G Marone

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi request reprint Role of superallergens in allergic disorders
    Gianni Marone
    Department of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, School of Medicine, Naples, Italy
    Chem Immunol Allergy 93:195-213. 2007
  2. ncbi request reprint Mast cells and basophils: friends as well as foes in bronchial asthma?
    Gianni Marone
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Trends Immunol 26:25-31. 2005
  3. ncbi request reprint Human mast cells and basophils in HIV-1 infection
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Trends Immunol 22:229-32. 2001
  4. ncbi request reprint Are mast cells MASTers in HIV-1 infection?
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 125:89-95. 2001
  5. ncbi request reprint Histamine-induced activation of human lung macrophages
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 124:249-52. 2001
  6. ncbi request reprint Probing the roles of mast cells and basophils in natural and acquired immunity, physiology and disease
    Gianni Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Trends Immunol 23:425-7. 2002
  7. ncbi request reprint Pharmacological modulation of human mast cells and basophils
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, School of Medicine, Naples, Italy
    Clin Exp Allergy 32:1682-9. 2002
  8. ncbi request reprint Role of human FcepsilonRI+ cells in HIV-1 infection
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
    Immunol Rev 179:128-38. 2001
  9. ncbi request reprint Superallergens: a new mechanism of immunologic activation of human basophils and mast cells
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131, Naples, Italy
    Inflamm Res 55:S25-7. 2006
  10. ncbi request reprint Treatment of mastocytosis: pharmacologic basis and current concepts
    G Marone
    Divisione di Immunologia Clinica e Allergologia, Universita di Napoli Federico II, Facolta di Medicina, Via S Pansini 5, 80131 Naples, Italy
    Leuk Res 25:583-94. 2001

Detail Information

Publications71

  1. ncbi request reprint Role of superallergens in allergic disorders
    Gianni Marone
    Department of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, School of Medicine, Naples, Italy
    Chem Immunol Allergy 93:195-213. 2007
    ....
  2. ncbi request reprint Mast cells and basophils: friends as well as foes in bronchial asthma?
    Gianni Marone
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Trends Immunol 26:25-31. 2005
    ..Preliminary evidence suggests that these cells might not always be detrimental in asthma but, under some circumstances, have a protective role in modulating certain aspects of innate and acquired immunity and allergic inflammation...
  3. ncbi request reprint Human mast cells and basophils in HIV-1 infection
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Trends Immunol 22:229-32. 2001
    ..Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is some evidence that human FcvarepsilonRI(+) cells could be infected in vitro by M-tropic HIV-1 strains...
  4. ncbi request reprint Are mast cells MASTers in HIV-1 infection?
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 125:89-95. 2001
    ..Incubation of basophils with Tat protein upregulates the surface expression of the CCR3 receptor. There is evidence that human Fc epsilon RI(+) cells could be infected in vitro by M-tropic HIV-1 strains...
  5. ncbi request reprint Histamine-induced activation of human lung macrophages
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 124:249-52. 2001
    ..Macrophages are primarily involved in inflammatory diseases of the lung. We explored the ability of low concentrations of histamine to induce the release of proinflammatory mediators from human lung macrophages...
  6. ncbi request reprint Probing the roles of mast cells and basophils in natural and acquired immunity, physiology and disease
    Gianni Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Napoli, Italy
    Trends Immunol 23:425-7. 2002
  7. ncbi request reprint Pharmacological modulation of human mast cells and basophils
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, School of Medicine, Naples, Italy
    Clin Exp Allergy 32:1682-9. 2002
  8. ncbi request reprint Role of human FcepsilonRI+ cells in HIV-1 infection
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
    Immunol Rev 179:128-38. 2001
    ..In addition, Tat upregulates the beta-chemokine receptor CCR3, making FcepsilonRI+ cells more susceptible to infection with CCR3 tropic HIV-1 isolates...
