Affiliation: FIRC Institute of Molecular Oncology
- Endothelial cell-cell junctions: happy togetherElisabetta Dejana
Department of Biomolecular and Biotechnological Sciences, School of Sciences, Milan University, Italy
Nat Rev Mol Cell Biol 5:261-70. 2004
- VE-cadherin regulates endothelial actin activating Rac and increasing membrane association of TiamMaria Grazia Lampugnani
Mario Negri Institute for Pharmacological Research, 20157 Milan, Italy
Mol Biol Cell 13:1175-89. 2002..Through this mechanism VEC may influence the constitutive organization of the actin cytoskeleton...
- Endothelial cadherins and tumor angiogenesisUgo Cavallaro
IFOM FIRC Institute of Molecular Oncology, Italy
Exp Cell Res 312:659-67. 2006..T cadherin, R-cadherin and VE-cadherin 2 were found in specific regions of the vascular tree but their role in vascular development or angiogenesis is still unclear...
- p120-Catenin regulates clathrin-dependent endocytosis of VE-cadherinKanyan Xiao
Department of Dermatology, Emory University, Atlanta, GA 30322, USA
Mol Biol Cell 16:5141-51. 2005....
- Epac1 regulates integrity of endothelial cell junctions through VE-cadherinMatthijs R H Kooistra
Department of Physiological Chemistry, Centre for Biomedical Genetics, University Medical Center, Utrecht, The Netherlands
FEBS Lett 579:4966-72. 2005..From these results we conclude that in human umbilical vein endothelial cells Epac1 controls VE-cadherin-mediated cell junction formation and induces reorganization of the actin cytoskeleton...
- Junctional adhesion molecule-A-deficient polymorphonuclear cells show reduced diapedesis in peritonitis and heart ischemia-reperfusion injuryMonica Corada
Fondazione Italiana per la Ricerca sul Cancro, Institute of Molecular Oncology, 20139 Milan, Italy
Proc Natl Acad Sci U S A 102:10634-9. 2005..This paper describes a nonredundant role of JAM-A in controlling PMN diapedesis through the vessel wall...
- Downregulation of vascular endothelial-cadherin expression is associated with an increase in vascular tumor growth and hemorrhagic complicationsLucia Zanetta
FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy
Thromb Haemost 93:1041-6. 2005..Overall, these data strongly suggest that downregulation of VE-cadherin in endothelial tumors may have important consequences for tumor growth and bleeding complications...
- Histone deacetylase activity is essential for the expression of HoxA9 and for endothelial commitment of progenitor cellsLothar Rossig
Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt am Main, Germany
J Exp Med 201:1825-35. 2005..Thus, HoxA9 is regulated by HDACs and is critical for postnatal neovascularization...
- Endoglin null endothelial cells proliferate faster and are more responsive to transforming growth factor beta1 with higher affinity receptors and an activated Alk1 pathwayNadia Pece-Barbara
Programme in Molecular Biology and Cancer, Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
J Biol Chem 280:27800-8. 2005..Thus an altered balance in TGFbeta receptors and downstream Smad pathways may underlie defects in vascular development and homeostasis...
- The transcellular railway: insights into leukocyte diapedesisElisabetta Dejana
Nat Cell Biol 8:105-7. 2006
- Unique role of junctional adhesion molecule-a in maintaining mucosal homeostasis in inflammatory bowel diseaseStefania Vetrano
Division of Gastroenterology, Istituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, University of Milan, Rozzano, Italy
Gastroenterology 135:173-84. 2008..Junctional adhesion molecule-A (JAM-A) is localized at the tight junctions and controls leukocyte migration into the tissues. However, its functional role in inflammatory bowel disease (IBD) is unexplored...
- Vascular endothelial cadherin controls VEGFR-2 internalization and signaling from intracellular compartmentsMaria Grazia Lampugnani
IFOM, Fondazione Italiana per la Ricerca sul Cancro Institute of Molecular Oncology, University of Milan, 20139 Milan, Italy
J Cell Biol 174:593-604. 2006..Thus, VEC limits cell proliferation by retaining VEGFR-2 at the membrane and preventing its internalization into signaling compartments...
- Hepatocyte-conditioned medium sustains endothelial differentiation of human hematopoietic-endothelial progenitorsVeronica Bordoni
National Institute for Infectious Diseases L Spallanzani, IRCCS, Rome, Italy
Hepatology 45:1218-28. 2007....
- JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigrationAbigail Woodfin
Cardiovascular Medicine Unit, National Heart and Lung Institute, Faculty of Medicine, Imperial College London, Hammersmith Hospital, London, United Kingdom
Blood 110:1848-56. 2007..The latter appeared to be due to the fact that JAM-A and PECAM-1 can act sequentially to mediate leukocyte migration through venular walls in vivo...
