G D Pinna

Summary

Affiliation: Fondazione Salvatore Maugeri
Country: Italy

Publications

  1. ncbi A hybrid approach for continuous detection of sleep-wakefulness fluctuations: validation in patients with Cheyne-Stokes respiration
    Gian D Pinna
    Department of Biomedical Engineering, S Maugeri Foundation IRCCS, Scientific Institute of Montescano, Montescano PV, Italy
    J Sleep Res 21:342-51. 2012
  2. ncbi Long-term time-course of nocturnal breathing disorders in heart failure patients
    G D Pinna
    Servizio di Bioingegneria Fondazione S Maugeri, IRCCS, Istituto Scientifico di Montescano, 27040 Montescano PV, Italy
    Eur Respir J 35:361-7. 2010
  3. ncbi Assessing the severity and improving the understanding of sleep-related breathing disorders in heart failure patients
    Gian Domenico Pinna
    Department of Biomedical Engineering, S Maugeri Foundation, Montescano, Italy
    Conf Proc IEEE Eng Med Biol Soc 2010:3571-4. 2010
  4. ncbi Pathophysiological and clinical relevance of simplified monitoring of nocturnal breathing disorders in heart failure patients
    Gian Domenico Pinna
    Department of Biomedical Engineering and Cardiology, Salvatore Maugeri Foundation IRCCS, Scientific Institute of Montescano, Montescano, PV 27040, Italy
    Eur J Heart Fail 11:264-72. 2009
  5. ncbi Periodic breathing and state instability during supine laboratory recordings in chronic heart failure patients
    Gian Domenico Pinna
    Department of Biomedical Engineering, S Maugeri Foundation, Montescano, Italy
    Conf Proc IEEE Eng Med Biol Soc 2008:5398-401. 2008
  6. ncbi Association between hemodynamic impairment and Cheyne-Stokes respiration and periodic breathing in chronic stable congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    A Mortara
    Division of Cardiology, Centro Medico di Montescano, S Maugeri Foundation, IRCCS, Pavia, Italy
    Am J Cardiol 84:900-4. 1999
  7. ncbi Assessing baroreflex sensitivity in post-myocardial infarction patients: comparison of spectral and phenylephrine techniques
    R Maestri
    Department of Biomedical Engineering, Institute of Care and Scientific Research, Rehabilitation Institute of Montescano, Pavia, Italy
    J Am Coll Cardiol 31:344-51. 1998
  8. ncbi Echo-Doppler mitral flow monitoring: an operative tool to evaluate day-to-day tolerance to and effectiveness of beta-adrenergic blocking agent therapy in patients with chronic heart failure
    S Capomolla
    Fondazione Salvatore Maugeri, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Scientifico di Montescano, Pavia, Italy
    J Am Coll Cardiol 38:1675-84. 2001
  9. ncbi Nonselective beta-adrenergic blocking agent, carvedilol, improves arterial baroflex gain and heart rate variability in patients with stable chronic heart failure
    A Mortara
    Department of Cardiology, Centro Medico di Montescano, S Maugeri Foundation, IRCCS, Pavia, Italy
    J Am Coll Cardiol 36:1612-8. 2000
  10. ncbi Cardiorespiratory interactions during periodic breathing in awake chronic heart failure patients
    G D Pinna
    Department of Biomedical Engineering, S Maugeri Foundation, Institute of Care and Scientific Research, Rehabilitation Institute of Montescano, I 27040 Montescano, Italy
    Am J Physiol Heart Circ Physiol 278:H932-41. 2000

Detail Information

Publications48

  1. ncbi A hybrid approach for continuous detection of sleep-wakefulness fluctuations: validation in patients with Cheyne-Stokes respiration
    Gian D Pinna
    Department of Biomedical Engineering, S Maugeri Foundation IRCCS, Scientific Institute of Montescano, Montescano PV, Italy
    J Sleep Res 21:342-51. 2012
    ..This approach has therefore the potential to be used to reliably measure the incidence and location of sleep-wake transitions during abnormal breathing patterns, as well as their temporal relationship with major ventilatory events...