  9. ncbi request reprint Superallergens: a new mechanism of immunologic activation of human basophils and mast cells
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131, Naples, Italy
    Inflamm Res 55:S25-7. 2006
  10. ncbi request reprint Treatment of mastocytosis: pharmacologic basis and current concepts
    G Marone
    Divisione di Immunologia Clinica e Allergologia, Universita di Napoli Federico II, Facolta di Medicina, Via S Pansini 5, 80131 Naples, Italy
    Leuk Res 25:583-94. 2001
    ..At the beginning of the new millennium, the therapy of severe forms of aggressive mastocytosis remains a challenge for students of this intriguing disorder...
  11. ncbi request reprint The immunoglobulin superantigen-binding site of HIV-1 gp120 activates human basophils
    G Florio
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
    AIDS 14:931-8. 2000
    ..To investigate the mechanism whereby HIV-1 envelope glycoprotein gp120 from four different isolates obtained in three different countries induces proinflammatory mediator release from normal human basophils...
  12. ncbi request reprint Mechanisms of IgE elevation in HIV-1 infection
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
    Crit Rev Immunol 20:477-96. 2000
    ..Our results indicate two novel mechanisms by which two HIV-1 proteins, gp120 and Tat, trigger the release of cytokines critical for T(H)2 polarization from human Fc epsilonRI+ cells...
  13. ncbi request reprint Molecular basis for the lack of HERG K+ channel block-related cardiotoxicity by the H1 receptor blocker cetirizine compared with other second-generation antihistamines
    M Taglialatela
    Section of Pharmacology, Department of Neuroscience, School of Medicine, University of Naples Federico II, 80131 Naples, Italy
    Mol Pharmacol 54:113-21. 1998
    ....
  14. ncbi request reprint FK-506, a potent novel inhibitor of the release of proinflammatory mediators from human Fc epsilon RI+ cells
    A de Paulis
    Department of Medicine, University of Naples Federico II, Italy
    J Immunol 146:2374-81. 1991
    ..These data indicate that FK-506 is a potent antiinflammatory agent that acts on human basophils presumably by binding to a receptor site (i.e., FK-506 binding protein)...
  15. ncbi request reprint Tat protein is an HIV-1-encoded beta-chemokine homolog that promotes migration and up-regulates CCR3 expression on human Fc epsilon RI+ cells
    A de Paulis
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Immunol 165:7171-9. 2000
    ..Tat protein is the first identified HIV-1-encoded beta-chemokine homologue that influences the directional migration of human FcepsilonRI(+) cells and the expression of surface receptor CCR3 on these cells...
  16. ncbi request reprint Protein L. A bacterial Ig-binding protein that activates human basophils and mast cells
    V Patella
    Department of Medicine, University of Naples Federico II, Italy
    J Immunol 145:3054-61. 1990
    ..01 to 10 micrograms/ml) in nonallergic subjects caused a dose-dependent wheal-and-flare reaction. Protein L activates human basophils and mast cells in vitro and in vivo presumably by interacting with kappa L chains of the IgE isotype...
  17. ncbi request reprint Human basophil/mast cell releasability. IX. Heterogeneity of the effects of opioids on mediator release
    C Stellato
    Second School of Medicine, University of Naples Federico II, Italy
    Anesthesiology 77:932-40. 1992
    ..Histamine release caused by buprenorphine from lung mast cells was slow (t1/2 = 11.2 +/- 3.6 min) compared with that induced by morphine from skin mast cells (t1/2 < 1 min, P < 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)..
  18. ncbi request reprint HIV-1 gp120 induces IL-4 and IL-13 release from human Fc epsilon RI+ cells through interaction with the VH3 region of IgE
    V Patella
    University of Naples Federico II, Division of Clinical Immunology and Allergy, Naples, Italy
    J Immunol 164:589-95. 2000
    ..These results indicate that gp120, which acts as a viral superantigen, interacts with the VH3 region of IgE to induce the release of IL-4 and IL-13 from human Fc epsilon RI+ cells...
  19. ncbi request reprint Cyclosporin A rapidly inhibits mediator release from human basophils presumably by interacting with cyclophilin
    R Cirillo
    Department of Medicine, University of Naples Federico II, Second School of Medicine, Italy
    J Immunol 144:3891-7. 1990
    ..99; p less than 0.001) and by A23187 (r = 0.87; p less than 0.001) and their affinity for cyclophilin...
