Research Topics
Genomes and Genes
| Natalina QuartoSummaryAffiliation: Federico II University Country: Italy Publications
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Detail Information
Publications
Molecular cloning and expression study of Xenopus latent TGF-beta binding protein-1 (LTBP-1)Natalina Quarto
Dipartimento di Chimica Biologica, Facoltà di Scienze dell Università di Napoli, Federico II, Napoli, Italy
Gene 290:53-61. 2002..These findings suggest an important role for XLTBP-1 in embryo axis formation...- Age-related changes in the biomolecular mechanisms of calvarial osteoblast biology affect fibroblast growth factor-2 signaling and osteogenesisCatherine M Cowan
Department of Surgery, Stanford University School of Medicine, Stanford University, Stanford, California 94305 5148, USA
J Biol Chem 278:32005-13. 2003..Collectively, these findings begin to explain why juvenile, but not adult, osteoblasts successfully heal calvarial defects... - Adipose-derived adult stromal cells heal critical-size mouse calvarial defectsCatherine M Cowan
The Department of Surgery, Stanford University School of Medicine, Stanford University, 257 Campus Drive, Stanford, California 94305, USA
Nat Biotechnol 22:560-7. 2004..The contribution of implanted cells to new bone formation was 84-99% by chromosomal detection. These data show that ADAS cells heal critical-size skeletal defects without genetic manipulation or the addition of exogenous growth factors... - Absence of the p53 tumor suppressor gene promotes osteogenesis in mesenchymal stem cellsMonika Tataria
Pediatric Surgery Research Laboratory, Department of Surgery, Stanford University School of Medicine and Lucille Packard Children's Hospital, Stanford, CA 94305, USA
J Pediatr Surg 41:624-32; discussion 624-32. 2006..These findings may have important implications for the regulation of the MSC compartment during the derivation of osteosarcoma in children... - FGF-2 inhibits osteogenesis in mouse adipose tissue-derived stromal cells and sustains their proliferative and osteogenic potential stateNatalina Quarto
Department of Surgery, School of Medicine, Stanford University, Stanford, California 94305 5148, USA
Tissue Eng 12:1405-18. 2006..These FGF-2 functional characteristics may assist with cell selection and enrichment for the purpose of bone tissue engineering... 
Exogenous activation of BMP-2 signaling overcomes TGFβ-mediated inhibition of osteogenesis in Marfan embryonic stem cells and Marfan patient-specific induced pluripotent stem cellsNatalina Quarto
Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University, School of Medicine, Stanford, California 94305, USA
Stem Cells 30:2709-19. 2012..This study advances our understanding of molecular mechanisms underlying the pathogenesis of bone loss/abnormal skeletogenesis in human diseases caused by mutations in FBN1...
Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patient-specific induced-pluripotent stem cellsNatalina Quarto
Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 109:215-20. 2012....- Differential expression of specific FGF ligands and receptor isoforms during osteogenic differentiation of mouse Adipose-derived Stem Cells (mASCs) recapitulates the in vivo osteogenic patternNatalina Quarto
Children s Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
Gene 424:130-40. 2008..Indeed, this observation further validates ASCs as a suitable resource for skeletal tissue engineering... - Temporal and spatial expression of RNases from zebrafish (Danio rerio)Natalina Quarto
Dipartimento di Biologia Strutturale e Funzionale, Universita di Napoli Federico II, Italy
Gene 427:32-41. 2008..Indeed, taking advantage of zebrafish as an excellent viable model to study gene function, this study opens the way to an investigation of the in vivo role(s) of ZF-RNase-1 during embryonic development, as well as, during organogenesis... - Differential FGF ligands and FGF receptors expression pattern in frontal and parietal calvarial bonesNatalina Quarto
Children s Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, Calif 94305 5148, USA
Cells Tissues Organs 190:158-69. 2009..Frontal bone also elaborated higher levels of Fgf receptor 1, 2 and 3 transcripts versus parietal bone. Taken together, these data suggest that the frontal bone is a domain with higher FGF-signaling competence than parietal bone... - Origin matters: differences in embryonic tissue origin and Wnt signaling determine the osteogenic potential and healing capacity of frontal and parietal calvarial bonesNatalina Quarto
Department of Surgery, Hagey Laboratory for Pediatric Regenerative Medicine, School of Medicine, Stanford, CA 94305, USA
J Bone Miner Res 25:1680-94. 2010.... - The zebrafish (Danio rerio): a model system for cranial suture patterningNatalina Quarto
Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5148, USA
Cells Tissues Organs 181:109-18. 2005..Indeed, the zebrafish represents a versatile and valuable model system for the study of the biogenesis of cranial sutures... - Gene profiling of cells expressing different FGF-2 formsNatalina Quarto
Department of Surgery, School of Medicine Stanford University, 257 Campus Drive, Stanford, CA 94305 5148, USA
