R Troncone

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi Adaptive and innate immune responses in celiac disease
    Carmen Gianfrani
    Institute of Food Science and Technology, CNR, Avellino, Italy
    Immunol Lett 99:141-5. 2005
  2. ncbi Markers of potential coeliac disease in patients with Hashimoto's thyroiditis
    Rossella Valentino
    CNR, Experimental Endocrinology and Oncology Center CEOS, Department of Cellular and Molecular Biology and Pathology, University Federico II, Naples, Italy
    Eur J Endocrinol 146:479-83. 2002
  3. ncbi Celiac disease and other immunologically mediated disorders of the gastrointestinal tract: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Riccardo Troncone
    J Pediatr Gastroenterol Nutr 39:S601-10. 2004
  4. ncbi Coeliac disease and extraintestinal autoimmunity
    Riccardo Troncone
    Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Via S. Pansini 5, I-80131 Naples, Italy
    J Pediatr Gastroenterol Nutr 39:S740-1. 2004
  5. ncbi Review article: future research on coeliac disease - a position report from the European multistakeholder platform on coeliac disease (CDEUSSA)
    R Troncone
    Department of Paediatrics and European Laboratory for Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Aliment Pharmacol Ther 27:1030-43. 2008
  6. ncbi Issues related to gluten-free diet in coeliac disease
    Riccardo Troncone
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Curr Opin Clin Nutr Metab Care 11:329-33. 2008
  7. ncbi Colon in food allergy
    Riccardo Troncone
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University of Naples Federico II, Naples, Italy
    J Pediatr Gastroenterol Nutr 48:S89-91. 2009
  8. ncbi Coeliac disease and gluten sensitivity
    R Troncone
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    J Intern Med 269:582-90. 2011
  9. ncbi Coeliac disease in the year 2000
    S Auricchio
    Department of Paediatrics, University Federico II, Naples, Italy
    Ital J Gastroenterol Hepatol 31:773-80. 1999
  10. ncbi Intranasal administration of one alpha gliadin can downregulate the immune response to whole gliadin in mice
    F Maurano
    Istituto di Scienze dell'Alimentazione, CNR, Via Roma 52, 83100 Avellino, Italy
    Scand J Immunol 53:290-5. 2001

Detail Information

Publications78

  1. ncbi Adaptive and innate immune responses in celiac disease
    Carmen Gianfrani
    Institute of Food Science and Technology, CNR, Avellino, Italy
    Immunol Lett 99:141-5. 2005
    ....
  2. ncbi Markers of potential coeliac disease in patients with Hashimoto's thyroiditis
    Rossella Valentino
    CNR, Experimental Endocrinology and Oncology Center CEOS, Department of Cellular and Molecular Biology and Pathology, University Federico II, Naples, Italy
    Eur J Endocrinol 146:479-83. 2002
    ..The aim of this paper was to look for signs of minor small bowel injury and immunohistochemical markers of gluten sensitivity in a group of patients with Hashimoto's disease...
  3. ncbi Celiac disease and other immunologically mediated disorders of the gastrointestinal tract: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Riccardo Troncone
    J Pediatr Gastroenterol Nutr 39:S601-10. 2004
  4. ncbi Coeliac disease and extraintestinal autoimmunity
    Riccardo Troncone
    Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Via S. Pansini 5, I-80131 Naples, Italy
    J Pediatr Gastroenterol Nutr 39:S740-1. 2004
  5. ncbi Review article: future research on coeliac disease - a position report from the European multistakeholder platform on coeliac disease (CDEUSSA)
    R Troncone
    Department of Paediatrics and European Laboratory for Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Aliment Pharmacol Ther 27:1030-43. 2008
    ..Its aim is to bring together basic and applied research in the area of coeliac disease (CD). This paper reviews the main issues that are a result of the CDEUSSA initiative...
  6. ncbi Issues related to gluten-free diet in coeliac disease
    Riccardo Troncone
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Curr Opin Clin Nutr Metab Care 11:329-33. 2008
    ..This review describes the latest progress in research concerning treatment with gluten-free diet in patients with coeliac disease...
  7. ncbi Colon in food allergy
    Riccardo Troncone
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University of Naples Federico II, Naples, Italy
    J Pediatr Gastroenterol Nutr 48:S89-91. 2009
    ..Finally, allergic proctitis may present clinically with refractory constipation; the true prevalence of food allergy-related constipation remains to be assessed...