- Endothelial adherens junctions control tight junctions by VE-cadherin-mediated upregulation of claudin-5Andrea Taddei
FIRC Institute of Molecular Oncology, 20139 Milan, Italy
Nat Cell Biol 10:923-34. 2008..These results offer a molecular basis for the link between AJs and TJs and explain why VE-cadherin inhibition may cause a marked increase in permeability...
- Phosphorylation of vascular endothelial cadherin controls lymphocyte emigrationPatric Turowski
Division of Cell Biology, Institute of Ophthalmology, University College London, 11 43 Bath Street, London, EC1V 9EL, UK
J Cell Sci 121:29-37. 2008..Taken together, these results demonstrate that phosphorylation of adherens junctions constitutes a molecular endpoint of lymphocyte-induced vascular EC signaling and may be exploited as a new target of anti-inflammatory therapies...
- Transcription factor Erg regulates angiogenesis and endothelial apoptosis through VE-cadherinGraeme M Birdsey
National Heart and Lung Institute Cardiovascular Sciences Unit, Hammersmith Hospital, Imperial College London, UK
Blood 111:3498-506. 2008..These results identify a new pathway regulating angiogenesis and endothelial survival, via the transcription factor Erg and the adhesion molecule VE-cadherin...
- The control of endothelial cell functions by adherens junctionsMaria Grazia Lampugnani
IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
Novartis Found Symp 283:4-13; discussion 13-7, 238-41. 2007....
- VE-cadherin is a critical endothelial regulator of TGF-beta signallingNoemi Rudini
Vascular Biology Unit, FIRC Institute of Molecular Oncology, Milan, Italy
EMBO J 27:993-1004. 2008..This suggests that reduction or inactivation of VE-cadherin may contribute to progression of diseases where TGF-beta signalling is impaired...
- Opposite effects of tumor necrosis factor and soluble fibronectin on junctional adhesion molecule-A in endothelial cellsOfelia M Martinez-Estrada
Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
Am J Physiol Lung Cell Mol Physiol 288:L1081-8. 2005..We found that fibronectin reduces the effect of TNF on the disassembly of JAM-A, but not on its dispersal, thus further stressing that disassembly and dispersal can be functionally dissociated...
- Junctional adhesion molecule-A deficiency increases hepatic ischemia-reperfusion injury despite reduction of neutrophil transendothelial migrationAndrej Khandoga
Institute for Surgical Research, Ludwig Maximilians University of Munich, Marchioninistr 27, D 81377 Munich, Germany
Blood 106:725-33. 2005..JAM-A deficiency does not reduce I/R-induced microvascular and hepatocellular necrotic injury, but increases hepatocyte apoptosis, despite attenuation of neutrophil infiltration...
- Gas1 is induced by VE-cadherin and vascular endothelial growth factor and inhibits endothelial cell apoptosisRaffaella Spagnuolo
Italian Foundation for Cancer Research FIRC Institute of Molecular Oncology, Milan, Italy
Blood 103:3005-12. 2004..Gas1 expression positively correlates with inhibition of endothelial cell apoptosis and may contribute to the integrity of resting endothelium...
- The conditional inactivation of the beta-catenin gene in endothelial cells causes a defective vascular pattern and increased vascular fragilityAnna Cattelino
FIRC Institute of Molecular Oncology, 16 20139, Milan, Italy
J Cell Biol 162:1111-22. 2003..This may become more marked when the vessels are exposed to high or turbulent flow, such as at bifurcations or in the beating heart, leading to fluid leakage or hemorrhages...
- Endothelial PDGF-B retention is required for proper investment of pericytes in the microvessel wallPer Lindblom
Department of Medical Biochemistry, Goteborg University, Göteborg SE 405 30, Sweden
Genes Dev 17:1835-40. 2003..We conclude that retention of PDGF-B in microvessels is essential for proper recruitment and organization of pericytes and for renal and retinal function in adult mice...
- Contact inhibition of VEGF-induced proliferation requires vascular endothelial cadherin, beta-catenin, and the phosphatase DEP-1/CD148Maria Grazia Lampugnani
FIRC Institute of Molecular Oncology, 20139 Milan, Italy
J Cell Biol 161:793-804. 2003..In sparse cells or in VE-cadherin-null cells, this phenomenon cannot occur and the receptor is fully activated by the growth factor...
