Affiliation: Federico II University
- Degradation of double-stranded RNA by human pancreatic ribonuclease: crucial role of noncatalytic basic amino acid residuesSalvatore Sorrentino
Department of Biological Chemistry, University Federico II of Naples, Naples, Italy
Biochemistry 42:10182-90. 2003..These data and the wide distribution of the enzyme in different organs and body fluids suggest that HP-RNase has evolved to perform both digestive and nondigestive physiological functions...
- The eight human "canonical" ribonucleases: molecular diversity, catalytic properties, and special biological actions of the enzyme proteinsSalvatore Sorrentino
Department of Structural and Functional Biology, University of Naples Federico II, Naples, Italy
FEBS Lett 584:2194-200. 2010..Recent evolutionary studies suggest that RNases started off in vertebrates as host defence or angiogenic proteins...
- On the thermal stability of the two dimeric forms of ribonuclease AEnrico Bucci
Istituto di Biostrutture e Bioimmagini, CNR, Via Mezzocannone 6, I 80134 Napoli, Italy
Biophys Chem 116:89-95. 2005..This finding is correlated to the structural features of the so-called open interface of the dimeric forms...
- Interactions of the cytotoxic RNase A dimers with the cytosolic ribonuclease inhibitorMariarosaria Naddeo
Dipartimento di Biologia Strutturale e Funzionale, Universita di Napoli Federico II, Italy
FEBS Lett 579:2663-8. 2005..However, when the interactions of the two cytotoxic RNase A dimers with cRI were investigated in a quantitative fashion and at the molecular level, the dimers were found to bind cRI with high affinity and to form tight complexes...