  8. ncbi Coeliac disease and gluten sensitivity
    R Troncone
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    J Intern Med 269:582-90. 2011
    ..Emphasis is given to specific autoantibodies as markers of the coeliac spectrum and to the hypothesis that innate epithelial stress can exist independently from adaptive intestinal immunity in gluten sensitivity...
  9. ncbi Coeliac disease in the year 2000
    S Auricchio
    Department of Paediatrics, University Federico II, Naples, Italy
    Ital J Gastroenterol Hepatol 31:773-80. 1999
    ....
  10. ncbi Intranasal administration of one alpha gliadin can downregulate the immune response to whole gliadin in mice
    F Maurano
    Istituto di Scienze dell'Alimentazione, CNR, Via Roma 52, 83100 Avellino, Italy
    Scand J Immunol 53:290-5. 2001
    ....
  11. ncbi High density of intraepithelial gammadelta lymphocytes and deposits of immunoglobulin (Ig)M anti-tissue transglutaminase antibodies in the jejunum of coeliac patients with IgA deficiency
    M Borrelli
    Department of Paediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Clin Exp Immunol 160:199-206. 2010
    ..Intestinal IgM anti-TG2 and immunohistochemical markers do not discriminate between IgAD and potential CD with IgAD. Therefore, the serum IgG CD-associated autoantibodies remains very important for the diagnosis of CD in IgAD...
  12. ncbi Keratinocyte growth factor and coeliac disease
    V M Salvati
    Department of Paediatrics, University Federico II, Naples, Italy
    Gut 49:176-81. 2001
    ..CONCLUSIONS: KGF is overexpressed in coeliac biopsies and in tissues with non-coeliac enteropathy. No evidence was found for KGF production by intraepithelial lymphocytes or lamina propria T cells...
  13. ncbi Short wheat challenge is a reproducible in-vivo assay to detect immune response to gluten
    A Camarca
    Institute of Food Sciences CNR, Avellino, Italy
    Clin Exp Immunol 169:129-36. 2012
    ..Our study has important implications for the application of this procedure to clinical practice...
  14. ncbi Faecal calprotectin as reliable non-invasive marker to assess the severity of mucosal inflammation in children with inflammatory bowel disease
    R Berni Canani
    Department of Paediatrics, University of Naples Federico II, Naples, Italy
    Dig Liver Dis 40:547-53. 2008
    ..An accurate monitoring of mucosal inflammation is important for an effective management of patients with inflammatory bowel disease. Intestinal inflammation can be detected by faecal calprotectin level determination...
  15. ncbi Recombinant human interleukin 10 suppresses gliadin dependent T cell activation in ex vivo cultured coeliac intestinal mucosa
    V M Salvati
    Department of Paediatrics, University Federico II, Via Pansini, No 5, 80131 Naples, Italy
    Gut 54:46-53. 2005
    ..Interestingly, rhIL-10 also induces a long term hyporesponsiveness of gliadin specific mucosal T cells. These results offer new perspectives for therapeutic strategies in coeliac patients based on immune modulation by IL-10...
  16. ncbi Transglutaminase 2 in celiac disease: minireview article
    I Caputo
    Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples, Italy
    Amino Acids 26:381-6. 2004
    ..In this paper we review the novel insights on the localization and enzymatic activity of TG2 in the small intestinal mucosa. Moreover, we report on the capability of gliadin and its peptides to act as TG2 substrates...
  17. ncbi Small intestinal enteropathy in non-obese diabetic mice fed a diet containing wheat
    F Maurano
    Institute of Food Science, CNR, Via Roma 52 A C, 83100 Avellino, Italy
    Diabetologia 48:931-7. 2005
    ..The aims of our work were to look for the presence of small intestinal enteropathy in non-obese diabetic (NOD) mice in relation to the presence of wheat proteins in the diet, and to assess their role in the risk of developing diabetes...
  18. ncbi Characterization of the inflammatory infiltrate in peptic oesophagitis
    A Tozzi
    Department of Paediatrics, Federico II University, Naples, Italy
    Dig Liver Dis 33:452-8. 2001
    ..CONCLUSIONS: Although there is a good correlation between symptoms and histology, in a subset of patients, immunohistochemical studies appear useful in supporting the histological diagnosis of gastro-oesophageal reflux disease...
