Dario Leosco

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi request reprint Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart
    Dario Leosco
    Cattedra di Geriatria, Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Via Pansini 5, 80131 Napoli, Italy
    Cardiovasc Res 78:385-94. 2008
  2. ncbi request reprint Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease
    Dario Leosco
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy
    Neurosci Lett 415:279-82. 2007
  3. ncbi request reprint Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation
    Dario Leosco
    Department of Internal Medicine, Cardiovascular Sciences and Immunology, University Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy
    Am J Physiol Heart Circ Physiol 293:H1596-603. 2007
  4. doi request reprint An active lifestyle prior to coronary surgery is associated with improved survival in elderly patients
    Giuseppe Rengo
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Pansini 5, 80131 Naples, Italy
    J Gerontol A Biol Sci Med Sci 65:758-63. 2010
  5. ncbi request reprint Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats
    Dario Leosco
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Pansini 5, Edificio 2, 80131 Naples, Italy
    J Gerontol A Biol Sci Med Sci 62:471-80. 2007
  6. ncbi request reprint Exercise restores beta-adrenergic vasorelaxation in aged rat carotid arteries
    Dario Leosco
    Department of Clinic Medicine, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
    Am J Physiol Heart Circ Physiol 285:H369-74. 2003
  7. ncbi request reprint Unrestricted use of endeavor resolute zotarolimus-eluting stent in daily clinical practice: a prospective registry
    Gennaro Galasso
    Department of Clinical Medicine, Cardiovascular Sciences and Immunology, Federico II University, Via S Pansini, 5 80131 Naples, Italy
    J Invasive Cardiol 24:251-5. 2012
  8. doi request reprint A new approach to percutaneous coronary revascularization in patients requiring undeferrable non-cardiac surgery
    Federico Piscione
    Department of Clinical Medicine, Cardiovascular Science and Immunology, Federico II University, Naples, Italy
    Int J Cardiol 146:399-403. 2011
  9. doi request reprint Multicentre experience with MGuard net protective stent in ST-elevation myocardial infarction: safety, feasibility, and impact on myocardial reperfusion
    Federico Piscione
    Department of Clinical Medicine, Cardiovascular Sciences and Immunology, Federico II University, Naples, Italy
    Catheter Cardiovasc Interv 75:715-21. 2010
  10. doi request reprint Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease
    Caterina Marciano
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
    Eur J Nucl Med Mol Imaging 39:1199-206. 2012

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart
    Dario Leosco
    Cattedra di Geriatria, Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Via Pansini 5, 80131 Napoli, Italy
    Cardiovasc Res 78:385-94. 2008
    ..We also explored the contribution of ameliorated beta-adrenergic receptor signalling and function on the overall improvement of cardiac contractility reserve induced by exercise...
  2. ncbi request reprint Lymphocyte G-protein-coupled receptor kinase-2 is upregulated in patients with Alzheimer's disease
    Dario Leosco
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy
    Neurosci Lett 415:279-82. 2007
    ..Further studies are needed in order to verify whether the lymphocyte GRK2 might be utilized as a novel biomarker in AD diagnosis and clinical monitoring...
  3. ncbi request reprint Exercise training and beta-blocker treatment ameliorate age-dependent impairment of beta-adrenergic receptor signaling and enhance cardiac responsiveness to adrenergic stimulation
    Dario Leosco
    Department of Internal Medicine, Cardiovascular Sciences and Immunology, University Federico II, Via Pansini 5, Edificio 2, 80131 Naples, Italy
    Am J Physiol Heart Circ Physiol 293:H1596-603. 2007
    ..In conclusion, we demonstrate for the first time that exercise and beta-AR blockade can similarly ameliorate beta-AR signaling in the aged heart, leading to improved beta-AR responsiveness and corresponding LV inotropic reserve...
  4. doi request reprint An active lifestyle prior to coronary surgery is associated with improved survival in elderly patients
    Giuseppe Rengo
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Pansini 5, 80131 Naples, Italy
    J Gerontol A Biol Sci Med Sci 65:758-63. 2010
    ..In the present study, we investigated the association between physical activity habits of elderly participants prior to coronary artery bypass grafting (CABG) and survival free from both all-cause and cardiac death...
  5. ncbi request reprint Prior exercise improves age-dependent vascular endothelial growth factor downregulation and angiogenesis responses to hind-limb ischemia in old rats
    Dario Leosco
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Pansini 5, Edificio 2, 80131 Naples, Italy
    J Gerontol A Biol Sci Med Sci 62:471-80. 2007
    ..In conclusion, prior exercise represents a valid tool to counteract age-related molecular alterations resulting in impaired angiogenesis in response to ischemia...
