Gianna Ferretti

Summary

Country: Italy

Publications

  1. pmc Altered inflammation, paraoxonase-1 activity and HDL physicochemical properties in obese humans with and without Prader-Willi syndrome
    Gianna Ferretti
    Dipartimento di Scienze Cliniche Specialistiche e Odontostomatologiche Università Politecnica delle Marche, 60100 Ancona, Italia
    Dis Model Mech 5:698-705. 2012
  2. doi Effect of dietary lipids on paraoxonase-1 activity and gene expression
    G Ferretti
    Dipartimento di Scienze Cliniche Sperimentali e Odontostomatologiche, Universita Politecnica delle Marche, 60131 Ancona, Italy
    Nutr Metab Cardiovasc Dis 22:88-94. 2012
  3. ncbi Structural modifications of HDL and functional consequences
    Gianna Ferretti
    Institute of Biochemistry, Faculty of Medicine, University of Ancona, via Ranieri 1 60131, Italy
    Atherosclerosis 184:1-7. 2006
  4. ncbi Intracellular oxidative activity and respiratory burst of leukocytes isolated from multiple sclerosis patients
    G Ferretti
    Istituto di Biochimica, Facolta di Medicina e Chirurgia, Universita Politecnica delle Marche, Via Ranieri, 60131 Ancona, Italy
    Neurochem Int 48:87-92. 2006
  5. ncbi Increased levels of lipid hydroperoxides in plasma of patients with multiple sclerosis: a relationship with paraoxonase activity
    G Ferretti
    Facolta di Medicina e Chirurgia, Istituto di Biochimica, Universita Politecnica delle Marche, Ancona, Italia
    Mult Scler 11:677-82. 2005
  6. ncbi Homocysteinylation of low-density lipoproteins (LDL) from subjects with Type 1 diabetes: effect on oxidative damage of human endothelial cells
    G Ferretti
    Istituto of Biochimica, Facolta di Medicina e Chirurgia, Universita Politecnica delle Marche, Ancona, Italy
    Diabet Med 23:808-13. 2006
  7. pdf Cherry antioxidants: from farm to table
    Gianna Ferretti
    Department of Biochemistry, Biology and Genetic Polytechnic University of Marche, Via Ranieri 65, 60100 Ancona, Italy
    Molecules 15:6993-7005. 2010
  8. doi Peroxidation of lipoproteins in multiple sclerosis
    Gianna Ferretti
    Dipartimento di Scienze Cliniche Sperimentali e Odontostomatologiche, Universita Politecnica delle Marche, 60131 Ancona, Italy
    J Neurol Sci 311:92-7. 2011
  9. pmc The gluten-free diet: safety and nutritional quality
    Letizia Saturni
    Centro Interdipartimentale di Educazione Sanitaria e Promozione alla Salute, Ancona, 60035 Italy
    Nutrients 2:16-34. 2010
  10. ncbi Paraoxonase activity in high-density lipoproteins: a comparison between healthy and obese females
    G Ferretti
    Istituto di Biochimica, Facolta di Medicina e Chirurgia, Universita Politecnica delle Marche, Via Ranieri, 60131 Ancona, Italy
    J Clin Endocrinol Metab 90:1728-33. 2005

