Elisabetta Dejana

Summary

Affiliation: FIRC Institute of Molecular Oncology
Country: Italy

Publications

  1. ncbi request reprint Endothelial cell-cell junctions: happy together
    Elisabetta Dejana
    Department of Biomolecular and Biotechnological Sciences, School of Sciences, Milan University, Italy
    Nat Rev Mol Cell Biol 5:261-70. 2004
  2. pmc VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam
    Maria Grazia Lampugnani
    Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Mol Biol Cell 13:1175-89. 2002
  3. ncbi request reprint Endothelial cadherins and tumor angiogenesis
    Ugo Cavallaro
    IFOM FIRC Institute of Molecular Oncology, Italy
    Exp Cell Res 312:659-67. 2006
  4. pmc p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin
    Kanyan Xiao
    Department of Dermatology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:5141-51. 2005
  5. ncbi request reprint Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
    Matthijs R H Kooistra
    Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center, Utrecht, The Netherlands
    FEBS Lett 579:4966-72. 2005
  6. pmc Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury
    Monica Corada
    Fondazione Italiana per la Ricerca sul Cancro, Institute of Molecular Oncology, 20139 Milan, Italy
    Proc Natl Acad Sci U S A 102:10634-9. 2005
  7. ncbi request reprint Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications
    Lucia Zanetta
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Thromb Haemost 93:1041-6. 2005
  8. pmc Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells
    Lothar Rossig
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt am Main, Germany
    J Exp Med 201:1825-35. 2005
  9. ncbi request reprint Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway
    Nadia Pece-Barbara
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Biol Chem 280:27800-8. 2005
  10. ncbi request reprint The transcellular railway: insights into leukocyte diapedesis
    Elisabetta Dejana
    Nat Cell Biol 8:105-7. 2006

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Endothelial cell-cell junctions: happy together
    Elisabetta Dejana
    Department of Biomolecular and Biotechnological Sciences, School of Sciences, Milan University, Italy
    Nat Rev Mol Cell Biol 5:261-70. 2004
  2. pmc VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of Tiam
    Maria Grazia Lampugnani
    Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
    Mol Biol Cell 13:1175-89. 2002
    ..Through this mechanism VEC may influence the constitutive organization of the actin cytoskeleton...
  3. ncbi request reprint Endothelial cadherins and tumor angiogenesis
    Ugo Cavallaro
    IFOM FIRC Institute of Molecular Oncology, Italy
    Exp Cell Res 312:659-67. 2006
    ..T cadherin, R-cadherin and VE-cadherin 2 were found in specific regions of the vascular tree but their role in vascular development or angiogenesis is still unclear...
  4. pmc p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherin
    Kanyan Xiao
    Department of Dermatology, Emory University, Atlanta, GA 30322, USA
    Mol Biol Cell 16:5141-51. 2005
    ....
  5. ncbi request reprint Epac1 regulates integrity of endothelial cell junctions through VE-cadherin
    Matthijs R H Kooistra
    Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center, Utrecht, The Netherlands
    FEBS Lett 579:4966-72. 2005
    ..From these results we conclude that in human umbilical vein endothelial cells Epac1 controls VE-cadherin-mediated cell junction formation and induces reorganization of the actin cytoskeleton...
  6. pmc Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injury
    Monica Corada
    Fondazione Italiana per la Ricerca sul Cancro, Institute of Molecular Oncology, 20139 Milan, Italy
    Proc Natl Acad Sci U S A 102:10634-9. 2005
    ..This paper describes a nonredundant role of JAM-A in controlling PMN diapedesis through the vessel wall...
  7. ncbi request reprint Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complications
    Lucia Zanetta
    FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
    Thromb Haemost 93:1041-6. 2005
    ..Overall, these data strongly suggest that downregulation of VE-cadherin in endothelial tumors may have important consequences for tumor growth and bleeding complications...
  8. pmc Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cells
    Lothar Rossig
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt am Main, Germany
    J Exp Med 201:1825-35. 2005
    ..Thus, HoxA9 is regulated by HDACs and is critical for postnatal neovascularization...
  9. ncbi request reprint Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathway
    Nadia Pece-Barbara
    Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Biol Chem 280:27800-8. 2005
    ..Thus an altered balance in TGFbeta receptors and downstream Smad pathways may underlie defects in vascular development and homeostasis...