  20. ncbi request reprint Dysregulation of the IgE/Fc epsilon RI network in HIV-1 infection
    G Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 107:22-30. 2001
    ....
  21. ncbi request reprint Histamine induces exocytosis and IL-6 production from human lung macrophages through interaction with H1 receptors
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Immunol 166:4083-91. 2001
    ....
  22. ncbi request reprint Differential modulation of mediator release from human basophils and mast cells by mizolastine
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Clin Exp Allergy 34:241-9. 2004
    ..Some histamine H1 receptor antagonists exert anti-inflammatory activities by modulating mediator release from basophils and mast cells...
  23. ncbi request reprint Expression of the chemokine receptor CCR3 on human mast cells
    A de Paulis
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 124:146-50. 2001
    ..CONCLUSIONS: These results indicate that CCR3 is expressed on human mast cells and that these cells are attracted by CCR3-binding chemokines...
  24. ncbi request reprint Human synovial mast cells. II. Heterogeneity of the pharmacologic effects of antiinflammatory and immunosuppressive drugs
    A de Paulis
    School of Medicine, University of Naples Federico II, Italy
    Arthritis Rheum 40:469-78. 1997
    ..To evaluate the in vitro effects of 4 antiinflammatory and 5 immunosuppressive agents on the release of preformed and de novo-synthesized mediators from human synovial mast cells (HSyMC) activated by immunologic and nonimmunologic stimuli...
  25. ncbi request reprint Secretory phospholipases A2 induce beta-glucuronidase release and IL-6 production from human lung macrophages
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Immunol 164:4908-15. 2000
    ..The secretion of enzymes and cytokines induced by sPLA2s from human macrophages may play an important role in inflammation and tissue damage associated with the release of sPLA2s...
  26. ncbi request reprint Maitotoxin, a novel activator of mediator release from human basophils, induces large increases in cytosolic calcium resulting in histamine, but not leukotriene C4, release
    M Columbo
    Division of Clinical Immunology, University of Naples Federico II, Second School of Medicine, Italy
    J Pharmacol Exp Ther 263:979-86. 1992
    ..1-10 microM) caused only minimal inhibition. These results suggest that MTX represents a novel stimulus useful to study the role of Ca++ in human basophil mediator release...
  27. doi request reprint Angiogenesis, lymphangiogenesis and atopic dermatitis
    A Genovese
    Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples, Italy
    Chem Immunol Allergy 96:50-60. 2012
    ..are major sources of a vast array of angiogenic and lymphangiogenic factors. The role of lymphangiogenesis in AD is largely unknown...
  28. ncbi request reprint Immunoglobulin superantigen protein L induces IL-4 and IL-13 secretion from human Fc epsilon RI+ cells through interaction with the kappa light chains of IgE
    Arturo Genovese
    Division of Clinical Immunology and Allergy, School of Medicine, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Immunol 170:1854-61. 2003
    ..Thus, protein L acts as a bacterial Ig superantigen to induce the synthesis and release of IL-4 and IL-13 from basophils by interacting with kappa L chains of the IgE isotype...
  29. ncbi request reprint Helicobacter pylori HP(2-20) induces eosinophil activation and accumulation in superficial gastric mucosa and stimulates VEGF-alpha and TGF-beta release by interacting with formyl-peptide receptors
    N Prevete
    Dipartimento di Scienze Mediche Traslazionali e Centro Interdipartimentale di Ricerca in Scienze Immunologiche di Base e Cliniche CISI, Universita di Napoli Federico II, Napoli, Italy
    Int J Immunopathol Pharmacol 26:647-62. 2013
    ..This study suggests that eosinophil infiltrate could modulate the capacity of gastric mucosa to maintain or recover its integrity thereby shedding light on the role of eosinophils in H. pylori infection. ..
  30. ncbi request reprint Human basophil releasability. VIII. Increased basophil releasability in patients with scleroderma
    A de Paulis
    Department of Medicine, Second School of Medicine, University of Naples Federico II, Italy
    Arthritis Rheum 34:1289-96. 1991
    ..These results show that spontaneous basophil releasability and releasability in response to IgE cross-linking and activation of interleukin-3 receptors are increased in patients with scleroderma...
