Francesco Angelucci

Summary

Affiliation: Fondazione Santa Lucia
Country: Italy

Publications

  1. ncbi request reprint BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, 00179 Rome, Italy Electronic address
    Brain Cogn 84:118-22. 2014
  2. ncbi request reprint Enhanced BDNF serum levels in patients with severe pathological gambling
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy Institute of Psychiatry, Catholic University, Rome, Italy
    Addict Biol 18:749-51. 2013
  3. doi request reprint Differential effects of olanzapine, haloperidol and risperidone on calcitonin gene-related peptide in the rat brain
    Francesco Angelucci
    Karolinska Institutet, Clinical Neuroscience, Psychiatry M56, Karolinska University Hospital Huddinge, SE 14186 Stockholm, Sweden
    Neuropeptides 42:535-41. 2008
  4. doi request reprint Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 17:203-11. 2009
  5. ncbi request reprint Increased concentrations of nerve growth factor and brain-derived neurotrophic factor in the rat cerebellum after exposure to environmental enrichment
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 304, Rome, Italy
    Cerebellum 8:499-506. 2009
  6. doi request reprint Facioscapulohumeral muscular dystrophy: do neurotrophins play a role?
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, 00179, Rome, Italy
    Muscle Nerve 41:120-7. 2010
  7. ncbi request reprint Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, 00179, Rome, Italy
    Curr Alzheimer Res 7:15-20. 2010
  8. ncbi request reprint Reduced serum concentrations of nerve growth factor, but not brain-derived neurotrophic factor, in chronic cannabis abusers
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy
    Eur Neuropsychopharmacol 18:882-7. 2008
  9. doi request reprint Paroxetine rapidly modulates the expression of brain-derived neurotrophic factor mRNA and protein in a human glioblastoma-astrocytoma cell line
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Rome, Italy
    Pharmacology 87:5-10. 2011
  10. doi request reprint Ecstasy (MDMA)-addicted subjects show increased serum levels of brain-derived neurotrophic factor, independently from a rise of drug-induced psychotic symptoms
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy
    Addict Biol 15:365-7. 2010

