G Spalletta

Summary

Affiliation: Fondazione Santa Lucia
Country: Italy

Publications

  1. ncbi Fluoxetine alone in the treatment of first episode anxious-depression: an open clinical trial
    Gianfranco Spalletta
    Department of Neuroscience, Tor Vergata University, Rome, Italy
    J Clin Psychopharmacol 22:263-6. 2002
  2. ncbi Alexithymic features in stroke: effects of laterality and gender
    G Spalletta
    IRCCS Fondazione Santa Lucia, Rome, Italy
    Psychosom Med 63:944-50. 2001
  3. ncbi Plasma dehydroepiandrosterone levels are strongly increased in schizophrenia
    Flavia di Michele
    Laboratorio di Neurologia Clinica e Comportamentale, IRCCS Santa Lucia Foundation, Via Ardeatina, 306 00179 Rome, Italy
    J Psychiatr Res 39:267-73. 2005
  4. ncbi Response of emotional unawareness after stroke to antidepressant treatment
    Gianfranco Spalletta
    IRCCS Fondazione Santa Lucia, Rome, Italy
    Am J Geriatr Psychiatry 14:220-7. 2006
  5. ncbi The early course of affective and cognitive symptoms in de novo patients with Parkinson's disease
    Gianfranco Spalletta
    Neuropsychiatry Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, 00179, Rome, Italy
    J Neurol 261:1126-32. 2014
  6. pmc Depressive symptoms in Parkinson's disease and in non-neurological medical illnesses
    Francesca Assogna
    I R C C S Santa Lucia Foundation, Rome, Italy
    Neuropsychiatr Dis Treat 9:389-96. 2013
  7. pmc Cortical grey matter and subcortical white matter brain microstructural changes in schizophrenia are localised and age independent: a case-control diffusion tensor imaging study
    Chiara Chiapponi
    Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    PLoS ONE 8:e75115. 2013
  8. pmc Cognitive and affective changes in mild to moderate Alzheimer's disease patients undergoing switch of cholinesterase inhibitors: a 6-month observational study
    Gianfranco Spalletta
    Neuropsychiatry Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    PLoS ONE 9:e89216. 2014
  9. ncbi Hippocampal multimodal structural changes and subclinical depression in healthy individuals
    Gianfranco Spalletta
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Rome, Italy Electronic address
    J Affect Disord 152:105-12. 2014
  10. doi Rivastigmine patch ameliorates depression in mild AD: preliminary evidence from a 6-month open-label observational study
    Gianfranco Spalletta
    IRCCS Santa Lucia Foundation, University La Sapienza, Rome, Italy
    Alzheimer Dis Assoc Disord 27:289-91. 2013

Collaborators

Detail Information

Publications88

  1. ncbi Fluoxetine alone in the treatment of first episode anxious-depression: an open clinical trial
    Gianfranco Spalletta
    Department of Neuroscience, Tor Vergata University, Rome, Italy
    J Clin Psychopharmacol 22:263-6. 2002
    ..This open study suggests that depression and anxiety symptoms in first-episode drug-naive patients with anxious depression diminished very quickly with fluoxetine...
  2. ncbi Alexithymic features in stroke: effects of laterality and gender
    G Spalletta
    IRCCS Fondazione Santa Lucia, Rome, Italy
    Psychosom Med 63:944-50. 2001
    ..This study tested the hypothesis that stroke patients with a lesion in the right hemisphere are at high risk of developing alexithymic features...
  3. ncbi Plasma dehydroepiandrosterone levels are strongly increased in schizophrenia
    Flavia di Michele
    Laboratorio di Neurologia Clinica e Comportamentale, IRCCS Santa Lucia Foundation, Via Ardeatina, 306 00179 Rome, Italy
    J Psychiatr Res 39:267-73. 2005
    ..Therefore, its study may provide further understanding of the pathophysiology of psychoses and open new avenues for their treatment...
  4. ncbi Response of emotional unawareness after stroke to antidepressant treatment
    Gianfranco Spalletta
    IRCCS Fondazione Santa Lucia, Rome, Italy
    Am J Geriatr Psychiatry 14:220-7. 2006
    ..Unawareness of impairment (anosognosia) is a phenomenon associated with right hemisphere lesions. Unawareness of emotion has rarely been studied...