  31. ncbi request reprint Mechanisms of activation of human mast cells and basophils by general anesthetic drugs
    G Marone
    Department of Medicine, University of Naples Federico II, School of Medicine, Italy
    Ann Fr Anesth Reanim 12:116-25. 1993
    ..From the results obtained with the in vitro model described here, it is clear that new drugs promising for the anesthesiologic arena should be tested in vitro before their potential histamine-releasing activity is experienced in vivo...
  32. ncbi request reprint HIV-1 envelope gp41 peptides promote migration of human Fc epsilon RI+ cells and inhibit IL-13 synthesis through interaction with formyl peptide receptors
    Amato de Paulis
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
    J Immunol 169:4559-67. 2002
    ..These data highlight the complexity of the interactions between viral and bacterial peptides with FPR subtypes on human basophils...
  33. pmc Expression of phospholipases A2 in primary human lung macrophages: role of cytosolic phospholipase A2-alpha in arachidonic acid release and platelet activating factor synthesis
    Giorgio Giannattasio
    Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    Biochim Biophys Acta 1791:92-102. 2009
    ..Our results indicate that human macrophages express cPLA(2)-alpha, iPLA(2) and several sPLA(2)s. Cytosolic PLA(2)-alpha is the major enzyme responsible for lipid mediator production in human macrophages...
  34. ncbi request reprint Role(s) of formyl-peptide receptors expressed in nasal epithelial cells
    N Prevete
    Department of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Biol Regul Homeost Agents 25:553-64. 2011
    ..Our results suggest a possible mechanisms initiating tissue remodeling observed during chronic rhinosinusitis. This study provides further evidence that FPRs play a more complex role in human pathophysiology than bacterial recognition...
  35. ncbi request reprint Adenosine receptors on human leukocytes. IV. Characterization of an A1/Ri receptor
    G Marone
    Department of Medicine, University of Naples Federico II, School of Medicine, Italy
    Int J Clin Lab Res 22:235-42. 1992
    ..The results support the existence of an A1/Ri receptor that regulates cyclic AMP metabolism of human lymphocytes and polymorphonuclear leukocytes...
  36. pmc Allergy and the cardiovascular system
    M Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Clin Exp Immunol 153:7-11. 2008
    ..A better understanding of the mechanisms involved in cardiac mast cell activation may lead to an improvement in prevention and treatment of systemic anaphylaxis...
  37. doi request reprint Angiogenesis and lymphangiogenesis in bronchial asthma
    A Detoraki
    Department of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples
    Allergy 65:946-58. 2010
    ..Specific antagonists to VEGF and other angiogenic factors and their receptors might help to control chronic airway inflammation and vascular remodeling and offer a novel approach for the treatment of chronic inflammatory lung disorders...
  38. doi request reprint Expression and function of Na+/Ca2+ exchangers 1 and 3 in human macrophages and monocytes
    Rosaria I Staiano
    Division of Clinical Immunology and Allergy, School of Medicine, University of Naples Federico II, Naples, Italy
    Eur J Immunol 39:1405-18. 2009
    ..Therefore, NCX may contribute to regulate Ca(2+) homeostasis and proinflammatory functions in human macrophages and monocytes...
  39. ncbi request reprint Signaling events involved in cytokine and chemokine production induced by secretory phospholipase A2 in human lung macrophages
    Francescopaolo Granata
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Eur J Immunol 36:1938-50. 2006
    ..These results indicate that sPLA(2) induce the production of cytokines and chemokines in human macrophages by a non-enzymatic mechanism involving the PI3 K/Akt system, the MAPK p38 and ERK1/2 and NF-kappaB...
  40. ncbi request reprint Urokinase induces basophil chemotaxis through a urokinase receptor epitope that is an endogenous ligand for formyl peptide receptor-like 1 and -like 2
    Amato de Paulis
    Divisione di Immunologia Clinica ed Allergologia, Universita di Napoli Federico II, Naples, Italy
    J Immunol 173:5739-48. 2004
    ..Thus, uPA is a potent chemoattractant for basophils that seems to act through exposure of the chemotactic uPAR epitope uPAR84-95, which is an endogenous ligand for FPRL2 and FPRL1...
