Antonio Simeone

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi The role of Otx genes in progenitor domains of ventral midbrain
    Antonio Simeone
    CEINGE Biotecnologie Avanzate and SEMM European School of Molecular Medicine, Via Comunale Margherita 482, 80145 Naples, Italy
    Adv Exp Med Biol 651:36-46. 2009
  2. ncbi Otx genes in neurogenesis of mesencephalic dopaminergic neurons
    Antonio Simeone
    CEINGE Biotecnologie Avanzate, SEMM European School of Molecular Medicine, Via Gaetano Salvatore 486, 80145 Naples, Italy
    Dev Neurobiol 71:665-79. 2011
  3. ncbi The role of otx2 in adult mesencephalic-diencephalic dopaminergic neurons
    Antonio Simeone
    CEINGE Biotecnologie Avanzate, and SEMM European School of Molecular Medicine, Via Comunale Margherita 482, 80145, Naples, Italy
    Mol Neurobiol 43:107-13. 2011
  4. ncbi Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP
    Michela Di Salvio
    CEINGE Biotecnologie Avanzate, Naples, Italy
    Nat Neurosci 13:1481-8. 2010
  5. ncbi Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm
    Dario Acampora
    CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
    Mech Dev 126:882-97. 2009
  6. ncbi Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain
    Michela Di Salvio
    CEINGE Biotecnologie Avanzate, A Buzzati Traverso, CNR, Naples, Italy
    Int J Dev Biol 54:939-45. 2010
  7. ncbi Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon
    Daniela Omodei
    CEINGE Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Naples, Italy
    Development 135:3459-70. 2008
  8. ncbi Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability
    Luca Giovanni Di Giovannantonio
    CEINGE Biotecnologie Avanzate and SEMM European School of Molecular Medicine Naples site, Via Gaetano Salvatore 486, 80145 Naples, Italy
    Dev Biol 373:176-83. 2013
  9. ncbi Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition
    Dario Acampora
    CEINGE Biotecnologie Avanzate, Via G Salvatore 486, 80145 Naples, Italy
    Development 140:43-55. 2013
  10. ncbi Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma
    Daniela Omodei
    Centro di Ingegneria Genetica CEINGE Biotecnologie Avanzate, Naples, Italy
    Am J Pathol 175:2609-17. 2009

Collaborators

  • Eduardo Puelles
  • Stefano Casola
  • Antonio Pinto
  • Dario Acampora
  • Michela Di Salvio
  • Daniela Omodei
  • Luca Giovanni Di Giovannantonio
  • Nilima Prakash
  • Wolfgang Wurst
  • Pietro Mancuso
  • Luca G Di Giovannantonio
  • Raffaele Prosperi
  • Raffaele Di Francia
  • Ferdinando Frigeri
  • Filippo Russo
  • Anna De Chiara
  • Valeria Severino
  • Rosaria De Filippi

Detail Information

Publications10

  1. ncbi The role of Otx genes in progenitor domains of ventral midbrain
    Antonio Simeone
    CEINGE Biotecnologie Avanzate and SEMM European School of Molecular Medicine, Via Comunale Margherita 482, 80145 Naples, Italy
    Adv Exp Med Biol 651:36-46. 2009
    ..In this context, the regulatory network involving Otx functional interactions with signalling molecules and transcription factors required to promote or prevent the development of mesDA neurons will be analyzed in detail...
  2. ncbi Otx genes in neurogenesis of mesencephalic dopaminergic neurons
    Antonio Simeone
    CEINGE Biotecnologie Avanzate, SEMM European School of Molecular Medicine, Via Gaetano Salvatore 486, 80145 Naples, Italy
    Dev Neurobiol 71:665-79. 2011
    ..In this context, the regulatory network involving Otx functional interactions with signaling molecules and transcription factors required to promote or prevent the development of mesDA neurons will be analyzed in detail...
  3. ncbi The role of otx2 in adult mesencephalic-diencephalic dopaminergic neurons
    Antonio Simeone
    CEINGE Biotecnologie Avanzate, and SEMM European School of Molecular Medicine, Via Comunale Margherita 482, 80145, Naples, Italy
    Mol Neurobiol 43:107-13. 2011
    ..Furthermore, when ectopically expressed in the SNpc, Otx2 suppresses Dat expression and confers efficient neuroprotection to MPTP toxicity by suppressing efficient DA uptake...
  4. ncbi Otx2 controls neuron subtype identity in ventral tegmental area and antagonizes vulnerability to MPTP
    Michela Di Salvio
    CEINGE Biotecnologie Avanzate, Naples, Italy
    Nat Neurosci 13:1481-8. 2010
    ..These findings indicate that Otx2 is required to specify neuron subtype identity in VTA and may antagonize vulnerability to the Parkinsonian toxin MPTP...
  5. ncbi Selective inactivation of Otx2 mRNA isoforms reveals isoform-specific requirement for visceral endoderm anteriorization and head morphogenesis and highlights cell diversity in the visceral endoderm
    Dario Acampora
    CEINGE Biotecnologie Avanzate, 80145 Naples, Italy
    Mech Dev 126:882-97. 2009
    ....
  6. ncbi Otx2 expression is restricted to dopaminergic neurons of the ventral tegmental area in the adult brain
    Michela Di Salvio
    CEINGE Biotecnologie Avanzate, A Buzzati Traverso, CNR, Naples, Italy
    Int J Dev Biol 54:939-45. 2010
    ..This supports the possibility that Otx2 may act as a post-mitotic selector controlling functional features (e.g. identity and/or survival) of a relevant fraction of VTA neurons in the adult...
  7. ncbi Anterior-posterior graded response to Otx2 controls proliferation and differentiation of dopaminergic progenitors in the ventral mesencephalon
    Daniela Omodei
    CEINGE Biotecnologie Avanzate, Via Comunale Margherita 482, 80145 Naples, Italy
    Development 135:3459-70. 2008
    ..Thus, our data provide new insights into the mechanism of mesDA neuron specification and suggest Otx2 as a potential target for cell replacement-based therapeutic approaches in PD...
  8. ncbi Otx2 selectively controls the neurogenesis of specific neuronal subtypes of the ventral tegmental area and compensates En1-dependent neuronal loss and MPTP vulnerability
    Luca Giovanni Di Giovannantonio
    CEINGE Biotecnologie Avanzate and SEMM European School of Molecular Medicine Naples site, Via Gaetano Salvatore 486, 80145 Naples, Italy
    Dev Biol 373:176-83. 2013
    ..In addition, these data suggest that Otx2 and En1 may share similar properties and control survival and vulnerability to MPTP neurotoxin respectively in VTA and SNpc...
  9. ncbi Otx2 is an intrinsic determinant of the embryonic stem cell state and is required for transition to a stable epiblast stem cell condition
    Dario Acampora
    CEINGE Biotecnologie Avanzate, Via G Salvatore 486, 80145 Naples, Italy
    Development 140:43-55. 2013
    ..We propose that Otx2 is a novel intrinsic determinant controlling the functional integrity of ESCs and EpiSCs...
  10. ncbi Expression of the brain transcription factor OTX1 occurs in a subset of normal germinal-center B cells and in aggressive Non-Hodgkin Lymphoma
    Daniela Omodei
    Centro di Ingegneria Genetica CEINGE Biotecnologie Avanzate, Naples, Italy
    Am J Pathol 175:2609-17. 2009
    ..Furthermore, OTX1 expression in a subset of normal GC B cells carrying plasma cell markers suggests its possible contribution to terminal B-cell differentiation...