  5. ncbi The early course of affective and cognitive symptoms in de novo patients with Parkinson's disease
    Gianfranco Spalletta
    Neuropsychiatry Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, 00179, Rome, Italy
    J Neurol 261:1126-32. 2014
    ..This study provides Class III evidence that antiparkinsonian treatment commonly used in the clinical practice improves memory performance and depression severity in de novo patients with PD. ..
  6. pmc Depressive symptoms in Parkinson's disease and in non-neurological medical illnesses
    Francesca Assogna
    I R C C S Santa Lucia Foundation, Rome, Italy
    Neuropsychiatr Dis Treat 9:389-96. 2013
    ..We compared the profile of depressive symptoms in Parkinson's disease (PD) patients with that of control subjects (CS) suffering from non-neurological medical illnesses...
  7. pmc Cortical grey matter and subcortical white matter brain microstructural changes in schizophrenia are localised and age independent: a case-control diffusion tensor imaging study
    Chiara Chiapponi
    Laboratory of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    PLoS ONE 8:e75115. 2013
    ..In individuals with SZ we found that localized brain cortical and white matter subcortical microstructural impairments appear early in life but do not worsen in the 18-65 year age range. ..
  8. pmc Cognitive and affective changes in mild to moderate Alzheimer's disease patients undergoing switch of cholinesterase inhibitors: a 6-month observational study
    Gianfranco Spalletta
    Neuropsychiatry Laboratory, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    PLoS ONE 9:e89216. 2014
    ..The evidence of apathy stabilization and the positive tendency of depressive symptom improvement should definitively be confirmed in double-blind controlled studies. ..
  9. ncbi Hippocampal multimodal structural changes and subclinical depression in healthy individuals
    Gianfranco Spalletta
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Rome, Italy Electronic address
    J Affect Disord 152:105-12. 2014
    ..Here, we investigated subclinical depression and its hippocampal correlates in a non-clinical sample of healthy individuals, with particular regard to gender differences...
  10. doi Rivastigmine patch ameliorates depression in mild AD: preliminary evidence from a 6-month open-label observational study
    Gianfranco Spalletta
    IRCCS Santa Lucia Foundation, University La Sapienza, Rome, Italy
    Alzheimer Dis Assoc Disord 27:289-91. 2013
    ..In AD patients with MDE rivastigmine alone can have a positive impact on depressive phenomena. Thus, future controlled study are justified to definitively verify if rivastigmine alone may improve depression in AD...
  11. pmc Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia
    Ilaria Palladino
    Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy
    J Neuroinflammation 9:206. 2012
    ....
  12. doi Rapid-onset apathy may be the only clinical manifestation after dorsal striatum hemorrhagic lesion: a case report
    Gianfranco Spalletta
    IRCCS Santa Lucia Foundation, University Tor Vergata, Rome, Italy
    Alzheimer Dis Assoc Disord 27:192-4. 2013
    ....
  13. pmc The neuroanatomical correlates of cognitive insight in schizophrenia
    Maria Donata Orfei
    IRCCS Santa Lucia Foundation, Laboratory of Clinical and Behavioural Neurology Via Ardeatina, 306 00179 Rome, Italy
    Soc Cogn Affect Neurosci 8:418-23. 2013
    ....
  14. doi Fronto-thalamic volumetry markers of somatic delusions and hallucinations in schizophrenia
    Gianfranco Spalletta
    IRCCS Santa Lucia Foundation, Neuropsychiatry Laboratory, Department of Clinical and Behavioral Neurology, Via Ardeatina, 306 00179 Rome, Italy
    Psychiatry Res 212:54-64. 2013
    ..e. delusions or hallucinations). These findings provide the first evidence that a frontal-thalamic structural perturbation mediates somatic psychotic phenomena in schizophrenia...
  15. doi Hedonic tone and its mood and cognitive correlates in Parkinson's disease
    Gianfranco Spalletta
    I R C C S Santa Lucia Foundation, Via Ardeatina 306, Rome, Italy
    Depress Anxiety 30:85-91. 2013
    ..Here, we investigated whether hedonic tone depends on depression and clarified its relationship with the cognitive performance of PD patients with different mood disorders...
