italy
    J Rheumatol 31:2242-50. 2004
    ....
  15. ncbi Rosuvastatin inhibits spontaneous and IL-1β-induced interleukin-6 production from human cultured osteoblastic cells
    Pietro Enea Lazzerini
    Department of Clinical Medicine and Immunological Sciences, Division of Clinical Immunology, University of Siena, Policlinico Le Scotte, Viale Bracci, Siena, Italy
    Joint Bone Spine 80:195-200. 2013
    ..Although statins inhibit IL-6 production from different cell types, currently no data exist on osteoblasts. The aim of the study was to evaluate the effect of rosuvastatin on IL-6 production by human osteoblasts...
  16. ncbi Relationship of focal erosions, bone mineral density, and parathyroid hormone in rheumatoid arthritis
    Maurizio Rossini
    Rheumatology Unit, Azienda Ospedaliera Universitaria Integrata, Piazzale Stefani 1, 37126 Verona, Italy
    J Rheumatol 38:997-1002. 2011
    ..To investigate the relationship among focal bone erosions and bone mineral density (BMD), 25(OH) vitamin D (25OHD), and parathyroid hormone (PTH) values in patients with rheumatoid arthritis (RA)...
  17. ncbi Ultrasound of enthesopathy in rheumatic diseases
    Paolo Falsetti
    Department of Clinical Medicine, Rheumatology Section, University of Siena, Viale Bracci, 53100 Siena, Italy
    Mod Rheumatol 19:103-13. 2009
    ..The usefulness of US and PDUS in the diagnosis and assessment of enthesopathy is discussed on the basis of the literature and our experience...
  18. ncbi Effects of 4-year treatment with once-weekly clodronate on prevention of corticosteroid-induced bone loss and fractures in patients with arthritis: evaluation with dual-energy X-ray absorptiometry and quantitative ultrasound
    B Frediani
    Institute of Rheumatology, University of Siena, Siena, Italy
    Bone 33:575-81. 2003
    ..63 (0.35-0.98, 95% CI) and 0.25 (0.15-0.91, 95% CI), respectively. We concluded that pulsatory administration of im clodronate once weekly is a safe therapy for preventing corticosteroid induced osteoporosis in patients with arthritis...
  19. ncbi Clinical determinants of bone mass and bone ultrasonometry in patients with systemic sclerosis
    B Frediani
    Institute of Rheumatology, University of Siena, Siena, Italy
    Clin Exp Rheumatol 22:313-8. 2004
    ..The aim of this study was to evaluate bone mass and bone ultrasonometry in patients affected with systemic sclerosis (SSc)...
  20. ncbi Enthesitis of proximal insertion of the deltoid in the course of seronegative spondyloarthritis. An atypical enthesitis that can mime impingement syndrome
    Paolo Falsetti
    Institute of Rheumatology, University of Siena, Policlinico Le Scotte, Viale Bracci, IT 53100 Siena, Italy
    Scand J Rheumatol 31:158-62. 2002
    ..To study the frequence of deltoideal proximal insertion enthesitis (DPIE) in patients affected with spondyloarthritis (SpA) and to evaluate its clinical, sonographic and radiological characteristics...
  21. ncbi The diagnostic evaluation of patients with potential adult-onset autoinflammatory disorders: our experience and review of the literature
    Isabella Muscari
    Interdepartmental Research Center of Systemic Autoimmune and Autoinflammatory Diseases, Rheumatology Unit, Policlinico Le Scotte, University of Siena, Siena, Italy
    Autoimmun Rev 12:10-3. 2012
    ..The present manuscript offers our suggestions on how to establish a differential diagnosis for adult-onset HPFs, as well as a review of the literature, and we also provide a score revision available online...
  22. ncbi Vascular endothelial growth factor-D activates VEGFR-3 expressed in osteoblasts inducing their differentiation
    Maurizio Orlandini
    Dipartimento di Biologia Molecolare, Sezione Reumatologia, Universita degli Studi di Siena, Via Fiorentina 1, 53100 Siena, Italy
    J Biol Chem 281:17961-7. 2006
    ..These experiments establish that VEGF-D/VEGFR-3 signaling plays a critical role in osteoblast maturation and suggest that VEGF-D is a downstream effector of VEGF in osteogenesis...
  23. ncbi Novel therapeutic agents for bone resorption. Part 1. Synthesis and protonation thermodynamics of poly(amido-amine)s containing bis-phosphonate residues
    Mario Casolaro
    Dipartimento di Scienze e Tecnologie Chimiche e dei Biosistemi, Universita di Siena, Via Aldo Moro 2, I 53100 Siena, Italy
    Biomacromolecules 7:3417-27. 2006
    ..Preliminary biological results show that both the oligomers do not negatively affect the in vitro viability, proliferation, and cellular activity of either normal animal or human osteoblasts...
  24. ncbi Osteoporosis treatment and fracture incidence: the ICARO longitudinal study
    S Adami
    Rheumatology Department, University of Verona, Valeggio Sul Mincio Hospital VR, 37067 Valeggio S Mincio, Verona, Italy
    Osteoporos Int 19:1219-23. 2008
    ..5%/year. This incidence is considerably higher than that observed in randomized clinical trials...