  41. ncbi request reprint Basophils infiltrate human gastric mucosa at sites of Helicobacter pylori infection, and exhibit chemotaxis in response to H. pylori-derived peptide Hp(2-20)
    Amato de Paulis
    Department of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Immunol 172:7734-43. 2004
    ..Hp(2-20) could be responsible, at least in part, for basophil infiltration of the gastric mucosa of H. pylori-infected patients presumably through the interaction with FPRL1 and FPRL2...
  42. ncbi request reprint The human heart as a shock organ in anaphylaxis
    Gianni Marone
    Department of Clinical Immunology and Allergy, University of Naples Federico II, School of Medicine, Via S Pansini 5, 80131 Naples, Italy
    Novartis Found Symp 257:133-49; discussion 149-60, 276-85. 2004
    ..Taken together, these results indicate that the human heart can be both the site and the target of anaphylactic reactions...
  43. ncbi request reprint Protein Fv produced during viral hepatitis is an endogenous immunoglobulin superantigen activating human heart mast cells
    Arturo Genovese
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 132:336-45. 2003
    ..Protein Fv acts as an endogenous immunoglobulin superantigen by interacting with the V(H)3 domain of IgE to induce the release of mediators from HHMC...
  44. ncbi request reprint Protein Fv: an endogenous immunoglobulin superantigen and superallergen
    Jean Pierre Bouvet
    Department of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research, University of Naples Federico II, School of Medicine, Naples, Italy
    Chem Immunol Allergy 93:58-76. 2007
    ..The mechanism of activation of immune cells by protein Fv represents a new pathogenetic cascade consisting of viral infection, endogenous immunoglobulin superantigen/superallergen production and tissue injury...
  45. doi request reprint Antiapoptotic seminal vesicle protein IV induces histamine release from human FcepsilonRI+ cells
    Nella Prevete
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 151:318-30. 2010
    ..SV-IV-immunorelated proteins occur in other rat tissues and in humans...
  46. ncbi request reprint In vitro effects of ultraviolet A on histamine release from human basophils
    G Monfrecola
    Division of Dermatology, University of Naples Federico II, Via S Pansini, 5, 80131 Naples, Italy
    J Eur Acad Dermatol Venereol 17:646-51. 2003
    ....
  47. ncbi request reprint Cardiac ion channels and antihistamines: possible mechanisms of cardiotoxicity
    M Taglialatela
    Section of Pharmacology, Department of Neuroscience, School of Medicine, University of Naples Federico II, Italy
    Clin Exp Allergy 29:182-9. 1999
    ....
  48. doi request reprint Inhibition of secretory phospholipase A2-induced cytokine production in human lung macrophages by budesonide
    Massimo Triggiani
    Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 150:144-55. 2009
    ..sPLA(2)s may activate inflammatory cells by both enzymatic and nonenzymatic mechanisms. The aim of this study was to evaluate the effect of the inhaled glucocorticoid budesonide on sPLA(2)-induced activation of primary human macrophages...
  49. pmc Lung mast cells are a source of secreted phospholipases A2
    Massimo Triggiani
    Department of Clinical Immunology and Allergy and the Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 124:558-65, 565.e1-3. 2009
    ..Secreted phospholipases A(2) (sPLA(2)s) are released in plasma and other biologic fluids of patients with inflammatory, autoimmune, and allergic diseases...
  50. doi request reprint Helicobacter pylori Hp(2-20) promotes migration and proliferation of gastric epithelial cells by interacting with formyl peptide receptors in vitro and accelerates gastric mucosal healing in vivo
    Amato de Paulis
    Divisione di Immunologia Clinica ed Allergologia e Centro Interdipartimentale di Ricerca di Scienze Immunologiche di Base e Cliniche, Universita di Napoli Federico II, Naples, Italy
    J Immunol 183:3761-9. 2009
    ..This study provides further evidence of the complexity of the relationship between H. pylori and human gastric mucosa, and it suggests that a bacterial product may be used to heal gastric mucosal injury...
