Research Topics
Genomes and Genes | M TriggianiSummaryAffiliation: Federico II University Country: Italy Publications
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Publications
Modulation of mast cell and basophil functions by benzene metabolitesMassimo Triggiani
Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples, Via S, Italy
Curr Pharm Des 17:3830-5. 2011..Together, currently available studies indicate that benzene metabolites interfere by multiple mechanisms with the role of basophils and mast cells in innate immunity and in chronic inflammation in the lung...
Lung mast cells are a source of secreted phospholipases A2Massimo Triggiani
Department of Clinical Immunology and Allergy and the Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
J Allergy Clin Immunol 124:558-65, 565.e1-3. 2009..Secreted phospholipases A(2) (sPLA(2)s) are released in plasma and other biologic fluids of patients with inflammatory, autoimmune, and allergic diseases...
Inhibition of secretory phospholipase A2-induced cytokine production in human lung macrophages by budesonideMassimo Triggiani
Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
Int Arch Allergy Immunol 150:144-55. 2009..sPLA(2)s may activate inflammatory cells by both enzymatic and nonenzymatic mechanisms. The aim of this study was to evaluate the effect of the inhaled glucocorticoid budesonide on sPLA(2)-induced activation of primary human macrophages...- Allergy and the cardiovascular systemM Triggiani
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
Clin Exp Immunol 153:7-11. 2008..A better understanding of the mechanisms involved in cardiac mast cell activation may lead to an improvement in prevention and treatment of systemic anaphylaxis... - Differentiation of monocytes into macrophages induces the upregulation of histamine H1 receptorMassimo Triggiani
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
J Allergy Clin Immunol 119:472-81. 2007..However, responses elicited by histamine differ depending on cell type, suggesting variable expression of histamine receptors in the monocyte/macrophage lineage... - Activation of human inflammatory cells by secreted phospholipases A2Massimo Triggiani
Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, 80131 Naples, Via Pansini 5, Italy
Biochim Biophys Acta 1761:1289-300. 2006..Selective inhibitors of sPLA(2)-enzymatic activity and specific antagonists of sPLA(2) receptors are current being tested for pharmacological treatment of inflammatory and autoimmune diseases... - Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptorsM Triggiani
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
J Immunol 166:4083-91. 2001.... - Lung involvement in rheumatoid arthritisMassimo Triggiani
Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
Sarcoidosis Vasc Diffuse Lung Dis 20:171-9. 2003..Those patients with clinical alterations and/or impaired lung function should undergo a complete radiological study... - Secretory phospholipases A2 induce beta-glucuronidase release and IL-6 production from human lung macrophagesM Triggiani
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
J Immunol 164:4908-15. 2000..The secretion of enzymes and cytokines induced by sPLA2s from human macrophages may play an important role in inflammation and tissue damage associated with the release of sPLA2s... - Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitineM Triggiani
Division of Clinical Immunology, University of Naples Federico II, Italy
Biochem Pharmacol 58:1341-8. 1999..This effect of PrC might represent an additional mechanism by which this molecule can exert protective effects in tissue ischemia and in other inflammatory diseases associated with neutrophil and platelet activation... - Secretory phospholipases A2 induce cytokine release from blood and synovial fluid monocytesMassimo Triggiani
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
Eur J Immunol 32:67-76. 2002..This effect may concur with the generation of AA in the proinflammatory activity of sPLA2 released during inflammatory diseases... - Role of human FcepsilonRI+ cells in HIV-1 infectionG Marone
Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
Immunol Rev 179:128-38. 2001..In addition, Tat upregulates the beta-chemokine receptor CCR3, making FcepsilonRI+ cells more susceptible to infection with CCR3 tropic HIV-1 isolates... - Are mast cells MASTers in HIV-1 infection?G Marone
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
Int Arch Allergy Immunol 125:89-95. 2001..Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is evidence that human Fc epsilon RI(+) cells could be infected in vitro by M-tropic HIV-1 strains... - Human mast cells and basophils in HIV-1 infectionG Marone
Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
Trends Immunol 22:229-32. 2001..Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is some evidence that human FcvarepsilonRI(+) cells could be infected in vitro by M-tropic HIV-1 strains... - Differential modulation of mediator release from human basophils and mast cells by mizolastineM Triggiani
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
Clin Exp Allergy 34:241-9. 2004..Therefore, mizolastine differentially regulates the production of mediators from basophils and mast cells in a cell- and stimulus-specific fashion... - Histamine-induced activation of human lung macrophagesG Marone
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
Int Arch Allergy Immunol 124:249-52. 2001..Macrophages are primarily involved in inflammatory diseases of the lung. We explored the ability of low concentrations of histamine to induce the release of proinflammatory mediators from human lung macrophages... - Mechanisms of IgE elevation in HIV-1 infectionG Marone
Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
