Bruno Trimarco

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. pmc Insufficient control of blood pressure and incident diabetes
    Raffaele Izzo
    Department of Clinical Medicine, Cardiovascular, and Immunological Sciences, Federico II University Naples, Naples, Italy
    Diabetes Care 32:845-50. 2009
  2. pmc Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
    Natalia V Rivera
    IRCCS Multimedica, via Fantoli 16 15, 20138, Milan, Italy
    BMC Med Genet 14:11. 2013
  3. doi request reprint Omega-3 in antiarrhythmic therapy : pros position
    Bruno Trimarco
    Department of Internal Medicine and Cardiovascular Sciences, Federico II University, Via Sergio Pansini 5, Naples, 80131, Italy
    High Blood Press Cardiovasc Prev 19:201-5. 2012
  4. pmc A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFkappaB activity
    Daniela Sorriento
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Napoli, Italia
    Mol Cancer 8:97. 2009
  5. pmc In vivo properties of the proangiogenic peptide QK
    Gaetano Santulli
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Cattedra di Medicina Interna, Università degli Studi Federico II di Napoli, Italy
    J Transl Med 7:41. 2009
  6. ncbi request reprint AKT participates in endothelial dysfunction in hypertension
    Guido Iaccarino
    Department of Clinical Medicine, University of Naples Federico II, Italy
    Circulation 109:2587-93. 2004
  7. doi request reprint Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression
    Daniela Sorriento
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy
    Hypertension 56:696-704. 2010
  8. ncbi request reprint Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system
    Guido Iaccarino
    Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Naples, Italy
    Circ Res 97:1182-9. 2005
  9. pmc Endovascular treatment of lower extremity arteries is associated with an improved outcome in diabetic patients affected by intermittent claudication
    Giuseppe Giugliano
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy
    BMC Surg 12:S19. 2012
  10. doi request reprint Effects of successful percutaneous lower extremity revascularization on cardiovascular outcome in patients with peripheral arterial disease
    Giuseppe Giugliano
    Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    Int J Cardiol 167:2566-71. 2013

Collaborators

Detail Information

Publications66

  1. pmc Insufficient control of blood pressure and incident diabetes
    Raffaele Izzo
    Department of Clinical Medicine, Cardiovascular, and Immunological Sciences, Federico II University Naples, Naples, Italy
    Diabetes Care 32:845-50. 2009
    ..There is no information on whether incident diabetes is predicted by blood pressure control. We evaluated the hazard of diabetes in relation to blood pressure control in treated hypertensive patients...
  2. pmc Assessment of the 9p21.3 locus in severity of coronary artery disease in the presence and absence of type 2 diabetes
    Natalia V Rivera
    IRCCS Multimedica, via Fantoli 16 15, 20138, Milan, Italy
    BMC Med Genet 14:11. 2013
    ..We investigated the association of 9p21.3 variants with severity of CAD (defined by the number of vessel diseased [VD]) in the presence and absence of T2D...
  3. doi request reprint Omega-3 in antiarrhythmic therapy : pros position
    Bruno Trimarco
    Department of Internal Medicine and Cardiovascular Sciences, Federico II University, Via Sergio Pansini 5, Naples, 80131, Italy
    High Blood Press Cardiovasc Prev 19:201-5. 2012
    ..Keeping these last points in mind, the answer to the previous question is a loud 'NO', also taking into account the fact that omega-3, in contrast to the other antiarrhythmics, do not negatively affect myocardial contractility...
  4. pmc A new synthetic protein, TAT-RH, inhibits tumor growth through the regulation of NFkappaB activity
    Daniela Sorriento
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Napoli, Italia
    Mol Cancer 8:97. 2009
    ..We recently demonstrated that the RH domain of GRK5 (GRK5-RH) inhibits NFkappaB, thus we evaluated its effects on cancer growth...
  5. pmc In vivo properties of the proangiogenic peptide QK
    Gaetano Santulli
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Cattedra di Medicina Interna, Università degli Studi Federico II di Napoli, Italy
    J Transl Med 7:41. 2009
    ..These data open to new fields of investigation on the mechanisms of activation of VEGF receptors, offering clinical implications for treatment of pathophysiological conditions such as chronic ischemia...
