P Bossu

Summary

Affiliation: Fondazione Santa Lucia
Country: Italy

Publications

  1. ncbi request reprint Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment
    Paola Bossù
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardeatina 306, 00179 Rome, Italy
    Brain Behav Immun 22:487-92. 2008
  2. pmc Blood dendritic cell frequency declines in idiopathic Parkinson's disease and is associated with motor symptom severity
    Antonio Ciaramella
    Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Rome, Italy
    PLoS ONE 8:e65352. 2013
  3. pmc Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia
    Ilaria Palladino
    Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy
    J Neuroinflammation 9:206. 2012
  4. pmc A single intraperitoneal injection of endotoxin in rats induces long-lasting modifications in behavior and brain protein levels of TNF-α and IL-18
    Paola Bossù
    Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Via Ardeatina 30600179, Rome, Italy
    J Neuroinflammation 9:101. 2012
  5. pmc High serum levels of transforming growth factor β1 are associated with increased cortical thickness in cingulate and right frontal areas in healthy subjects
    Fabrizio Piras
    Fondazione IRCCS Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy
    J Neuroinflammation 9:42. 2012
  6. pmc Mucosal delivery of anti-inflammatory IL-1Ra by sporulating recombinant bacteria
    Stefano Porzio
    Inpharzam Ricerche SA, Zambon Group, Via Ai Soi, CH 6807 Taverne, Switzerland
    BMC Biotechnol 4:27. 2004
  7. pmc Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease
    Paola Bossù
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Neurol Neurosurg Psychiatry 78:807-11. 2007
  8. ncbi request reprint Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke
    Paola Bossù
    Department of Clinical and Behavioral Neurology, Santa Lucia Foundation, Rome, Italy
    Curr Neurovasc Res 6:163-70. 2009
  9. pmc Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients
    Paola Bossù
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Neuroinflammation 8:65. 2011
  10. ncbi request reprint Interleukin-18, from neuroinflammation to Alzheimer's disease
    P Bossu
    IRCCS Fondazione Santa Lucia, Department of Clinical and Behavioral Neurology, Experimental Neuro psychobiology Lab Via Ardeatina, 306, I 00179 Roma, Italy
    Curr Pharm Des 16:4213-24. 2010