  10. ncbi request reprint The transcellular railway: insights into leukocyte diapedesis
    Elisabetta Dejana
    Nat Cell Biol 8:105-7. 2006
  11. doi request reprint Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel disease
    Stefania Vetrano
    Division of Gastroenterology, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, University of Milan, Rozzano, Italy
    Gastroenterology 135:173-84. 2008
    ..Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored...
  12. pmc Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartments
    Maria Grazia Lampugnani
    IFOM, Fondazione Italiana per la Ricerca sul Cancro Institute of Molecular Oncology, University of Milan, 20139 Milan, Italy
    J Cell Biol 174:593-604. 2006
    ..Thus, VEC limits cell proliferation by retaining VEGFR-2 at the membrane and preventing its internalization into signaling compartments...
  13. ncbi request reprint Hepatocyte-conditioned medium sustains endothelial differentiation of human hematopoietic-endothelial progenitors
    Veronica Bordoni
    National Institute for Infectious Diseases L Spallanzani, IRCCS, Rome, Italy
    Hepatology 45:1218-28. 2007
    ....
  14. ncbi request reprint JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration
    Abigail Woodfin
    Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
    Blood 110:1848-56. 2007
    ..The latter appeared to be due to the fact that JAM-A and PECAM-1 can act sequentially to mediate leukocyte migration through venular walls in vivo...
  15. doi request reprint Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5
    Andrea Taddei
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    Nat Cell Biol 10:923-34. 2008
    ..These results offer a molecular basis for the link between AJs and TJs and explain why VE-cadherin inhibition may cause a marked increase in permeability...
  16. ncbi request reprint Phosphorylation of vascular endothelial cadherin controls lymphocyte emigration
    Patric Turowski
    Division of Cell Biology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
    J Cell Sci 121:29-37. 2008
    ..Taken together, these results demonstrate that phosphorylation of adherens junctions constitutes a molecular endpoint of lymphocyte-induced vascular EC signaling and may be exploited as a new target of anti-inflammatory therapies...
  17. pmc Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherin
    Graeme M Birdsey
    National Heart and Lung Institute Cardiovascular Sciences Unit, Hammersmith Hospital, Imperial College London, UK
    Blood 111:3498-506. 2008
    ..These results identify a new pathway regulating angiogenesis and endothelial survival, via the transcription factor Erg and the adhesion molecule VE-cadherin...
  18. ncbi request reprint The control of endothelial cell functions by adherens junctions
    Maria Grazia Lampugnani
    IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
    Novartis Found Symp 283:4-13; discussion 13-7, 238-41. 2007
    ....
  19. pmc VE-cadherin is a critical endothelial regulator of TGF-beta signalling
    Noemi Rudini
    Vascular Biology Unit, FIRC Institute of Molecular Oncology, Milan, Italy
    EMBO J 27:993-1004. 2008
    ..This suggests that reduction or inactivation of VE-cadherin may contribute to progression of diseases where TGF-beta signalling is impaired...
  20. ncbi request reprint Opposite effects of tumor necrosis factor and soluble fibronectin on junctional adhesion molecule-A in endothelial cells
    Ofelia M Martinez-Estrada
    Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Am J Physiol Lung Cell Mol Physiol 288:L1081-8. 2005
    ..We found that fibronectin reduces the effect of TNF on the disassembly of JAM-A, but not on its dispersal, thus further stressing that disassembly and dispersal can be functionally dissociated...
  21. ncbi request reprint Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migration
    Andrej Khandoga
    Institute for Surgical Research, Ludwig Maximilians University of Munich, Marchioninistr 27, D 81377 Munich, Germany
    Blood 106:725-33. 2005
    ..JAM-A deficiency does not reduce I/R-induced microvascular and hepatocellular necrotic injury, but increases hepatocyte apoptosis, despite attenuation of neutrophil infiltration...
  22. ncbi request reprint Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosis
    Raffaella Spagnuolo
    Italian Foundation for Cancer Research FIRC Institute of Molecular Oncology, Milan, Italy
    Blood 103:3005-12. 2004
    ..Gas1 expression positively correlates with inhibition of endothelial cell apoptosis and may contribute to the integrity of resting endothelium...
  23. pmc The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragility
    Anna Cattelino
    FIRC Institute of Molecular Oncology, 16 20139, Milan, Italy
    J Cell Biol 162:1111-22. 2003
    ..This may become more marked when the vessels are exposed to high or turbulent flow, such as at bifurcations or in the beating heart, leading to fluid leakage or hemorrhages...