  2. ncbi Long-term time-course of nocturnal breathing disorders in heart failure patients
    G D Pinna
    Servizio di Bioingegneria Fondazione S Maugeri, IRCCS, Istituto Scientifico di Montescano, 27040 Montescano PV, Italy
    Eur Respir J 35:361-7. 2010
    ..Rarely do they show a steady increase or decrease over time. A single baseline recording predicts a persistent behaviour with moderate-to-high accuracy...
  3. ncbi Assessing the severity and improving the understanding of sleep-related breathing disorders in heart failure patients
    Gian Domenico Pinna
    Department of Biomedical Engineering, S Maugeri Foundation, Montescano, Italy
    Conf Proc IEEE Eng Med Biol Soc 2010:3571-4. 2010
    ....
  4. ncbi Pathophysiological and clinical relevance of simplified monitoring of nocturnal breathing disorders in heart failure patients
    Gian Domenico Pinna
    Department of Biomedical Engineering and Cardiology, Salvatore Maugeri Foundation IRCCS, Scientific Institute of Montescano, Montescano, PV 27040, Italy
    Eur J Heart Fail 11:264-72. 2009
    ..We aimed to assess the pathophysiological and clinical relevance of a simplified method for monitoring of PB suitable to be self-managed by the patient at home...
  5. ncbi Periodic breathing and state instability during supine laboratory recordings in chronic heart failure patients
    Gian Domenico Pinna
    Department of Biomedical Engineering, S Maugeri Foundation, Montescano, Italy
    Conf Proc IEEE Eng Med Biol Soc 2008:5398-401. 2008
    ..These results suggest that in these patients chemical instability secondary to the impaired hemodynamics coexists and interacts with state instability...
  6. ncbi Association between hemodynamic impairment and Cheyne-Stokes respiration and periodic breathing in chronic stable congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy
    A Mortara
    Division of Cardiology, Centro Medico di Montescano, S Maugeri Foundation, IRCCS, Pavia, Italy
    Am J Cardiol 84:900-4. 1999
    ..001). In conclusion, abnormalities of breathing activity during daytime are significantly associated with a prolonged circulation time and a more severe impairment of systolic and diastolic LV indexes...
  7. ncbi Assessing baroreflex sensitivity in post-myocardial infarction patients: comparison of spectral and phenylephrine techniques
    R Maestri
    Department of Biomedical Engineering, Institute of Care and Scientific Research, Rehabilitation Institute of Montescano, Pavia, Italy
    J Am Coll Cardiol 31:344-51. 1998
    ....
  8. ncbi Echo-Doppler mitral flow monitoring: an operative tool to evaluate day-to-day tolerance to and effectiveness of beta-adrenergic blocking agent therapy in patients with chronic heart failure
    S Capomolla
    Fondazione Salvatore Maugeri, Istituto di Ricovero e Cura a Carattere Scientifico, Istituto Scientifico di Montescano, Pavia, Italy
    J Am Coll Cardiol 38:1675-84. 2001
    ....
  9. ncbi Nonselective beta-adrenergic blocking agent, carvedilol, improves arterial baroflex gain and heart rate variability in patients with stable chronic heart failure
    A Mortara
    Department of Cardiology, Centro Medico di Montescano, S Maugeri Foundation, IRCCS, Pavia, Italy
    J Am Coll Cardiol 36:1612-8. 2000
    ..The purpose of this study was to investigate in a case-controlled study whether carvedilol increased baroreflex sensitivity and heart rate variability (HRV)...
  10. ncbi Cardiorespiratory interactions during periodic breathing in awake chronic heart failure patients
    G D Pinna
    Department of Biomedical Engineering, S Maugeri Foundation, Institute of Care and Scientific Research, Rehabilitation Institute of Montescano, I 27040 Montescano, Italy
    Am J Physiol Heart Circ Physiol 278:H932-41. 2000
    ..The timing relationship between ITV and blood pressure signals excludes the possibility that PB represents the effect of a central vasomotor rhythm...