  6. ncbi request reprint AKT participates in endothelial dysfunction in hypertension
    Guido Iaccarino
    Department of Clinical Medicine, University of Naples Federico II, Italy
    Circulation 109:2587-93. 2004
    ..It was recently reported that AKT phosphorylates and activates endothelial nitric oxide synthase and that impaired kinase activity may be involved in endothelial dysfunction...
  7. doi request reprint Intracardiac injection of AdGRK5-NT reduces left ventricular hypertrophy by inhibiting NF-kappaB-dependent hypertrophic gene expression
    Daniela Sorriento
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy
    Hypertension 56:696-704. 2010
    ..In conclusion, our study supports the regulation of LVH based on the GRK5-NT inhibition of the NF-κB transduction signaling...
  8. ncbi request reprint Ischemic neoangiogenesis enhanced by beta2-adrenergic receptor overexpression: a novel role for the endothelial adrenergic system
    Guido Iaccarino
    Dipartimento di Medicina Clinica e Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Naples, Italy
    Circ Res 97:1182-9. 2005
    ..Therefore, beta2ARs play a critical role in endothelial cell proliferation and function including revascularization, suggesting a novel and physiologically relevant role in neoangiogenesis in response to ischemia...
  9. pmc Endovascular treatment of lower extremity arteries is associated with an improved outcome in diabetic patients affected by intermittent claudication
    Giuseppe Giugliano
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy
    BMC Surg 12:S19. 2012
    ....
  10. doi request reprint Effects of successful percutaneous lower extremity revascularization on cardiovascular outcome in patients with peripheral arterial disease
    Giuseppe Giugliano
    Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    Int J Cardiol 167:2566-71. 2013
    ..Endovascular revascularization of LE-PAD improves walking performance and quality of life. In the present study, we determined whether successful lower limbs revascularization also impacts cardiovascular outcome in LE-PAD patients...
  11. doi request reprint Effects of nutraceuticals on prevalence of metabolic syndrome and on calculated Framingham Risk Score in individuals with dyslipidemia
    Raffaele Izzo
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    J Hypertens 28:1482-7. 2010
    ..Nutraceuticals (NUTs) are forms of compounds with biological activity and are used to improve health in dosage largely exceeding those obtainable in food...
  12. doi request reprint Antihypertensive response to combination of olmesartan and amlodipine does not depend on method and time of drug administration
    Francesco Rozza
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University Hospital, Via S Pansini 5, 80131, Naples, Italy
    High Blood Press Cardiovasc Prev 20:25-32. 2013
    ..The simultaneous or separate administration of the 2 drugs fully overlapped, suggesting that the fixed combination and the separate administration induce a similar and sustained BP control...
  13. pmc The GPIIIA PlA2 polymorphism is associated with an increased risk of cardiovascular adverse events
    Gennaro Galasso
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University School of Medicine, Naples, Italy
    BMC Cardiovasc Disord 10:41. 2010
    ..We aimed to explore the effect of PlA2 polymorphism on outcome in patients with atherosclerosis...
  14. doi request reprint Cardiovascular disease and high-mobility group box 1--is a new inflammatory killer in town?
    Plinio Cirillo
    Department of Clinical Medicine, Cardiovascular and Immunological Science, University of Naples Federico II, Naples, Italy
    Angiology 64:343-55. 2013
    ..In this review, we consider the role of HMGB-1 in pathological conditions and comment on the role of this protein in the cardiovascular disease...
  15. pmc Ankle/brachial index to everyone
    Giuseppe Giugliano
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy
    BMC Surg 12:S18. 2012
    ..In the last years significant attention has been paid in identifying markers of subclinical atherosclerosis or of increased cardiovascular risk...
  16. ncbi request reprint Endothelial beta2 adrenergic signaling to AKT: role of Gi and SRC
    Michele Ciccarelli
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    Cell Signal 19:1949-55. 2007
    ..We propose a novel signal transduction pathway for beta(2)AR stimulation trough G(alphai) and SRC, leading to activation of AKT...