  24. pmc Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wall
    Per Lindblom
    Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
    Genes Dev 17:1835-40. 2003
    ..We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice...
  25. pmc Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148
    Maria Grazia Lampugnani
    FIRC Institute of Molecular Oncology, 20139 Milan, Italy
    J Cell Biol 161:793-804. 2003
    ..In sparse cells or in VE-cadherin-null cells, this phenomenon cannot occur and the receptor is fully activated by the growth factor...
  26. ncbi request reprint A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeability
    Monica Corada
    FIRC Institute of Molecular Oncology, Milan, Italy
    Blood 100:905-11. 2002
    ..In contrast, in growing vessels, where endothelial cells are migrating and junctions are weaker, antibody binding to EC4 may be sufficient to disrupt cell-to-cell adhesion and inhibit assembly of new vascular structures...
  27. pmc VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cells
    Ayelet Shay-Salit
    Department of Anatomy and Cell Biology, Bruce Rappaport Research Institute and the Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
    Proc Natl Acad Sci U S A 99:9462-7. 2002
    ..These results suggest that VEGF receptor 2 and the adherens junction act as shear-stress cotransducers, mediating the transduction of shear-stress signals into vascular endothelial cells...
  28. ncbi request reprint Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeability
    Fang Liao
    ImClone Systems Incorporated, New York, NY 10014, USA
    Cancer Res 62:2567-75. 2002
    ..Our data also suggest that antibody E4G10 recognizes VE-cadherin epitopes that are only accessible on endothelial cells forming new adherens junctions, such as in angiogenic tumor vasculature...
  29. ncbi request reprint Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signaling
    Adriana Zanetti
    Mario Negri Institute of Pharmacological Research, Milan, Italy
    Arterioscler Thromb Vasc Biol 22:617-22. 2002
    ..These data suggest that VE-cadherin expression exerts a negative effect on Shc phosphorylation by VEGFR-2. We speculate that VE-cadherin binding to Shc promotes its dephosphorylation through associated phosphatases...
  30. pmc VE-cadherin expression and clustering maintain low levels of survivin in endothelial cells
    Monica Iurlaro
    Italian Foundation for Cancer Research, Institute of Molecular Oncology, Milan, Italy
    Am J Pathol 165:181-9. 2004
    ..Consistently, in epidermal and pancreatic cell lines or ovarian tumors, epithelial-cadherin (E-cadherin) and survivin expression is inversely related, suggesting a non-cell-specific role of cadherins in reducing survivin synthesis...
  31. ncbi request reprint Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis
    Gianfranco Bazzoni
    Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
    Physiol Rev 84:869-901. 2004
    ..Finally, we analyze in vivo studies and highlight information that specifically relates to the role of junctions in vascular endothelial cells...
  32. ncbi request reprint Expression of junctional adhesion molecule-A prevents spontaneous and random motility
    Gianfranco Bazzoni
    Laboratory of Systems Biology, Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
    J Cell Sci 118:623-32. 2005
    ..Thus, by regulating cytoskeletal and adhesive structures, JAM-A expression prevents cell motility, probably in a PSD95-Dlg-ZO1-dependent manner...
  33. ncbi request reprint VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassembly
    Christopher V Crosby
    Cardiovascular Developmental Biology Center, Department of Cell Biology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
    Blood 105:2771-6. 2005
    ....
  34. ncbi request reprint Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryo
    Fay C Thomas
    School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
    J Cell Sci 117:5599-608. 2004
    ....
  35. pmc SIRT1 controls endothelial angiogenic functions during vascular growth
    Michael Potente
    Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt, Germany
    Genes Dev 21:2644-58. 2007
    ..These findings uncover a novel and unexpected role for SIRT1 as a critical modulator of endothelial gene expression governing postnatal vascular growth...
  36. ncbi request reprint Effects of exercise training on endothelial progenitor cells in patients with chronic heart failure
    Patrizio Sarto
    Department of Cardiology and Sports Medicine, Mirano Hospital, Mirano, Venice, Italy
    J Card Fail 13:701-8. 2007
    ....
  37. pmc Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient mice
    Maria Rosaria Cera
    Department of Vascular Biology, Italian Foundation for Cancer Research FIRC Institute of Molecular Oncology, Milan, Italy
    J Clin Invest 114:729-38. 2004
    ..Thus, we identified here a novel, non-redundant role of JAM-A in controlling DC motility, trafficking to lymph nodes, and activation of specific immunity...