Collaborators

Detail Information

Publications36

  1. pmc Altered inflammation, paraoxonase-1 activity and HDL physicochemical properties in obese humans with and without Prader-Willi syndrome
    Gianna Ferretti
    Dipartimento di Scienze Cliniche Specialistiche e Odontostomatologiche Università Politecnica delle Marche, 60100 Ancona, Italia
    Dis Model Mech 5:698-705. 2012
    ..Whatever the cause of obesity, the increase of adiposity is associated with inflammation, oxidative stress and alterations in HDL compositional and functional properties...
  2. doi Effect of dietary lipids on paraoxonase-1 activity and gene expression
    G Ferretti
    Dipartimento di Scienze Cliniche Sperimentali e Odontostomatologiche, Universita Politecnica delle Marche, 60131 Ancona, Italy
    Nutr Metab Cardiovasc Dis 22:88-94. 2012
    ..PON1 exerts a protective effect against oxidative damage of cells and lipoproteins and modulates the susceptibility of HDL and LDL to atherogenic modifications such as homocysteinylation...
  3. ncbi Structural modifications of HDL and functional consequences
    Gianna Ferretti
    Institute of Biochemistry, Faculty of Medicine, University of Ancona, via Ranieri 1 60131, Italy
    Atherosclerosis 184:1-7. 2006
    ..HDL modification induces generally the loss of their anti-inflammatory and cytoprotective properties. This could play a role in the pathogenesis of atherosclerosis and neurodegenerative diseases such as Alzheimer's disease...
  4. ncbi Intracellular oxidative activity and respiratory burst of leukocytes isolated from multiple sclerosis patients
    G Ferretti
    Istituto di Biochimica, Facolta di Medicina e Chirurgia, Universita Politecnica delle Marche, Via Ranieri, 60131 Ancona, Italy
    Neurochem Int 48:87-92. 2006
    ..In conclusion, our results demonstrate higher levels of intracellular ROS in untreated or in PMA-treated leukocytes isolated from MS patients with respect to healthy subjects confirming the role of oxidative stress in multiple sclerosis...
  5. ncbi Increased levels of lipid hydroperoxides in plasma of patients with multiple sclerosis: a relationship with paraoxonase activity
    G Ferretti
    Facolta di Medicina e Chirurgia, Istituto di Biochimica, Universita Politecnica delle Marche, Ancona, Italia
    Mult Scler 11:677-82. 2005
    ..Therefore, our study demonstrates alterations of lipoprotein peroxidation in MS and provides further evidence that oxidative stress and impairment of the anti-oxidant system may play a role in MS...
  6. ncbi Homocysteinylation of low-density lipoproteins (LDL) from subjects with Type 1 diabetes: effect on oxidative damage of human endothelial cells
    G Ferretti
    Istituto of Biochimica, Facolta di Medicina e Chirurgia, Universita Politecnica delle Marche, Ancona, Italy
    Diabet Med 23:808-13. 2006
    ....
  7. pdf Cherry antioxidants: from farm to table
    Gianna Ferretti
    Department of Biochemistry, Biology and Genetic Polytechnic University of Marche, Via Ranieri 65, 60100 Ancona, Italy
    Molecules 15:6993-7005. 2010
    ..Moreover the health benefits of cherries and their polyphenols against human diseases such as heart disease, cancers, diabetes are reviewed...
  8. doi Peroxidation of lipoproteins in multiple sclerosis
    Gianna Ferretti
    Dipartimento di Scienze Cliniche Sperimentali e Odontostomatologiche, Universita Politecnica delle Marche, 60131 Ancona, Italy
    J Neurol Sci 311:92-7. 2011
    ..Oxidized lipoproteins show several alterations of their functions, they are neurotoxic and have pro-inflammatory properties. Therefore lipoprotein lipid peroxidation products could be involved in demyelination and axonal injury in MS...
  9. pmc The gluten-free diet: safety and nutritional quality
    Letizia Saturni
    Centro Interdipartimentale di Educazione Sanitaria e Promozione alla Salute, Ancona, 60035 Italy
    Nutrients 2:16-34. 2010
    ..The paper is focused on the new definition of gluten-free products in food label, the nutritional properties of the gluten-free cereals and their use to prevent nutritional deficiencies of celiac subjects...
  10. ncbi Paraoxonase activity in high-density lipoproteins: a comparison between healthy and obese females
    G Ferretti
    Istituto di Biochimica, Facolta di Medicina e Chirurgia, Universita Politecnica delle Marche, Via Ranieri, 60131 Ancona, Italy
    J Clin Endocrinol Metab 90:1728-33. 2005
    ..The lower paraoxonase activity and the compositional changes in HDL and LDL could contribute to the greater risk of cardiovascular disease associated with obesity...
  11. ncbi Protective effect of human HDL against Cu(2+)-induced oxidation of astrocytes
    Gianna Ferretti
    Institute of Biochemistry, Faculty of Medicine, University of Ancona, Ancona, Italy
    J Trace Elem Med Biol 17:25-30. 2003
    ....
  12. doi Effect of homocysteinylation on high density lipoprotein physico-chemical properties
    Gianna Ferretti
    Dipartimento di Biochimica, Biologia e Genetica, Universita Politecnica delle Marche, Via Ranieri, 60131 Ancona, Italy
