M Triggiani

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
  2. ncbi request reprint Lung involvement in rheumatoid arthritis
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 20:171-9. 2003
  3. ncbi request reprint Differentiation of monocytes into macrophages induces the upregulation of histamine H1 receptor
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 119:472-81. 2007
  4. pmc Allergy and the cardiovascular system
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Clin Exp Immunol 153:7-11. 2008
  5. doi request reprint Inhibition of secretory phospholipase A2-induced cytokine production in human lung macrophages by budesonide
    Massimo Triggiani
    Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 150:144-55. 2009
  6. pmc Lung mast cells are a source of secreted phospholipases A2
    Massimo Triggiani
    Department of Clinical Immunology and Allergy and the Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 124:558-65, 565.e1-3. 2009
  7. ncbi request reprint Modulation of mast cell and basophil functions by benzene metabolites
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples, Via S, Italy
    Curr Pharm Des 17:3830-5. 2011
  8. ncbi request reprint Secretory phospholipases A2 induce cytokine release from blood and synovial fluid monocytes
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Eur J Immunol 32:67-76. 2002
  9. ncbi request reprint Activation of human inflammatory cells by secreted phospholipases A2
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, 80131 Naples, Via Pansini 5, Italy
    Biochim Biophys Acta 1761:1289-300. 2006
  10. ncbi request reprint Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Immunol 166:4083-91. 2001

Collaborators

  • G Marone
  • G D'Amato
  • M H Gelb
  • P Golino
  • Mario Santini
  • M Russo
  • Lucio Annunziato
  • G Liccardi
  • M Taglialatela
  • P Valent
  • Silvano Sozzani
  • Stephan C Bischoff
  • Barbara Balestrieri
  • K Brockow
  • K Sotlar
  • Luis Escribano
  • G Brevetti
  • W R Sperr
  • T Zuberbier
  • Hans Peter Horny
  • M Arock
  • Francescopaolo Granata
  • Nikolaos G Papadopoulos
  • Luigi Servillo
  • Giorgio Giannattasio
  • Angelica Petraroli
  • Amato de Paulis
  • Jan Demonchy
  • Matteo Bonini
  • Antti Lauerma
  • Graham Roberts
  • Carsten Schmidt-Weber
  • Cezmi A Akdis
  • Aline Sprikkelman
  • Peter Burney
  • Philippe Gevaert
  • Ines Swoboda
  • Javier Fernandez
  • Milena Sokolowska
  • Jörg Kleine-Tebbe
  • Sevcan Celenk
  • Ayse Fusun Kalpaklioglu
  • James Gardner
  • Clare Mills
  • Bodo Niggemann
  • Francesco Annunziato
  • Sven Seys
  • Omer Kalayci
  • Chrysanthi Skevaki
  • Cemal Cingi
  • Susanne Lau
  • Oliver Pfaar
  • Beatrice M Bilò
  • Constantinos Pitsios
  • Ewa Cichocka-Jarosz
  • Maia Rukhadze
  • Rodrigo Rodrigues Alves
  • Ronald Vanree
  • Victoria Cardona
  • Alberto Papi
  • Enrico Heffler
  • Jeroen Buters
  • Hans Jurgen Hoffmann
  • Claudia Traidl-Hoffmann
  • Anna Groblewska
  • Lars K Poulsen
  • Edward Knol
  • Ervinç Mingomataj
  • Jean Luc Fauquert
  • Eckard Hamelmann
  • Ioana Agache
  • Odilija Rudzeviciene
  • Serena O'Neil
  • Marcin Kurowski
  • Adnan Custovic
  • Franziska Rueff
  • Elina Toskala
  • Radoslaw Spiewak
  • Berber Vlieg-Boerstra
  • Felicia Manole
  • Nikolaos Douladiris
  • Ulrike Raap
  • Joanna Makowska
  • Gunnar Nilsson
  • Gianenrico Senna
  • Miguel Blanca
  • Paula Robson-Ansley
  • Gianni Pala
  • Christian Scharf
  • Ingrid Terreehorst