  19. ncbi Intestinal anti-tissue transglutaminase antibodies in potential coeliac disease
    A Tosco
    Department of Pediatrics, University Federico II, Naples, Italy European Laboratory for the Investigation of Food Induced Diseases ELFID, University Federico II, Naples, Italy
    Clin Exp Immunol 171:69-75. 2013
    ..The measurement of intestinal anti-TG2 antibodies may prove useful in clinical practice to predict evolution towards mucosal atrophy in potential coeliac patients and identify patients with gluten sensitivity...
  20. ncbi Coeliac disease and unfavourable outcome of pregnancy
    P Martinelli
    Department of Obsetrics and Gynaecology, University of Naples Federico II, Naples, Italy
    Gut 46:332-5. 2000
    ..In most cases, after 6-12 months of a gluten free diet, no excess of unfavourable outcome of pregnancy is observed. The prevalence of undiagnosed coeliac disease among pregnant women is not known...
  21. ncbi Eosinophilic oesophagitis and coeliac disease: is there an association?
    L Quaglietta
    Department of Pediatrics, University of Naples Federico II, Italy
    Aliment Pharmacol Ther 26:487-93. 2007
    ..To report a series of 17 children affected by eosinophilic oesophagitis. Six of them also received a diagnosis of coeliac disease...
  22. ncbi In vitro-deranged intestinal immune response to gliadin in type 1 diabetes
    Renata Auricchio
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Diabetes 53:1680-3. 2004
    ..In conclusion, signs of mucosal inflammation were present in jejunal biopsies from type 1 diabetic patients, and organ culture studies indicate a deranged mucosal immune response to gliadin...
  23. ncbi Diagnostic value of faecal calprotectin in paediatric gastroenterology clinical practice
    R Berni Canani
    Department of Pediatrics, University Federico II of Naples, Via S Pansini, 5, 80131 Naples, Italy
    Dig Liver Dis 36:467-70. 2004
    ..Faecal calprotectin (FC) is a new marker of intestinal inflammation. Data on FC in paediatric gastroenterology clinical practice are still scarce...
  24. ncbi Gliadin-mediated proliferation and innate immune activation in celiac disease are due to alterations in vesicular trafficking
    M Vittoria Barone
    Department of Pediatrics, European Laboratory for the Investigation of Food Induced Diseases, University of Naples Federico II, Naples, Italy
    PLoS ONE 6:e17039. 2011
    ..Aims of this study were to investigate the role of P31-43 in the induction of cellular proliferation and innate immune activation...
  25. ncbi Safety for patients with celiac disease of baked goods made of wheat flour hydrolyzed during food processing
    Luigi Greco
    Department of Pediatrics and European Laboratory for the Study of Food Induced Diseases, University of Naples, Federico II, Naples, Italy
    Clin Gastroenterol Hepatol 9:24-9. 2011
    ..We evaluated the safety of daily administration of baked goods made from this hydrolyzed form of wheat flour to patients with CD...
  26. ncbi Majority of children with type 1 diabetes produce and deposit anti-tissue transglutaminase antibodies in the small intestine
    Mariantonia Maglio
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Diabetes 58:1578-84. 2009
    ..Given the close association between celiac disease and type 1 diabetes, we investigated the production and deposition of anti-TG2 antibodies in the jejunal mucosa of type 1 diabetic children...
  27. ncbi Butyrate as an effective treatment of congenital chloride diarrhea
    Roberto Berni Canani
    Department of Pediatrics, University Federico II, Naples, Italy
    Gastroenterology 127:630-4. 2004
    ..In this case report, we report the therapeutic efficacy of butyrate on an 11-year-old patient affected by congenital chloride diarrhea...
  28. ncbi Immunoglobulin A anti-tissue transglutaminase antibody deposits in the small intestinal mucosa of children with no villous atrophy
    Antonella Tosco
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    J Pediatr Gastroenterol Nutr 47:293-8. 2008
    ..The aim of this study was to look for anti-TG2 IgA deposits in the intestine of children with normal villous architecture and to relate them with other markers of gluten sensitivity...