  6. ncbi request reprint Exercise restores beta-adrenergic vasorelaxation in aged rat carotid arteries
    Dario Leosco
    Department of Clinic Medicine, University of Naples Federico II, Via Sergio Pansini 5, 80131 Naples, Italy
    Am J Physiol Heart Circ Physiol 285:H369-74. 2003
    ..Exercise restores this response and reverts age-related modification in beta-ARs and beta-ARK. Our data support an important role for beta-ARK in vascular beta-AR vasorelaxation...
  7. ncbi request reprint Unrestricted use of endeavor resolute zotarolimus-eluting stent in daily clinical practice: a prospective registry
    Gennaro Galasso
    Department of Clinical Medicine, Cardiovascular Sciences and Immunology, Federico II University, Via S Pansini, 5 80131 Naples, Italy
    J Invasive Cardiol 24:251-5. 2012
    ..To evaluate the safety and efficacy of unrestricted Endeavor Resolute zotarolimus-eluting stent (ZES) use. Furthermore, we sought to evaluate clinical outcomes associated with on- and off-label use of Resolute ZES...
  8. doi request reprint A new approach to percutaneous coronary revascularization in patients requiring undeferrable non-cardiac surgery
    Federico Piscione
    Department of Clinical Medicine, Cardiovascular Science and Immunology, Federico II University, Naples, Italy
    Int J Cardiol 146:399-403. 2011
    ..We performed a pilot study of dual antiplatelet therapy discontinuation followed by major non-cardiac surgery and endovascular aortic repair early after successful endothelial-progenitor cell-capture coronary stent deployment...
  9. doi request reprint Multicentre experience with MGuard net protective stent in ST-elevation myocardial infarction: safety, feasibility, and impact on myocardial reperfusion
    Federico Piscione
    Department of Clinical Medicine, Cardiovascular Sciences and Immunology, Federico II University, Naples, Italy
    Catheter Cardiovasc Interv 75:715-21. 2010
    ....
  10. doi request reprint Effects of type 2 diabetes mellitus on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease
    Caterina Marciano
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University Federico II, Napoli, Italy
    Eur J Nucl Med Mol Imaging 39:1199-206. 2012
    ..We assessed the impact of type 2 diabetes, in the presence of other major cardiovascular risk factors, on coronary microvascular function and myocardial perfusion in patients without obstructive coronary artery disease (CAD)...
  11. doi request reprint The G protein coupled receptor kinase 2 plays an essential role in beta-adrenergic receptor-induced insulin resistance
    Ersilia Cipolletta
    Dipartimento di Medicina Clinica, Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita Federico II, Via Pansini 5, 80131 Naples, Italy
    Cardiovasc Res 84:407-15. 2009
    ..The cellular levels of G protein coupled receptor kinase 2 (GRK2) increase during chronic betaAR stimulation, leading to betaAR desensitization. We tested the hypothesis that GRK2 plays a role in betaAR-induced IRES...
  12. ncbi request reprint Rheolytic thrombectomy during percutaneous coronary intervention improves long-term outcome in high-risk patients with acute myocardial infarction
    Salvatore De Rosa
    Division of Cardiology, University of Naples Federico II, Naples, Italy
    J Interv Cardiol 20:292-8. 2007
    ....
  13. ncbi request reprint Echocardiographic evaluation of left ventricular end-systolic elastance in the elderly
    Domenico De Santis
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita degli Studi di Napoli Federico II, Via S Pansini, 5, 80131 Naples, Italy
    Eur J Heart Fail 7:829-33. 2005
    ..However, important changes in systolic function may also occur. Left ventricular end-systolic elastance (E(es)) is a major determinant of cardiac systolic function and ventricular-arterial interaction...
  14. pmc Natriuretic Peptide-guided therapy in chronic heart failure: a meta-analysis of 2,686 patients in 12 randomized trials
    Gianluigi Savarese
    Department of Advanced Biomedical Sciences, Federico II University, Naples, Italy
    PLoS ONE 8:e58287. 2013
    ..In particular, NT-proBNP-guided therapy reduced all-cause mortality and HF-related hospitalization but not all-cause hospitalization, whereas BNP-guided therapy did not significantly reduce both mortality and morbidity...