Gene 356:49-68. 2005..These results demonstrated that HMWFGF-2 and LMWFGF-2 target the expression of different genes. Particularly, our data suggest that HMWFGF-2 forms may function as inducers of growth inhibition and tumor suppression activities... - Molecular mechanisms of FGF-2 inhibitory activity in the osteogenic context of mouse adipose-derived stem cells (mASCs)Natalina Quarto
Children s Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, CA, USA
Bone 42:1040-52. 2008..Moreover, the present study also indicates that differences exist between mouse and human ASCs in relationship to FGF-2 activity in the osteogenic context... - Different endogenous threshold levels of Fibroblast Growth Factor-ligands determine the healing potential of frontal and parietal bonesBjorn Behr
Children s Surgical Research Program, Department of Surgery Stanford University School of Medicine, Stanford, CA, USA
Bone 47:281-94. 2010..The present study thereby opens new avenues for translational medicine... - Nonintegrating knockdown and customized scaffold design enhances human adipose-derived stem cells in skeletal repairBenjamin Levi
Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, California 94305 5148, USA
Stem Cells 29:2018-29. 2011..This study therefore suggests that genetic targeting of hASCs combined with custom scaffold design can optimize hASCs for skeletal regenerative medicine... - Activation of FGF signaling mediates proliferative and osteogenic differences between neural crest derived frontal and mesoderm parietal derived boneShuli Li
Department of Surgery, Children s Surgical Research Program, Stanford University School of Medicine, Stanford, California, USA
PLoS ONE 5:e14033. 2010.... - Osteogenic differentiation of mouse adipose-derived adult stromal cells requires retinoic acid and bone morphogenetic protein receptor type IB signalingDerrick C Wan
Department of Surgery, Stanford University School of Medicine, 257 Campus Drive West, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 103:12335-40. 2006..Our data therefore demonstrate that the osteogenic commitment of multipotent mouse ADAS requires retinoic acid, which enhances expression of the critical BMPR-IB isoform... - Sox9 neural crest determinant gene controls patterning and closure of the posterior frontal cranial sutureDavid E Sahar
Department of Surgery, The Children s Surgical Research Program, Stanford University, CA 94305 5148, USA
Dev Biol 280:344-61. 2005..These results demonstrate a unique development of the PF suture complex and the role of Sox9 as an important contributor to timely and proper closure of the PF suture through endochondral ossification... - A comparative analysis of the osteogenic effects of BMP-2, FGF-2, and VEGFA in a calvarial defect modelBjorn Behr
Children s Surgical Research Program, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5148, USA
Tissue Eng Part A 18:1079-86. 2012..These data provide a valuable comparative analysis, which can be used to further optimize growth factor-based strategies in skeletal tissue engineering... - CD105 protein depletion enhances human adipose-derived stromal cell osteogenesis through reduction of transforming growth factor β1 (TGF-β1) signalingBenjamin Levi
Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Plastic and Reconstructive Surgery Division, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 286:39497-509. 2011..These findings thus highlight a potential avenue to promote osteogenesis in adipose-derived mesenchymal cells for skeletal regeneration... - Differential expression of sclerostin in adult and juvenile mouse calvariaeMatthew D Kwan
Hagey Laboratory for Pediatric Regenerative Medicine, Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Stanford, Calif 94305 5148, USA
Plast Reconstr Surg 127:595-602. 2011..Thus, the authors compared expression of sclerostin, a bone inhibitor, between the calvariae of juvenile and adult mice... - Locally applied vascular endothelial growth factor A increases the osteogenic healing capacity of human adipose-derived stem cells by promoting osteogenic and endothelial differentiationBjorn Behr
Children s Surgical Research Program, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, California, USA
Stem Cells 29:286-96. 2011..Thus, locally applied VEGFA might prove to be a valuable growth factor that can mediate both osteogenesis and angiogenesis of multipotent hASCs in the context of bone regeneration... - Fgf-18 is required for osteogenesis but not angiogenesis during long bone repairBjorn Behr
Hagey Laboratory, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305, USA
Tissue Eng Part A 17:2061-9. 2011..This study provides hints on how to engineering efficiently programmed bony tissue for long bone repair... - Unique modulation of cadherin expression pattern during posterior frontal cranial suture development and closureDavid E Sahar
Department of Surgery, Hagey Laboratory for Pediatric Regenerative Medicine, School of Medicine, Stanford, CA, USA
Cells Tissues Organs 191:401-13. 2010.... - Role of GSK-3β in the osteogenic differentiation of palatal mesenchymeEmily R Nelson
Hagey Laboratory for Pediatric Regenerative Medicine, Plastic and Reconstructive Surgery Division, Department of Surgery, Stanford University School of Medicine, Stanford, California, United States of America