  29. ncbi Gliadin activates HLA class I-restricted CD8+ T cells in celiac disease intestinal mucosa and induces the enterocyte apoptosis
    Giuseppe Mazzarella
    Institute of Food Sciences, CNR, Avellino, Italy
    Gastroenterology 134:1017-27. 2008
    ..The target of pA2-mediated cytotoxicity was also investigated by using the intestinal epithelial cell lines Caco2 and HT29, A2(+) and A2(-), respectively, as target cells...
  30. ncbi Combined use of noninvasive tests is useful in the initial diagnostic approach to a child with suspected inflammatory bowel disease
    Roberto Berni Canani
    Department of Pediatrics, University Federico II of Naples, Naples, Italy
    J Pediatr Gastroenterol Nutr 42:9-15. 2006
    ....
  31. ncbi Gliadin regulates the NK-dendritic cell cross-talk by HLA-E surface stabilization
    Giuseppe Terrazzano
    Department of Cellular and Molecular Biology and Pathology, University Federico II, Naples, Italy
    J Immunol 179:372-81. 2007
    ..Analysis of HLA-E expression in the small intestinal mucosa of gluten-containing diet celiac patients and organ culture experiments confirmed the in vitro data...
  32. ncbi Dietary proteins and mechanisms of gastrointestinal diseases: gliadin as a model
    Salvatore Auricchio
    Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Via S. Pansini 5, 80131 Naples, Italy
    J Pediatr Gastroenterol Nutr 39:S738-9. 2004
  33. ncbi Gluten sensitivity in a subset of children with insulin dependent diabetes mellitus
    Riccardo Troncone
    Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples, Italy
    Am J Gastroenterol 98:590-5. 2003
    ..CONCLUSIONS: Approximately 20% of IDDM children react to rectal instillation of gliadin. Long term follow-up is necessary to establish whether these subjects are at increased risk for developing celiac disease...
  34. ncbi Altered intestinal permeability is predictive of early relapse in children with steroid-responsive ulcerative colitis
    E Miele
    Department of Pediatrics, University of Naples Federico II, Naples, Italy
    Aliment Pharmacol Ther 25:933-9. 2007
    ..To determine if small bowel involvement at diagnosis could predict early relapse in children with ulcerative colitis...
  35. ncbi Severe clinical onset of diabetes and increased prevalence of other autoimmune diseases in children with coeliac disease diagnosed before diabetes mellitus
    G Valerio
    Faculty of Motoric Sciences, University Parthenope, Naples, Italy
    Diabetologia 45:1719-22. 2002
    ..Distinct phenotypes might imply the contribution of a peculiar genetic background...
  36. ncbi Adjuvant effect of Lactobacillus casei in a mouse model of gluten sensitivity
    Rossana D'Arienzo
    Institute of Food Sciences, CNR, Avellino, Italy
    Immunol Lett 119:78-83. 2008
    ..Moreover, our data imply that the intrinsic adjuvanticity of L. casei can be exploited to further enhance both mucosal and systemic T cell-mediated responses...
  37. ncbi Clinical, HLA, and small bowel immunohistochemical features of children with positive serum antiendomysium antibodies and architecturally normal small intestinal mucosa
    Francesco Paparo
    Department of Pediatrics and European Laboratory for the Investigation of Food-Induced Diseases, University Federico II, Naples, Italy
    Am J Gastroenterol 100:2294-8. 2005
    ..We recommend that such patients be monitored to assess their progress and to determine whether they need a gluten-free diet...
  38. ncbi Diagnostic accuracy of the atopy patch test in children with food allergy-related gastrointestinal symptoms
    R Berni Canani
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University of Naples Federico II, Naples, Italy
    Allergy 62:738-43. 2007
    ..Moreover, APTs containing purified food extracts have recently become available, but their diagnostic accuracy is largely undefined...
  39. ncbi Immune response of the coeliac nasal mucosa to locally-instilled gliadin
    P Torre
    European Laboratory for Food-Induced Diseases and Department of Paediatrics, University of Naples Federico II, Italy
    Clin Exp Immunol 127:513-8. 2002
    ..In control subjects, both gliadin and albumin induced a moderate but not significant increase in total cell number. In conclusion, the gliadin antigen provokes a mild inflammatory response in coeliac nasal mucosa...
  40. ncbi Interleukin 18 and associated markers of T helper cell type 1 activity in coeliac disease
    V M Salvati
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Gut 50:186-90. 2002
    ..IL-18 is a recently described cytokine capable of promoting T cell interferon (IFN)-gamma production and facilitating Th1 cell polarisation...