  17. ncbi request reprint Cardiac side effects of chemotherapy: state of art and strategies for a correct management
    Cinzia Perrino
    Division of Cardiology, Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy
    Curr Vasc Pharmacol 12:106-16. 2014
    ..The purpose of this review is to discuss the clinical features of cardiotoxicity, its molecular basis and novel possible strategies to reduce the likelihood of serious cardiac complications. ..
  18. pmc Mitochondrial localization unveils a novel role for GRK2 in organelle biogenesis
    Anna Fusco
    Clinical Medicine, Cardiovascular and Immunological Sciences Federico II University, Naples, Italy
    Cell Signal 24:468-75. 2012
    ..Our data show a novel sub-cellular localization of GRK2 in the mitochondria and an unexpected role in regulating mitochondrial biogenesis and ATP generation...
  19. doi request reprint Pharmacological approach to cardiovascular risk in metabolic syndrome
    Alessandro Bellis
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences Federico II University, Naples, Italy
    J Cardiovasc Med (Hagerstown) 14:403-9. 2013
    ....
  20. ncbi request reprint Benefits of statins in elderly subjects without established cardiovascular disease: a meta-analysis
    Gianluigi Savarese
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
    J Am Coll Cardiol 62:2090-9. 2013
    ..The purpose of this paper was to assess whether statins reduce all-cause mortality and cardiovascular (CV) events in elderly people without established CV disease...
  21. doi request reprint Usefulness of satisfactory control of low-density lipoprotein cholesterol to predict left ventricular remodeling after a first ST-elevation myocardial infarction successfully reperfused
    Francesco Buono
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, University of Naples Federico II, Naples, Italy
    Am J Cardiol 107:1772-8. 2011
    ..91 to 171.9, p = 0.003). In conclusion, the present study shows that unsatisfactory control of LDL cholesterol independently predicts LV remodeling in patients with first ST-segment elevation myocardial infarction...
  22. ncbi request reprint Multi-slice computed tomography assessment of stent position in a patient with acute coronary syndrome and anomalous origin of the coronary arteries
    Plinio Cirillo
    Division of Cardiology, Department of Advanced Biomedical Sciences, University of Naples, Naples, Italy
    Cardiovasc J Afr 24:e1-3. 2013
    ....
  23. ncbi request reprint Reperfusion Correlates and Clinical Outcomes of Right Ventricular Dysfunction in Patients With Inferior ST-Segment Elevation Myocardial Infarction Undergoing Percutaneous Coronary Intervention
    Raffaele Piccolo
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
    Am J Cardiol 114:243-9. 2014
    ..In conclusion, in patients with inferior STEMI undergoing coronary revascularization, RV dysfunction is associated with a worse long-term prognosis. Postprocedural TIMI flow grade may be a useful tool to predict RV dysfunction. ..
  24. doi request reprint Persistence and adherence to antihypertensive treatment in relation to initial prescription: diuretics versus other classes of antihypertensive drugs
    Valentina Trimarco
    Department of Neurosciences, Federico II University, Naples, Italy
    J Hypertens 30:1225-32. 2012
    ..This indication is not unanimous, because thiazides can cause metabolic alterations, and other side effects that reduce compliance and persistence on treatment...
  25. doi request reprint G protein-coupled receptor kinase 2 in patients with acute myocardial infarction
    Gaetano Santulli
    Division of Internal Medicine, Department of Clinical Medicine and Cardiovascular and Immunologic Sciences, Federico II University, Naples, Italy
    Am J Cardiol 107:1125-30. 2011
    ..Taken together, these data indicate that GRK2 could be predictive of ventricular remodeling after myocardial infarction and could facilitate the tailoring of appropriate therapy for high-risk patients...
  26. ncbi request reprint Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats
    Dario Leosco
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Pansini 5, Edificio 2, 80131 Naples, Italy
    J Gerontol A Biol Sci Med Sci 62:471-80. 2007
    ..In conclusion, prior exercise represents a valid tool to counteract age-related molecular alterations resulting in impaired angiogenesis in response to ischemia...
