F Roperto

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. pmc BAG3 protects Bovine Papillomavirus type 1-transformed equine fibroblasts against pro-death signals
    Roberta Cotugno
    Department of Pharmacy, University of Salerno, Via Giovanni Paolo II n, 132, 84084, Fisciano, Salerno, Italy
    Vet Res 44:61. 2013
  2. pmc Bovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors: are two better than one?
    Annunziata Corteggio
    Department of Pathology and Animal Health, University of Naples Federico II, Via Veterinaria, Napoli 1 80137, Italy
    Infect Agent Cancer 8:1. 2013
  3. pmc O(6)-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis
    Gennaro Altamura
    Department of Pathology and Animal Health, University of Naples Federico II, Via Veterinaria, 1 80137, Napoli, Italy
    BMC Vet Res 8:218. 2012
  4. pmc Molecular and epigenetic analysis of the fragile histidine triad tumour suppressor gene in equine sarcoids
    Maria Strazzullo
    Department of Pathology and Animal Health, University of Naples Federico II, Via Veterinaria, Naples, Italy
    BMC Vet Res 8:30. 2012
  5. ncbi request reprint Exposure of nonmigratory pigeons to mancozeb: a sentinel model for humans
    F Roperto
    Department of Veterinary Pathology, Naples University Federico II, Italy
    J Toxicol Environ Health A 54:459-66. 1998
  6. ncbi request reprint Bovine papillomavirus type-2 (BPV-2) infection and expression of uroplakin IIIb, a novel urothelial cell marker, in urinary bladder tumors of cows
    S Roperto
    Department of Pathology and Animal Health, Division of General Pathology, Faculty of Veterinary Medicine, Via Delpino 1, 80137 Naples, Italy
    Vet Pathol 42:812-8. 2005
  7. ncbi request reprint Atypical cilia in the oviductal epithelium of healthy dogs
    F Roperto
    Department of Pathology and Animal Health, Federico II University, Naples, Italy
    J Submicrosc Cytol Pathol 30:581-3. 1998
  8. doi request reprint Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoid
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via F Delpino 1, 80137 Naples
    J Comp Pathol 139:231-7. 2008
  9. doi request reprint Sigma-2 receptor expression in bovine papillomavirus-associated urinary bladder tumours
    S Roperto
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, 80137 Naples, Italy
    J Comp Pathol 142:19-26. 2010
  10. doi request reprint Ferritin heavy chain (FHC) is up-regulated in papillomavirus-associated urothelial tumours of the urinary bladder in cattle
    S Roperto
    Department of Veterinary Pathology and Animal Health, Naples University Federico II, Naples, Italy
    J Comp Pathol 142:9-18. 2010

Collaborators

Detail Information

Publications34

  1. pmc BAG3 protects Bovine Papillomavirus type 1-transformed equine fibroblasts against pro-death signals
    Roberta Cotugno
    Department of Pharmacy, University of Salerno, Via Giovanni Paolo II n, 132, 84084, Fisciano, Salerno, Italy
    Vet Res 44:61. 2013
    ..Derm cells, an equine BPV-negative fibroblast cell line taken as a normal counterpart. Altogether our findings might suggest a mutual cooperation between BAG3 and viral oncoproteins to sustain cell survival. ..
  2. pmc Bovine papillomavirus E5 and E7 oncoproteins in naturally occurring tumors: are two better than one?
    Annunziata Corteggio
    Department of Pathology and Animal Health, University of Naples Federico II, Via Veterinaria, Napoli 1 80137, Italy
    Infect Agent Cancer 8:1. 2013
    ..Studies on the role of BPV E5 and E7 oncoproteins in naturally occurring tumours are of scientific value, as they may shed new light on the biological role of these two oncogenes in cell transformation...
  3. pmc O(6)-methylguanine-DNA methyltransferase in equine sarcoids: molecular and epigenetic analysis
    Gennaro Altamura
    Department of Pathology and Animal Health, University of Naples Federico II, Via Veterinaria, 1 80137, Napoli, Italy
    BMC Vet Res 8:218. 2012
    ..The expression of the oncosuppressor protein was assessed in normal and sarcoid cells and tissues. In addition, the DNA methylation profile was analysed to assess the role of epigenetic mechanism in regulation of MGMT expression...
