Daria Nurzynska

Summary

Affiliation: University of Naples "Federico II"
Location: Naples, Italy
URL: https://www.docenti.unina.it/cercaDocente.do?cognome=nurzynska&submit1=avvia+ricerca
Summary:
University rsearcher: characterization of cardiac stem cells in the normal and pathological conditions, methods for the enhancement of cardiac tissue regeneration, origin of cardiac stem cells in the human heart
Faculty of Medicine and Surgery member: human anatomy lectures, seminars and examination
Member of the Working Group in Developmental Anatomy and Pathology (WG17)and Cellular Biology of the Heart (WG03) of the European Society of Cardiology

Publications

  1. ncbi Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression
    Daniele Torella
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 94:514-24. 2004
  2. ncbi Localization and origin of cardiac CD117-positive cells: identification of a population of epicardially-derived cells in adult human heart
    Franca Di Meglio
    Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy
    Ital J Anat Embryol 115:71-8. 2010
  3. ncbi Epithelial-mesenchymal transition of epicardial mesothelium is a source of cardiac CD117-positive stem cells in adult human heart
    Franca Di Meglio
    Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy
    J Mol Cell Cardiol 49:719-27. 2010
  4. ncbi Epicardial cells are missing from the surface of hearts with ischemic cardiomyopathy: a useful clue about the self-renewal potential of the adult human heart?
    Franca Di Meglio
    Int J Cardiol 145:e44-6. 2010
  5. ncbi CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and alpha6 integrin expression
    Clotilde Castaldo
    aDepartment of Biomorphological and Functional Sciences, University Federico II, Naples, Italy
    Stem Cells 26:1723-31. 2008
  6. ncbi Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan
    Arantxa Gonzalez
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circ Res 102:597-606. 2008
  7. ncbi Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: focus on cell-matrix signaling
    Alessandro Della Corte
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, V Monaldi Hospital, Naples, Italy
    J Thorac Cardiovasc Surg 135:8-18, 18.e1-2. 2008
  8. ncbi Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart
    Daria Nurzynska
    Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy
    Ultrasound Med Biol 34:334-42. 2008
  9. ncbi Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 97:663-73. 2005
  10. ncbi Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function
    Axel Linke
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:8966-71. 2005

Collaborators

Detail Information

Publications15

  1. ncbi Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression
    Daniele Torella
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 94:514-24. 2004
    ..The differential response of TG mice to chronological age may result from preservation of functional CSCs undergoing myocyte commitment. In conclusion, senescence of CSCs and myocytes conditions the development of an aging myopathy...
  2. ncbi Localization and origin of cardiac CD117-positive cells: identification of a population of epicardially-derived cells in adult human heart
    Franca Di Meglio
    Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy
    Ital J Anat Embryol 115:71-8. 2010
    ..These data support the hypothesis of epicardial origin of cardiac primitive cells in the adult human heart...
  3. ncbi Epithelial-mesenchymal transition of epicardial mesothelium is a source of cardiac CD117-positive stem cells in adult human heart
    Franca Di Meglio
    Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy
    J Mol Cell Cardiol 49:719-27. 2010
    ..Moreover, the epicardially-derived cells expressed CD117 antigen. Thus, this study provides evidence that cardiac stem cells can originate from epithelial-mesenchymal transition of the epicardial cells in the adult human heart...
  4. ncbi Epicardial cells are missing from the surface of hearts with ischemic cardiomyopathy: a useful clue about the self-renewal potential of the adult human heart?
    Franca Di Meglio
    Int J Cardiol 145:e44-6. 2010
    ..Hence, observation of the epicardium of patients with cardiovascular disease, although not offering immediate diagnostic advantage, could provide some urging answers concerning the self-renewal potential of the adult heart...
  5. ncbi CD117-positive cells in adult human heart are localized in the subepicardium, and their activation is associated with laminin-1 and alpha6 integrin expression
    Clotilde Castaldo
    aDepartment of Biomorphological and Functional Sciences, University Federico II, Naples, Italy
    Stem Cells 26:1723-31. 2008
    ....
  6. ncbi Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan
    Arantxa Gonzalez
    Department of Anesthesia, Brigham and Women s Hospital, Harvard Medical School, Boston, MA, USA
    Circ Res 102:597-606. 2008
    ..The senescent heart phenotype and heart failure are corrected to some extent, leading to prolongation of maximum lifespan...
  7. ncbi Spatiotemporal patterns of smooth muscle cell changes in ascending aortic dilatation with bicuspid and tricuspid aortic valve stenosis: focus on cell-matrix signaling
    Alessandro Della Corte
    Department of Cardiothoracic and Respiratory Sciences, Second University of Naples, V Monaldi Hospital, Naples, Italy
    J Thorac Cardiovasc Surg 135:8-18, 18.e1-2. 2008
    ..The present study examined temporal and spatial patterns of extracellular matrix and smooth muscle cell changes in the ascending aorta with bicuspid and tricuspid aortic valve stenosis...
  8. ncbi Shock waves activate in vitro cultured progenitors and precursors of cardiac cell lineages from the human heart
    Daria Nurzynska
    Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy
    Ultrasound Med Biol 34:334-42. 2008
    ..Our results suggest that SW treatment could inhibit or retard the pathologic remodeling and functional degradation of the heart if applied during the early stages of heart failure...
  9. ncbi Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 97:663-73. 2005
    ..In conclusion, the heart has an endogenous reserve of CSCs-ECCs that can be activated to reconstitute dead myocardium and recover cardiac function...
  10. ncbi Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function
    Axel Linke
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:8966-71. 2005
    ..These results suggest that strategies capable of activating the growth reserve of the myocardium may be important in cardiac repair after ischemic injury...
  11. ncbi Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure
    Konrad Urbanek
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Proc Natl Acad Sci U S A 102:8692-7. 2005
    ..The loss of functionally competent CSCs in chronic ischemic cardiomyopathy may underlie the progressive functional deterioration and the onset of terminal failure...
  12. ncbi Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion
    Jan Kajstura
    Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, NY 10595, USA
    Circ Res 96:127-37. 2005
    ..In conclusion, BMCs adopt the cardiac cell lineages and have an important therapeutic impact on ischemic heart failure...
  13. ncbi Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes
    Isao Shiraishi
    The Children s Hospital Research Foundation, Division of Molecular Cardiovascular Biology Cincinnati, Ohio, USA
    Circ Res 94:884-91. 2004
    ....
  14. ncbi Regeneration of the infarcted heart with stem cells derived by nuclear transplantation
    Robert Lanza
    Advanced Cell Technology, Worcester, Mass, USA
    Circ Res 94:820-7. 2004
    ..Importantly, the magnitude of myocardial regeneration obtained in this study is significantly superior to that achieved with adult bone marrow cells...
  15. ncbi Cardiac primitive cells become committed to a cardiac fate in adult human heart with chronic ischemic disease but fail to acquire mature phenotype: genetic and phenotypic study
    Daria Nurzynska
    Department of Biomorphological and Functional Sciences, University of Naples Federico II, Naples, Italy
    Basic Res Cardiol 108:320. 2013
    ....