  51. ncbi request reprint Differentiation of monocytes into macrophages induces the upregulation of histamine H1 receptor
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 119:472-81. 2007
    ..However, responses elicited by histamine differ depending on cell type, suggesting variable expression of histamine receptors in the monocyte/macrophage lineage...
  52. ncbi request reprint Activation of cytokine production by secreted phospholipase A2 in human lung macrophages expressing the M-type receptor
    Francescopaolo Granata
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, 80131 Naples, Italy
    J Immunol 174:464-74. 2005
    ..HLM express the M-type receptor, but its involvement in eliciting cytokine production deserves further investigation...
  53. ncbi request reprint Secretory phospholipases A2 as multivalent mediators of inflammatory and allergic disorders
    Francescopaolo Granata
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 131:153-63. 2003
    ..Therefore, sPLA(2)s may have an important role in inflammatory and allergic reactions by activating multiple mechanisms within inflammatory and immune cells, leading to the production of eicosanoids, cytokines and chemokines...
  54. ncbi request reprint Secretory phospholipases A2 activate selective functions in human eosinophils
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    J Immunol 170:3279-88. 2003
    ..These results indicate that sPLA(2)s selectively activate certain proinflammatory and immunoregulatory functions of human eosinophils through mechanism(s) independent from enzymatic activity and from the generation of arachidonic acid...
  55. ncbi request reprint Lung involvement in rheumatoid arthritis
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Italy
    Sarcoidosis Vasc Diffuse Lung Dis 20:171-9. 2003
    ..Those patients with clinical alterations and/or impaired lung function should undergo a complete radiological study...
  56. ncbi request reprint Activation of human inflammatory cells by secreted phospholipases A2
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, 80131 Naples, Via Pansini 5, Italy
    Biochim Biophys Acta 1761:1289-300. 2006
    ..Selective inhibitors of sPLA(2)-enzymatic activity and specific antagonists of sPLA(2) receptors are current being tested for pharmacological treatment of inflammatory and autoimmune diseases...
  57. ncbi request reprint Secretory phospholipases A2 induce cytokine release from blood and synovial fluid monocytes
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Eur J Immunol 32:67-76. 2002
    ..This effect may concur with the generation of AA in the proinflammatory activity of sPLA2 released during inflammatory diseases...
  58. doi request reprint Mast cells have a protumorigenic role in human thyroid cancer
    R M Melillo
    Dipartimento di Biologia e Patologia Cellulare e Molecolare, Istituto di Endocrinologia ed Oncologia Sperimentale del CNR, Naples, Italy
    Oncogene 29:6203-15. 2010
    ..In conclusion, our study data suggest that mast cells are recruited into thyroid carcinomas and promote proliferation, survival and invasive ability of cancer cells, thereby contributing to thyroid carcinoma growth and invasiveness...
  59. ncbi request reprint Inhibition of platelet-activating factor synthesis in human neutrophils and platelets by propionyl-L-carnitine
    M Triggiani
    Division of Clinical Immunology, University of Naples Federico II, Italy
    Biochem Pharmacol 58:1341-8. 1999
    ..This effect of PrC might represent an additional mechanism by which this molecule can exert protective effects in tissue ischemia and in other inflammatory diseases associated with neutrophil and platelet activation...
  60. ncbi request reprint Secretory phospholipases A2 in inflammatory and allergic diseases: not just enzymes
    Massimo Triggiani
    Division of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 116:1000-6. 2005
    ..Selective inhibitors of sPLA(2)s and specific antagonists of sPLA(2) receptors might prove useful in the treatment of allergic and autoimmune diseases, such as bronchial asthma and rheumatoid arthritis...
  61. ncbi request reprint The histamine-cytokine network in allergic inflammation
    Gianni Marone
    Division of Clinical Immunology and Allergy, University of Naples Federico II, School of Medicine, Naples, Italy
    J Allergy Clin Immunol 112:S83-8. 2003
    ..This observation raises the possibility that long-term treatment with fexofenadine might have beneficial effects on immune dysregulation and tissue damage/remodeling associated with histamine-mediated macrophage activation...