  27. pmc β1-adrenergic receptor and sphingosine-1-phosphate receptor 1 (S1PR1) reciprocal downregulation influences cardiac hypertrophic response and progression to heart failure: protective role of S1PR1 cardiac gene therapy
    Alessandro Cannavo
    Division of Geriatrics, Department of Translational Medical Sciences A C, G R, D L, G P, N F, D L, Department of Pediatrics and European Laboratory for the Investigation of Food Induced Diseases M V B, and Division of Cardiology, Department of Advanced Biomedical Sciences M C D A, R P, E D P, P C, B T, A R, Federico II University, Naples, Italy Center of Translational Medicine, Temple University, Philadelphia, PA A C, J E R, W J K Division of Cardiology, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Terme BN, Italy G R, C Z, N F and the Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom T M P
    Circulation 128:1612-22. 2013
    ....
  28. doi request reprint Classes of antihypertensive medications and blood pressure control in relation to metabolic risk factors
    Marina De Marco
    Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
    J Hypertens 30:188-93. 2012
    ..This study was performed to assess whether the use of different classes of antihypertensive drugs might influence this association...
  29. pmc Age-related impairment in insulin release: the essential role of β(2)-adrenergic receptor
    Gaetano Santulli
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Naples, Italy
    Diabetes 61:692-701. 2012
    ..Our data indicate that reduced β(2)AR expression contributes to the age-related decline of glucose tolerance in mice...
  30. ncbi request reprint The Pl(A1/A2) polymorphism of glycoprotein IIIa and cerebrovascular events in hypertension: increased risk of ischemic stroke in high-risk patients
    Francesca Lanni
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Naples, Italy
    J Hypertens 25:551-6. 2007
    ..We explored the possibility that this polymorphism represents a risk factor for stroke in hypertensive patients...
  31. doi request reprint No-reflow phenomenon: pathophysiology, diagnosis, prevention, and treatment. A review of the current literature and future perspectives
    Gennaro Galasso
    1Department of Clinical Medicine, Cardiovascular Sciences and Immunology, Federico II University, Naples, Italy
    Angiology 65:180-9. 2014
    ..This review also summarizes the strategies of prevention and treatment of no-reflow, considering the most recent studies results regarding medical therapy and devices. ..
  32. ncbi request reprint Association of suboptimal blood pressure control with body size and metabolic abnormalities
    Oreste Arcucci
    Department of Internal Medicine, Cardiovascular and Immunological Pathology, Geriatrics, Cardiac Surgery, Federico II University Hospital, Naples, Italy
    J Hypertens 25:2296-300. 2007
    ..Whether metabolic abnormalities influence blood pressure control is unclear. We evaluated the relationship between metabolic risk factors and blood pressure control in a large population of patients with hypertension...
  33. ncbi request reprint The Glu27 allele of the beta2 adrenergic receptor increases the risk of cardiac hypertrophy in hypertension
    Guido Iaccarino
    Department of Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Naples, Italy
    J Hypertens 22:2117-22. 2004
    ..We evaluated the impact on hypertension-associated TOD of a highly polymorphic gene with elevated significance for the regulation of the cardiovascular system, the beta2AR gene...
  34. doi request reprint Effects of Ile164 polymorphism of beta2-adrenergic receptor gene on coronary artery disease
    Federico Piscione
    Department of Clinical Medicine, Cardiovascular and Immunology Sciences, Federico II University School of Medicine, Naples, Italy
    J Am Coll Cardiol 52:1381-8. 2008
    ..This study investigated the relationship between beta(2)-adrenergic receptor (B2AR) Ile164 polymorphism and coronary artery disease (CAD)...
  35. doi request reprint Prothymosin alpha protects cardiomyocytes against ischemia-induced apoptosis via preservation of Akt activation
    Alessandro Cannavo
    Division of Cardiology, Department of Advanced Biomedical Sciences, Federico II University of Naples, Via Pansini, 5, 80131, Naples, Italy
    Apoptosis 18:1252-61. 2013
    ..The present study provides for the first time the demonstration that PTα offers cardioprotection against ischemic injury by an Akt-dependent mechanism. ..