    Chem Phys Lipids 163:228-35. 2010
    ....
  13. doi HDL-paraoxonase and membrane lipid peroxidation: a comparison between healthy and obese subjects
    Gianna Ferretti
    Department of Biochemistry, Biology and Genetics, Marche Polytechnic University, Ancona, Italy
    Obesity (Silver Spring) 18:1079-84. 2010
    ..In conclusion, the decrease of HDL-PON activity and the lower HDL protective action against membrane peroxidation in obese patients could contribute to accelerate the cellular oxidative damage and arteriosclerosis in obesity...
  14. ncbi Lipid peroxidation in stroke patients
    Gianna Ferretti
    Istituto di Biochimica, Universita Politecnica delle Marche, Ancona, Italy
    Clin Chem Lab Med 46:113-7. 2008
    ..The aim of this study was to further investigate the relationship between lipoprotein oxidative damage and stroke...
  15. ncbi Effect of acylethanolamides on lipid peroxidation and paraoxonase activity
    Giovanna Zolese
    Dipartimento di Biochimica, Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Italy
    Biofactors 33:201-9. 2008
    ..The results demonstrated that the NAEs protect plasma lipids and PON1 activity against AAPH and/or copper-induced oxidation...
  16. doi Effect of phytosterols on copper lipid peroxidation of human low-density lipoproteins
    Gianna Ferretti
    Dipartimento di Biochimica, Biologia e Genetica, Universita Politecnica delle Marche, Ancona, Italy
    Nutrition 26:296-304. 2010
    ..Moreover, their antioxidant effect against in vitro-induced lipid peroxidation of human LDL was investigated...
  17. ncbi Effect of homocysteinylation of low density lipoproteins on lipid peroxidation of human endothelial cells
    Gianna Ferretti
    Istituto di Biochimica, Facolta di Medicina e Chirurgia, Universita Politecnica delle Marche, Ancona, Italy
    J Cell Biochem 92:351-60. 2004
    ..These results suggest that Hcy-LDL exert a cytotoxic effect that is likely related to an increase in lipid peroxidation and oxidative damage of EC...
  18. doi Lipid peroxidation in hemodialysis patients: effect of vitamin C supplementation
    Gianna Ferretti
    Istituto di Biochimica, Università Politecnica delle Marche Via Ranieri, 60131, Ancona, Italy
    Clin Biochem 41:381-6. 2008
    ..Aim of the study was to further investigate the relationship between oxidative stress and chronic renal failure...
  19. ncbi Increased plasma concentrations of palmitoylethanolamide, an endogenous fatty acid amide, affect oxidative damage of human low-density lipoproteins: an in vitro study
    Giovanna Zolese
    Istituto di Biochimica, Via Ranieri 65, Universita Politecnica delle Marche, Ancona 60131, Italy
    Atherosclerosis 182:47-55. 2005
    ..1 microM), while the pro-oxidative effect is obtained at a higher PEA concentration (1 microM). Fluorescence and circular dichroism data indicate that the effect of PEA occurs mainly by affecting the conformational features of ApoB-100...
  20. ncbi Protective effect of paraoxonase activity in high-density lipoproteins against erythrocyte membranes peroxidation: a comparison between healthy subjects and type 1 diabetic patients
    G Ferretti
    Instituto di Biochimica, Universita Politecnica delle Marche, I 60131 Ancona, Italy
    J Clin Endocrinol Metab 89:2957-62. 2004
    ..It might be hypothesized that the decrease of PON activity in diabetic patients and the lower HDL protective action against membrane peroxidation could contribute to acceleration of arteriosclerosis in type 1 diabetes mellitus...
  21. pmc Celiac disease, inflammation and oxidative damage: a nutrigenetic approach
    Gianna Ferretti
    Department of Odontostomatologic and Specialistic Clinics Sciences, Polytechnic University of Marche, Ancona, Italy
    Nutrients 4:243-57. 2012
    ..Therefore their adoption could preserve intestinal barrier integrity, play a protective role against toxicity of gliadin peptides and have a role in nutritional therapy of celiac disease...
  22. ncbi Modification induced by homocysteine and low-density lipoprotein on human aortic endothelial cells: an in vitro study
    A Vignini
    Institute of Biochemistry, Universita Politecnica delle Marche, Via P Ranieri 65, 60131 Ancona, Italy
    J Clin Endocrinol Metab 89:4558-61. 2004
    ..In conclusion, our results demonstrated that LDL homocysteinylated in vitro induced alterations of functional properties and NO metabolism of human endothelial cells...
  23. ncbi Copper-induced oxidative damage on astrocytes: protective effect exerted by human high density lipoproteins
    Gianna Ferretti
    Istituto di Biochimica, Facoltà of Medicina, Universita Politecnica delle Marche, Via Ranieri, I 60131 Ancona, Italy
    Biochim Biophys Acta 1635:48-54. 2003
    ....
  24. ncbi Effect of glycation of high density lipoproteins on their physicochemical properties and on paraoxonase activity
    G Ferretti
    Institute of Biochemistry, Faculty of Medicine, University of Ancona, Italy