  11. ncbi Periodic breathing in heart failure patients: testing the hypothesis of instability of the chemoreflex loop
    G D Pinna
    Department of Biomedical Engineering, Fondazione S Maugeri, Clinica del Lavoro e della Riabilitazione, IRCCS, Istituto Scientifico di Montescano, 27040 Montescano PV, Italy
    J Appl Physiol 89:2147-57. 2000
    ....
  12. ncbi The development of hyperventilation in patients with chronic heart failure and Cheyne-Strokes respiration: a possible role of chronic hypoxia
    F Fanfulla
    Respiratory Function Laboratory, IRCCS, S Maugeri Foundation, Montescano Medical Center, Pavia, Italy
    Chest 114:1083-90. 1998
    ..To analyze the relationship between daytime respiratory and cardiac function in patients with compensated chronic heart failure (CHF) with and without periodic breathing (PB) or Cheyne-Stokes respiration (CSR)...
  13. ncbi Noninvasive measurement of blood pressure variability: accuracy of the Finometer monitor and comparison with the Finapres device
    R Maestri
    Department of Biomedical Engineering, S Maugeri Foundation, IRCCS, Scientific Institute of Montescano, 27040 Montescano, PV, Italy
    Physiol Meas 26:1125-36. 2005
    ....
  14. ncbi Effects of record length selection on the accuracy of spectral estimates of heart rate variability: a simulation study
    G D Pinna
    Department of Biomedical Engineering, Salvatore Maugeri Foundation, IRCCS Medical Centre of Rehabilitation, Montescano PV, Italy
    IEEE Trans Biomed Eng 43:754-7. 1996
    ..In the final part of the paper a procedure for the computation of approximate upper bounds of the relative absolute error of spectral measures at each record length, based on the knowledge of the NB and NV, is presented...
  15. ncbi Reproducibility of the six-minute walking test in chronic heart failure patients
    G D Pinna
    Department of Biomedical Engineering, S Maugeri Foundation, Institute of Care and Scientific Research, Medical Center of Montescano PV, Italy
    Stat Med 19:3087-94. 2000
    ..When follow-up studies > or = 3 months are performed, unpredictable changes in individual walking performance due to spontaneous clinical evolution are to be expected. Their clinical significance, however, is not known...
  16. ncbi Effect of paced breathing on ventilatory and cardiovascular variability parameters during short-term investigations of autonomic function
    G D Pinna
    Department of Biomedical Engineering, Fondazione S Maugeri, IRCCS, Istituto Scientifico di Montescano, 27040 Montescano, Pavia, Italy
    Am J Physiol Heart Circ Physiol 290:H424-33. 2006
    ..These findings support the notion that PB does not alter cardiovascular autonomic regulation compared with spontaneous breathing...
  17. ncbi Reliability of transfer function estimates in cardiovascular variability analysis
    G D Pinna
    Istituto Scientifico di Montescano, Italy
    Med Biol Eng Comput 39:338-47. 2001
    ..5, much greater values can be necessary when accurate point estimates are needed. Theoretical expressions for the computation of confidence intervals of the TF are adequate for practical purposes...
  18. ncbi POLYAN: a computer program for polyparametric analysis of cardio-respiratory variability signals
    R Maestri
    Department of Biomedical Engineering, S Maugeri Foundation, Rehabilitation Institute of Montescano, Pavia, Italy
    Comput Methods Programs Biomed 56:37-48. 1998
    ..Establishing a common analysis framework, POLYAN has made sharing new findings and co-operating in research work much easier...
  19. ncbi Six-minute walking performance in patients with moderate-to-severe heart failure; is it a useful indicator in clinical practice?
    C Opasich
    Cardiology Division, Medical Center of Pavia, S Maugeri Foundation, Institute of Care and Scientific Research, Pavia, Italy
    Eur Heart J 22:488-96. 2001
    ....
  20. ncbi Beta-blockade therapy in chronic heart failure: diastolic function and mitral regurgitation improvement by carvedilol
    S Capomolla
    Salvatore Maugeri Foundation, Institute of Medical Care and Research, Pavia, Italy
    Am Heart J 139:596-608. 2000
    ....