  36. doi request reprint Initial left-ventricular mass predicts probability of uncontrolled blood pressure in arterial hypertension
    Raffaele Izzo
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, and Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
    J Hypertens 29:803-8. 2011
    ..Initial left-ventricular mass (LVM) is also a predictor of progression to hypertension, independently of initial blood pressure (BP) and other confounders...
  37. doi request reprint Adenosine-induced torsade de pointes complicating a fractional flow reserve measurement in a right coronary artery intermediate stenosis
    Raffaele Piccolo
    Department of Clinical Medicine, Cardiovascular Sciences and Immunology, Federico II University, Naples, Italy
    Cardiovasc Revasc Med 14:118-20. 2013
    ..Despite this being a very rare arrhythmic complication during FFR, its prompt recognition and treatment are of utmost importance...
  38. doi request reprint Smoking selectively accelerates carotid atherosclerosis in hypertensive patients
    Raffaele Izzo
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Via S Pansini n 5, 80131, Naples, Italy
    High Blood Press Cardiovasc Prev 15:269-73. 2008
    ..Conclusions: Together, these data indicate that in hypertensive patients who have a high risk of developing atherosclerosis, smoking could potentiate the development of atherosclerotic plaques...
  39. pmc CaMK4 Gene Deletion Induces Hypertension
    Gaetano Santulli
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Naples, Italy G S, E C, D S, C D G, A A, B T
    J Am Heart Assoc 1:e001081. 2012
    ....
  40. pmc Abdominal aortic aneurysm in patients affected by intermittent claudication: prevalence and clinical predictors
    Giuseppe Giugliano
    Department of Clinical Medicine and Cardiovascular and Immunological Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy
    BMC Surg 12:S17. 2012
    ..We aimed this study at assessing the prevalence and the clinical predictors of the presence of AAA in a homogeneous cohort of LE-PAD patients affected by intermittent claudication...
  41. ncbi request reprint Reduction of albumin urinary excretion is associated with reduced cardiovascular events in hypertensive and/or diabetic patients. A meta-regression analysis of 32 randomized trials
    Gianluigi Savarese
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
    Int J Cardiol 172:403-10. 2014
    ..Therefore, we sought to investigate, in a meta-regression analysis of randomized studies enrolling hypertensive and/or diabetic patients, whether changes in UAE are associated with changes in CV outcomes and all-cause mortality...
  42. ncbi request reprint Changes of natriuretic peptides predict hospital admissions in patients with chronic heart failure: a meta-analysis
    Gianluigi Savarese
    Department of Advanced Biomedical Sciences, Federico II University of Naples, Naples, Italy
    JACC Heart Fail 2:148-58. 2014
    ....
  43. ncbi request reprint Exercise restores beta-adrenergic vasorelaxation in aged rat carotid arteries
    Dario Leosco
    Department of Clinic Medicine, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
    Am J Physiol Heart Circ Physiol 285:H369-74. 2003
    ..Exercise restores this response and reverts age-related modification in beta-ARs and beta-ARK. Our data support an important role for beta-ARK in vascular beta-AR vasorelaxation...
  44. pmc Transradial versus Transfemoral Approach in Patients Undergoing Percutaneous Coronary Intervention for Acute Coronary Syndrome. A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials
    Raffaele Piccolo
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
    PLoS ONE 9:e96127. 2014
    ..A meta-analysis, meta-regression and trial sequential analysis of safety and efficacy of TRA in ACS setting was performed...
  45. doi request reprint The prognostic value of normal stress cardiac magnetic resonance in patients with known or suspected coronary artery disease: a meta-analysis
    Paola Gargiulo
    SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy
    Circ Cardiovasc Imaging 6:574-82. 2013
    ..The aim of this study was to define the prognostic value of stress CMR for prediction of adverse cardiac events in patients with known or suspected coronary artery disease...