Collaborators

Detail Information

Publications42

  1. ncbi request reprint BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, 00179 Rome, Italy Electronic address
    Brain Cogn 84:118-22. 2014
    ..Thus, these data suggest that BDNF might be involved in pathophysiology of PTSD and consequently therapeutic approaches aimed at restoring BDNF serum levels may be beneficial to this pathology. ..
  2. ncbi request reprint Enhanced BDNF serum levels in patients with severe pathological gambling
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy Institute of Psychiatry, Catholic University, Rome, Italy
    Addict Biol 18:749-51. 2013
    ..Thus, the data demonstrate that patients affected by severe pathological gambling show enhanced BDNF serum levels...
  3. doi request reprint Differential effects of olanzapine, haloperidol and risperidone on calcitonin gene-related peptide in the rat brain
    Francesco Angelucci
    Karolinska Institutet, Clinical Neuroscience, Psychiatry M56, Karolinska University Hospital Huddinge, SE 14186 Stockholm, Sweden
    Neuropeptides 42:535-41. 2008
    ..The differential effects on CGRP could reflect a different profile of side effects and further suggest that CGRP is involved in CNS functions related to psychiatric disorders...
  4. doi request reprint Delusion symptoms and response to antipsychotic treatment are associated with the 5-HT2A receptor polymorphism (102T/C) in Alzheimer's disease: a 3-year follow-up longitudinal study
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Alzheimers Dis 17:203-11. 2009
    ....
  5. ncbi request reprint Increased concentrations of nerve growth factor and brain-derived neurotrophic factor in the rat cerebellum after exposure to environmental enrichment
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 304, Rome, Italy
    Cerebellum 8:499-506. 2009
    ....
  6. doi request reprint Facioscapulohumeral muscular dystrophy: do neurotrophins play a role?
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, 00179, Rome, Italy
    Muscle Nerve 41:120-7. 2010
    ..In this article we put together the experimental evidence that indicates neurotrophins might be involved in the pathophysiology of FSHD and discuss the possible implications of this assumption...
  7. ncbi request reprint Alzheimer's disease (AD) and Mild Cognitive Impairment (MCI) patients are characterized by increased BDNF serum levels
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, 00179, Rome, Italy
    Curr Alzheimer Res 7:15-20. 2010
    ..Other studies are necessary to establish a direct link between BDNF peripheral levels and AD longitudinal course, as well as the role of other factors, such as blood cell activation, in determining these events...
  8. ncbi request reprint Reduced serum concentrations of nerve growth factor, but not brain-derived neurotrophic factor, in chronic cannabis abusers
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy
    Eur Neuropsychopharmacol 18:882-7. 2008
    ..These data also suggest that chronic cannabis consumption may be a risk factor for developing psychosis among drug users...
  9. doi request reprint Paroxetine rapidly modulates the expression of brain-derived neurotrophic factor mRNA and protein in a human glioblastoma-astrocytoma cell line
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Rome, Italy
    Pharmacology 87:5-10. 2011
    ..These data may contribute to explain the action of paroxetine on cells of nonneuronal origin...
  10. doi request reprint Ecstasy (MDMA)-addicted subjects show increased serum levels of brain-derived neurotrophic factor, independently from a rise of drug-induced psychotic symptoms
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, 00179 Rome, Italy
    Addict Biol 15:365-7. 2010
    ..We found that BDNF serum levels were significantly increased in both groups of 'ecstasy-addicted' as compared with 'healthy subjects', supporting the hypothesis that BDNF is involved in MDMA action...
  11. doi request reprint BDNF concentrations are decreased in serum and parietal cortex in immunotoxin 192 IgG-Saporin rat model of cholinergic degeneration
    Francesco Angelucci
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, 00179 Rome, Italy
    Neurochem Int 59:1-4. 2011
    ..Even if the cause for the relationship between BDNF in serum and this brain region is unknown, these data may help to elucidate the significance of peripheral and central BDNF changes in brain pathological conditions...
  12. ncbi request reprint NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamus
    Francesca Gelfo
    Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    CNS Neurosci Ther 18:487-92. 2012
    ....
  13. ncbi request reprint In vivo effects of mitoxantrone on the production of pro- and anti-inflammatory cytokines by peripheral blood mononuclear cells of secondary progressive multiple sclerosis patients
    Francesco Angelucci
    Department of Neuroscience, Institute of Neurology, Catholic University, Rome, Italy
    Neuroimmunomodulation 13:76-81. 2006
    ....
  14. ncbi request reprint NPY modulates miR-30a-5p and BDNF in opposite direction in an in vitro model of Alzheimer disease: a possible role in neuroprotection?
    Nicoletta Croce
    Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    Mol Cell Biochem 376:189-95. 2013
    ....
  15. pmc Neuropeptide Y protects rat cortical neurons against β-amyloid toxicity and re-establishes synthesis and release of nerve growth factor
    Nicoletta Croce
    IRCCS Santa Lucia Foundation, Rome, Italy
    ACS Chem Neurosci 3:312-8. 2012
    ..These data also suggest that NPY may influence the synthesis and the release of NGF by cortical neurons...