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Interleukin-18 produced by peripheral blood cells is increased in Alzheimer's disease and correlates with cognitive impairment
    Paola Bossù
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardeatina 306, 00179 Rome, Italy
    Brain Behav Immun 22:487-92. 2008
    ....
  2. pmc Blood dendritic cell frequency declines in idiopathic Parkinson's disease and is associated with motor symptom severity
    Antonio Ciaramella
    Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Rome, Italy
    PLoS ONE 8:e65352. 2013
    ....
  3. pmc Elevated levels of circulating IL-18BP and perturbed regulation of IL-18 in schizophrenia
    Ilaria Palladino
    Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy
    J Neuroinflammation 9:206. 2012
    ....
  4. pmc A single intraperitoneal injection of endotoxin in rats induces long-lasting modifications in behavior and brain protein levels of TNF-α and IL-18
    Paola Bossù
    Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Via Ardeatina 30600179, Rome, Italy
    J Neuroinflammation 9:101. 2012
    ..However, the potential contribution of these cytokines to behavioral impairment in the long-term period has not been fully investigated...
  5. pmc High serum levels of transforming growth factor β1 are associated with increased cortical thickness in cingulate and right frontal areas in healthy subjects
    Fabrizio Piras
    Fondazione IRCCS Santa Lucia, Via Ardeatina 306, 00179 Rome, Italy
    J Neuroinflammation 9:42. 2012
    ..To date, however, its neuroprotective effects in non-disease conditions have not been studied..
  6. pmc Mucosal delivery of anti-inflammatory IL-1Ra by sporulating recombinant bacteria
    Stefano Porzio
    Inpharzam Ricerche SA, Zambon Group, Via Ai Soi, CH 6807 Taverne, Switzerland
    BMC Biotechnol 4:27. 2004
    ..However, the possible systemic effects of mucosally delivered recombinant bacteria have not been investigated...
  7. pmc Interleukin 18 gene polymorphisms predict risk and outcome of Alzheimer's disease
    Paola Bossù
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Neurol Neurosurg Psychiatry 78:807-11. 2007
    ..The aim of this study was to investigate the impact of two polymorphisms of the human IL-18 gene promoter at positions -607 (C/A) and -137 (G/C) on both susceptibility to and progression of AD...
  8. ncbi request reprint Disease outcome, alexithymia and depression are differently associated with serum IL-18 levels in acute stroke
    Paola Bossù
    Department of Clinical and Behavioral Neurology, Santa Lucia Foundation, Rome, Italy
    Curr Neurovasc Res 6:163-70. 2009
    ..These results suggest that IL-18 might be specifically implicated in the pathogenesis of post-stroke alexithymia, ultimately contributing to impaired recovery from stroke...
  9. pmc Loss of function mutations in the progranulin gene are related to pro-inflammatory cytokine dysregulation in frontotemporal lobar degeneration patients
    Paola Bossù
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Neuroinflammation 8:65. 2011
    ..Thus, our findings point to IL-6 as a possible specific mediator and a potential therapeutic target in this monogenic disease, suggesting that an enhanced inflammatory response might be indeed involved in its progression...
  10. ncbi request reprint Interleukin-18, from neuroinflammation to Alzheimer's disease
    P Bossu
    IRCCS Fondazione Santa Lucia, Department of Clinical and Behavioral Neurology, Experimental Neuro psychobiology Lab Via Ardeatina, 306, I 00179 Roma, Italy
    Curr Pharm Des 16:4213-24. 2010
    ....
  11. ncbi request reprint Glutathione S-transferase P1 *C allelic variant increases susceptibility for late-onset Alzheimer disease: association study and relationship with apolipoprotein E epsilon4 allele
    Sergio Bernardini
    Department of Internal Medicine, University of Rome Tor Vergata, Rome, Italy
    Clin Chem 51:944-51. 2005
    ....
  12. doi request reprint Increased pro-inflammatory response by dendritic cells from patients with Alzheimer's disease
    Antonio Ciaramella
    Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 19:559-72. 2010
    ....
  13. ncbi request reprint Glutathione S-transferase P1 and T1 gene polymorphisms predict longitudinal course and age at onset of Alzheimer disease
    Gianfranco Spalletta
    Istituto di Ricovero e Cura a Carattere Scientifico Santa Lucia Foundation, Rome, Italy
    Am J Geriatr Psychiatry 15:879-87. 2007
    ..Therefore, the authors studied the effect of glutathione S-transferase (GST) P1-M1-T1 gene polymorphisms and their interactions with the apolipoprotein E (ApoE) epsilon4 allelic variant on the three-year longitudinal course of AD...
  14. ncbi request reprint Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, 00179, Rome, Italy
    Curr Alzheimer Res 7:15-20. 2010
    ..Other studies are necessary to establish a direct link between BDNF peripheral levels and AD longitudinal course, as well as the role of other factors, such as blood cell activation, in determining these events...
  15. ncbi request reprint Amyloid beta peptide promotes differentiation of pro-inflammatory human myeloid dendritic cells
    Antonio Ciaramella
    Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, 00179 Rome, Italy
    Neurobiol Aging 30:210-21. 2009
    ..These results demonstrate that A beta 42 can modulate the immune system by inducing pro-inflammatory DC differentiation, thus gaining new insights into AD pathogenesis and immune-based therapeutic intervention...
  16. doi request reprint Increased concentrations of nerve growth factor and brain-derived neurotrophic factor in the rat cerebellum after exposure to environmental enrichment
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 304, Rome, Italy
    Cerebellum 8:499-506. 2009
    ....
  17. doi request reprint Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 17:203-11. 2009
    ....
  18. doi request reprint Combined volumetry and DTI in subcortical structures of mild cognitive impairment and Alzheimer's disease patients
    Andrea Cherubini
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 19:1273-82. 2010
    ..Combining different MRI modalities can allow identifying sensitive indicators of the subtle pathogenic mechanisms that occur in subcortical areas of AD patients...
  19. doi request reprint A multimodal MRI investigation of the subventricular zone in mild cognitive impairment and Alzheimer's disease patients
    Andrea Cherubini
    Department of Clinical and Behavioral Neurology, Santa Lucia Foundation, Rome, Italy
    Neurosci Lett 469:214-8. 2010
    ..Multimodal MRI, being able to highlight structural changes of microscopic tissue in humans in vivo, could represent a precious tool to complement histological studies of neurogenesis...
  20. ncbi request reprint The etiology of poststroke depression: a review of the literature and a new hypothesis involving inflammatory cytokines
    G Spalletta
    Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    Mol Psychiatry 11:984-91. 2006
    ..Future investigations may explore this hypothesis through more extensive studies on the role of proinflammatory cytokines, such as IL-1beta, TNF-alpha or even IL-18, in patients with poststroke depression...
  21. doi request reprint BDNF Val66Met polymorphism is associated with aggressive behavior in schizophrenia
    G Spalletta
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Via Ardetina, 306, 00179 Rome, Italy
    Eur Psychiatry 25:311-3. 2010
    ..Our results showed that increased number of BDNF Met alleles was associated with increased aggressive behaviour...
  22. ncbi request reprint Depression and cancer: an unexplored and unresolved emergent issue in elderly patients
    Ilaria Spoletini
    IRCCS Santa Lucia Foundation, Rome, Italy
    Crit Rev Oncol Hematol 65:143-55. 2008
    ..In the near future, we need to develop validated mood disorder diagnoses and verify antidepressant treatment efficacy for elderly cancer patients with depression in order to improve their clinical outcome and quality of life...