  16. doi The role of persistent and incident major depression on rate of cognitive deterioration in newly diagnosed Alzheimer's disease patients
    Gianfranco Spalletta
    Fondazione Santa Lucia, Instituto di Ricovero e Cura a Carettere Scientifico, and Memory Clinic, Rome, Italy
    Psychiatry Res 198:263-8. 2012
    ..In conclusion, persistent or incident depression worsens cognitive outcome while no or recovered depression does not affect it in early AD patients...
  17. doi Glutathione S-transferase alpha 1 risk polymorphism and increased bilateral thalamus mean diffusivity in schizophrenia
    Gianfranco Spalletta
    IRCCS Santa Lucia Foundation, Rome, Italy
    Psychiatry Res 203:180-3. 2012
    ..Thus, oxidative stress associated factors may be implicated in specific mechanisms of schizophrenia such as altered microstructure of the thalami and specific psychopathological features of auditory hallucinations...
  18. pmc High serum levels of transforming growth factor β1 are associated with increased cortical thickness in cingulate and right frontal areas in healthy subjects
    Fabrizio Piras
    Fondazione IRCCS Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy
    J Neuroinflammation 9:42. 2012
    ..To date, however, its neuroprotective effects in non-disease conditions have not been studied..
  19. doi Anosognosia and neuropsychiatric symptoms and disorders in mild Alzheimer disease and mild cognitive impairment
    Gianfranco Spalletta
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Neuropsychiatry Laboratory, Rome, Italy
    J Alzheimers Dis 29:761-72. 2012
    ..In mild AD, the frequent co-occurrence of frontally mediated behavioral disorders and anosognosia, particularly apathy, supports the hypothesis of a shared neuropsychogenic process due to the disruption of frontal brain networks...
  20. pmc Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients
    Paola Bossù
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Neuroinflammation 8:65. 2011
    ..Thus, our findings point to IL-6 as a possible specific mediator and a potential therapeutic target in this monogenic disease, suggesting that an enhanced inflammatory response might be indeed involved in its progression...
  21. ncbi Cognition and behaviour are independent and heterogeneous dimensions in Alzheimer's disease
    Gianfranco Spalletta
    Department of Neuroscience, University of Tor Vergata, Rome, Italy
    J Neurol 251:688-95. 2004
    ..In conclusion, many cognitive and behavioural syndromes exist in patients with AD. However, the results of this study suggest that cognition and behaviour are independent dimensions...
  22. ncbi Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease
    Gianfranco Spalletta
    Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy
    Am J Geriatr Psychiatry 15:879-87. 2007
    ..Therefore, the authors studied the effect of glutathione S-transferase (GST) P1-M1-T1 gene polymorphisms and their interactions with the apolipoprotein E (ApoE) epsilon4 allelic variant on the three-year longitudinal course of AD...
  23. ncbi Unawareness of motor impairment and emotions in right hemispheric stroke: a preliminary investigation
    Gianfranco Spalletta
    IRCCS Fondazione Santa Lucia, Rome, Italy
    Int J Geriatr Psychiatry 22:1241-6. 2007
    ..Thus, unawareness may have different forms such as anosognosia, neglect, and alexithymia or unawareness of emotions. In this study we investigated the relationship among anosognosia, neglect, alexithymia, and cognition...
  24. ncbi Delusion symptoms are associated with ApoE epsilon4 allelic variant at the early stage of Alzheimer's disease with late onset
    G Spalletta
    Department of Neuroscience, University of Tor Vergata, Rome, Italy
    Eur J Neurol 13:176-82. 2006
    ..01; P < 0.02). In this study, which considers the entire range of behavioural expressions in LOAD patients at the early stage of the illness, the relationship between behaviour and ApoE epsilon4 allele is confirmed for delusions only...
  25. ncbi Predictors of cognitive level and depression severity are different in patients with left and right hemispheric stroke within the first year of illness
    Gianfranco Spalletta
    Department of Neuroscience, Tor Vergata University, Rome, Italy
    J Neurol 249:1541-51. 2002
    ..The study confirms the hypothesis that predictors of cognitive level and depression severity are different in subjects with different laterality of lesion and that MDD is associated with cognitive impairment in left stroke patients...
  26. ncbi Is left stroke a risk-factor for selective serotonin reuptake inhibitor antidepressant treatment resistance?