  4. pmc Molecular and epigenetic analysis of the fragile histidine triad tumour suppressor gene in equine sarcoids
    Maria Strazzullo
    Department of Pathology and Animal Health, University of Naples Federico II, Via Veterinaria, Naples, Italy
    BMC Vet Res 8:30. 2012
    ..The expression of the oncosuppressor protein was assessed in normal and sarcoid cells and tissue...
  5. ncbi request reprint Exposure of nonmigratory pigeons to mancozeb: a sentinel model for humans
    F Roperto
    Department of Veterinary Pathology, Naples University Federico II, Italy
    J Toxicol Environ Health A 54:459-66. 1998
    ..The use of nonmigratory pigeons may serve as an important biological source from which helpful data may be obtained for assessing risks to human health and gaining new insight into pathogenetic mechanisms...
  6. ncbi request reprint Bovine papillomavirus type-2 (BPV-2) infection and expression of uroplakin IIIb, a novel urothelial cell marker, in urinary bladder tumors of cows
    S Roperto
    Department of Pathology and Animal Health, Division of General Pathology, Faculty of Veterinary Medicine, Via Delpino 1, 80137 Naples, Italy
    Vet Pathol 42:812-8. 2005
    ..Although UP IIIb expression does not seem to correlate with the biological behavior of urothelial tumors, it appears to be a highly sensitive marker for bovine urothelial tumors...
  7. ncbi request reprint Atypical cilia in the oviductal epithelium of healthy dogs
    F Roperto
    Department of Pathology and Animal Health, Federico II University, Naples, Italy
    J Submicrosc Cytol Pathol 30:581-3. 1998
    ..An electron-dense plug into the lumen was seen in 1-3% of the basal bodies; occasionally an abnormal spatial configuration of them was also observed. The incidence of abnormal cilia hence is lower than found in the tracheae...
  8. doi request reprint Expression of platelet-derived growth factor-beta receptor and bovine papillomavirus E5 and E7 oncoproteins in equine sarcoid
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via F Delpino 1, 80137 Naples
    J Comp Pathol 139:231-7. 2008
    ..These findings add further weight to the theory that BPV and the PDGF-betaR may have a role in the pathogenesis of this disease...
  9. doi request reprint Sigma-2 receptor expression in bovine papillomavirus-associated urinary bladder tumours
    S Roperto
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, 80137 Naples, Italy
    J Comp Pathol 142:19-26. 2010
    ..03-1.86) and in high-grade carcinomas the mean B(max) was 10.9+/-2.8 pmol/mg of protein (range 8.2-14). The difference in B(max) between low- and high-grade carcinomas was statistically significant (P=0.0001)...
  10. doi request reprint Ferritin heavy chain (FHC) is up-regulated in papillomavirus-associated urothelial tumours of the urinary bladder in cattle
    S Roperto
    Department of Veterinary Pathology and Animal Health, Naples University Federico II, Naples, Italy
    J Comp Pathol 142:9-18. 2010
    ..These findings suggest that FHC up-regulation may be mediated by activation of NF-kappaB and that in turn this may be related to the resistance of bovine papillomavirus type-2 (BPV-2) infected urothelial cells to apoptosis...
  11. doi request reprint Expression of gap junction protein connexin 43 in bovine urinary bladder tumours
    A Corteggio
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via F Delpino 1, 80137 Napoli, Italy
    J Comp Pathol 144:86-90. 2011
    ..Papillary urothelial carcinomas showed moderate cytoplasmic and membrane labelling, while invasive carcinoma showed loss of connexin 43 expression...
  12. doi request reprint A review of bovine urothelial tumours and tumour-like lesions of the urinary bladder
    S Roperto
    Department of Pathology and Animal Health, Naples University Federico II, Naples, Italy
    J Comp Pathol 142:95-108. 2010
    ..High-grade carcinomas, and low and high-grade invasive tumours, are less commonly seen. Bovine papillomavirus (BPV) infection and ingestion of bracken fern both play a central role in carcinogenesis of these lesions...
  13. doi request reprint Heterogeneous shedding of Brucella abortus in milk and its effect on the control of animal brucellosis
    R Capparelli
    Faculty of Biotechnological Sciences, University of Naples Federico II, Naples, Italy
    J Appl Microbiol 106:2041-7. 2009
    ..To ascertain whether in Brucella abortus-infected water buffalo herds, the number of newly infected animals could be reduced by culling superspreaders (the animals secreting > or =10(4) CFU per ml of milk)...