  25. ncbi [Efficacy of Cellfood's therapy (deutrosulfazyme) in fibromyalgia]
    M E Nieddu
    Servizio di Reumatologia, Clinica Rugani, 53035 Monteriggioni SI, Italia
    Reumatismo 59:316-21. 2007
    ..To assess the efficacy of Cellfood's therapy in the treatment of fibromyalgia...
  26. ncbi Bone mineral density in patients with psoriatic arthritis
    B Frediani
    Institute of Rheumatology, University of Siena, Italy
    J Rheumatol 28:138-43. 2001
    ..This demineralization was not related to the indices of inflammation or disease duration, but there is a delayed correlation with HAQ score, as well as age and the number of years since menopause...
  27. ncbi Sonographic and electrodiagnostic features of hereditary neuropathy with liability to pressure palsies
    Federica Ginanneschi
    Department of Neurological, Neurosurgical and Behavioural Sciences, University of Siena, Siena, Italy
    J Peripher Nerv Syst 17:391-8. 2012
    ..We speculate that a mixture of mechanical insults and an axon-initiated process in the distal nerves underlies the distal slowing and/or conduction failure in HNPP...
  28. ncbi Evidences for antinociceptive effect of 17-α-hydroxyprogesterone caproate in carpal tunnel syndrome
    Federica Ginanneschi
    Department of Neurological, Neurosurgical and Behavioural Sciences, Clinical Neurophysiology Unit, University of Siena, Policlinico Le Scotte, Viale Bracci 1, 53100 Siena, Italy
    J Mol Neurosci 47:59-66. 2012
    ..The present study indicates that intra-carpal injection with a long-acting PROG derivative is effective for relief of symptoms in CTS. This effect is apparently mediated by a mechanism distinct from that of the CS...
  29. ncbi Ultrasound and clinical evaluation of quadricipital tendon enthesitis in patients with psoriatic arthritis and rheumatoid arthritis
    Bruno Frediani
    Institute of Rheumatology, University of Siena, Policlinico Le Scotte, Viale Bracci, 53100 Siena, Italy
    Clin Rheumatol 21:203-6. 2002
    ..Sonographic examinations of patients with enthesitis revealed that those with RA had dominantly inflammatory lesions, whereas PsA patients also showed major new bone deposition...
  30. ncbi Long-term effects of neridronate on human osteoblastic cell cultures
    Bruno Frediani
    Rheumatology Unit, Department of Clinical Medicine and Immunological Sciences, University of Siena, Siena, Italy
    Bone 35:859-69. 2004
    ..Many in vitro studies have reported positive effects on osteoblasts proliferation and mineralization for several BPs; however, the observed effects differ, depending on the variety of different model system that has been used...
  31. ncbi Treatment strategies for childhood noninfectious chronic uveitis: an update
    Luca Cantarini
    Anna Meyer Children s Hospital and University of Florence, Department of Paediatrics, Rheumatology Unit, Italy
    Expert Opin Investig Drugs 21:1-6. 2012
    ..Conclusion: Uveitis in children can be severe. Methotrexate is the drug of choice for recalcitrant cases, and biologic therapies can be useful in selected situations...
  32. ncbi Clodronic acid formulations available in Europe and their use in osteoporosis: a review
    Bruno Frediani
    Istituto di Reumatologia, Universita di Siena, Siena, Italy
    Clin Drug Investig 29:359-79. 2009
    ..The drug is well tolerated, with no deleterious effects on bone mineralization, and use of parenteral therapy eliminates the risk of gastrointestinal adverse effects that may be seen in patients receiving bisphosphonate therapy...
  33. ncbi Effect of inhaled glucocorticoids and beta(2) agonists on vertebral fracture risk in COPD patients: the EOLO study
    S Gonnelli
    Department of Internal Medicine, Endocrine Metabolic Science, and Biochemistry, University of Siena, Policlinico Le Scotte, Viale Bracci 2, 53100 Siena, Italy
    Calcif Tissue Int 87:137-43. 2010
    ..28, and OR = 1.40, CI 1.06-1.82, respectively). In conclusion, in COPD patients high doses of inhaled GCs, but not beta(2) agonists, are associated with an increased risk of vertebral fractures and a reduction of QUS at the calcaneus...
  34. ncbi Diagnostic utility of ultrasonography versus nerve conduction studies in mild carpal tunnel syndrome
    Mauro Mondelli
    EMG Service ASL 7, Siena, Italy
    Arthritis Rheum 59:357-66. 2008
    ..To prospectively compare high-resolution ultrasonography (US) and nerve conduction velocity (NCV) in clinically diagnosed mild carpal tunnel syndrome (CTS)...
  35. ncbi Sonographic study of calcaneal entheses in erosive osteoarthritis, nodal osteoarthritis, rheumatoid arthritis and psoriatic arthritis
    P Falsetti
    Institute of Rheumatology, University of Siena, Policlinico Le Scotte Viale Bracci, 53100, Siena, Italy
    Scand J Rheumatol 32:229-34. 2003
    ..A comparison between US results and radiography was also made...