  62. ncbi request reprint The role of mast cell-derived secreted phospholipases A2 in respiratory allergy
    Francescopaolo Granata
    Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, 80131 Naples, Via Pansini 5, Italy
    Biochimie 92:588-93. 2010
    ..Thus, mast cell-derived sPLA(2)s may play an important role in the initiation and amplification of the inflammatory reactions in patients with allergic rhinitis and bronchial asthma...
  63. ncbi request reprint 8-Methoxypsoralen and long-wave ultraviolet A inhibit the release of proinflammatory mediators and cytokines from human Fc epsilon RI+ cells: an in vitro study
    Amato de Paulis
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Via S Pansini 5, Italy
    J Photochem Photobiol B 69:169-77. 2003
    ..Histamine release from HSMC activated with A23187 is not modified either by 8-MOP alone or by 8-MOP plus UVA...
  64. pmc Production of vascular endothelial growth factors from human lung macrophages induced by group IIA and group X secreted phospholipases A2
    Francescopaolo Granata
    Division of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research, University of Naples Federico II, Naples
    J Immunol 184:5232-41. 2010
    ..Thus, sPLA(2)s may play an important role in inflammatory and/or neoplastic angiogenesis and lymphangiogenesis...
  65. ncbi request reprint Novel autocrine and paracrine loops of the stem cell factor/chymase network
    A de Paulis
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Int Arch Allergy Immunol 118:422-5. 1999
    ..We also addressed the question whether mast cell chymase, a chymotrypsin-like protease, also present in the secretory granules of human mast cells cleaves SCF at the peptide bound between Phe 158 and Met159...
  66. ncbi request reprint Immunopathogenesis of psoriasis and psoriatic arthritis and pharmacological perspectives
    S Loffredo
    Division of Clinical Immunology and Allergy, University of Naples Federico II, Naples, Italy
    Reumatismo 59:28-39. 2007
    ..Future potential targets in the treatment of these disorders include biologic agents aimed at blockade of other cytokines, chemokines and angiogenic factors...
  67. ncbi request reprint Human cardiac mast cells in anaphylaxis
    Arturo Genovese
    Department of Clinical Immunology and Allergy and Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    Chem Immunol Allergy 95:98-109. 2010
    ..These results indicate that HHMC probably have a role in anaphylactic reactions...
  68. doi request reprint Vascular endothelial growth factors synthesized by human lung mast cells exert angiogenic effects
    Aikaterini Detoraki
    Department of Clinical Immunology and Allergy, Center for Basic and Clinical Immunology Research CISI, University of Naples Federico II, Naples, Italy
    J Allergy Clin Immunol 123:1142-9, 1149.e1-5. 2009
    ..Angiogenesis and lymphangiogenesis are critical for several allergic, inflammatory, and neoplastic disorders. Mast cells infiltrate the sites of inflammation and tumors...
  69. ncbi request reprint Expression and functions of the vascular endothelial growth factors and their receptors in human basophils
    Amato de Paulis
    Divisione di Immunologia Clinica ed Allergologia e Centro Interdipartimentale di Ricerca di Scienze Immunologiche di Base e Cliniche Università di Napoli Federico II, Naples, Italy
    J Immunol 177:7322-31. 2006
    ..Our data suggest that basophils could play a role in angiogenesis and inflammation through the expression of several forms of VEGF and their receptors...
  70. ncbi request reprint The European Competence Network on Mastocytosis (ECNM)
    Peter Valent
    Division of Hematology and Hemostaseology, Department of Internal Medicine I, Medical University of Vienna, Austria
    Wien Klin Wochenschr 116:647-51. 2004
    ..In addition, the ECNM is dedicated to provide the best available information about the disease to patients and physicians...
  71. ncbi request reprint Risk assessment in anaphylaxis: current and future approaches
    F Estelle R Simons
    Department of Pediatrics and Child Health, University of Manitoba, Winnipeg, Canada, and Department of Respiratory Medicine, Brighton General Hospital, Belfast, UK
    J Allergy Clin Immunol 120:S2-24. 2007
    ....