  41. ncbi Nuclear factor kappa B is activated in small intestinal mucosa of celiac patients
    Maria Chiara Maiuri
    Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
    J Mol Med (Berl) 81:373-9. 2003
    ..These results show for the first time that NF-kappa B is activated in the inflamed mucosa of celiac patients and suggest that it may represent a molecular target for the modulation of inflammatory response in celiac disease...
  42. ncbi Italian paediatricians' approach to coeliac disease diagnosis
    Renata Auricchio
    Department of Pediatrics, University Federico II, Naples, Italy
    J Pediatr Gastroenterol Nutr 49:374-6. 2009
    ..In conclusion, ESPGHAN criteria are widely followed by Italian CD centres. However, their revision may be useful, but it should be evidence based. Large, multicentre studies are greatly needed...
  43. ncbi A deregulated immune response to gliadin causes a decreased villus height in DQ8 transgenic mice
    Rossana D'Arienzo
    Institute of Food Sciences, CNR, Avellino, Italy
    Eur J Immunol 39:3552-61. 2009
    ..The lesion was induced by a deregulated mucosal cell immunity to gliadin, thus triggering activation of a specific ECM protein pathway responsible for lamina propria remodeling...
  44. ncbi Humoral immune response to tissue transglutaminase is related to epithelial cell proliferation in celiac disease
    Maria V Barone
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Gastroenterology 132:1245-53. 2007
    ..The aim of this study was to determine whether these autoantibodies are involved in the pathogenesis of the mucosal lesion typical of celiac disease...
  45. ncbi Gliadin peptide P31-43 localises to endocytic vesicles and interferes with their maturation
    Maria Vittoria Barone
    Pediatric Department and European Laboratory for the Investigation of Food Induced Disease, University of Naples Federico II, Naples, Italy
    PLoS ONE 5:e12246. 2010
    ..These effects are mediated by delayed EGFR degradation and prolonged EGFR activation in endocytic vesicles. In the present study we investigated the effects of gliadin peptides on the trafficking and maturation of endocytic vesicles...
  46. ncbi Intranasal administration of a recombinant alpha-gliadin down-regulates the immune response to wheat gliadin in DQ8 transgenic mice
    Stefania Senger
    Istituto di Scienze dell' Alimentazione, CNR, Via Roma 52, 83100 Avellino, Italy
    Immunol Lett 88:127-34. 2003
    ..As the Th1 phenotype and the HLA-DQ8 molecule play a role in the pathogenesis of CD, our data underlined the potential usefulness of this recombinant protein for the immunomodulation of this disease...
  47. ncbi Possible drug targets for celiac disease
    Carmen Gianfrani
    Institute of Food Science and Technology, CNR, Avellino, Italy
    Expert Opin Ther Targets 10:601-11. 2006
    ....
  48. ncbi Enhanced expression of interferon regulatory factor-1 in the mucosa of children with celiac disease
    Virginia M Salvati
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Pediatr Res 54:312-8. 2003
    ....
  49. ncbi Coeliac families
    L Greco
    Department of Pediatrics, University Federico II, Naples, Italy
    Acta Paediatr 91:16-7. 2002
  50. ncbi Serum and intestinal celiac disease-associated antibodies in children with celiac disease younger than 2 years of age
    Mariantonia Maglio
    Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    J Pediatr Gastroenterol Nutr 50:43-8. 2010
    ....
  51. ncbi Clinical response to amino acid-based formula in neurologically impaired children with refractory esophagitis
    Erasmo Miele
    Department of Pediatrics and European Laboratory for the Invstigation of Food-Induced Diseases, University Federico II, Naples, Italy
    J Pediatr Gastroenterol Nutr 35:314-9. 2002
    ....
  52. ncbi Functional consequences of NOD2/CARD15 mutations in Crohn disease
    Lucia Quaglietta
    Department of Pediatrics, University Federico II, Naples, Italy
    J Pediatr Gastroenterol Nutr 44:529-39. 2007
    ....
  53. ncbi The influence of gluten free diet on quantitative ultrasound of proximal phalanxes in children and adolescents with type 1 diabetes mellitus and celiac disease
    Giuliana Valerio
    School of Movement Sciences DiSiST, Parthenope University, Naples, Italy
    Bone 43:322-6. 2008
    ..The gluten free diet, as well as the optimization of glycemic control, plays an important role in preventing the osteopenic status caused by the clustering of these two chronic diseases...
