Pasquale Maffia

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi request reprint Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury
    Pasquale Maffia
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Circulation 114:430-7. 2006
  2. ncbi request reprint Images in cardiovascular medicine. Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery
    Pasquale Maffia
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Circulation 115:e326-8. 2007
  3. doi request reprint The I{kappa}B kinase inhibitor nuclear factor-{kappa}B essential modulator-binding domain peptide for inhibition of injury-induced neointimal formation
    Gianluca Grassia
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Arterioscler Thromb Vasc Biol 30:2458-66. 2010
  4. pmc Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching
    Marcella Maddaluno
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    PLoS ONE 7:e47464. 2012
  5. ncbi request reprint Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent
    Gabriella Corea
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    J Med Chem 48:7055-62. 2005
  6. doi request reprint Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Arterioscler Thromb Vasc Biol 31:2448-54. 2011
  7. ncbi request reprint Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophages
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
    Eur J Pharmacol 509:89-96. 2005
  8. ncbi request reprint 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB
    Angela Ianaro
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    FEBS Lett 553:21-7. 2003
  9. pmc The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice
    Gianluca Grassia
    Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Naples, Italy
    Cardiovasc Res 84:485-93. 2009
  10. ncbi request reprint Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Mol Pharmacol 67:1620-8. 2005

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury
    Pasquale Maffia
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Circulation 114:430-7. 2006
    ..We investigated the effective role of IL-18 in neointimal formation in a balloon-induced rat model of vascular injury...
  2. ncbi request reprint Images in cardiovascular medicine. Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery
    Pasquale Maffia
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Circulation 115:e326-8. 2007
  3. doi request reprint The I{kappa}B kinase inhibitor nuclear factor-{kappa}B essential modulator-binding domain peptide for inhibition of injury-induced neointimal formation
    Gianluca Grassia
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Arterioscler Thromb Vasc Biol 30:2458-66. 2010
    ..The aim of the present study was to evaluate the effect of the NBD peptide on neointimal formation...
  4. pmc Bindarit inhibits human coronary artery smooth muscle cell proliferation, migration and phenotypic switching
    Marcella Maddaluno
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    PLoS ONE 7:e47464. 2012
    ..Our results demonstrate that bindarit induces the differentiated state of human coronary smooth muscle cells, suggesting a novel underlying mechanisms by which this drug inhibits neointimal formation...
  5. ncbi request reprint Discovery and biological evaluation of the novel naturally occurring diterpene pepluanone as antiinflammatory agent
    Gabriella Corea
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    J Med Chem 48:7055-62. 2005
    ....
  6. doi request reprint Inhibition of in-stent stenosis by oral administration of bindarit in porcine coronary arteries
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Arterioscler Thromb Vasc Biol 31:2448-54. 2011
    ..The aim of the current study was to evaluate the efficacy of bindarit on in-stent stenosis in the preclinical porcine coronary stent model...
  7. ncbi request reprint Inhibition of cyclooxygenase-2 gene expression by the heat shock response in J774 murine macrophages
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
    Eur J Pharmacol 509:89-96. 2005
    ..e. by preventing the activation of nuclear factor-kappaB, and provide additional information about mechanism(s) underlying the anti-inflammatory effect of the heat shock proteins...
  8. ncbi request reprint 2-Cyclopenten-1-one and prostaglandin J2 reduce restenosis after balloon angioplasty in rats: role of NF-kappaB
    Angela Ianaro
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    FEBS Lett 553:21-7. 2003
    ..Our results show that cyclopentenone PGs and their derivatives reduce restenosis and may have therapeutic relevance for the prevention of human restenosis...
  9. pmc The anti-inflammatory agent bindarit inhibits neointima formation in both rats and hyperlipidaemic mice
    Gianluca Grassia
    Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano, 49, 80131 Naples, Italy
    Cardiovasc Res 84:485-93. 2009
    ....
  10. ncbi request reprint Mechanism of the anti-inflammatory effect of thiazolidinediones: relationship with the glucocorticoid pathway
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Mol Pharmacol 67:1620-8. 2005
    ....