  21. ncbi Chronic infusion of dobutamine and nitroprusside in patients with end-stage heart failure awaiting heart transplantation: safety and clinical outcome
    S Capomolla
    Fondazione S Maugeri, Clinica del Lavoro e della Riabilitazione, IRCCS Istituto Scientifico di Montescano, Pavia, Italy
    Eur J Heart Fail 3:601-10. 2001
    ..No data comparing the use and efficacy of chronic intravenous inotropic and vasodilator therapy in patients with advanced heart failure are available...
  22. ncbi Nutritional status and airflow obstruction: two independent contributors to CO diffusing capacity impairment in COPD
    S Baldi
    Divisione di Pneumologia, Fondazione Salvatore Maugeri, Clinica del Lavoro e della Riabilitazione, I R C C S, Istituto Scientifico di Montescano, Pavia, Italy
    Monaldi Arch Chest Dis 63:13-6. 2005
    ....
  23. ncbi Baroreflex sensitivity and heart rate variability in the identification of patients at risk for life-threatening arrhythmias: implications for clinical trials
    M T La Rovere
    Centro Medico di Montescano, Fondazione Salvatore Maugeri IRCCS, Pavia, Italy
    Circulation 103:2072-7. 2001
    ....
  24. ncbi Reliability of heart rate variability measurements in patients with a history of myocardial infarction
    Roberto Maestri
    Department of Cardiology and Biomedical Engineering, S Maugeri Foundation IRCCS, Scientific Institute of Montescano, 27040 Montescano PV, Italy
    Clin Sci (Lond) 118:195-201. 2010
    ....
  25. ncbi Baroreflex sensitivity: measurement and clinical implications
    Maria Teresa La Rovere
    Department of Cardiology, S Maugeri Foundation IRCCS, Scientific Institute of Mentescano, Montescano PV, Italy
    Ann Noninvasive Electrocardiol 13:191-207. 2008
    ..Most relevant clinical applications of BRS measurement are finally reviewed with particular reference to patients with myocardial infarction and heart failure...
  26. ncbi Prognostic implications of baroreflex sensitivity in heart failure patients in the beta-blocking era
    Maria Teresa La Rovere
    Divisione di Cardiologia, e Bioingegneria, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Montescano, Italy
    J Am Coll Cardiol 53:193-9. 2009
    ..This study investigated the clinical correlates and prognostic value of depressed baroreceptor-heart rate reflex sensitivity (BRS) among patients with heart failure (HF), with and without beta-blockade...
  27. ncbi An elderly-centered, personalized, physiotherapy program early after cardiac surgery
    Cristina Opasich
    Salvatore Maugeri Foundation, IRCCS, Department of Cardiology, Scientific Institute of Pavia, Pavia, Italy
    Eur J Cardiovasc Prev Rehabil 17:582-7. 2010
    ..Early post-surgery in-hospital rehabilitation in elderly patients should be aimed at accelerating the recovery of the highest level of functional autonomy and reducing the hospital stay...
  28. ncbi C-reactive protein correlates with tissue oxygen availability in patients with stable COPD
    Simonetta Baldi
    Department of Pneumology and Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation IRCCS, Pavia, Italy
    Int J Chron Obstruct Pulmon Dis 3:745-51. 2008
    ....
  29. ncbi Fluctuations of the fractal dimension of the electroencephalogram during periodic breathing in heart failure patients
    Roberto Maestri
    Department of Biomedical Engineering, S Maugeri Foundation, IRCCS, Scientific Institute of Montescano, 27040, Montescano, PV, Italy
    J Comput Neurosci 28:557-65. 2010
    ..Other mechanisms, particularly chemical instability in the respiratory control system, are likely to play a role in the genesis of PB...
  30. ncbi Day-by-day variability of spontaneous baroreflex sensitivity measurements: implications for their reliability in clinical and research applications
    Roberto Maestri
    Department of Cardiology and Biomedical Engineering, S Maugeri Foundation IRCCS, Scientific Institute of Montescano, Montescano, Pavia, Italy
    J Hypertens 27:806-12. 2009
    ..To assess day-by-day variability of spontaneous baroreflex sensitivity (BRS) measurements, providing implications for their reliability in clinical and research studies...
