Research Topics
Species | G FinazziSummaryCountry: Italy Publications
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Publications
Should we include anti-prothrombin antibodies in the screening for the antiphospholipid syndrome?M Galli
Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy
J Autoimmun 15:101-5. 2000..These data do not allow to recommend the measurement of anti-prothrombin antibodies in the routine laboratory workout of antiphospholipid-positive patients in order to define their thrombotic risk...
Which antiphospholipid antibodies should be measured in the antiphospholipid syndrome?M Galli
Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy
Haemostasis 30:57-62. 2000..Furthermore, they only partially support the notion that anti-beta 2-glycoprotein I and antiprothrombin antibodies may be independent risk factors for thrombosis...
Risk-oriented postremission strategies in adult acute lymphoblastic leukemia: prospective confirmation of anthracycline activity in standard-risk class and role of hematopoietic stem cell transplants in high-risk groupsR Bassan
Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy
Hematol J 2:117-26. 2001..So, a prospective validation of the therapeutic efficacy of a protocol (or a component thereof) in specific risk groups is uncommon...
The epidemiology of the antiphospholipid syndrome: who is at risk?G Finazzi
Divisione di Ematologia, Ospedali Riuniti, Largo Barozzi 1, 24128 Bergamo, Italy
Curr Rheumatol Rep 3:271-6. 2001..The data only partially support the concept that anti-beta 2-GPI and aPT antibodies may be considered as independent risk factors for thrombosis. Further prospective studies are required...
Stage-modified international prognostic index effectively predicts clinical outcome of localized primary gastric diffuse large B-cell lymphoma. International Extranodal Lymphoma Study Group (IELSG)S Cortelazzo
Divisione di Ematologia, Ospedali Riuniti di Bergamo, Italy
Ann Oncol 10:1433-40. 1999....
Fractionated cyclophosphamide added to the IVAP regimen (idarubicin-vincristine-L-asparaginase-prednisone) could lower the risk of primary refractory disease in T-lineage but not B-lineage acute lymphoblastic leukemia: first results from a phase II clinicR Bassan
Ematologia, Ospedali Riuniti, Largo Barozzi 1, 24100 Bergamo, Italy
Haematologica 84:1088-93. 1999..04). Aiming to minimize this percentage of resistant disease, fractionated cyclophosphamide (f-CY) was then added to the IVAP regimen...
Treatment of essential thrombocythemia with special emphasis on leukemogenic riskG Finazzi
Division of Hematology, Ospedali Riuniti, Largo Barozzi 1, I 24100 Bergamo, Italy
Ann Hematol 78:389-92. 1999....
Clinical outcome after autologous transplantation in non-Hodgkin's lymphoma patients with high international prognostic index (IPI)S Cortelazzo
Division of Hematology, Ospedali Riuniti di Bergamo, Italy
Ann Oncol 10:427-32. 1999....
The risk of thrombosis in patients with lupus anticoagulants is predicted by their specific coagulation profileM Galli
Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy
Thromb Haemost 81:695-700. 1999..In conclusion, the "dRVVT" profile appears to have predictive value with respect to the thrombotic complications suffered by patients with antiphospholipid antibodies...
Prothrombin as cofactor for antiphospholipidsM Galli
Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy
Lupus 7:S37-40. 1998..Similarly, most of the studies that measured anti-prothrombin antibodies by ELISA failed to find a significant association with thrombosis. In conclusion, the clinical relevance of these antibodies has not yet been established...
Congenital resistance to activated protein C in patients with lupus anticoagulants: evaluation of two functional assaysM Galli
Divisione di Ematologia, Ospedali Riuniti, Bergamo, Italy
Thromb Haemost 80:246-9. 1998..Both assays, when negative, make unlikely the presence of the R506Q mutation. Polymerase chain reaction analysis remains, however, to be performed when either test is positive...
Treatment of polycythemia veraT Barbui
Department of Hematology, Ospedali Riuniti, Bergamo, Italy
Haematologica 83:143-9. 1998..The purpose of this paper is to critically review the available evidence in literature for selecting the best treatment in the single patient...
Antiphospholipid antibodies: predictive value of laboratory testsM Galli
Division of Haematology, Ospedali Riunlti, Bergamo, Italy
Thromb Haemost 78:75-8. 1997....
Different anticoagulant and immunological properties of anti-prothrombin antibodies in patients with antiphospholipid antibodiesM Galli
Department of Haematology, Ospedali Riuniti, Bergamo, Italy
Thromb Haemost 77:486-91. 1997..These findings suggest that anti-prothrombin antibodies resemble aCL antibodies with respect to the behaviour in "in vitro" coagulation reactions and underline the wide heterogeneity of antiphospholipid antibodies...