- A monoclonal antibody to vascular endothelial-cadherin inhibits tumor angiogenesis without side effects on endothelial permeabilityMonica Corada
FIRC Institute of Molecular Oncology, Milan, Italy
Blood 100:905-11. 2002..In contrast, in growing vessels, where endothelial cells are migrating and junctions are weaker, antibody binding to EC4 may be sufficient to disrupt cell-to-cell adhesion and inhibit assembly of new vascular structures...
- VEGF receptor 2 and the adherens junction as a mechanical transducer in vascular endothelial cellsAyelet Shay-Salit
Department of Anatomy and Cell Biology, Bruce Rappaport Research Institute and the Rappaport Faculty of Medicine, Technion, Haifa 31096, Israel
Proc Natl Acad Sci U S A 99:9462-7. 2002..These results suggest that VEGF receptor 2 and the adherens junction act as shear-stress cotransducers, mediating the transduction of shear-stress signals into vascular endothelial cells...
- Selective targeting of angiogenic tumor vasculature by vascular endothelial-cadherin antibody inhibits tumor growth without affecting vascular permeabilityFang Liao
ImClone Systems Incorporated, New York, NY 10014, USA
Cancer Res 62:2567-75. 2002..Our data also suggest that antibody E4G10 recognizes VE-cadherin epitopes that are only accessible on endothelial cells forming new adherens junctions, such as in angiogenic tumor vasculature...
- Vascular endothelial growth factor induces SHC association with vascular endothelial cadherin: a potential feedback mechanism to control vascular endothelial growth factor receptor-2 signalingAdriana Zanetti
Mario Negri Institute of Pharmacological Research, Milan, Italy
Arterioscler Thromb Vasc Biol 22:617-22. 2002..These data suggest that VE-cadherin expression exerts a negative effect on Shc phosphorylation by VEGFR-2. We speculate that VE-cadherin binding to Shc promotes its dephosphorylation through associated phosphatases...
- VE-cadherin expression and clustering maintain low levels of survivin in endothelial cellsMonica Iurlaro
Italian Foundation for Cancer Research, Institute of Molecular Oncology, Milan, Italy
Am J Pathol 165:181-9. 2004..Consistently, in epidermal and pancreatic cell lines or ovarian tumors, epithelial-cadherin (E-cadherin) and survivin expression is inversely related, suggesting a non-cell-specific role of cadherins in reducing survivin synthesis...
- Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasisGianfranco Bazzoni
Istituto di Ricerche Farmacologiche Mario Negri, Via Eritrea 62, I 20157 Milan, Italy
Physiol Rev 84:869-901. 2004..Finally, we analyze in vivo studies and highlight information that specifically relates to the role of junctions in vascular endothelial cells...
- Expression of junctional adhesion molecule-A prevents spontaneous and random motilityGianfranco Bazzoni
Laboratory of Systems Biology, Department of Immunology and Cell Biology, Istituto di Ricerche Farmacologiche Mario Negri, 20157 Milano, Italy
J Cell Sci 118:623-32. 2005..Thus, by regulating cytoskeletal and adhesive structures, JAM-A expression prevents cell motility, probably in a PSD95-Dlg-ZO1-dependent manner...
- VE-cadherin is not required for the formation of nascent blood vessels but acts to prevent their disassemblyChristopher V Crosby
Cardiovascular Developmental Biology Center, Department of Cell Biology, Medical University of South Carolina, 173 Ashley Ave, Charleston, SC 29425, USA
Blood 105:2771-6. 2005....
- Contribution of JAM-1 to epithelial differentiation and tight-junction biogenesis in the mouse preimplantation embryoFay C Thomas
School of Biological Sciences, University of Southampton, Bassett Crescent East, Southampton, SO16 7PX, UK
J Cell Sci 117:5599-608. 2004....
- SIRT1 controls endothelial angiogenic functions during vascular growthMichael Potente
Molecular Cardiology, Department of Internal Medicine III, University of Frankfurt, 60590 Frankfurt, Germany
Genes Dev 21:2644-58. 2007..These findings uncover a novel and unexpected role for SIRT1 as a critical modulator of endothelial gene expression governing postnatal vascular growth...
- Effects of exercise training on endothelial progenitor cells in patients with chronic heart failurePatrizio Sarto
Department of Cardiology and Sports Medicine, Mirano Hospital, Mirano, Venice, Italy
J Card Fail 13:701-8. 2007....
- Increased DC trafficking to lymph nodes and contact hypersensitivity in junctional adhesion molecule-A-deficient miceMaria Rosaria Cera
Department of Vascular Biology, Italian Foundation for Cancer Research FIRC Institute of Molecular Oncology, Milan, Italy
J Clin Invest 114:729-38. 2004..Thus, we identified here a novel, non-redundant role of JAM-A in controlling DC motility, trafficking to lymph nodes, and activation of specific immunity...