  15. ncbi request reprint Elevated myocardial and lymphocyte GRK2 expression and activity in human heart failure
    Guido Iaccarino
    Department of Medicina Clinica Scienze Cardiovascolari ed Immunologiche, Federico II University, Via Pansini 5, 80131 Naples, Italy
    Eur Heart J 26:1752-8. 2005
    ..Moreover, we were interested in determining whether GRK2 levels in myocardium and lymphocytes may be associated with beta-AR dysfunction and HF severity...
  16. doi request reprint Coronary computed tomography: current role and future perspectives for cardiovascular risk stratification
    Pasquale Perrone-Filardi
    Department of Internal Medicine, Cardiovascular and Immunological Sciences, Federico II University, Via S Pansini 5, Naples, Italy
    Eur Heart J Cardiovasc Imaging 13:453-8. 2012
    ..Further studies are needed to assess the impact of CCT on clinical outcomes and its cost-effectiveness in different clinical settings...
  17. doi request reprint Abciximab in elderly with acute coronary syndrome invasively treated: effect on outcome
    Gennaro Galasso
    Division of Cardiology, Federico II University, Naples, Italy
    Int J Cardiol 130:380-5. 2008
    ....
  18. doi request reprint Exercise training early after acute myocardial infarction reduces stress-induced hypoperfusion and improves left ventricular function
    Francesco Giallauria
    Department of Clinical Medicine, Cardiovascular and Immunological Sciences, University of Naples Federico II, Naples, Italy
    Eur J Nucl Med Mol Imaging 40:315-24. 2013
    ..We evaluated whether long-term exercise-based cardiac rehabilitation started early after ST-elevation acute myocardial infarction (STEMI) improves myocardial perfusion and left ventricular (LV) function...
  19. doi request reprint Prevalence and severity of asymptomatic coronary and carotid artery disease in patients with lower limbs arterial disease
    Fabio Marsico
    Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini, 5, I 80131 Naples, Italy
    Atherosclerosis 228:386-9. 2013
    ..The purpose of this study was to evaluate the prevalence and severity of CAD and CVD in patients with LLAD of the lower extremities...
  20. ncbi request reprint [Clinical and therapeutic value of carotid intima-media thickness]
    Enrico Vassallo
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita degli Studi di Napoli Federico II, Napoli, Italia
    Monaldi Arch Chest Dis 76:132-5. 2011
    ..Thus, IMT represents a valuable risk marker in population studies but its role for tailoring cardiovascular therapy in clinical practice remains currently uncertain...
  21. ncbi request reprint Body mass index and preinfarction angina in elderly patients with acute myocardial infarction
    Pasquale Abete
    Cattedra di Geriatria, Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Università degli Studi di Naples Federico II, Naples, Italy
    Am J Clin Nutr 78:796-801. 2003
    ..Experimental evidence indicates that caloric restriction may restore ischemic preconditioning in aged animals...
  22. doi request reprint Adrenal GRK2 lowering is an underlying mechanism for the beneficial sympathetic effects of exercise training in heart failure
    Giuseppe Rengo
    Cardiology Division, Salvatore Maugeri Foundation, IRCCS, Via Bagni Vecchi, 1 82037 Telese Terme, Italy
    Am J Physiol Heart Circ Physiol 298:H2032-8. 2010
    ....
  23. doi request reprint Cardiovascular involvement in patients affected by acromegaly: An appraisal
    Susanna Mosca
    Department of Advanced Biomedical Sciences, University of Naples Federico II, Italy
    Int J Cardiol 167:1712-8. 2013
    ....
  24. ncbi request reprint Statins and the elderly: recent evidence and current indications
    Gabriele Giacomo Schiattarella
    Department of Clinical Medicine and Cardiovascular and Immunology Sciences, University of Naples Federico II, Via Pansini 5, 80131 Napoli, Italy
    Aging Clin Exp Res 24:47-55. 2012
    ..Also discussed is the latest evidence regarding the putative protective effects of statins on senile dementia and the relationship between statin treatment and cancer...
  25. ncbi request reprint Immediate and long-term outcome of recanalization of chronic total coronary occlusions
    Federico Piscione
    Division of Cardiology, Federico II University, Via S Pansini 5, 80131 Naples, Italy
    J Interv Cardiol 15:173-9. 2002
    ..Family history of CAD and occlusion of left anterior descending or right coronary arteries are independent predictors of procedural success...