  14. ncbi request reprint Uroplakin expression in the urothelial tumors of cows
    V Ambrosio
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Italy
    Vet Pathol 38:657-60. 2001
    ..Although UP expression is remarkably changed in bladder carcinogenesis of cattle, the UP gene(s) remains expressed during cell transformation and tumor progression...
  15. doi request reprint Melanosis of the urinary bladder in a cow
    V Russo
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    Vet Pathol 45:46-50. 2008
    ..Finally, virologic examination revealed the presence of bovine papillomavirus type 2...
  16. doi request reprint Lymphoepithelioma-like carcinoma of the urinary bladder in a cow associated with bovine papillomavirus type-2
    R Brun
    Department of Pathology and Animal Health, Divisions of General Pathology and Infectious Diseases, Faculty of Veterinary Medicine, Via Delpino 1, Naples University Federico II, Naples, Italy
    J Comp Pathol 139:121-5. 2008
    ..This report extends the spectrum of neoplastic urothelial lesions described in cattle and provides further evidence that some features of these tumours are similar to human counterparts...
  17. ncbi request reprint Sialic acid and GM3 ganglioside expression in papillomavirus-associated urinary bladder tumours of cattle with chronic enzootic haematuria
    S Roperto
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Via Delpino 1, 80137 Naples, Itatly
    J Comp Pathol 137:87-93. 2007
    ..GM1, GM2, GD1a, GD3 and FucGM1 were found as minor components. The study suggested that GM3 ganglioside may have a crucial role in "downregulation" of the metastatic potential of bovine urothelial cancers...
  18. ncbi request reprint Cyclooxygenase-1 and -2 expression in urothelial carcinomas of the urinary bladder in cows
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology Division, Faculty of Veterinary Medicine, Federico II University of Naples, Via Veterinaria 1, 80137 Naples, Italy
    Vet Pathol 40:455-9. 2003
    ..Coexpression of both enzyme isoforms was also revealed by confocal laser scanning microscopic investigations. This study indicates that COX-2 is overexpressed in naturally occurring urothelial carcinomas of cows...
  19. doi request reprint Phosphatidylinositol-3-kinase-AKT pathway, phospho-JUN and phospho-JNK expression in spontaneously arising bovine urinary bladder tumours
    A Corteggio
    Division of Anatomic Pathology and General Pathology, Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Napoli, Italy
    J Comp Pathol 143:173-8. 2010
    ..These findings provide new insights into the aetiopathogenic mechanisms underlying naturally occurring bovine urothelial carcinogenesis and contribute to understanding of the role of E5 oncoprotein in naturally occurring tumorigenesis...
  20. ncbi request reprint Bovine papillomavirus E5 oncoprotein binds to the activated form of the platelet-derived growth factor beta receptor in naturally occurring bovine urinary bladder tumours
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    Oncogene 25:1251-60. 2006
    ..Successful bladder tumour regression would provide a valuable model for therapeutic vaccination against papillomavirus-associated tumours...
  21. doi request reprint Co-expression of bovine papillomavirus E5 and E7 oncoproteins in naturally occurring carcinomas of the urinary bladder in cattle
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    J Comp Pathol 141:84-8. 2009
    ..This is the first report of co-expression of these two oncoproteins in bovine urinary bladder carcinomas. The results suggest that the E7 oncogene has a role in urothelial carcinogenesis...
  22. doi request reprint Short communication: Detection of human Torque teno virus in the milk of water buffaloes (Bubalus bubalis)
    S Roperto
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    J Dairy Sci 92:5928-32. 2009
    ..Finally, the mode of transmission of TTV has not been determined. Contaminated of the food chain with TTV may be a potential risk for human health, representing one of the multiple routes of infection...
  23. doi request reprint Multiple glomus tumors of the urinary bladder in a cow associated with bovine papillomavirus type 2 (BPV-2) infection
    S Roperto
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    Vet Pathol 45:39-42. 2008
    ..Finally, the microscopic pattern of tumor described here shares striking morphologic and immunohistochemical similarities with the angiomatous form of glomus tumor known to occur in man...