Crit Rev Immunol 20:477-96. 2000..Our results indicate two novel mechanisms by which two HIV-1 proteins, gp120 and Tat, trigger the release of cytokines critical for T(H)2 polarization from human Fc epsilonRI+ cells... - Pharmacological modulation of human mast cells and basophilsG Marone
Division of Clinical Immunology and Allergy, University of Naples Federico II, School of Medicine, Naples, Italy
Clin Exp Allergy 32:1682-9. 2002 - Treatment of mastocytosis: pharmacologic basis and current conceptsG Marone
Divisione di Immunologia Clinica e Allergologia, Universita di Napoli Federico II, Facolta di Medicina, Via S Pansini 5, 80131 Naples, Italy
Leuk Res 25:583-94. 2001..At the beginning of the new millennium, the therapy of severe forms of aggressive mastocytosis remains a challenge for students of this intriguing disorder... - The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophilsG Florio
Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
AIDS 14:931-8. 2000..To investigate the mechanism whereby HIV-1 envelope glycoprotein gp120 from four different isolates obtained in three different countries induces proinflammatory mediator release from normal human basophils... - Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilinR Cirillo
Department of Medicine, University of Naples Federico II, Second School of Medicine, Italy
J Immunol 144:3891-7. 1990..99; p less than 0.001) and by A23187 (r = 0.87; p less than 0.001) and their affinity for cyclophilin... - A multicenter evaluation of the CARLA system for the measurement of specific IgE antibodies vs. other different methods and skin prick testsG Liccardi
Division of Pneumology and Allergology, A Cardarelli Hospital, Naples, Italy
J Investig Allergol Clin Immunol 12:235-41. 2002..In conclusion, the CARLA system represents an efficient and reliable immunoassay for the evaluation of serum specific IgE... - Secretory phospholipases A2 activate selective functions in human eosinophilsMassimo Triggiani
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
J Immunol 170:3279-88. 2003..These results indicate that sPLA(2)s selectively activate certain proinflammatory and immunoregulatory functions of human eosinophils through mechanism(s) independent from enzymatic activity and from the generation of arachidonic acid... - Secretory phospholipases A2 as multivalent mediators of inflammatory and allergic disordersFrancescopaolo Granata
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
Int Arch Allergy Immunol 131:153-63. 2003..Therefore, sPLA(2)s may have an important role in inflammatory and allergic reactions by activating multiple mechanisms within inflammatory and immune cells, leading to the production of eicosanoids, cytokines and chemokines... - The histamine-cytokine network in allergic inflammationGianni Marone
Division of Clinical Immunology and Allergy, University of Naples Federico II, School of Medicine, Naples, Italy
J Allergy Clin Immunol 112:S83-8. 2003..This observation raises the possibility that long-term treatment with fexofenadine might have beneficial effects on immune dysregulation and tissue damage/remodeling associated with histamine-mediated macrophage activation... - Signaling events involved in cytokine and chemokine production induced by secretory phospholipase A2 in human lung macrophagesFrancescopaolo Granata
Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
Eur J Immunol 36:1938-50. 2006..These results indicate that sPLA(2) induce the production of cytokines and chemokines in human macrophages by a non-enzymatic mechanism involving the PI3 K/Akt system, the MAPK p38 and ERK1/2 and NF-kappaB... - Lysophospholipid transacetylase in the regulation of PAF levels in human monocytes and macrophagesLuigi Servillo
Department of Biochemistry and Biophysics, Second University of Naples, Via L De Crecchio 7, Naples 80138, Italy
FASEB J 20:1015-7. 2006..The differences observed in macrophages as compared to monocytes can be explained by 1) p38/ERKs-independent phosphorylation of PAF-AH (II) and 2) appearance of plasma PAF-AH in the course of macrophage differentiation... - Secretory phospholipases A2 in inflammatory and allergic diseases: not just enzymesMassimo Triggiani
Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research (CISI, University of Naples Federico II, Naples, Italy
J Allergy Clin Immunol 116:1000-6. 2005..Selective inhibitors of sPLA(2)s and specific antagonists of sPLA(2) receptors might prove useful in the treatment of allergic and autoimmune diseases, such as bronchial asthma and rheumatoid arthritis... - Mast cells and basophils: friends as well as foes in bronchial asthma?Gianni Marone
Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
Trends Immunol 26:25-31. 2005..Preliminary evidence suggests that these cells might not always be detrimental in asthma but, under some circumstances, have a protective role in modulating certain aspects of innate and acquired immunity and allergic inflammation... - Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptorFrancescopaolo Granata
Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
J Immunol 174:464-74. 2005..HLM express the M-type receptor, but its involvement in eliciting cytokine production deserves further investigation... - The European Competence Network on Mastocytosis (ECNM)Peter Valent
Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria
Wien Klin Wochenschr 116:647-51. 2004..In addition, the ECNM is dedicated to provide the best available information about the disease to patients and physicians... - HIV-1 envelope gp41 peptides promote migration of human Fc epsilon RI+ cells and inhibit IL-13 synthesis through interaction with formyl peptide receptorsAmato de Paulis
Division of Clinical Immunology and Allergy, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
J Immunol 169:4559-67. 2002..These data highlight the complexity of the interactions between viral and bacterial peptides with FPR subtypes on human basophils...