Efficacy and safety of hydroxyurea in patients with essential thrombocythemiaG Finazzi
Division of Hematology, Ospedali Riuniti, Bergamo, Italy
Pathol Biol (Paris) 49:167-9. 2001..Sequential multiple chemotherapy, such busulphan followed by HU, should be avoided in any case because of the high risk of secondary leukemias...
A randomized clinical trial of high-intensity warfarin vs. conventional antithrombotic therapy for the prevention of recurrent thrombosis in patients with the antiphospholipid syndrome (WAPS)G Finazzi
The Ospedali Riuniti, Bergamo, Italy
J Thromb Haemost 3:848-53. 2005..18; 95% CI 0.92-5.15). CONCLUSIONS: High-intensity warfarin was not superior to standard treatment in preventing recurrent thrombosis in patients with APS and was associated with an increased rate of minor hemorrhagic complications...
The G1691 --> A mutation of factor V, but not the G20210 --> A mutation of factor II or the C677 --> T mutation of methylenetetrahydrofolate reductase genes, is associated with venous thrombosis in patients with lupus anticoagulantsM Galli
Divisione di Ematologia, Ospedali Riuniti di Bergamo Angelo Bianchi Bonomi Haemophilia and Thrombosis Centre, Institute of Internal Medicine and IRCCS, Maggiore Hospital, Milano, Italy
Br J Haematol 108:865-70. 2000..No significant correlation was found among the three groups. In conclusion, only the G1691 --> A mutation in the factor V gene was associated with the thrombotic risk of patients with lupus anticoagulants...
Treatment strategies in essential thrombocythemia. A critical appraisal of various experiences in different centersT Barbui
Division of Hematology, Ospedali Riuniti Bergamo, Italy
Leuk Lymphoma 22:149-60. 1996..However, both IFN and Anagrelide have shown to have frequent and clinically important side effects. Thus, further clinical studies are required to establish their role in the strategy of ET patient treatment...
Evidence and expertise in the management of polycythemia vera and essential thrombocythemiaG Finazzi
Department of Transfusion Medicine, Ospedali Riuniti di Bergamo, Bergamo, Italy
Leukemia 22:1494-502. 2008..Finally, there is great expectation for novel drugs targeting the constitutively active JAK2/STAT pathway...
Primary antithrombotic prevention in carriers of antiphospholipid antibodies without systemic autoimmune disordersG Finazzi
Division of Hematology, Ospedali Riuniti di Bergamo, Italy
Lupus 21:747-50. 2012....
Incidence and risk factors for bleeding in 1104 patients with essential thrombocythemia or prefibrotic myelofibrosis diagnosed according to the 2008 WHO criteriaG Finazzi
Division of Hematology, Research Foundation, Ospedali Riuniti di Bergamo, Bergamo, Italy
Leukemia 26:716-9. 2012..These observations carry significant therapeutic implications in these two WHO entities...
Polymorphonuclear leukocyte activation and hemostasis in patients with essential thrombocythemia and polycythemia veraA Falanga
Hematology Division, Ospedali Riuniti, Bergamo, Italy
Blood 96:4261-6. 2000..Blood. 2000;96:4261-4266)..
How to manage essential thrombocythemiaG Finazzi
Department of Hematology, Ospedali Riuniti di Bergamo, Bergamo, Italy
Leukemia 26:875-82. 2012..Low-risk women are given low-dose aspirin throughout pregnancy and prophylactic low-molecular-weight heparin (LMWH) post partum, whereas LMWH throughout pregnancy and/or interferon-alpha can be required in high-risk cases...
Recurrence after first cerebral infarction in young adultsM Camerlingo
Unit of Neurology, Azienda Ospedaliera Ospedali Riuniti, Bergamo, Italy
Acta Neurol Scand 102:87-93. 2000..We have investigated recurrence of stroke in a consecutive series of young adults, aged 16 to 45 years, after a first cerebral infarction...
The treatment of polycythaemia vera: an update in the JAK2 eraG Finazzi
Department of Hematology, Ospedali Riuniti di Bergamo, Largo Barozzi 1, I 24128, Bergamo, Italy
Intern Emerg Med 2:13-8. 2007..Nevertheless, these drugs require further clinical experience and, for the time being, should be reserved for selected cases...
Pathogenesis of antiphospholipid syndromeM Galli
Division of Hematology, Ospedali Riuniti, Bergamo, Italy
Thromb Res 115:103-7. 2005