  54. ncbi The diagnosis of food allergy in children
    Roberto Berni Canani
    Department of Paediatrics and European Laboratory for the Investigation of Food Induced Diseases, University Federico II, Naples, Italy
    Curr Opin Pediatr 20:584-9. 2008
    ..To give an update about the optimal diagnostic work-up for children with suspected food allergy...
  55. ncbi Genome search in celiac disease
    L Greco
    Department of Pediatrics, University of Federico II, Naples, Italy
    Am J Hum Genet 62:669-75. 1998
    ..Furthermore, a factor on 11qter possibly differentiates the two forms. In contrast, none of the regions recently published was confirmed by the present screening...
  56. ncbi Zonula occludens toxin (Zot) interferes with the induction of nasal tolerance to gliadin
    Mauro Rossi
    Istituto di Scienze dell Alimentazione, CNR, Via Roma 52, 83100, Avellino, Italy
    Immunol Lett 81:217-21. 2002
    ....
  57. ncbi Screening for celiac disease in non-Hodgkin's lymphoma patients: a serum anti-transglutaminase-based approach
    Antonio Carroccio
    Department of Internal Medicine, University Hospital of Palermo, Palermo, Italy
    Dig Dis Sci 48:1530-6. 2003
    ..In conclusion, NHL patients the anti-tTG assay often gives discordant data with the EmA assay, with a high frequency of anti-tTG false positive results for CD diagnosis...
  58. ncbi The gut as site of production of autoimmune antibodies
    Daniele Sblattero
    Department of Biology, University of Trieste, Via L. Giorgieri 10, 34127 Trieste, Italy
    J Pediatr Gastroenterol Nutr 39:S730-1. 2004
  59. ncbi Tissue transglutaminase and celiac disease
    Carla Esposito
    Department of Chemistry, University of Salerno, Via S. Allende, IT-84081 Baronissi, Salerno, Italy
    Prog Exp Tumor Res 38:158-73. 2005
  60. ncbi Identification of immunodominant epitopes of alpha-gliadin in HLA-DQ8 transgenic mice following oral immunization
    Stefania Senger
    Istituto di Scienze dell'Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy
    J Immunol 175:8087-95. 2005
    ..Taken together, these data suggest that, in this model of gluten hypersensitivity, deamidation is not a prerequisite for the initiation of gluten responses...
  61. ncbi Growth factor-like activity of gliadin, an alimentary protein: implications for coeliac disease
    Maria Vittoria Barone
    Dipartimento di Pediatria European Laboratory For the Investigation of Food Induced Disease, Universita degli Studi di Napoli Federico II, CAP 80131, Napoli, Italy
    Gut 56:480-8. 2007
    ..In addition to 'immunogenic' effects, gliadin directly affects cultured cells and intestine preparations, and produces damage in vivo, via a separate 'toxic' peptide, such as A-gliadin p31-43 (P31-43)...
  62. ncbi Celiac disease: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Ivor D Hill
    North American Society of Gastroenterology, Hepatology, and Nutrition, USA
    J Pediatr Gastroenterol Nutr 35:S78-88. 2002
  63. ncbi Celiac disease association with CD8+ T cell responses: identification of a novel gliadin-derived HLA-A2-restricted epitope
    Carmen Gianfrani
    Institute of Food Science and Technology, Consiglio Nazionale delle Ricerche, Avellino, Italy
    J Immunol 170:2719-26. 2003
    ..Finally, we speculate on a possible mechanism leading to processing and presentation of class I-restricted gliadin-derived epitopes in celiac disease patients...
  64. ncbi Constitutive activation of the signal transducer and activator of transcription pathway in celiac disease lesions
    Giuseppe Mazzarella
    Istituto di Scienze dell Alimentazione, Consiglio Nazionale delle Ricerche, Avellino, Italy
    Am J Pathol 162:1845-55. 2003
    ..Furthermore, inhibition of STAT-1 prevented the gliadin-mediated induction of ICAM-1 and B7-2. These data suggest that persistent STAT-1 activation can contribute to maintaining and expanding the local inflammatory response in CD...