    Gianfranco Spalletta
    I R C C S, Fondazione Santa Lucia, Rome, Italy
    J Neurol 250:449-55. 2003
    ..The SSRIs fluoxetine and sertraline could be efficacious treatments for post-stroke MDD but these findings suggest that left stroke could be a predictor of treatment resistance...
  27. ncbi Chronic schizophrenia as a brain misconnection syndrome: a white matter voxel-based morphometry study
    Gianfranco Spalletta
    IRCCS Fondazione Santa Lucia, and Department of Neuroscience, University of Rome Tor Vergata, Rome, Italy
    Schizophr Res 64:15-23. 2003
    ..Thus, the white matters of these cerebral areas were structurally modified particularly in the left hemisphere and in those structures that control language and hearing processes...
  28. ncbi Sertraline treatment of post-stroke major depression: an open study in patients with moderate to severe symptoms
    Gianfranco Spalletta
    Department of Neuroscience, University of Rome Tor Vergata and IRCCS Santa Lucia Foundation, Rome, Italy
    Funct Neurol 18:227-32. 2003
    ..However, non responders to the treatment are at risk of poor outcome. Double blind studies with a greater number of patients are necessary to confirm these preliminary results...
  29. pmc Preliminary evidence for an association between aggressive and hostile behaviour and 3alpha,5alpha-tetrahydroprogesterone plasma levels in schizophrenia
    Gianfranco Spalletta
    Department of Neuroscience, University of Tor Vergata, the IRCCS Fondazione Santa Lucia, Rome, Italy
    J Psychiatry Neurosci 30:49-52. 2005
    ....
  30. ncbi Differences in temperament, character and psychopathology among subjects with different patterns of cannabis use
    Gianfranco Spalletta
    IRCCS Fondazione Santa Lucia, Rome, Italy
    Psychopathology 40:29-34. 2007
    ..For this reason we aimed at identifying predictors of cannabis use severity using a multivariate model in which different clinical and socio-demographic variables were included...
  31. ncbi Symptom profile of DSM-IV major and minor depressive disorders in first-ever stroke patients
    Gianfranco Spalletta
    IRCCS Santa Lucia, Laboratorio di Neurologia Clinica e Comportamentale, Via Ardeatina 306, 00179 Rome, Italy
    Am J Geriatr Psychiatry 13:108-15. 2005
    ....
  32. doi The evaluation of anosognosia in stroke patients
    M D Orfei
    IRCCS Santa Lucia Foundation, Rome, Italy
    Cerebrovasc Dis 27:280-9. 2009
    ..Although a number of reliable scales for the assessment of anosognosia in stroke and traumatic brain injury have been developed, at present no single measure fully explores the multifaceted nature of the phenomenon...
  33. ncbi Prefrontal-thalamic-cerebellar gray matter networks and executive functioning in schizophrenia
    NICOLAS RUSCH
    IRCCS Fondazione Santa Lucia, Rome, Italy
    Schizophr Res 93:79-89. 2007
    ....
  34. doi When, where, and how the corpus callosum changes in MCI and AD: a multimodal MRI study
    M Di Paola
    Laboratory of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    Neurology 74:1136-42. 2010
    ..The corpus callosum (CC) has been shown to be susceptible to atrophy in Alzheimer disease (AD) as a correlate of wallerian degeneration or retrogenesis. However, when and where these 2 mechanisms intervene is still unclear...
  35. doi Regional cortical thickness and cognitive functions in non-demented Parkinson's disease patients: a pilot study
    C Pellicano
    Movement Disorder Unit, Sant Andrea Hospital, Rome, Italy
    Eur J Neurol 19:172-5. 2012
    ..The pathology of neuropsychological deficits in Parkinson's disease (PD) is incompletely defined...
  36. doi BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia
    G Spalletta
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179 Rome, Italy
    Eur Psychiatry 25:311-3. 2010
    ..Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour...
  37. doi Hippocampal abnormalities and memory deficits in Parkinson disease: a multimodal imaging study
    G A Carlesimo
    Department of Neuroscience, Tor Vergata University, Rome, Italy
    Neurology 78:1939-45. 2012
    ....