  46. ncbi request reprint Retrospective analysis of coagulation factor II receptor (F2R) sequence variation and coronary heart disease in hypertensive patients
    Bruna Gigante
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Division of Pharmacology, Federico II University, CNR, Naples, Italy
    Arterioscler Thromb Vasc Biol 27:1213-9. 2007
    ..The purpose of this study was to evaluate the role of genetic variants within the coagulation factor II receptor (F2R) in the occurrence of coronary heart disease (CHD)...
  47. doi request reprint Ischemic heart disease in systemic inflammatory diseases. An appraisal
    Paola Gargiulo
    SDN Foundation, Institute of Diagnostic and Nuclear Development, Naples, Italy
    Int J Cardiol 170:286-90. 2014
    ..The aims of this review are to summarize cardiac involvement in systemic inflammatory diseases and to identify areas where evidence is currently lacking that deserve further investigation in the future. ..
  48. pmc Evaluation of the anti-angiogenic properties of the new selective αVβ3 integrin antagonist RGDechiHCit
    Gaetano Santulli
    Department of Clinical Medicine, Cardiovascular and Immunologic Sciences, Federico II University of Naples, Italy
    J Transl Med 9:7. 2011
    ..We have recently synthesized a new and selective ligand of αVβ3 receptor, referred to as RGDechiHCit, that contains a cyclic RGD motif and two echistatin moieties...
  49. pmc Natriuretic peptide-guided therapy in chronic heart failure: a meta-analysis of 2,686 patients in 12 randomized trials
    Gianluigi Savarese
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
    PLoS ONE 8:e58287. 2013
    ..The purpose of this study was to evaluate whether natriuretic peptide-guided therapy, compared to clinically-guided therapy, improves mortality and hospitalization rate in patients with chronic HF...
  50. ncbi request reprint An exaggerated systolic blood pressure response to exercise is associated with cardiovascular remodeling in subjects with prehypertension
    Serafino Fazio
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples Federico II, School of Medicine, Naples, Italy
    Ital Heart J 6:886-92. 2005
    ....
  51. doi request reprint Unexpected preserved brain perfusion imaging despite severe and diffuse atherosclerosis of supra-aortic trunks
    Giuseppe Gargiulo
    Division of Cardiology, Department of Clinical Medicine, Cardiovascular Sciences and Immunology, Federico II University, Naples, Italy
    Cardiovasc J Afr 24:e12-4. 2013
    ..An accurate imaging analysis together with clinical features allowed us to decide on a strategy based on optimal medical therapy and careful clinical monitoring...
  52. ncbi request reprint Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure
    Guido Iaccarino
    Department of Medicina Clinica Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Pansini 5, 80131 Naples, Italy
    Eur Heart J 26:1752-8. 2005
    ..Moreover, we were interested in determining whether GRK2 levels in myocardium and lymphocytes may be associated with beta-AR dysfunction and HF severity...
  53. doi request reprint Nutraceuticals for treatment of high blood pressure values in patients with metabolic syndrome
    Francesco Rozza
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, Federico II University, Via Sergio Pansini 5, BLD 2, 80131, Naples, Italy
    High Blood Press Cardiovasc Prev 16:177-82. 2009
    ....
  54. pmc Use of statins in lower extremity artery disease: a review
    Giuseppe Gargiulo
    Department of Clinical Medicine and Cardiovascular and Immunology Sciences, Federico II University, Via Pansini 5, 80131 Naples, Italy
    BMC Surg 12:S15. 2012
    ..Lower extremity artery disease (LE-PAD) is one of the most common manifestations of atherosclerosis, particularly in elderly patients, and it is related to a high cardiovascular risk...
  55. ncbi request reprint Relationship between changes in platelet reactivity and ischemic events following percutaneous coronary intervention: a meta-regression analysis of 30 randomized trials
    Raffaele Piccolo
    Department of Advanced Biomedical Sciences, Federico II University, Via S Pansini 5, 80131 Naples, Italy
    Atherosclerosis 234:176-84. 2014
    ..However, whether reducing platelet reactivity can lead to a lower incidence of ischemic events after PCI is still controversial. Therefore, we sought to investigate this issue by a meta-regression analysis of randomized trials...