Detail Information

Publications33

  1. pmc Research needs in allergy: an EAACI position paper, in collaboration with EFA
    Nikolaos G Papadopoulos
    Allergy Department, 2nd Pediatric Clinic, University of Athens, Athens, Greece
    Clin Transl Allergy 2:21. 2012
    ..Active involvement of all stakeholders, including Patient Organizations and policy makers are necessary to achieve the aims emphasized herein...
  2. ncbi request reprint Lung involvement in rheumatoid arthritis
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 20:171-9. 2003
    ..Those patients with clinical alterations and/or impaired lung function should undergo a complete radiological study...
  3. ncbi request reprint Differentiation of monocytes into macrophages induces the upregulation of histamine H1 receptor
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 119:472-81. 2007
    ..However, responses elicited by histamine differ depending on cell type, suggesting variable expression of histamine receptors in the monocyte/macrophage lineage...
  4. pmc Allergy and the cardiovascular system
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Clin Exp Immunol 153:7-11. 2008
    ..A better understanding of the mechanisms involved in cardiac mast cell activation may lead to an improvement in prevention and treatment of systemic anaphylaxis...
  5. doi request reprint Inhibition of secretory phospholipase A2-induced cytokine production in human lung macrophages by budesonide
    Massimo Triggiani
    Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 150:144-55. 2009
    ..sPLA(2)s may activate inflammatory cells by both enzymatic and nonenzymatic mechanisms. The aim of this study was to evaluate the effect of the inhaled glucocorticoid budesonide on sPLA(2)-induced activation of primary human macrophages...
  6. pmc Lung mast cells are a source of secreted phospholipases A2
    Massimo Triggiani
    Department of Clinical Immunology and Allergy and the Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 124:558-65, 565.e1-3. 2009
    ..Secreted phospholipases A(2) (sPLA(2)s) are released in plasma and other biologic fluids of patients with inflammatory, autoimmune, and allergic diseases...
  7. ncbi request reprint Modulation of mast cell and basophil functions by benzene metabolites
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples, Via S, Italy
    Curr Pharm Des 17:3830-5. 2011
    ..Together, currently available studies indicate that benzene metabolites interfere by multiple mechanisms with the role of basophils and mast cells in innate immunity and in chronic inflammation in the lung...
  8. ncbi request reprint Secretory phospholipases A2 induce cytokine release from blood and synovial fluid monocytes
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Eur J Immunol 32:67-76. 2002
    ..This effect may concur with the generation of AA in the proinflammatory activity of sPLA2 released during inflammatory diseases...
  9. ncbi request reprint Activation of human inflammatory cells by secreted phospholipases A2
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, 80131 Naples, Via Pansini 5, Italy
    Biochim Biophys Acta 1761:1289-300. 2006
    ..Selective inhibitors of sPLA(2)-enzymatic activity and specific antagonists of sPLA(2) receptors are current being tested for pharmacological treatment of inflammatory and autoimmune diseases...
  10. ncbi request reprint Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Immunol 166:4083-91. 2001
    ....
  11. ncbi request reprint Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine
    M Triggiani
    Division of Clinical Immunology, University of Naples Federico II, Italy
    Biochem Pharmacol 58:1341-8. 1999
    ..This effect of PrC might represent an additional mechanism by which this molecule can exert protective effects in tissue ischemia and in other inflammatory diseases associated with neutrophil and platelet activation...
  12. ncbi request reprint Secretory phospholipases A2 induce beta-glucuronidase release and IL-6 production from human lung macrophages
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Immunol 164:4908-15. 2000
    ..The secretion of enzymes and cytokines induced by sPLA2s from human macrophages may play an important role in inflammation and tissue damage associated with the release of sPLA2s...
  13. ncbi request reprint Role of human FcepsilonRI+ cells in HIV-1 infection
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
    Immunol Rev 179:128-38. 2001
    ..In addition, Tat upregulates the beta-chemokine receptor CCR3, making FcepsilonRI+ cells more susceptible to infection with CCR3 tropic HIV-1 isolates...
  14. ncbi request reprint Are mast cells MASTers in HIV-1 infection?
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 125:89-95. 2001
    ..Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is evidence that human Fc epsilon RI(+) cells could be infected in vitro by M-tropic HIV-1 strains...
  15. ncbi request reprint Human mast cells and basophils in HIV-1 infection
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Trends Immunol 22:229-32. 2001
    ..Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is some evidence that human FcvarepsilonRI(+) cells could be infected in vitro by M-tropic HIV-1 strains...
  16. ncbi request reprint Differential modulation of mediator release from human basophils and mast cells by mizolastine
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Clin Exp Allergy 34:241-9. 2004
    ..Some histamine H1 receptor antagonists exert anti-inflammatory activities by modulating mediator release from basophils and mast cells...
  17. ncbi request reprint Histamine-induced activation of human lung macrophages
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 124:249-52. 2001
    ..Macrophages are primarily involved in inflammatory diseases of the lung. We explored the ability of low concentrations of histamine to induce the release of proinflammatory mediators from human lung macrophages...
  18. ncbi request reprint Mechanisms of IgE elevation in HIV-1 infection
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
    Crit Rev Immunol 20:477-96. 2000