  38. ncbi Season of birth, gender and negative symptoms in schizophrenia
    A Troisi
    Department of Psychiatry, University of Rome Tor Vergata, Rome, Italy
    Eur Psychiatry 16:342-8. 2001
    ..These results suggest that gender plays a role in modulating the effect of the season of birth on symptoms of schizophrenia...
  39. ncbi Reduced fronto-temporal connectivity is associated with frontal gray matter density reduction and neuropsychological deficit in schizophrenia
    Ilaria Spoletini
    IRCCS Santa Lucia Foundation, Rome, Italy
    Schizophr Res 108:57-68. 2009
    ..The second objective was to identify the neuropsychological correlates of white matter abnormalities in the schizophrenic group, using a comprehensive neuropsychological battery...
  40. doi Facial emotion recognition deficit in amnestic mild cognitive impairment and Alzheimer disease
    Ilaria Spoletini
    IRCCS Santa Lucia Foundation, Rome, Italy
    Am J Geriatr Psychiatry 16:389-98. 2008
    ..A secondary aim was to investigate relationships between facial emotion recognition and cognitive performances...
  41. ncbi Anosognosia for hemiplegia after stroke is a multifaceted phenomenon: a systematic review of the literature
    M D Orfei
    IRCCS Santa Lucia Foundation, Laboratory of Clinical and Behavioural Neurology, Rome, Italy
    Brain 130:3075-90. 2007
    ..We highlight the need for a multidimensional assessment procedure and suggest some potentially productive directions for future research about unawareness of illness...
  42. ncbi Psychiatric symptoms in male cannabis users not using other illicit drugs
    A Troisi
    Department of Psychiatry, University of Rome Tor Vergata, Italy
    Addiction 93:487-92. 1998
    ..To assess the prevalence of DSM-III-R axes I and II disorders and the severity of psychiatric symptoms in cannabis users who did not use other illicit drugs...
  43. ncbi Glutathione S-transferase P1 *C allelic variant increases susceptibility for late-onset Alzheimer disease: association study and relationship with apolipoprotein E epsilon4 allele
    Sergio Bernardini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Clin Chem 51:944-51. 2005
    ....
  44. doi Inferior frontal white matter volume and suicidality in schizophrenia
    NICOLAS RUSCH
    IRCCS Fondazione Santa Lucia, Rome, Italy
    Psychiatry Res 164:206-14. 2008
    ..Inferior frontal white matter alterations in fronto-temporo-limbic circuits may be associated with suicidality and self-aggression in schizophrenia...
  45. ncbi The structure of the corpus callosum in obsessive compulsive disorder
    M Di Paola
    IRCCS Santa Lucia Foundation, Laboratory of Clinical and Behavioural Neurology, Via Ardeatina 306, 00179 Rome, Italy Department of Internal Medicine and Public Health, University of L Aquila, Piazzale Salvatore Tommasi 1, 67010 L Aquila Coppito, Italy Electronic address
    Eur Psychiatry 28:499-506. 2013
    ..Callosal attributes were related to GM density in cortical areas innervated by the CC, and were also related to performance in cognitive domains impaired in the disorder. The CC may therefore be integrally involved in OCD. ..
  46. doi The potential prognostic role of cardiovascular autonomic failure in α-synucleinopathies
    A Fanciulli
    Department of Neurology and Psychiatry, Sapienza University of Rome, Rome, Italy
    Eur J Neurol 20:231-5. 2013
    ....
  47. doi Working memory performance and thalamus microstructure in healthy subjects
    F Piras
    Fondazione Santa Lucia, Via Ardeatina 306, 00179, Rome, Italy
    Neuroscience 171:496-505. 2010
    ..Results highlight the specific involvement of thalamus microstructure, not volume, in modulating WM performance, possibly by regulating the connections among cortical areas that are recruited during WM tasks...
  48. doi Increased pro-inflammatory response by dendritic cells from patients with Alzheimer's disease
    Antonio Ciaramella
    Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 19:559-72. 2010
    ....
  49. ncbi White matter microstructure and apathy level in amnestic mild cognitive impairment
    Claudia Cacciari
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 20:501-7. 2010
    ..These results support the view that alterations in the neural mechanisms underlying apathy level occur in the early phase of degenerative dementias...