  31. ncbi Fat-free mass change after nutritional rehabilitation in weight losing COPD: role of insulin, C-reactive protein and tissue hypoxia
    Simonetta Baldi
    Department of Pneumology and Biomedical Engineering, Scientific Institute of Montescano, Salvatore Maugeri Foundation I R C C S Pavia, Italy
    Int J Chron Obstruct Pulmon Dis 5:29-39. 2010
    ..To date, the role of essential amino acid supplementation (EAAs) in FFM repletion has not been fully acknowledged. A pilot study was undertaken in patients attending pulmonary rehabilitation...
  32. ncbi Assessing nonlinear properties of heart rate variability from short-term recordings: are these measurements reliable?
    Roberto Maestri
    Dipartimento di Bioingegneria, Fondazione S Maugeri, IRCCS, 27040 Montescano, Italy
    Physiol Meas 28:1067-77. 2007
    ..Compared to classical linear indices, nonlinear HRV parameters seem more suitable for individual test-retest evaluations but, due to a reduced ICC, they need increased sample size in comparative studies involving two groups of subjects...
  33. ncbi Clinical relevance of short-term day-time breathing disorders in chronic heart failure patients
    Maria Teresa La Rovere
    Divisione di Cardiologia, Pneumologia e Bioingegneria, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Montescano, 27040 Montescano, Pavia, Italy
    Eur J Heart Fail 9:949-54. 2007
    ..Periodic Breathing (PB, waxing and waning of tidal volume in which hyperventilation alternates with periods of apnoea or hypopnoea), is common during sleep and wakefulness in patients with Heart Failure (HF) and may increase mortality...
  34. ncbi Measuring baroreflex sensitivity from the gain function between arterial pressure and heart period
    Gian Domenico Pinna
    Fondazione S Maugeri, Clinica del Lavoro e della Riabilitazione, IRCCS Istituto Scientifico di Montescano, 27040 Montescano, PV, Italy
    Clin Sci (Lond) 103:81-8. 2002
    ..Compared with Phe-BRS, WBA-BRS tends to give negatively biased results. The correlation and the magnitude of the limits of agreement between the two methods are similar to those observed previously using coherence-based spectral methods...
  35. ncbi Distance walked in the 6-minute test soon after cardiac surgery: toward an efficient use in the individual patient
    Cristina Opasich
    IRCCS Salvatore Maugeri Foundation, Cardiology Department, Via Ferrata 8, I 27100 Pavia, Italy
    Chest 126:1796-801. 2004
    ....
  36. ncbi Applicability and clinical relevance of the transfer function method in the assessment of baroreflex sensitivity in heart failure patients
    Gian Domenico Pinna
    Department of Cardiology and Biomedical Engineering, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Montescano, Montescano, PV, Italy
    J Am Coll Cardiol 46:1314-21. 2005
    ..We sought to assess applicability, clinical correlates, and prognostic value of the transfer function method for measuring baroreflex sensitivity (TF-BRS)...
  37. ncbi [Domiciliary telemonitoring of vital and cardiorespiratory signs of the HHH project]
    Gian Domenico Pinna
    IRCCS Fondazione Salvatore Maugeri, Istituto Scientifico di Montescano
    Monaldi Arch Chest Dis 64:145-7. 2005
  38. ncbi Clinical correlates of non-linear indices of heart rate variability in chronic heart failure patients
    Roberto Maestri
    Dipartimento di Bioingegneria, Fondazione S Maugeri, IRCCS, Montescano and Telese, Italy
    Biomed Tech (Berl) 51:220-3. 2006
    ..This indicates that further studies should be designed to investigate the physiopathological mechanisms involved in such links...
  39. ncbi Home telemonitoring of vital signs and cardiorespiratory signals in heart failure patients: system architecture and feasibility of the HHH model
    Gian Domenico Pinna
    Department of Biomedical Engineering, Salvatore Maugeri Foundation IRCCS, Scientific Institute of Montescano, Montescano PV, Italy
    Int J Cardiol 120:371-9. 2007
    ..We developed an integrated HT system for monitoring of both vital signs and respiration. All measurements were patient-managed. This paper describes the architecture of this system, and assesses its feasibility...
