Research Topics
Genomes and GenesSpecies | Antonio CiaramellaSummaryAffiliation: Fondazione Santa Lucia Country: Italy Publications
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Detail Information
Publications
Amyloid beta peptide promotes differentiation of pro-inflammatory human myeloid dendritic cellsAntonio Ciaramella
Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, 00179 Rome, Italy
Neurobiol Aging 30:210-21. 2009..These results demonstrate that A beta 42 can modulate the immune system by inducing pro-inflammatory DC differentiation, thus gaining new insights into AD pathogenesis and immune-based therapeutic intervention...
Effect of age on surface molecules and cytokine expression in human dendritic cellsAntonio Ciaramella
Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, 00179 Rome, Italy
Cell Immunol 269:82-9. 2011..Altogether, the present results point to additional molecules whose role might be relevant in immunosenescence of human DCs, confirming that these cells undergo functional changes during aging...
Increased pro-inflammatory response by dendritic cells from patients with Alzheimer's diseaseAntonio Ciaramella
Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
J Alzheimers Dis 19:559-72. 2010....
Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairmentPaola Bossù
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardeatina 306, 00179 Rome, Italy
Brain Behav Immun 22:487-92. 2008....
Increased expression of Interleukin-18 receptor in blood cells of subjects with Mild Cognitive Impairment and Alzheimer's diseaseFrancesca Salani
Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, I 00179 Rome, Italy
Cytokine 61:360-3. 2013....
Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophreniaIlaria Palladino
Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy
J Neuroinflammation 9:206. 2012....
Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levelsFrancesco Angelucci
Department of Clinical and Behavioural Neurology, 00179, Rome, Italy
Curr Alzheimer Res 7:15-20. 2010..Other studies are necessary to establish a direct link between BDNF peripheral levels and AD longitudinal course, as well as the role of other factors, such as blood cell activation, in determining these events...
Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's diseasePaola Bossù
IRCCS Santa Lucia Foundation, Rome, Italy
J Neurol Neurosurg Psychiatry 78:807-11. 2007..The aim of this study was to investigate the impact of two polymorphisms of the human IL-18 gene promoter at positions -607 (C/A) and -137 (G/C) on both susceptibility to and progression of AD...
IL-18 cDNA vaccination protects mice from spontaneous lupus-like autoimmune diseasePaola Bossù
Laboratory of Clinical and Behavioral Neurology, Istituto di Ricovero e Cura a Carattere Scientifico Fondazione Santa Lucia, 00179 Rome, Italy
Proc Natl Acad Sci U S A 100:14181-6. 2003..These studies support the concept that IL-18 plays a major role in the pathogenesis of the autoimmune syndrome of lpr mice and that a reduction in IL-18 activity could be a therapeutic strategy in autoimmune diseases...