  36. ncbi Ultrasound and clinical evaluation of quadricipital tendon enthesitis in patients with psoriatic arthritis and rheumatoid arthritis
    B Frediani
    Rheumatology Institute, University of Siena, Italy
    Clin Rheumatol 21:294-8. 2002
    ..Sonographic examinations of patients with enthesitis revealed that those with RA had predominantly inflammatory lesions, whereas PsA patients also showed major new bone deposition...
  37. ncbi Efficacy of extracorporeal shock wave treatment in calcaneal enthesophytosis
    R Cosentino
    Institute of Rheumatology, University of Siena, Italy
    Ann Rheum Dis 60:1064-7. 2001
    ..To evaluate the efficacy of extracorporeal shock wave treatment (ESWT) in calcaneal enthesophytosis...
  38. ncbi Extracorporeal shock wave therapy for chronic calcific tendinitis of the shoulder: single blind study
    R Cosentino
    Institute of Rheumatology, University of Siena, Italy
    Ann Rheum Dis 62:248-50. 2003
    ..To evaluate the clinical and radiological response of chronic calcific tendinitis of the shoulder to extracorporeal shock wave therapy (ESWT) in a single blind study...
  39. ncbi Ultrasonography and magnetic resonance imaging of heel fat pad inflammatory-oedematous lesions in rheumatoid arthritis
    P Falsetti
    Department of Clinical Medicine and Immunological Sciences, Section of Rheumatology, University of Siena, Italy
    Scand J Rheumatol 35:454-8. 2006
    ....
  40. ncbi Validation and further development of the WHO 10-year fracture risk assessment tool in Italian postmenopausal women: project rationale and description
    S Adami
    Rheumatology Unit, University of Verona, Italy
    Clin Exp Rheumatol 28:561-70. 2010
    ..The new tool will be offered for the routine clinical use only at the completion of the DeFRA project, requiring the prospective collection of at least 60.000 patient-years. Here we report the rational and the design of the project...
  41. ncbi [Anabolic effects and inhibition of interleukin 6 production induced by neridronate on human osteoblasts]
    A Spreafico
    Dipartimento di Medicina Clinica e Scienze Immunologiche, Sezione di Reumatologia, Universita di Siena, Italia
    Reumatismo 58:288-300. 2006
    ..The researches concerning the BPs effects on osteoblasts (OBs) have instead shown variable results...
  42. ncbi Heel fat pad involvement in rheumatoid arthritis and in spondyloarthropathies: an ultrasonographic study
    P Falsetti
    Department of Clinical Medicine and Immunological Sciences, Section of Rheumatology, University of Siena, Italy
    Scand J Rheumatol 33:327-31. 2004
    ..Scanty data are available about heel fat pad involvement in the course of chronic polyarthritis...
  43. ncbi Role of apoptosis in osteoporosis induced by glucocorticoids
    A Spreafico
    Department of Clinical Medicine and Immunological Sciences, Division of Rheumathology, Policlinico S Maria alle Scotte, University of Siena, 53100 Siena, Italy
    J Endocrinol Invest 31:22-7. 2008
    ....
  44. ncbi Ultrasonography in ulnar neuropathy at the elbow: relationships to clinical and electrophysiological findings
    M Mondelli
    EMG Service, Public Health Unit 7, Via Pian d Ovile 9, 53100 Siena, Italy
    Neurophysiol Clin 38:217-26. 2008
    ..The aims of this study were to measure the cross-sectional area (CSA) of the ulnar nerve at the elbow and to correlate CSA values with clinical and electrophysiological findings...
  45. ncbi [The hand: a reflection of arthritis]
    G Filippou
    Dipartimento di Medicina Clinica e Scienze Immunologiche, Sezione di Reumatologia, Policlinico Santa Maria alle Scotte, Siena, Italia
    Reumatismo 59:71-4. 2007
    ..Articular ultrasonography is an innocuous methodology, easily reproducible and directly applied by a rheumatologist. The aim of this vignette is to present ultrasonography elementary lesions of the hand for a prompt diagnosis...
  46. ncbi Effect of cyclosporine A on bone density in female rheumatoid arthritis patients: results from a multicenter, cross-sectional study
    M Mazzantini
    Rheumatology Units of the University of Pisa, Italy
    Clin Exp Rheumatol 25:709-15. 2007
    ..To analyze the influence of cyclosporine A (CYA) on bone using data from a large multicenter, cross-sectional study on bone mineral density (BMD) in rheumatoid arthritis (RA)...
  47. ncbi Extracorporeal shock wave therapy in the treatment of inferior calcaneal enthesophytosis: outcome by fan-beam dual x ray absorptiometry (DXA)
    R Cosentino
    Ann Rheum Dis 63:1704-5. 2004
  48. ncbi Bone mineral density in patients with systemic sclerosis
    B Frediani
    Ann Rheum Dis 63:326-7. 2004