  40. ncbi Nonlinear indices of heart rate variability in chronic heart failure patients: redundancy and comparative clinical value
    Roberto Maestri
    Dipartimento di Bioingegneria, Fondazione S Maugeri, IRCCS, Montescano and Telese, Italy
    J Cardiovasc Electrophysiol 18:425-33. 2007
    ..We aimed to assess the mutual interrelationships and to compare the prognostic value of a comprehensive set of nonlinear indices of heart rate variability (HRV) in a population of chronic heart failure (CHF) patients...
  41. ncbi Heart rate variability measures: a fresh look at reliability
    Gian Domenico Pinna
    Department of Cardiology and Biomedical Engineering, S Maugeri Foundation IRCCS, Scientific Institute of Montescano, Montescano PV, Italy
    Clin Sci (Lond) 113:131-40. 2007
    ..Overall, paced breathing improves reliability...
  42. ncbi Short-term heart rate variability strongly predicts sudden cardiac death in chronic heart failure patients
    Maria Teresa La Rovere
    Divisione di Cardiologia e Bioingegneria, Fondazione Salvatore Maugeri, IRCCS Istituto Scientifico di Montescano, Pavia, Italy
    Circulation 107:565-70. 2003
    ....
  43. ncbi Clinical value of baroreflex sensitivity
    M T La Rovere
    Department of Cardiology, Fondazione Salvatore Maugeri, IRCCS, Istituto Scientifico di Montescano, Montescano, Pavia, Italy
    Neth Heart J 21:61-3. 2013
    ..The evaluation of BRS has been shown to provide clinical and prognostic information in a variety of cardiovascular diseases, including myocardial infarction and heart failure that are reviewed in the present article...
  44. ncbi Left atrial function: bridge to central and hormonal determinants of exercise capacity in patients with chronic heart failure
    M Ceresa
    Istituto Scientifico di Montescano, Fondazione Salvatore Maugeri, IRCCS, Italy, Pavia
    Monaldi Arch Chest Dis 58:87-94. 2002
    ..We performed this study to investigate the relationship between exercise capacity and diastolic and systolic left atrium function in patients with chronic heart failure...
  45. ncbi New criteria for estimating baroreflex sensitivity using the transfer function method
    G D Pinna
    Department of Biomedical Engineering, Fondazione S Maugeri, Clinica del Lavoro e della Riabilitazione, IRCCS, Scientific Institute of Montescano, PV, Italy
    Med Biol Eng Comput 40:79-84. 2002
    ....
  46. ncbi RESP-24: a computer program for the investigation of 24-h breathing abnormalities in heart failure patients
    R Maestri
    Department of Biomedical Engineering, Fondazione S Maugeri, Clinica del Lavoro e della Riabilitazione, IRCCS, Istituto Scientifico di Montescano, Montescano, 27040 Pavia, Italy
    Comput Methods Programs Biomed 68:147-59. 2002
    ..We conclude that measurements provided automatically by the RESP-24 software are suitable for screening purposes and clinical trials, although a preventive check of signal quality should be recommended...
  47. ncbi Relationship between ventilatory oscillations and fractal dimension of the EEG during daytime periodic breathing in heart failure patients
    Roberto Maestri
    Department of Biomedical Engineering, S Maugeri Foundation, IRCCS, Scientific Institute of Montescano, Italy
    Conf Proc IEEE Eng Med Biol Soc 2009:6276-9. 2009
    ..We have also demonstrated that such oscillations can be detected very effectively by a technique based on nonlinear methods...
  48. ncbi Limitations of the computerized laryngeal analyzer (CLA) in the assessment of the swallowing mechanism
    R Maestri
    Department of Biomedical Engineering, S Maugeri Foundation, Institute of Care and Scientific Research, Rehabilitation Medical Center of Montescano, PV, Montescano, Italy
    Med Eng Phys 22:223-7. 2000
    ....