  65. ncbi Gliadin-specific type 1 regulatory T cells from the intestinal mucosa of treated celiac patients inhibit pathogenic T cells
    Carmen Gianfrani
    Institute of Food Science Consiglio Nazionale delle Ricerche, Avellino, Italy
    J Immunol 177:4178-86. 2006
    ..In conclusion, dietary Ag-specific Tr1 cells are present in the human intestinal mucosa, and strategies to boost their numbers and/or function may offer new therapeutic opportunities to restore gut homeostasis...
  66. ncbi Evidence for the role of interferon-alfa production by dendritic cells in the Th1 response in celiac disease
    Antonio Di Sabatino
    Centre for Infectious Disease, Institute of Cell and Molecular Science, Barts and the London School of Medicine and Dentistry, London, United Kingdom
    Gastroenterology 133:1175-87. 2007
    ..We examined mucosal DCs in celiac disease in terms of phenotype, activation/maturation state, cytokine production, and function...
  67. ncbi Latest developments in the pathogenesis and treatment of celiac disease
    David Branski
    Department of Pediatrics, Hadassah University Hospitals, Hadassah Medical Organization, 91120 Jerusalem, Israel
    J Pediatr 149:295-300. 2006
  68. ncbi Clinical quiz. Chronic granulomatous disease
    Joseph F Fitzgerald
    Department of Gastroenterology, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania, USA
    J Pediatr Gastroenterol Nutr 34:198, 223. 2002
  69. ncbi HLA related genetic risk for coeliac disease
    Mathieu Bourgey
    INSERM U535, Universite Paris XI, Villejuif, France
    Gut 56:1054-9. 2007
    ..Several studies have shown an elevated prevalence of coeliac disease (CD) in sibs of coeliac patients (risk 8-12%)...
  70. ncbi Rotavirus and celiac disease: clues to the pathogenesis and perspectives on prevention
    Riccardo Troncone
    J Pediatr Gastroenterol Nutr 44:527-8. 2007
  71. ncbi Leiomyomatosis of the oesophagus
    Joseph F Fitzgerald
    Paediatric Gastroenterology, Royal Gwent Hospital, Newport, UK
    J Pediatr Gastroenterol Nutr 39:211, 231. 2004
  72. ncbi Clinical quiz. Secondary carnitine deficiency due to celiac disease
    Joseph F Fitzgerald
    Paediatrics Department University Medical School Milan, Italy
    J Pediatr Gastroenterol Nutr 36:636, 646. 2003
  73. ncbi Clinical quiz. Choledocholithiasis with subsequent bile linkage
    Joseph F Fitzgerald
    Pediatric Gastroenterology and Hepatology, Pediatric Surgery and Pediatric Radiology, Necker-Enfants Malades Hospital, Paris, France
    J Pediatr Gastroenterol Nutr 38:281, 323. 2004
  74. ncbi New therapeutic strategies for coeliac disease: tissue transglutaminase as a target
    Carla Esposito
    Department of Chemistry, University of Salerno, Italy
    Curr Med Chem 14:2572-80. 2007
    ..We also examine their potential as therapeutic tools for coeliac disease...
  75. ncbi Autoimmunity and celiac disease
    Carmen Gianfrani
    Institute of Food Sciences of CNR, Avellino, Italy
    Mini Rev Med Chem 8:129-34. 2008
    ..We review the most recent studies on CD pathogenesis and the possibilities to modulate immune dysfunction in CD...
  76. ncbi Expression and enzymatic activity of small intestinal tissue transglutaminase in celiac disease
    Carla Esposito
    Department of Chemistry, University of Salerno, Salerno, Italy
    Am J Gastroenterol 98:1813-20. 2003
    ....
  77. ncbi Characterization of the anti-tissue transglutaminase antibody response in nonobese diabetic mice
    Daniele Sblattero
    Department of Biology, University of Trieste, Trieste, Italy
    J Immunol 174:5830-6. 2005
    ..Data from NOD mice on a gluten-free diet suggest that the anti-tTG response is not gluten-dependent. The intestinal Ab response to tTG is a feature of NOD mice, but the underlying mechanisms remain obscure...
  78. ncbi Clinical quiz: cat scratch disease
    Riccardo Troncone
    Clinica Pediatrica, Serviuzio di Radiologia, UCO di Igiene e Medicina Preventiva IRCCS Burlo Garafalo, Universita' di Trieste, Trieste, Italy
    J Pediatr Gastroenterol Nutr 36:227, 265. 2003