Research Topics
Species | Paola PedrazziSummaryAffiliation: Federico II University Country: Italy Publications
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Detail Information
Publications
Acquired inhibitors of coagulation factors: part I-acquired hemophilia AAntonio Coppola
Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
Semin Thromb Hemost 38:433-46. 2012..Present knowledge about this often overlooked and challenging condition has significantly increased following establishment of recent national and international studies, as will also be reviewed in this article...
Prophylaxis in children with hemophilia: evidence-based achievements, old and new challengesAntonio Coppola
Regional Reference Center for Coagulation Disorders, Federico II University Hospital, Naples, Italy
Semin Thromb Hemost 38:79-94. 2012..Scientific evidence, current clinical strategies, and open issues of prophylaxis in children with hemophilia will be addressed in this review...
Bleeding and thrombosis in multiple myeloma and related plasma cell disordersAntonio Coppola
Regional Reference Center for Coagulation Disorders, Federico II University Hospital, Naples, Italy
Semin Thromb Hemost 37:929-45. 2011..The clinical impact of bleeding and thrombotic complications in patients with PCD, with emphasis on MM, will be discussed in this review, reporting the current knowledge about pathophysiologic mechanisms and implications for management...
Optimizing management of immune tolerance induction in patients with severe haemophilia A and inhibitors: towards evidence-based approachesAntonio Coppola
Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
Br J Haematol 150:515-28. 2010..This article reviews the available literature evidence and clinical implications with current recommendations on ITI management, and highlights the issues still unsolved...
Understanding inhibitor development in haemophilia A: towards clinical prediction and prevention strategiesA Coppola
Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Via S Pansini, 5 80131 Naples, Italy
Haemophilia 16:13-9. 2010....
Inherited thrombophilia: implications for prevention and treatment of venous thromboembolismAntonio Coppola
Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
Semin Thromb Hemost 35:683-94. 2009..These considerations should be taken into account when assessing the need and modalities of primary and secondary thromboprophylaxis in patients carrying inherited thrombophilic traits...
Factor VIII gene (F8) mutations as predictors of outcome in immune tolerance induction of hemophilia A patients with high-responding inhibitorsA Coppola
Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
J Thromb Haemost 7:1809-15. 2009..Predictors of ITI outcome are still debated, and the role of F8 gene mutations in this is not well established...
Prophylaxis in people with haemophiliaAntonio Coppola
Regional Reference Centre for Coagulation Disorders, Federico II University Hospital, Naples, Italy
Thromb Haemost 101:674-81. 2009....
Primary prophylaxis in children with haemophiliaAntonio Coppola
Centro di Riferimento Regionale per le Emocoagulopatie, Universita Federico II, Napoli, Italia
Blood Transfus 6:s4-11. 2008..Open issues concerning optimal regimens and barriers to the implementation of prophylaxis are also discussed...
Desmopressin in inherited disorders of platelet functionA Coppola
Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University of Naples, Naples, Italy
Haemophilia 14:31-9. 2008..This review will focus the available clinical data and the open issues of DDAVP in this setting...
Recombinant activated factor VII for hemostatic cover of orthopedic interventions in a girl with thrombocytopenia with absent radii syndromeAntonio Coppola
Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University of Naples, Naples, Italy
Blood Coagul Fibrinolysis 18:199-201. 2007....
Long-term prophylaxis with intermediate-purity factor VIII concentrate (Haemate P) in a patient with type 3 von Willebrand disease and recurrent gastrointestinal bleedingA Coppola
Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
Haemophilia 12:90-4. 2006..Long-term prophylaxis with Haemate P has been shown to be safe, effective (also in terms of quality of life) and cost saving in this patient with severe gastrointestinal bleeding due to MVA and VWD...
Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotypeAntonio Coppola
Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
Br J Haematol 131:100-8. 2005..In parallel with long-lasting tHcy-lowering effects, a short-course 5-MTHF supplementation reduces in vivo formation of 8-iso-PGF2alpha in this population, supporting the antioxidant protective effects of folate in vascular disease...
Long-lasting intestinal bleeding in an old patient with multiple mucosal vascular abnormalities and Glanzmann's thrombasthenia: 3-year pharmacological managementA Coppola
Centro di Coordinamento Regionale per le Emocoagulopatie, Cattedra di Gastroenterologia, Dipartimento di Medicina Clinica e Sperimentale, Universita Federico II, Napoli, Italy
J Intern Med 252:271-5. 2002....
