Research Topics
Genomes and Genes | Francesco AngelucciSummaryAffiliation: Fondazione Santa Lucia Country: Italy Publications
| Collaborators
|
Detail Information
Publications
Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levelsFrancesco Angelucci
Department of Clinical and Behavioural Neurology, 00179, Rome, Italy
Curr Alzheimer Res 7:15-20. 2010..Other studies are necessary to establish a direct link between BDNF peripheral levels and AD longitudinal course, as well as the role of other factors, such as blood cell activation, in determining these events...
BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degenerationFrancesco Angelucci
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, 00179 Rome, Italy
Neurochem Int 59:1-4. 2011..Even if the cause for the relationship between BDNF in serum and this brain region is unknown, these data may help to elucidate the significance of peripheral and central BDNF changes in brain pathological conditions...- Paroxetine rapidly modulates the expression of brain-derived neurotrophic factor mRNA and protein in a human glioblastoma-astrocytoma cell lineFrancesco Angelucci
IRCCS Santa Lucia Foundation, Rome, Italy
Pharmacology 87:5-10. 2011..These data may contribute to explain the action of paroxetine on cells of nonneuronal origin... - Ecstasy (MDMA)-addicted subjects show increased serum levels of brain-derived neurotrophic factor, independently from a rise of drug-induced psychotic symptomsFrancesco Angelucci
Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy
Addict Biol 15:365-7. 2010..We found that BDNF serum levels were significantly increased in both groups of 'ecstasy-addicted' as compared with 'healthy subjects', supporting the hypothesis that BDNF is involved in MDMA action... - Facioscapulohumeral muscular dystrophy: do neurotrophins play a role?Francesco Angelucci
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, 00179, Rome, Italy
Muscle Nerve 41:120-7. 2010..In this article we put together the experimental evidence that indicates neurotrophins might be involved in the pathophysiology of FSHD and discuss the possible implications of this assumption... - Increased concentrations of nerve growth factor and brain-derived neurotrophic factor in the rat cerebellum after exposure to environmental enrichmentFrancesco Angelucci
Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 304, Rome, Italy
Cerebellum 8:499-506. 2009.... - Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal studyFrancesco Angelucci
IRCCS Santa Lucia Foundation, Rome, Italy
J Alzheimers Dis 17:203-11. 2009.... - Reduced serum concentrations of nerve growth factor, but not brain-derived neurotrophic factor, in chronic cannabis abusersFrancesco Angelucci
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy
Eur Neuropsychopharmacol 18:882-7. 2008..These data also suggest that chronic cannabis consumption may be a risk factor for developing psychosis among drug users... - Differential effects of olanzapine, haloperidol and risperidone on calcitonin gene-related peptide in the rat brainFrancesco Angelucci
Karolinska Institutet, Clinical Neuroscience, Psychiatry M56, Karolinska University Hospital Huddinge, SE 14186 Stockholm, Sweden
Neuropeptides 42:535-41. 2008..The differential effects on CGRP could reflect a different profile of side effects and further suggest that CGRP is involved in CNS functions related to psychiatric disorders... - NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamusFrancesca Gelfo
Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
CNS Neurosci Ther 18:487-92. 2012.... - Music exposure differentially alters the levels of brain-derived neurotrophic factor and nerve growth factor in the mouse hypothalamusFrancesco Angelucci
Fondazione Don C Gnocchi, Rome, Italy
Neurosci Lett 429:152-5. 2007..Our results demonstrate that exposure to music in mice can influence neurotrophin production in the hypothalamus. Our findings also suggest that physiological effects of music might be in part mediated by modulation of neurotrophins... - Neuroprotective effect of neuropeptide Y against β-amyloid 25-35 toxicity in SH-SY5Y neuroblastoma cells is associated with increased neurotrophin productionNicoletta Croce
IRCCS Santa Lucia Foundation, Rome, Italy
Neurodegener Dis 8:300-9. 2011..Interestingly, these effects are also influenced by neurotrophins, critical molecules for the function and survival of neurons that degenerate in AD... - Functional recovery after cerebellar damage is related to GAP-43-mediated reactive responses of pre-cerebellar and deep cerebellar nucleiLorena Burello
Fondazione Santa Lucia, Via Ardeatina 306, 00179, Rome, Italy
Exp Neurol 233:273-82. 2012.... - Chronic amphetamine treatment reduces NGF and BDNF in the rat brainFrancesco Angelucci
Karolinska Institutet, Clinical Neuroscience, Psychiatry M56, Karolinska University Hospital Huddinge, SE 14186 Stockholm, Sweden
Eur Neuropsychopharmacol 17:756-62. 2007..This reduction may account for some of the effects of amphetamine in the CNS neurons and provides evidences for the role of neurotrophins in schizophrenia... - Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brainFrancesco Angelucci
Karolinska Institutet, Neurotec Department, Karolinska University Hospital-Huddinge, Psychiatry, SE-14186 Stockholm, Sweden
Eur Neuropsychopharmacol 15:311-7. 2005..Although the significance of these findings is not clear, a heuristic hypothesis is that olanzapine's clinical effects and a favorable side effect profile are in part mediated by neurotrophins... - In vivo effects of mitoxantrone on the production of pro- and anti-inflammatory cytokines by peripheral blood mononuclear cells of secondary progressive multiple sclerosis patientsFrancesco Angelucci
Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy
Neuroimmunomodulation 13:76-81. 2006.... - Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophreniaFrancesco Angelucci
Institute of Neurology, Catholic University, Largo Gemelli 8, I 00168, Rome, Italy
Prog Brain Res 146:151-65. 2004..Overall, these studies indicate that alteration of brain level of NGF and BDNF could constitute part of the biochemical alterations induced by antipsychotic drugs... - Enriched environment improves motor function and increases neurotrophins in hemicerebellar lesioned ratsFrancesca Gelfo
IRCCS Santa Lucia, Rome, Italy
Neurorehabil Neural Repair 25:243-52. 2011..The beneficial effects of EE in the presence of brain damage have been partially attributed to upregulation of neurotrophins, proteins involved in neuronal survival and in activity-dependent plasticity... 