    ..Our results indicate two novel mechanisms by which two HIV-1 proteins, gp120 and Tat, trigger the release of cytokines critical for T(H)2 polarization from human Fc epsilonRI+ cells...
  19. ncbi request reprint Pharmacological modulation of human mast cells and basophils
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, School of Medicine, Naples, Italy
    Clin Exp Allergy 32:1682-9. 2002
  20. ncbi request reprint Treatment of mastocytosis: pharmacologic basis and current concepts
    G Marone
    Divisione di Immunologia Clinica e Allergologia, Universita di Napoli Federico II, Facolta di Medicina, Via S Pansini 5, 80131 Naples, Italy
    Leuk Res 25:583-94. 2001
    ..At the beginning of the new millennium, the therapy of severe forms of aggressive mastocytosis remains a challenge for students of this intriguing disorder...
  21. ncbi request reprint The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils
    G Florio
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
    AIDS 14:931-8. 2000
    ..To investigate the mechanism whereby HIV-1 envelope glycoprotein gp120 from four different isolates obtained in three different countries induces proinflammatory mediator release from normal human basophils...
  22. ncbi request reprint Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin
    R Cirillo
    Department of Medicine, University of Naples Federico II, Second School of Medicine, Italy
    J Immunol 144:3891-7. 1990
    ..99; p less than 0.001) and by A23187 (r = 0.87; p less than 0.001) and their affinity for cyclophilin...
  23. ncbi request reprint A multicenter evaluation of the CARLA system for the measurement of specific IgE antibodies vs. other different methods and skin prick tests
    G Liccardi
    Division of Pneumology and Allergology, A Cardarelli Hospital, Naples, Italy
    J Investig Allergol Clin Immunol 12:235-41. 2002
    ..In conclusion, the CARLA system represents an efficient and reliable immunoassay for the evaluation of serum specific IgE...
  24. ncbi request reprint Secretory phospholipases A2 activate selective functions in human eosinophils
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Immunol 170:3279-88. 2003
    ..These results indicate that sPLA(2)s selectively activate certain proinflammatory and immunoregulatory functions of human eosinophils through mechanism(s) independent from enzymatic activity and from the generation of arachidonic acid...
  25. ncbi request reprint Secretory phospholipases A2 as multivalent mediators of inflammatory and allergic disorders
    Francescopaolo Granata
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 131:153-63. 2003
    ..Therefore, sPLA(2)s may have an important role in inflammatory and allergic reactions by activating multiple mechanisms within inflammatory and immune cells, leading to the production of eicosanoids, cytokines and chemokines...
  26. ncbi request reprint The histamine-cytokine network in allergic inflammation
    Gianni Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, School of Medicine, Naples, Italy
    J Allergy Clin Immunol 112:S83-8. 2003
    ..This observation raises the possibility that long-term treatment with fexofenadine might have beneficial effects on immune dysregulation and tissue damage/remodeling associated with histamine-mediated macrophage activation...
  27. ncbi request reprint Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor
    Francescopaolo Granata
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Immunol 174:464-74. 2005
    ..HLM express the M-type receptor, but its involvement in eliciting cytokine production deserves further investigation...
  28. ncbi request reprint Signaling events involved in cytokine and chemokine production induced by secretory phospholipase A2 in human lung macrophages
    Francescopaolo Granata
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Eur J Immunol 36:1938-50. 2006
    ..These results indicate that sPLA(2) induce the production of cytokines and chemokines in human macrophages by a non-enzymatic mechanism involving the PI3 K/Akt system, the MAPK p38 and ERK1/2 and NF-kappaB...
  29. ncbi request reprint Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophages
    Luigi Servillo
    Department of Biochemistry and Biophysics, Second University of Naples, Via L De Crecchio 7, Naples 80138, Italy
    FASEB J 20:1015-7. 2006
    ..The differences observed in macrophages as compared to monocytes can be explained by 1) p38/ERKs-independent phosphorylation of PAF-AH (II) and 2) appearance of plasma PAF-AH in the course of macrophage differentiation...
  30. ncbi request reprint Secretory phospholipases A2 in inflammatory and allergic diseases: not just enzymes
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 116:1000-6. 2005
    ..Selective inhibitors of sPLA(2)s and specific antagonists of sPLA(2) receptors might prove useful in the treatment of allergic and autoimmune diseases, such as bronchial asthma and rheumatoid arthritis...
  31. ncbi request reprint Mast cells and basophils: friends as well as foes in bronchial asthma?
    Gianni Marone
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Trends Immunol 26:25-31. 2005
    ..Preliminary evidence suggests that these cells might not always be detrimental in asthma but, under some circumstances, have a protective role in modulating certain aspects of innate and acquired immunity and allergic inflammation...
  32. ncbi request reprint The European Competence Network on Mastocytosis (ECNM)
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria
    Wien Klin Wochenschr 116:647-51. 2004
    ..In addition, the ECNM is dedicated to provide the best available information about the disease to patients and physicians...
  33. ncbi request reprint HIV-1 envelope gp41 peptides promote migration of human Fc epsilon RI+ cells and inhibit IL-13 synthesis through interaction with formyl peptide receptors
    Amato de Paulis
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
    J Immunol 169:4559-67. 2002
    ..These data highlight the complexity of the interactions between viral and bacterial peptides with FPR subtypes on human basophils...