  26. ncbi request reprint [From myocardium to the atherosclerotic plaque: new perspectives in cardiologic imaging]
    Paola Gargiulo
    Dipartimento di Medicina Clinica, Scienze Cardiovascolari ed Immunologiche, Universita degli Studi di Napoli Federico II, Italy
    Monaldi Arch Chest Dis 76:60-5. 2011
    ..Purpose of this review is to describe state of the art and potential areas of clinical applications of molecular imaging of atherosclerosis...
  27. ncbi request reprint Angiotensin II-receptor antagonist losartan does not prevent nitroglycerin tolerance in patients with coronary artery disease
    Giancarlo Longobardi
    Division of Cardiology, Fondazione Salvatore Maugeri, IRCCS Scientific Institute of Telese Terme, Via Bagni Vecchi, 82037 Telese Termi, Italy
    Cardiovasc Drugs Ther 18:363-70. 2004
    ..001). The AT(1) antagonist Losartan administration does not prevent the development of nitrate tolerance during continuous TD-GTN therapy...
  28. ncbi request reprint Aging exacerbates negative remodeling and impairs endothelial regeneration after balloon injury
    Daniele Torella
    Div of Cardiology, Magna Graecia Univ, Via Tommaso Campanella, 115, 88100 Catanzaro, Italy
    Am J Physiol Heart Circ Physiol 287:H2850-60. 2004
    ..The molecular mechanisms underlying these responses seem to be a reduced Akt and eNOS activity...
  29. ncbi request reprint Insulin-induced changes in beta-adrenergic response: an experimental study in the isolated rat papillary muscle
    Nicola Ferrara
    Department of Health Sciences, University of Molise, Salvatore Maugeri Foundation, IRCCS, Scientific Institute of Telese Campoli, Via dei Bagni Vecchi, 82037 Telese Terme, Italy
    Am J Hypertens 18:348-53. 2005
    ..The aim was to investigate the ability of insulin to modulate the response to beta-adrenergic action on myocardial contractility, assessed as percentage changes of developed tension, in isolated rat papillary muscle...
  30. ncbi request reprint Exercise training affects age-induced changes in SOD and heat shock protein expression in rat heart
    Barbara Rinaldi
    Department of Experimental Medicine and Excellence Center of Cardiovascular Disease, Second University of Naples, Naples 80138, Italy
    Exp Gerontol 41:764-70. 2006
    ..These findings suggest that the beneficial effects on aged-related cardiovascular changes could be connected to the "anti-oxidant" effects of prolonged exercise training...
  31. ncbi request reprint Physical training increases eNOS vascular expression and activity and reduces restenosis after balloon angioplasty or arterial stenting in rats
    Ciro Indolfi
    Division of Cardiology, Magna Graecia University, Catanzaro, Italy
    Circ Res 91:1190-7. 2002
    ..Increase in eNOS expression and activity might contribute to the potential beneficial effects of exercise on the vessel wall after vascular injury...
  32. ncbi request reprint An active lifestyle improves outcome of primary angioplasty in elderly patients with acute myocardial infarction
    Giuseppe Rengo
    Fondazione Salvatore Maugeri IRCCS, Telese BN, Italy
    Am Heart J 154:352-60. 2007
    ..The aim of this study was to evaluate whether the positive role of an active lifestyle on cardiac prognosis extends to elderly patients with AMI who undergo primary percutaneous transluminal coronary angioplasty (PTCA)...
  33. ncbi request reprint Efficacy of transdermal nitroglycerin patches evaluated by dipyridamole-induced myocardial ischemia in patients with coronary artery disease. Comparison between continuous and intermittent schedule
    Giancarlo Longobardi
    Fondazione Salvatore Maugeri, IRCCS, Rehabilitation Institute of Telese Terme, Division of Cardiology, Italy
    Cardiovasc Drugs Ther 16:535-42. 2002
    ..Moreover the dipyridamole echocardiographic stress test, besides evaluating myocardial ischemia-induced wall motion abnormalities, is adequate to assess both the efficacy and the tolerance of transdermal nitrate therapy...
  34. ncbi request reprint Disability and 6-year mortality in elderly population. Role of visual impairment
    Francesco Cacciatore
    Department of Rehabilitation, Salvatore Maugeri Foundation, Telese Campoli Bn, Italy
    Aging Clin Exp Res 16:382-8. 2004
    ..A cross-sectional survey in a large population randomly selected in 1992 with a 6-year mortality evaluation in Campania, a region in southern Italy...