  16. ncbi request reprint pSTAT1, pSTAT3, and T-bet expression in peripheral blood mononuclear cells from relapsing-remitting multiple sclerosis patients correlates with disease activity
    Giovanni Frisullo
    Institute of Neurology, Department of Neuroscience, Catholic University, Rome, Italy
    J Neurosci Res 84:1027-36. 2006
    ..The evaluation of T-bet and pSTAT1 expression in peripheral blood CD4+, CD8+ T cells and monocytes could be used as a marker of disease activity in relapsing-remitting MS...
  17. ncbi request reprint Neurotrophic factors in relapsing remitting and secondary progressive multiple sclerosis patients during interferon beta therapy
    Marcella Caggiula
    Institute of Neurology, Catholic University, Largo Gemelli 8, 00168 Rome, Italy
    Clin Immunol 118:77-82. 2006
    ..Instead, in the group of RRMS patients who did not present clinical exacerbation of disease up to the end of the study, we found a significant increase in BDNF production as from 6 months after starting therapy...
  18. ncbi request reprint Music exposure differentially alters the levels of brain-derived neurotrophic factor and nerve growth factor in the mouse hypothalamus
    Francesco Angelucci
    Fondazione Don C Gnocchi, Rome, Italy
    Neurosci Lett 429:152-5. 2007
    ..Our results demonstrate that exposure to music in mice can influence neurotrophin production in the hypothalamus. Our findings also suggest that physiological effects of music might be in part mediated by modulation of neurotrophins...
  19. doi request reprint The stimulation of dendritic cells by amyloid beta 1-42 reduces BDNF production in Alzheimer's disease patients
    Antonio Ciaramella
    Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 306, 00179 Rome, Italy
    Brain Behav Immun 32:29-32. 2013
    ..Thus, possibly due to their Aβ-induced reduction of neurotrophic support to neurons, DCs from AD patients might contribute to brain damage by playing a part in Aβ-dependent neuronal toxicity...
  20. pmc Regulatory T cells fail to suppress CD4T+-bet+ T cells in relapsing multiple sclerosis patients
    Giovanni Frisullo
    Department of Neuroscience, Institute of Neurology, Catholic University, Rome
    Immunology 127:418-28. 2009
    ..Moreover, the inhibitory capacity of CD4+ CD25+ T cells seems to be impaired in relapsing patients under inflammatory conditions, as shown by the high levels of T-bet expression in CD4+ T cells...
  21. doi request reprint Neuroprotective effect of neuropeptide Y against β-amyloid 25-35 toxicity in SH-SY5Y neuroblastoma cells is associated with increased neurotrophin production
    Nicoletta Croce
    IRCCS Santa Lucia Foundation, Rome, Italy
    Neurodegener Dis 8:300-9. 2011
    ..Interestingly, these effects are also influenced by neurotrophins, critical molecules for the function and survival of neurons that degenerate in AD...
  22. ncbi request reprint Functional recovery after cerebellar damage is related to GAP-43-mediated reactive responses of pre-cerebellar and deep cerebellar nuclei
    Lorena Burello
    Fondazione Santa Lucia, Via Ardeatina 306, 00179, Rome, Italy
    Exp Neurol 233:273-82. 2012
    ....
  23. ncbi request reprint Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain
    Francesco Angelucci
    Karolinska Institutet, Neurotec Department, Karolinska University Hospital Huddinge, Psychiatry, SE 14186 Stockholm, Sweden
    Eur Neuropsychopharmacol 15:311-7. 2005
    ..Although the significance of these findings is not clear, a heuristic hypothesis is that olanzapine's clinical effects and a favorable side effect profile are in part mediated by neurotrophins...
  24. ncbi request reprint Chronic amphetamine treatment reduces NGF and BDNF in the rat brain
    Francesco Angelucci
    Karolinska Institutet, Clinical Neuroscience, Psychiatry M56, Karolinska University Hospital Huddinge, SE 14186 Stockholm, Sweden
    Eur Neuropsychopharmacol 17:756-62. 2007
    ..This reduction may account for some of the effects of amphetamine in the CNS neurons and provides evidences for the role of neurotrophins in schizophrenia...
  25. pmc A single intraperitoneal injection of endotoxin in rats induces long-lasting modifications in behavior and brain protein levels of TNF-α and IL-18
    Paola Bossù
    Clinical and Behavioral Neurology, IRCCS Fondazione Santa Lucia, Via Ardeatina 30600179, Rome, Italy
    J Neuroinflammation 9:101. 2012
    ..However, the potential contribution of these cytokines to behavioral impairment in the long-term period has not been fully investigated...
  26. ncbi request reprint Chronic heroin and cocaine abuse is associated with decreased serum concentrations of the nerve growth factor and brain-derived neurotrophic factor
    Francesco Angelucci
    Institute of Neurology and Institute of Psychiatry, Catholic University, Rome, Italy
    J Psychopharmacol 21:820-5. 2007
    ..In view of the neurotrophin hypothesis of schizophrenia the data also suggest that reduced level of neurotrophins may increase the risk of developing psychosis in drug users...
  27. ncbi request reprint Neurotrophic factors and CNS disorders: findings in rodent models of depression and schizophrenia
    Francesco Angelucci
    Institute of Neurology, Catholic University, Largo Gemelli 8, I 00168, Rome, Italy
    Prog Brain Res 146:151-65. 2004
    ..Overall, these studies indicate that alteration of brain level of NGF and BDNF could constitute part of the biochemical alterations induced by antipsychotic drugs...
  28. doi request reprint Enriched environment improves motor function and increases neurotrophins in hemicerebellar lesioned rats
    Francesca Gelfo
    IRCCS Santa Lucia, Rome, Italy
    Neurorehabil Neural Repair 25:243-52. 2011
    ..The beneficial effects of EE in the presence of brain damage have been partially attributed to upregulation of neurotrophins, proteins involved in neuronal survival and in activity-dependent plasticity...