- Importance of junctional adhesion molecule-A for neointimal lesion formation and infiltration in atherosclerosis-prone miceAlma Zernecke
Department of Molecular Cardiovascular Research, RWTH University Hospital, Aachen, Germany
Arterioscler Thromb Vasc Biol 26:e10-3. 2006....
- Women in cell science. Elisabetta Dejana. Interview by Fiona WattElisabetta Dejana
J Cell Sci 118:2789-90. 2005
- Mesoangioblasts, vessel-associated multipotent stem cells, repair the infarcted heart by multiple cellular mechanisms: a comparison with bone marrow progenitors, fibroblasts, and endothelial cellsDaniela Galli
Stem Cell Research Institute, DIBIT, H San Raffaele, Milan, Italy
Arterioscler Thromb Vasc Biol 25:692-7. 2005....
- Functionally specialized junctions between endothelial cells of lymphatic vesselsPeter Baluk
Cardiovascular Research Institute, University of California, San Francisco, San Francisco, CA 94143, USA
J Exp Med 204:2349-62. 2007..Our findings suggest that fluid enters throughout initial lymphatics via openings between buttons, which open and close without disrupting junctional integrity, but most leukocytes enter the proximal half of initial lymphatics...
- Foxs and Ets in the transcriptional regulation of endothelial cell differentiation and angiogenesisElisabetta Dejana
IFOM, FIRC Institute of Molecular Oncology, Milan, Italy
Biochim Biophys Acta 1775:298-312. 2007....
- Generation and characterization of a mouse lymphatic endothelial cell lineMarina Sironi
Department of Immunology and Cell Biology, Mario Negri Institute for Pharmacological Research, Milan, Italy
Cell Tissue Res 325:91-100. 2006..Whole genome transcriptional profiling identified a set of 150 known genes differentially expressed in MELC versus vascular endothelial cells. Thus, the MELC line may represent an invaluable source of lymphatic endothelium...
- The multiple languages of endothelial cell-to-cell communicationStefan Liebner
Institute of Neurology, Medical School, University of Frankfurt Main, Germany
Arterioscler Thromb Vasc Biol 26:1431-8. 2006..The role of this adhesion molecule-mediated signaling is discussed in the context of developmental and pathological angiogenesis...
- Increase in vascular permeability and vasodilation are critical for proangiogenic effects of stem cell therapyDong You
Cardiovascular Research Center, INSERM U689, Hopital Lariboisiere, 41 Boulevard de la Chapelle, 75475 Paris Cedex 10, France
Circulation 114:328-38. 2006..However, mechanisms leading to the beneficial effects of BMCs and EPCs remain unclear...
- The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissuesSussan Nourshargh
National Heart and Lung Institute, Imperial College London, UK
J Leukoc Biol 80:714-8. 2006..In vivo data with blocking antibodies or inactivation of JAM-A and PECAM genes indicate that the role of these two proteins depends on the stimulus and the experimental model used...
- Skeletal myogenic progenitors in the endothelium of lung and yolk sacMaria Gabriella Cusella De Angelis
Department of Experimental Medicine, University of Pavia, Pavia, Italy
Exp Cell Res 290:207-16. 2003..The number (or potency to generate skeletal muscle) of these vessels associated cells decreases rapidly with age and is very low in mature animals, possibly correlating with reduced regenerative capacity of adult mammalian tissues...
- Immune regulation by microvascular endothelial cells: directing innate and adaptive immunity, coagulation, and inflammationSilvio Danese
Instituto di Ricerca e Cura a Carattere Scientifico Istituto Clinico Humanitas, Milan, Italy
J Immunol 178:6017-22. 2007....
- Beta-catenin is required for endothelial-mesenchymal transformation during heart cushion development in the mouseStefan Liebner
FIRC Institute of Molecular Oncology, University of Milan, Italy
J Cell Biol 166:359-67. 2004....
- The role of junctional adhesion molecules in vascular inflammationChristian Weber
Institute for Molecular Cardiovascular Research, RWTH University Hospital, 52074 Aachen, Germany
Nat Rev Immunol 7:467-77. 2007..This Review summarizes recent progress and future directions in understanding the role of JAMs as 'gate keepers' in inflammation and vascular pathology...
- Sox18 and Sox7 play redundant roles in vascular developmentSolei Cermenati
Dipartimento di Scienze Biomolecolari e Biotecnologie, Universita degli Studi di Milano, Via Celoria 26, Milan, Italy
Blood 111:2657-66. 2008..Our data suggest that a defect in arteriovenous identity could be responsible for the formation of telangiectases in patients with HLT...