  24. doi request reprint Activated platelet-derived growth factor beta receptor expression, PI3K-AKT pathway molecular analysis, and transforming signals in equine sarcoids
    G Borzacchiello
    Department of Pathology and Animal Health, Faculty of Veterinary Medicine, University of Naples Federico II, Via F Delpino, 1 80137, Naples, Italy
    Vet Pathol 46:589-97. 2009
    ..Our results provide new insights into the pathogenesis of equine sarcoids and support the validity of this in-vivo model to further characterize the molecular pathways underlying BPV E5-induced carcinogenesis...
  25. ncbi request reprint Chromosome fragility in cattle with chronic enzootic haematuria
    V Peretti
    Department of Animal Science and Food Inspection, Faculty of Veterinary Medicine, University Federico II, Naples, Italy
    Mutagenesis 22:317-20. 2007
    ..001) of SCEs were observed in animals with CEH (7.35+/-3.59 SCE/cell, group 1) than those in the control (5.40+/-2.68 SCE/cell)...
  26. ncbi request reprint Bovine papillomavirus type 4 in oesophageal papillomas of cattle from the south of Italy
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology and Infectious Diseases Division, Faculty of Veterinary Medicine, Naples University Federico II, Rome, Italy
    J Comp Pathol 128:203-6. 2003
    ..Nucleotide sequencing of the PCR amplicons confirmed the presence of BPV-4 in the papillomas. This is the first report of such infections in a European country other than Britain...
  27. ncbi request reprint First report of morphological variants of urothelial carcinoma in the dog
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology Division, Faculty of Veterinary Medicine, Naples University Federico II, Naples, Italy
    Vet Res Commun 27:327-30. 2003
  28. ncbi request reprint Comparative mapping of the fragile histidine triad (FHIT) gene in cattle, river buffalo, sheep and goat by FISH and assignment to BTA22 by RH-mapping: a comparison with HSA3
    G P Di Meo
    National Research Council CNR, ISPAAM, Laboratory of Animal Cytogenetics and Gene Mapping, Naples, Italy
    Anim Genet 36:363-4. 2005
  29. doi request reprint Mannose-binding lectin haplotypes influence Brucella abortus infection in the water buffalo (Bubalus bubalis)
    R Capparelli
    Faculty of Biotechnological Sciences, University of Naples Federico II, Naples, Italy
    Immunogenetics 60:157-65. 2008
    ..abortus. A replication study (comprising 100 cases and 100 controls) confirmed the results from the original study...
  30. ncbi request reprint Association of bovine papillomavirus type-2 and urinary bladder tumours in cattle from Romania
    L G F Balcos
    Faculty of Veterinary Medicine, Department of Biochemistry and Toxicology, University of Agriculture, Mihail Sadoveanu Alee, 3, 700490 Iasi, Romania
    Res Vet Sci 85:145-8. 2008
    ..This is the first report of BPV-2 infection in Eastern European country, confirming the role of BPV-2 in naturally occurring bovine urothelial carcinogenesis...
  31. ncbi request reprint Rare tumours in domestic animals: a lipid cell variant of urothelial carcinoma of the urinary bladder in a cow and a case of vesical carcinosarcoma in a dog
    G Borzacchiello
    Department of Pathology and Animal Health, General Pathology and Anatomic Pathology Divisions Faculty of Veterinary Medicine Naples University FEDERICO II 80137 Naples Italy
    Vet Res Commun 28:273-4. 2004
  32. ncbi request reprint The pagetoid variant of urothelial carcinoma in situ of urinary bladder in a cow
    G Borzacchiello
    Department of Pathology Animal Health, University of Naples, Italy
    Vet Pathol 38:113-6. 2001
    ..To our knowledge, this is the first report of an unusual pattern of spread of urothelial carcinoma in situ in a cow...
  33. ncbi request reprint Chromosome aberrations in cattle with chronic enzootic haematuria
    M B Lioi
    Department of Animal Production Sciences, University of Basilicata, Via N Sauro 85, 85100 Potenza, Italy
    J Comp Pathol 131:233-6. 2004
    ..In 19 of 20 animals with CEH, two bracken fern toxic compounds (quercitin and ptaquiloside) were demonstrated in urine, serum and milk...
  34. ncbi request reprint Double-labeling immunofluorescence: an alternative to detect multiple antigens in tissue sections
    G Borzacchiello
    Vet Pathol 43:83. 2006