  50. doi A multimodal MRI investigation of the subventricular zone in mild cognitive impairment and Alzheimer's disease patients
    Andrea Cherubini
    Department of Clinical and Behavioral Neurology, Santa Lucia Foundation, Rome, Italy
    Neurosci Lett 469:214-8. 2010
    ..Multimodal MRI, being able to highlight structural changes of microscopic tissue in humans in vivo, could represent a precious tool to complement histological studies of neurogenesis...
  51. doi Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer's disease patients
    Andrea Cherubini
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 19:1273-82. 2010
    ..Combining different MRI modalities can allow identifying sensitive indicators of the subtle pathogenic mechanisms that occur in subcortical areas of AD patients...
  52. ncbi Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment
    Paola Bossù
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardeatina 306, 00179 Rome, Italy
    Brain Behav Immun 22:487-92. 2008
    ....
  53. ncbi Paranoid/belligerence and neuroleptic dosage in newly admitted schizophrenic patients
    A Troisi
    Department of Psychiatry, University of Rome Tor Vergata, Italy
    J Clin Psychopharmacol 17:84-7. 1997
    ..These findings suggest that clinicians' strategy of increasing neuroleptic dosage at the manifestation of hostility is not limited to assaultive or uncooperative schizophrenic patients who are on very high dosages of neuroleptics...
  54. ncbi Prefrontal blood flow dysregulation in drug naive ADHD children without structural abnormalities
    G Spalletta
    Department of Psychiatry, Tor Vergata University, Rome, Italy
    J Neural Transm 108:1203-16. 2001
    ..The results of this study highlight the role of the DLPFC blood flow impairment in the pathogenesis of ADHD even in young subjects without structural abnormalities...
  55. doi Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature
    Patrice Peran
    Department of Radiology, I R C C S Foundation Santa Lucia, Via Ardeatina 306, 00179 Rome
    Brain 133:3423-33. 2010
    ..These findings demonstrate that multimodal magnetic resonance imaging of subcortical grey matter structures is useful for the evaluation of Parkinson's disease and, possibly, of other subcortical pathologies...
  56. ncbi Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke
    Paola Bossù
    Department of Clinical and Behavioral Neurology, Santa Lucia Foundation, Rome, Italy
    Curr Neurovasc Res 6:163-70. 2009
    ..These results suggest that IL-18 might be specifically implicated in the pathogenesis of post-stroke alexithymia, ultimately contributing to impaired recovery from stroke...
  57. doi Education mediates microstructural changes in bilateral hippocampus
    Fabrizio Piras
    Fondazione Santa Lucia, Rome, Italy
    Hum Brain Mapp 32:282-9. 2011
    ..The present findings suggest that the hippocampal formation might be one site where education-mediated microstructural changes occur, possibly compensating for cognitive decline...
  58. ncbi Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, 00179, Rome, Italy
    Curr Alzheimer Res 7:15-20. 2010
    ..Other studies are necessary to establish a direct link between BDNF peripheral levels and AD longitudinal course, as well as the role of other factors, such as blood cell activation, in determining these events...
  59. doi Aging of subcortical nuclei: microstructural, mineralization and atrophy modifications measured in vivo using MRI
    Andrea Cherubini
    IRCCS Santa Lucia Foundation, Via Ardeatina, 306, 00179, Rome, Italy
    Neuroimage 48:29-36. 2009
    ..These findings contribute in establishing a baseline for comparison with pathological changes in the basal ganglia and thalamus...
  60. doi Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 17:203-11. 2009
    ....
  61. pmc Predictors of progression of cognitive decline in Alzheimer's disease: the role of vascular and sociodemographic factors
    Massimo Musicco
    Institute of Biomedical Technologies National Research Council, Via F lli Cervi 93, 20099 Segrate, Milan, Italy
    J Neurol 256:1288-95. 2009
    ..Our findings suggest a slower disease progression in Alzheimer's patients with diabetes. If confirmed, this result will contribute new insights into Alzheimer's disease pathogenesis and lead to relevant suggestions for disease treatment...
  62. doi Characterization of white matter fiber bundles with T2* relaxometry and diffusion tensor imaging
    Andrea Cherubini
    Department of Clinical and Behavioral Neurology, Santa Lucia Foundation, Rome, Italy
    Magn Reson Med 61:1066-72. 2009
    ..This has tremendous potential to allow for a more detailed understanding of brain development and pathology, in particular in the context of age-related cognitive decline...