    Acta Diabetol 38:163-9. 2001
    ..The modification of order and polarity of glycated HDL and the alterations in paraoxonase activity could potentially contribute to the accelerated atherosclerosis in diabetic patients...
  25. ncbi Effect of aluminium on lipid peroxidation of human high density lipoproteins
    G Ferretti
    Institute of Biochemistry, Faculty of Medicine, University of Ancona, Via Ranieri, 1 60131, Ancona, Italy
    Free Radic Res 37:515-21. 2003
    ..Aluminium-induced oxidative damage of HDL could be involved in the development of neurological diseases...
  26. ncbi Coenzyme Q10, antioxidant status and ApoE isoforms
    M Battino
    Institute of Biochemistry, Facolta di Medicina, Universita Politecnica delle Marche, Ancona, Italy
    Biofactors 18:299-305. 2003
    ..The only E2 homozygous subject found had high levels of PON and low levels of CHP; the two E4/E4 subjects had low PON activity together with low levels of CHP...
  27. pmc Lipid peroxidation and paraoxonase-1 activity in celiac disease
    Gianna Ferretti
    Dipartimento di Scienze Cliniche Sperimentali e Odontostomatologiche, Universita Politecnica delle Marche, 60131 Ancona, Italy
    J Lipids 2012:587479. 2012
    ..The alteration of PON1 activity and markers of lipid peroxidation realized at lower extent in patients who were on a gluten-free diet...
  28. ncbi Effect of non-enzymatic glycation on aluminium-induced lipid peroxidation of human high density lipoproteins (HDL)
    G Ferretti
    Istituto di Biochimica, Facolta di Medicina e Chirurgia, Universita Politecnica delle Marche, Ancona, Italy
    Nutr Metab Cardiovasc Dis 14:358-65. 2004
    ....
  29. ncbi The Na+/H+ exchanger modulates the fibrogenic effect of oxidative stress in rat hepatic stellate cells
    G Svegliati-Baroni
    Department of Gastroenterology, University of Ancona, Italy
    J Hepatol 30:868-75. 1999
    ..Its role in different HSC features, such as collagen accumulation, is still unknown. We thus evaluated if the Na+/H+ exchanger modulates the fibrogenic effect of oxidative stress in rat HSC...
  30. ncbi Effect of homocysteinylation on human high-density lipoproteins: a correlation with paraoxonase activity
    G Ferretti
    Institute of Biochemistry, Faculty of Medicine, University of Ancona, Italy
    Metabolism 52:146-51. 2003
    ..Therefore the significant decrease of the enzyme activity in HDL incubated with Hcy-thiolactone suggests that homocysteinylation could render HDL less protective against oxidative damage and against toxicity of Hcy-thiolactone...
  31. pmc A model of insulin resistance and nonalcoholic steatohepatitis in rats: role of peroxisome proliferator-activated receptor-alpha and n-3 polyunsaturated fatty acid treatment on liver injury
    Gianluca Svegliati-Baroni
    Department of Gastroenterology, Institute of Biochemistry, Polytechnic University of Marche, Ancona, Italy
    Am J Pathol 169:846-60. 2006
    ....
  32. ncbi Effect of human Apo AIV against lipid peroxidation of very low density lipoproteins
    G Ferretti
    Faculty of Medicine, Institute of Biochemistry, University of Ancona, Via Ranieri, 60131, Ancona, Italy
    Chem Phys Lipids 114:45-54. 2002
    ....
  33. ncbi Glycated low density lipoproteins modify platelet properties: a compositional and functional study
    G Ferretti
    Institute of Biochemistry, University of Ancona School of Medicine, Italy
    J Clin Endocrinol Metab 87:2180-4. 2002
    ..The present work demonstrates that glycation induces compositional and structural changes in LDL and suggests that an altered interaction between glycLDL and platelets might play a role in the vascular complications of diabetes...
  34. ncbi Effect of genistein against copper-induced lipid peroxidation of human high density lipoproteins (HDL)
    G Ferretti
    Institute of Biochemistry, Faculty of Medicine, University of Ancona, Via Ranieri, I 60131, Ancona, Italy
    Atherosclerosis 172:55-61. 2004
    ..Therefore, we suggested that antioxidant activity exerted by genistein against lipid peroxidation of HDL in vitro could be of physiological relevance...
  35. ncbi Evidence that plasma membrane fluidity of isolated hepatocytes is modified by exposure to microtubule-depolymerizing drugs
    A Benedetti
    Institute of Experimental Pathology, University of Ancona, School of Medicine, Italy
    J Hepatol 10:144-8. 1990
    ..No changes were observed in cells exposed to 10.0 microM beta-lumicolchicine. These observations support the hypothesis that the microtubular system plays a role in the modulations of physico-chemical properties of the plasma membrane...
  36. ncbi Antioxidant and cytoprotective properties of high-density lipoproteins in vascular cells
    Anne Negre-Salvayre
    INSERM U 466, Hôpital Rangueil Toulouse, France
    Free Radic Biol Med 41:1031-40. 2006
    ..Recent evidences indicate that, beside their strong antiatherogenic properties, HDL could exert their protective effect in diseases generally associated to inflammatory events...