  38. ncbi request reprint Importance of junctional adhesion molecule-A for neointimal lesion formation and infiltration in atherosclerosis-prone mice
    Alma Zernecke
    Department of Molecular Cardiovascular Research, RWTH University Hospital, Aachen, Germany
    Arterioscler Thromb Vasc Biol 26:e10-3. 2006
    ....
  39. ncbi request reprint Women in cell science. Elisabetta Dejana. Interview by Fiona Watt
    Elisabetta Dejana
    J Cell Sci 118:2789-90. 2005
  40. ncbi request reprint Mesoangioblasts, vessel-associated multipotent stem cells, repair the infarcted heart by multiple cellular mechanisms: a comparison with bone marrow progenitors, fibroblasts, and endothelial cells
    Daniela Galli
    Stem Cell Research Institute, DIBIT, H San Raffaele, Milan, Italy
    Arterioscler Thromb Vasc Biol 25:692-7. 2005
    ....
  41. pmc Functionally specialized junctions between endothelial cells of lymphatic vessels
    Peter Baluk
    Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
    J Exp Med 204:2349-62. 2007
    ..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics...
  42. ncbi request reprint Foxs and Ets in the transcriptional regulation of endothelial cell differentiation and angiogenesis
    Elisabetta Dejana
    IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
    Biochim Biophys Acta 1775:298-312. 2007
    ....
  43. ncbi request reprint Generation and characterization of a mouse lymphatic endothelial cell line
    Marina Sironi
    Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
    Cell Tissue Res 325:91-100. 2006
    ..Whole genome transcriptional profiling identified a set of 150 known genes differentially expressed in MELC versus vascular endothelial cells. Thus, the MELC line may represent an invaluable source of lymphatic endothelium...
  44. ncbi request reprint The multiple languages of endothelial cell-to-cell communication
    Stefan Liebner
    Institute of Neurology, Medical School, University of Frankfurt Main, Germany
    Arterioscler Thromb Vasc Biol 26:1431-8. 2006
    ..The role of this adhesion molecule-mediated signaling is discussed in the context of developmental and pathological angiogenesis...
  45. ncbi request reprint Increase in vascular permeability and vasodilation are critical for proangiogenic effects of stem cell therapy
    Dong You
    Cardiovascular Research Center, INSERM U689, Hopital Lariboisiere, 41 Boulevard de la Chapelle, 75475 Paris Cedex 10, France
    Circulation 114:328-38. 2006
    ..However, mechanisms leading to the beneficial effects of BMCs and EPCs remain unclear...
  46. ncbi request reprint The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues
    Sussan Nourshargh
    National Heart and Lung Institute, Imperial College London, UK
    J Leukoc Biol 80:714-8. 2006
    ..In vivo data with blocking antibodies or inactivation of JAM-A and PECAM genes indicate that the role of these two proteins depends on the stimulus and the experimental model used...
  47. ncbi request reprint Skeletal myogenic progenitors in the endothelium of lung and yolk sac
    Maria Gabriella Cusella De Angelis
    Department of Experimental Medicine, University of Pavia, Pavia, Italy
    Exp Cell Res 290:207-16. 2003
    ..The number (or potency to generate skeletal muscle) of these vessels associated cells decreases rapidly with age and is very low in mature animals, possibly correlating with reduced regenerative capacity of adult mammalian tissues...
  48. ncbi request reprint Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammation
    Silvio Danese
    Instituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, Milan, Italy
    J Immunol 178:6017-22. 2007
    ....
  49. pmc Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouse
    Stefan Liebner
    FIRC Institute of Molecular Oncology, University of Milan, Italy
    J Cell Biol 166:359-67. 2004
    ....
  50. ncbi request reprint The role of junctional adhesion molecules in vascular inflammation
    Christian Weber
    Institute for Molecular Cardiovascular Research, RWTH University Hospital, 52074 Aachen, Germany
    Nat Rev Immunol 7:467-77. 2007
    ..This Review summarizes recent progress and future directions in understanding the role of JAMs as 'gate keepers' in inflammation and vascular pathology...
  51. ncbi request reprint Sox18 and Sox7 play redundant roles in vascular development
    Solei Cermenati
    Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, Milan, Italy
    Blood 111:2657-66. 2008
    ..Our data suggest that a defect in arteriovenous identity could be responsible for the formation of telangiectases in patients with HLT...