  63. doi Volume and iron content in basal ganglia and thalamus
    Patrice Peran
    Department of Radiology, IRCCS Foundation Santa Lucia, Rome, Italy
    Hum Brain Mapp 30:2667-75. 2009
    ..Our work suggests that combining volumetry and iron estimation in MRI permits to investigate in vivo neurophysiological and neuropathological changes of basal ganglia...
  64. doi Reduced serum concentrations of nerve growth factor, but not brain-derived neurotrophic factor, in chronic cannabis abusers
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy
    Eur Neuropsychopharmacol 18:882-7. 2008
    ..These data also suggest that chronic cannabis consumption may be a risk factor for developing psychosis among drug users...
  65. ncbi Amyloid beta peptide promotes differentiation of pro-inflammatory human myeloid dendritic cells
    Antonio Ciaramella
    Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, 00179 Rome, Italy
    Neurobiol Aging 30:210-21. 2009
    ..These results demonstrate that A beta 42 can modulate the immune system by inducing pro-inflammatory DC differentiation, thus gaining new insights into AD pathogenesis and immune-based therapeutic intervention...
  66. pmc Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease
    Paola Bossù
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Neurol Neurosurg Psychiatry 78:807-11. 2007
    ..The aim of this study was to investigate the impact of two polymorphisms of the human IL-18 gene promoter at positions -607 (C/A) and -137 (G/C) on both susceptibility to and progression of AD...
  67. doi Ecstasy (MDMA)-addicted subjects show increased serum levels of brain-derived neurotrophic factor, independently from a rise of drug-induced psychotic symptoms
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy
    Addict Biol 15:365-7. 2010
    ..We found that BDNF serum levels were significantly increased in both groups of 'ecstasy-addicted' as compared with 'healthy subjects', supporting the hypothesis that BDNF is involved in MDMA action...
  68. pmc Callosal atrophy in mild cognitive impairment and Alzheimer's disease: different effects in different stages
    Margherita Di Paola
    IRCCS Santa Lucia Foundation, Via Ardeatina 306, Rome, Italy
    Neuroimage 49:141-9. 2010
    ....
  69. doi Neuropsychiatric predictors of progression from amnestic-mild cognitive impairment to Alzheimer's disease: the role of depression and apathy
    Katie Palmer
    Fondazione Santa Lucia, Instituto di Ricovero e Cura a Carettere Scientifico, Rome, Italy
    J Alzheimers Dis 20:175-83. 2010
    ..Thus, apathy has an important impact on amnestic-MCI and should be considered a mixed cognitive/psychiatric disturbance related to ongoing AD neurodegeneration...
  70. doi Hippocampal mean diffusivity and memory in healthy elderly individuals: a cross-sectional study
    Giovanni A Carlesimo
    Department of Neuroscience, Tor Vergata University, Rome
    Neurology 74:194-200. 2010
    ..The relationship between age-related memory decline and hippocampal anatomic changes is a matter of debate...
  71. doi In vivo structural neuroanatomy of corpus callosum in Alzheimer's disease and mild cognitive impairment using different MRI techniques: a review
    Margherita Di Paola
    Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 20:67-95. 2010
    ..Instead, the myelin breakdown process affects the later-myelinating CC subregion and explains the earlier involvement of the genu in CC atrophy...
  72. doi The SNRI venlafaxine improves emotional unawareness in patients with post-stroke depression
    Luca Cravello
    IRCCS Fondazione Santa Lucia, Rome, Italy
    Hum Psychopharmacol 24:331-6. 2009
    ....
  73. doi Occurrence of neuropsychiatric symptoms and psychiatric disorders in mild Alzheimer's disease and mild cognitive impairment subtypes
    Fulvia Di Iulio
    Fondazione Santa Lucia, Istituto di Ricovero e Cura a Carettere Scientifico IRCCS, 00179 Rome, Italy
    Int Psychogeriatr 22:629-40. 2010
    ..We aimed to investigate the frequency of psychiatric disorders and neuropsychiatric symptoms in AD and MCI patients, compared to controls...