A single intraperitoneal injection of endotoxin in rats induces long-lasting modifications in behavior and brain protein levels of TNF-α and IL-18Paola Bossù
Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Via Ardeatina 30600179, Rome, Italy
J Neuroinflammation 9:101. 2012..However, the potential contribution of these cytokines to behavioral impairment in the long-term period has not been fully investigated...- Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role?Aleksander A Mathe
Karolinska Institutet, Department of Clinical Neuroscience, Karolinska University Hospital Huddinge, Psychiatry M56, E 141 86 Stockholm, Sweden
Physiol Behav 92:226-31. 2007..Consequently, if these data are confirmed, the ethical and medical question that will be asked is whether it is permissible and advisable to consider prophylactically treating persons at risk... - Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factorFrancesco Angelucci
Institute of Neurology and Institute of Psychiatry, Catholic University, Rome, Italy
J Psychopharmacol 21:820-5. 2007..In view of the neurotrophin hypothesis of schizophrenia the data also suggest that reduced level of neurotrophins may increase the risk of developing psychosis in drug users... - Intraperitoneal injection of neuropeptide Y (NPY) alters neurotrophin rat hypothalamic levels: Implications for NPY potential role in stress-related disordersFrancesca Gelfo
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, 00179 Rome, Italy
Peptides 32:1320-3. 2011.... - Effects of psychostimulants on neurotrophins implications for psychostimulant-induced neurotoxicityFrancesco Angelucci
Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
Int Rev Neurobiol 88:1-24. 2009.... - Brain and serum levels of nerve growth factor in a rat model of Alzheimer's diseaseFrancesca Gelfo
IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Rome, Italy
J Alzheimers Dis 25:213-7. 2011..When compared to human data, these findings further elucidate the role of NGF in early and late AD disease stages... - Investigating the neurobiology of music: brain-derived neurotrophic factor modulation in the hippocampus of young adult miceFrancesco Angelucci
Fondazione Don C Gnocchi, Catholic University, Largo Gemelli, Rome, Italy
Behav Pharmacol 18:491-6. 2007..Our results demonstrate that exposure to music can modulate the activity of the hippocampus by influencing BDNF production. Our findings also suggest that music exposure might be of help in several central nervous system pathologies... - Exposure to an enriched environment accelerates recovery from cerebellar lesionFrancesca Foti
IRCCS Santa Lucia Foundation, Rome, Italy
Cerebellum 10:104-19. 2011..The plastic changes induced by enhanced mental and physical activity seem to provide the development of compensatory responses against the disrupting motor and cognitive consequences of the cerebellar damage... - Neuropeptide Y protects rat cortical neurons against β-amyloid toxicity and re-establishes synthesis and release of nerve growth factorNicoletta Croce
IRCCS Santa Lucia Foundation, Rome, Italy
ACS Chem Neurosci 3:312-8. 2012..These data also suggest that NPY may influence the synthesis and the release of NGF by cortical neurons... - Chronic ketamine use increases serum levels of brain-derived neurotrophic factorValerio Ricci
Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
Psychopharmacology (Berl) 215:143-8. 2011..In addition, neurotrophins, particularly BDNF, may regulate LTP in the hippocampus and influence synaptic plasticity... - Brain-derived neurotrophic factor and electroconvulsive therapy in a schizophrenic patient with treatment-resistant paranoid-hallucinatory symptomsGiovanni Martinotti
Institute of Psychiatry, Catholic University, Rome, Italy
J ECT 27:e44-6. 2011..Moreover, ECT therapeutic effect is associated with an increase in BDNF serum levels. Further studies are needed to characterize the relationship between BDNF and ECT in schizophrenic patients... - NPY modulates miR-30a-5p and BDNF in opposite direction in an in vitro model of Alzheimer disease: a possible role in neuroprotection?Nicoletta Croce
Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
Mol Cell Biochem 376:189-95. 2013.... - Effects of olanzapine on extracellular concentrations and tissue content of neurotensin in rat brain regionsSusanne H M Gruber
Institution of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Huddinge University Hospital, Sweden
Eur Neuropsychopharmacol 21:918-27. 2011.... - pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activityGiovanni Frisullo
Institute of Neurology, Department of Neuroscience, Catholic University, Rome, Italy
J Neurosci Res 84:1027-36. 2006..The evaluation of T-bet and pSTAT1 expression in peripheral blood CD4+, CD8+ T cells and monocytes could be used as a marker of disease activity in relapsing-remitting MS... - Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depressionFrancesco Angelucci
Karolinska Institutet, Department of Physiology and Pharmacology, Division of Pharmacology, Stockholm, Sweden
Int J Neuropsychopharmacol 6:225-31. 2003..Moreover, the changes were different in the two rat strains. Our data support the notion that neurotrophic factors play a role in depression and in the mechanism of the action of lithium...