  11. ncbi request reprint A protective role for proteinase activated receptor 2 in airways of lipopolysaccharide-treated rats
    Silvana Morello
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Biochem Pharmacol 71:223-30. 2005
    ..Our work supports a role for PAR2 as a defence mechanism aimed to preserve bronchial functionality under systemic inflammatory conditions; both COX-2-derived PGE2 and CGRP are involved in this effect...
  12. ncbi request reprint A novel lipid A from Halomonas magadiensis inhibits enteric LPS-induced human monocyte activation
    Armando Ialenti
    Department of Experimental Pharmacology, University of Naples Federico II, 80131 Naples, Italy
    Eur J Immunol 36:354-60. 2006
    ..This result defines Hm LIP A as a novel class of LPS antagonist whose structural features could be utilized for the design of compounds for the treatment of Gram-negative sepsis...
  13. pmc Macrophage autophagy in atherosclerosis
    Maria Chiara Maiuri
    Department of Experimental Pharmacology, University of Naples Federico II, 80131 Naples, Italy
    Mediators Inflamm 2013:584715. 2013
    ..Finally, we will discuss how AP could be targeted for therapeutic utility...
  14. ncbi request reprint Anti-inflammatory activity of 15-deoxy-delta12,14-PGJ2 and 2-cyclopenten-1-one: role of the heat shock response
    Angela Ianaro
    Department of Experimental Pharmacology, University of Naples Federico II, Via D Montesano 4, 80131, Naples, Italy
    Mol Pharmacol 64:85-93. 2003
    ....
  15. ncbi request reprint Beneficial effects of NO-releasing derivative of flurbiprofen (HCT-1026) in rat model of vascular injury and restenosis
    Pasquale Maffia
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Arterioscler Thromb Vasc Biol 22:263-7. 2002
    ..In conclusion, HCT-1026 caused a significant reduction in restenosis that appears to be directly related to NO release. HCT-1026 may prove to be beneficial in preventing or delaying restenosis in humans...
  16. doi request reprint Plasmacytoid dendritic cells: biomarkers or potential therapeutic targets in atherosclerosis?
    Gianluca Grassia
    Department of Experimental Pharmacology, University of Naples Federico II, 80131 Naples, Italy
    Pharmacol Ther 137:172-82. 2013
    ..Finally, we will discuss how pDCs could be targeted for therapeutic utility...
  17. pmc Hydrogen sulfide as a mediator of human corpus cavernosum smooth-muscle relaxation
    Roberta d'Emmanuele di Villa Bianca
    Department of Experimental Pharmacology, University of Naples Federico II, Via Domenico Montesano 49, 80131 Naples, Italy
    Proc Natl Acad Sci U S A 106:4513-8. 2009
    ..In rats, NaHS and L-Cys promote penile erection, and the response to L-Cys is blocked by PAG. Our data demonstrate that the L-Cys/H(2)S pathway mediates human corpus cavernosum smooth-muscle relaxation...
  18. ncbi request reprint Rosiglitazone, a ligand of the peroxisome proliferator-activated receptor-gamma, reduces acute inflammation
    Salvatore Cuzzocrea
    Department of Clinical and Experimental Medicine and Pharmacology, School of Medicine, University of Messina, Torre Biologica, Policlinico Universitario Via C Valeria, Gazzi, 98100 Messina, Italy
    Eur J Pharmacol 483:79-93. 2004
    ..We propose that rosiglitazone and other potent PPAR-gamma agonists may be useful in the therapy of inflammation...
  19. ncbi request reprint Time course of vascular reactivity to contracting and relaxing agents after endothelial denudation by balloon angioplasty in rat carotid artery
    Laura Lippolis
    Department of Pharmaceutical Sciences, University of Salerno, Salerno, Italy
    Atherosclerosis 171:171-9. 2003
    ....
  20. pmc Beneficial effects of caffeic acid phenethyl ester in a rat model of vascular injury
    Pasquale Maffia
    Department of Pharmaceutical Science, University of Salerno, via Ponte Don Melillo Fisciano, Salerno, Italy
    Br J Pharmacol 136:353-60. 2002
    ..4. These results indicate that treatment with CAPE may lead to a reduction of neointima formation by inhibiting NF-kappaB activation and suggest that this agent may have therapeutic relevance for the prevention of human restenosis...