  29. ncbi request reprint Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role?
    Aleksander A Mathe
    Karolinska Institutet, Department of Clinical Neuroscience, Karolinska University Hospital Huddinge, Psychiatry M56, E 141 86 Stockholm, Sweden
    Physiol Behav 92:226-31. 2007
    ..Consequently, if these data are confirmed, the ethical and medical question that will be asked is whether it is permissible and advisable to consider prophylactically treating persons at risk...
  30. doi request reprint Intraperitoneal injection of neuropeptide Y (NPY) alters neurotrophin rat hypothalamic levels: Implications for NPY potential role in stress-related disorders
    Francesca Gelfo
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, 00179 Rome, Italy
    Peptides 32:1320-3. 2011
    ....
  31. doi request reprint Brain and serum levels of nerve growth factor in a rat model of Alzheimer's disease
    Francesca Gelfo
    IRCCS Santa Lucia Foundation, Department of Clinical and Behavioral Neurology, Rome, Italy
    J Alzheimers Dis 25:213-7. 2011
    ..When compared to human data, these findings further elucidate the role of NGF in early and late AD disease stages...
  32. doi request reprint Effects of psychostimulants on neurotrophins implications for psychostimulant-induced neurotoxicity
    Francesco Angelucci
    Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    Int Rev Neurobiol 88:1-24. 2009
    ....
  33. doi request reprint Exposure to an enriched environment accelerates recovery from cerebellar lesion
    Francesca Foti
    IRCCS Santa Lucia Foundation, Rome, Italy
    Cerebellum 10:104-19. 2011
    ..The plastic changes induced by enhanced mental and physical activity seem to provide the development of compensatory responses against the disrupting motor and cognitive consequences of the cerebellar damage...
  34. ncbi request reprint Investigating the neurobiology of music: brain-derived neurotrophic factor modulation in the hippocampus of young adult mice
    Francesco Angelucci
    Fondazione Don C Gnocchi, Catholic University, Largo Gemelli, Rome, Italy
    Behav Pharmacol 18:491-6. 2007
    ..Our results demonstrate that exposure to music can modulate the activity of the hippocampus by influencing BDNF production. Our findings also suggest that music exposure might be of help in several central nervous system pathologies...
  35. ncbi request reprint The effect of neuropeptide Y on cell survival and neurotrophin expression in in-vitro models of Alzheimer's disease
    Francesco Angelucci
    a Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Via Ardeatina 354, 00142 Rome, Italy
    Can J Physiol Pharmacol 92:621-30. 2014
    ....
  36. doi request reprint Brain-derived neurotrophic factor and electroconvulsive therapy in a schizophrenic patient with treatment-resistant paranoid-hallucinatory symptoms
    Giovanni Martinotti
    Institute of Psychiatry, Catholic University, Rome, Italy
    J ECT 27:e44-6. 2011
    ..Moreover, ECT therapeutic effect is associated with an increase in BDNF serum levels. Further studies are needed to characterize the relationship between BDNF and ECT in schizophrenic patients...
  37. doi request reprint Chronic ketamine use increases serum levels of brain-derived neurotrophic factor
    Valerio Ricci
    Department of Clinical and Behavioural Neurology, IRCCS Santa Lucia Foundation, Rome, Italy
    Psychopharmacology (Berl) 215:143-8. 2011
    ..In addition, neurotrophins, particularly BDNF, may regulate LTP in the hippocampus and influence synaptic plasticity...
  38. doi request reprint Hydrochloric acid alters the effect of L-glutamic acid on cell viability in human neuroblastoma cell cultures
    Nicoletta Croce
    IRCCS Santa Lucia Foundation, Rome, Italy
    J Neurosci Methods 217:26-30. 2013
    ..Thus, this information might be useful to scientists who use l-glutamate to induce excitotoxicity or to test neuroprotective agents...
  39. ncbi request reprint Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression
    Francesco Angelucci
    Karolinska Institutet, Department of Physiology and Pharmacology, Division of Pharmacology, Stockholm, Sweden
    Int J Neuropsychopharmacol 6:225-31. 2003
    ..Moreover, the changes were different in the two rat strains. Our data support the notion that neurotrophic factors play a role in depression and in the mechanism of the action of lithium...
  40. doi request reprint Effects of olanzapine on extracellular concentrations and tissue content of neurotensin in rat brain regions
    Susanne H M Gruber
    Institution of Clinical Neuroscience, Division of Psychiatry, Karolinska Institutet, Huddinge University Hospital, Sweden
    Eur Neuropsychopharmacol 21:918-27. 2011
    ....
  41. ncbi request reprint Transcranial magnetic stimulation and BDNF plasma levels in amyotrophic lateral sclerosis
    Francesco Angelucci
    Institute of Neurology, Catholic University, Largo Gemelli 8, 00168 Rome, Italy
    Neuroreport 15:717-20. 2004
    ..High frequency rTMS determined a transitory decrease in BDNF plasma levels. Cumulatively these findings suggest that rTMS might influence the BDNF production by interfering with neuronal activity...
  42. ncbi request reprint Evidence of involvement of leptin and IL-6 peptides in the action of interferon-beta in secondary progressive multiple sclerosis
    Francesco Angelucci
    Institute of Neurology, Department of Neuroscience, Catholic University, Largo Gemelli 8, 00168 Rome, Italy
    Peptides 26:2289-93. 2005
    ..Thus, our pilot data show that the beneficial effect of IFN-beta on some SPMS patients might be associated with the reduced levels of leptin and reduced IL-6 production by PBMC...