  56. doi request reprint GRK2 levels in umbilical arteries of pregnancies complicated by gestational hypertension and preeclampsia
    Raffaele Napolitano
    Department of Obstetrics and Gynecology, Prenatal Diagnosis and High Risk Pregnancy Unit, University of Naples, Federico II, Naples, Italy
    Am J Hypertens 25:366-71. 2012
    ..The aim of this study is to ascertain if this feature is present in the fetal placental vasculature of pregnancies complicated by hypertensive disorders...
  57. ncbi request reprint Calcium-calmodulin-dependent kinase II (CaMKII) mediates insulin-stimulated proliferation and glucose uptake
    Maddalena Illario
    Department of Biologia e Patologia Cellulare e Molecolare, University of Naples Federico II, Naples, Italy
    Cell Signal 21:786-92. 2009
    ..This represents a novel mechanism in the selective control of insulin signals, and a possible site for pharmacological intervention...
  58. doi request reprint G-protein-coupled receptor kinase 2 and hypertension: molecular insights and pathophysiological mechanisms
    Gaetano Santulli
    Department of Advanced Biomedical Sciences, Federico II University of Naples, 80131, Naples, Italy
    High Blood Press Cardiovasc Prev 20:5-12. 2013
    ..This review attempts to assemble the currently available information concerning GRK2 and hypertension, opening new potential fields of translational investigation to treat this vexing disease...
  59. ncbi request reprint Endothelial dysfunction: its clinical value and methods of assessment
    Teresa Strisciuglio
    Department of Advanced Biomedical Sciences, University of Naples Federico II, Via S Pansini 5, Naples, Italy
    Curr Atheroscler Rep 16:417. 2014
    ..In this review, we underline the clinical value of ED in the cardiovascular field and summarize the principal methods currently available for its assessment. ..
  60. doi request reprint Cardiovascular involvement in patients affected by acromegaly: an appraisal
    Susanna Mosca
    Department of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy
    Int J Cardiol 167:1712-8. 2013
    ....
  61. pmc Genetic deletion of uncoupling protein 3 exaggerates apoptotic cell death in the ischemic heart leading to heart failure
    Cinzia Perrino
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
    J Am Heart Assoc 2:e000086. 2013
    ..In this study, we investigated the effects of ucp3 genetic deletion on mitochondrial function and cell survival under low oxygen conditions in vitro and in vivo...
  62. pmc Impact of diabetes on cardiac sympathetic innervation in patients with heart failure: a 123I meta-iodobenzylguanidine (123I MIBG) scintigraphic study
    Stefania Paolillo
    Department of Advanced Biomedical Sciences, Section of Cardiology, Federico II University, Naples, Italy
    Diabetes Care 36:2395-401. 2013
    ..Few data are available on the effect of DM on cardiac neuropathy in heart failure (HF). The aim of the current study was to assess cardiac sympathetic activity in HF patients with and without DM...
  63. doi request reprint The adipokine visfatin induces tissue factor expression in human coronary artery endothelial cells: another piece in the adipokines puzzle
    Plinio Cirillo
    Department of Clinical Medicine, Cardiovascular and Immunological Science Division of Cardiology, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
    Thromb Res 130:403-8. 2012
    ..This study investigates the effects of visfatin on TF in human coronary endothelial cells (HCAECs)...
  64. ncbi request reprint Effects of ranolazine in symptomatic patients with stable coronary artery disease. A systematic review and meta-analysis
    Gianluigi Savarese
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
    Int J Cardiol 169:262-70. 2013
    ..Aim of the study was to assess in a meta-analysis the effects of R on angina, nitroglycerin consumption, functional capacity, electrocardiographic signs of ischemia and hemodynamic parameters in patients with chronic CAD...
  65. doi request reprint SAR study and conformational analysis of a series of novel peptide G protein-coupled receptor kinase 2 inhibitors
    Isabel Gomez-Monterrey
    Department of Pharmacy, Federico II University of Naples, Naples, Italy
    Biopolymers 101:121-8. 2014
    ..These information can help the design of peptides and peptido-mimetics with enhanced GRK2 inhibition properties. © 2013 Wiley Periodicals, Inc. Biopolymers 101: 121-128, 2014. ..