  74. doi Cortico-subcortical underpinnings of narrative processing impairment in schizophrenia
    Gianfranco Spalletta
    IRCCS Santa Lucia Foundation, Rome, Italy
    Psychiatry Res 182:77-80. 2010
    ..These data confirm that the brain structure of specific cortical and subcortal areas, as determined by magnetic resonance imaging, is related to the compromised semantic retrieval and language control in schizophrenia...
  75. ncbi Depression and cancer: an unexplored and unresolved emergent issue in elderly patients
    Ilaria Spoletini
    IRCCS Santa Lucia Foundation, Rome, Italy
    Crit Rev Oncol Hematol 65:143-55. 2008
    ..In the near future, we need to develop validated mood disorder diagnoses and verify antidepressant treatment efficacy for elderly cancer patients with depression in order to improve their clinical outcome and quality of life...
  76. ncbi Unawareness of illness in neuropsychiatric disorders: phenomenological certainty versus etiopathogenic vagueness
    Maria D Orfei
    IRCCS Santa Lucia Foundation, Rome, Italy
    Neuroscientist 14:203-22. 2008
    ....
  77. ncbi The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines
    G Spalletta
    Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    Mol Psychiatry 11:984-91. 2006
    ..Future investigations may explore this hypothesis through more extensive studies on the role of proinflammatory cytokines, such as IL-1beta, TNF-alpha or even IL-18, in patients with poststroke depression...
  78. ncbi Ethical perspectives on relations between industry and neuropsychiatric medicine
    Maria Donata Orfei
    IRCCS Santa Lucia Foundation, Rome, Italy
    Int Rev Psychiatry 22:281-7. 2010
    ....
  79. ncbi Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia
    Alessandro De Luca
    IRCCS CSS San Giovanni Rotondo, Rome, Italy
    Am J Med Genet B Neuropsychiatr Genet 116:32-5. 2003
    ..0051; schizophrenics: n = 378, W = 161,002.5, Mean rank = 425.9325; controls: n = 444, W = 177,250.5, Mean rank = 399.2128). This result may indicate a possible involvement of the multiprotein complex PC2 in schizophrenia susceptibility...
  80. doi The recognition of facial emotion expressions in Parkinson's disease
    Francesca Assogna
    IRCCS Santa Lucia Foundation, Via Ardeatina 306, Rome, Italy
    Eur Neuropsychopharmacol 18:835-48. 2008
    ..It is clear that future studies should be directed to clarify all these issues...
  81. doi Management of pain in cancer patients with depression and cognitive deterioration
    Ilaria Spoletini
    IRCCS Santa Lucia Foundation, Rome, Italy
    Surg Oncol 19:160-6. 2010
    ..In clinical practice, an appropriate assessment of pain should take into account the relationships with depression and cognitive decline, in order to develop more personalised and effective therapies for its management...
  82. pmc Hippocampi, thalami, and accumbens microstructural damage in schizophrenia: a volumetry, diffusivity, and neuropsychological study
    Ilaria Spoletini
    Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy
    Schizophr Bull 37:118-30. 2011
    ..Thus, DTI appears to be an invaluable tool to investigate subcortical pathology in schizophrenia, greatly enhancing the ability to detect subtle brain changes in this complex disorder...
  83. ncbi Residential facilities for older people in Italy: a five-region survey
    Giovanni de Girolamo
    Department of Mental Health, ASL Bologna, and Mental Health Unit, National Institute of Health, Rome, Italy
    Aging Clin Exp Res 19:132-8. 2007
    ....
  84. ncbi Sensitivity of somatic symptoms in post-stroke depression (PSD)
    Gianfranco Spalletta
    Int J Geriatr Psychiatry 20:1103-4; author reply 1104-5. 2005
  85. ncbi Mutations of the Nogo-66 receptor (RTN4R) gene in schizophrenia
    Lorenzo Sinibaldi
    IRCCS C S S San Giovanni Rotondo, 00198 Rome, Italy
    Hum Mutat 24:534-5. 2004
    ..Both missense changes were absent in 300 control subjects. Molecular modeling revealed that both changes lead to putative structural alterations of the native protein...
  86. ncbi Global cognitive level and antidepressant efficacy in post-stroke depression
    Gianfranco Spalletta
    Psychopharmacology (Berl) 175:262-3; author reply 264. 2004