PLoS ONE 6:e25847. 2011..Using GSK-3ß null mouse embryos, we examine the potential coordinate roles of Wnt and Hedgehog signaling on palatal ossification... - Dura mater-derived FGF-2 mediates mitogenic signaling in calvarial osteoblastsShuli Li
Children s Surgical Research Program, Department of Surgery Stanford University, School of Medicine, Stanford, CA 94305 5148, USA
Am J Physiol Cell Physiol 293:C1834-42. 2007.... - Chemical control of FGF-2 release for promoting calvarial healing with adipose stem cellsMatthew D Kwan
Hagey Laboratory for Pediatric Regenerative Medicine, Stanford University School of Medicine, Stanford, California 94305, USA
J Biol Chem 286:11307-13. 2011..These results suggest that chemically controlled FGF-2 secretion can significantly increase bone formation by ASCs in vivo. This study represents a novel approach toward refining protein delivery for tissue engineering applications... - Cranial osteogenesis and suture morphology in Xenopus laevis: a unique model system for studying craniofacial developmentBethany J Slater
Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Hagey Laboratory for Pediatric Regenerative Medicine, Stanford, California, United States of America
PLoS ONE 4:e3914. 2009..Because of the extended larval period in Xenopus, the molecular basis of these alterations has not been well studied... - Opposite spectrum of activity of canonical Wnt signaling in the osteogenic context of undifferentiated and differentiated mesenchymal cells: implications for tissue engineeringNatalina Quarto
Children s Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, California 94305 5148, USA
Tissue Eng Part A 16:3185-97. 2010..Indeed, this study has important potential implications for tissue engineering, specifically for repair of juvenile bone defects... - Differential activation of canonical Wnt signaling determines cranial sutures fate: a novel mechanism for sagittal suture craniosynostosisBjorn Behr
Children s Surgical Research Program, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine, Stanford, CA, USA
Dev Biol 344:922-40. 2010..We propose that regulation of canonical Wnt signaling is of crucial importance during the physiological patterning of PF and SAG sutures. Importantly, dysregulation of this pathway may lead to craniosynostosis... - Fgf-9 is required for angiogenesis and osteogenesis in long bone repairBjorn Behr
Children s Surgical Research Program, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 107:11853-8. 2010..Moreover, this study further supports the embryonic phenotype previously observed in the developing limb, thus promoting the concept that healing processes in adult organisms may recapitulate embryonic skeletal development... - Integration of Multiple Signaling Regulates through Apoptosis the Differential Osteogenic Potential of Neural Crest-Derived and Mesoderm-Derived OsteoblastsShuli Li
Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University, School of Medicine, Stanford, California, United States of America
PLoS ONE 8:e58610. 2013..Taken together, our findings demonstrate that integration of multiple signaling pathways contribute to imparting greater osteogenic potential to FOb by decreasing apoptosis... - CD90 (Thy-1)-positive selection enhances osteogenic capacity of human adipose-derived stromal cellsMichael T Chung
Hagey Laboratory for Pediatric Regenerative Medicine, Plastic and Reconstructive Surgery Division, Department of Surgery, Stanford University School of Medicine, Stanford, CA 94305 5148, USA
Tissue Eng Part A 19:989-97. 2013..The purpose of the present study was to compare the ability of CD90 (Thy-1) to identify osteoprogenitors relative to CD(105)... - Integration of multiple signaling pathways determines differences in the osteogenic potential and tissue regeneration of neural crest-derived and mesoderm-derived calvarial bonesKshemendra Senarath-Yapa
Hagey Laboratory for Pediatric Regenerative Medicine, Department of Surgery, Stanford University, School of Medicine, Stanford, CA 94305, USA
Int J Mol Sci 14:5978-97. 2013..Furthermore, we explore recent studies which have provided a tantalizing insight into way these pathways interact, with evidence accumulating for certain transcription factors, such as Runx2, acting as a nexus for cross-talk... - Craniosynostosis of coronal suture in twist1 mice occurs through endochondral ossification recapitulating the physiological closure of posterior frontal sutureBjorn Behr
Hagey Laboratory for Regenerative Medicine, Department of Surgery, Division of Plastic and Reconstructive Surgery, Stanford University School of Medicine Stanford, CA, USA
Front Physiol 2:37. 2011..Moreover, it suggests that haploinsufficiency of Twist1 gene, a target of canonical Wnt-signaling, and inhibitor of chondrogenesis, mimics conditions of inactive canonical Wnt-signaling leading to craniosynostosis... - Ribonucleases and angiogenins from fishElio Pizzo
Department of Structural and Functional Biology, University of Naples Federico II, Complesso M S Angelo, Via Cintia, 80126 Napoli, Italy
J Biol Chem 281:27454-60. 2006..They later evolved into both mammalian angiogenins and, through a successful phylogenesis, RNases endowed with digestive features or with diverse bioactivities...