A A Izzo

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. doi request reprint Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects
    A A Izzo
    Department of Experimental Pharmacology, Endocannabinoid Research Group, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Gut 57:1140-55. 2008
  2. pmc Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection
    Francesca Guida
    Department of Experimental Medicine, Section of Pharmacology, The Second University of Naples, Naples, Italy
    Mol Pain 8:60. 2012
  3. doi request reprint Interactions between herbs and conventional drugs: overview of the clinical data
    Angelo A Izzo
    Department of Experimental Pharmacology, Federico II University of Naples, Naples, Italy
    Med Princ Pract 21:404-28. 2012
  4. pmc Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 166:1444-60. 2012
  5. ncbi request reprint St John's wort: Prozac from the plant kingdom
    G Di Carlo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Trends Pharmacol Sci 22:292-7. 2001
  6. ncbi request reprint Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Int J Clin Pharmacol Ther 42:139-48. 2004
  7. pmc Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples Italy
    Br J Pharmacol 134:563-70. 2001
  8. ncbi request reprint The gastrointestinal pharmacology of cannabinoids
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Curr Opin Pharmacol 1:597-603. 2001
  9. ncbi request reprint An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples, Frederico II, Naples, Italy
    Gastroenterology 125:765-74. 2003
  10. doi request reprint Cannabinoids in intestinal inflammation and cancer
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II and Endocannabinoid Research Group, Naples, Italy
    Pharmacol Res 60:117-25. 2009

Collaborators

Detail Information

Publications99

  1. doi request reprint Emerging role of cannabinoids in gastrointestinal and liver diseases: basic and clinical aspects
    A A Izzo
    Department of Experimental Pharmacology, Endocannabinoid Research Group, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Gut 57:1140-55. 2008
    ....
  2. pmc Salvinorin A reduces mechanical allodynia and spinal neuronal hyperexcitability induced by peripheral formalin injection
    Francesca Guida
    Department of Experimental Medicine, Section of Pharmacology, The Second University of Naples, Naples, Italy
    Mol Pain 8:60. 2012
    ..Moreover, the involvement of microglial and glial cells in formalin-induced chronic pain condition and in SA-mediated effects has been evaluated...
  3. doi request reprint Interactions between herbs and conventional drugs: overview of the clinical data
    Angelo A Izzo
    Department of Experimental Pharmacology, Federico II University of Naples, Naples, Italy
    Med Princ Pract 21:404-28. 2012
    ..Healthcare professionals should remain vigilant for potential interactions between herbal medicines and prescribed drugs, especially when drugs with a narrow therapeutic index are used...
  4. pmc Inhibitory effect of cannabichromene, a major non-psychotropic cannabinoid extracted from Cannabis sativa, on inflammation-induced hypermotility in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 166:1444-60. 2012
    ..Both endocannabinoids and TRPA1 may modulate gastrointestinal motility. Here, we investigated the effect of CBC on mouse intestinal motility in physiological and pathological states...
  5. ncbi request reprint St John's wort: Prozac from the plant kingdom
    G Di Carlo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Trends Pharmacol Sci 22:292-7. 2001
    ..However, important herb--drug interactions have been described. In view of its efficacy and safety records, St John's wort should be considered for the first-line treatment of mild to moderate depression...
  6. ncbi request reprint Drug interactions with St. John's Wort (Hypericum perforatum): a review of the clinical evidence
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Int J Clin Pharmacol Ther 42:139-48. 2004
    ..g. sertaline, paroxetine, nefazodone) or buspirone, SJW can cause serotonergic syndrome. SJW represents a herbal medicine with a high potential for drug interactions. Some of such interactions may have serious clinical consequences...
  7. pmc Cannabinoid CB1-receptor mediated regulation of gastrointestinal motility in mice in a model of intestinal inflammation
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples Italy
    Br J Pharmacol 134:563-70. 2001
    ....
  8. ncbi request reprint The gastrointestinal pharmacology of cannabinoids
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Curr Opin Pharmacol 1:597-603. 2001
    ..Activation of CB1 receptors inhibits gastrointestinal motility, intestinal secretion and gastric acid secretion. The enteric location of CB1 receptors could provide new strategies for the management of gut disorders...
  9. ncbi request reprint An endogenous cannabinoid tone attenuates cholera toxin-induced fluid accumulation in mice
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples, Frederico II, Naples, Italy
    Gastroenterology 125:765-74. 2003
    ..In this study, we investigated the role of the endogenous cannabinoid system (i.e., the cannabinoid receptors and their endogenous ligands) in CT-induced fluid accumulation in the mouse small intestine...
  10. doi request reprint Cannabinoids in intestinal inflammation and cancer
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II and Endocannabinoid Research Group, Naples, Italy
    Pharmacol Res 60:117-25. 2009
    ..Pharmacological elevation of endocannabinoid levels may be a promising strategy to counteract intestinal inflammation and colon cancer...
  11. doi request reprint Interactions between herbal medicines and prescribed drugs: an updated systematic review
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, Naples 80131, Italy
    Drugs 69:1777-98. 2009
    ..While the significance of many interactions is uncertain, several interactions, particularly those with St John's wort, may have serious clinical consequences...
  12. doi request reprint Non-psychotropic plant cannabinoids: new therapeutic opportunities from an ancient herb
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Trends Pharmacol Sci 30:515-27. 2009
    ....
  13. pmc Effect of vanilloid drugs on gastrointestinal transit in mice
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 132:1411-6. 2001
    ..The effect of piperine involves capsaicin-sensitive neurones, but not vanilloid receptors, while the effect of anandamide involves cannabinoid CB(1), but not vanilloid receptors...
  14. ncbi request reprint The cannabinoid CB(2) receptor: a good friend in the gut
    A A Izzo
    Endocannabinoid Research Group, Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Neurogastroenterol Motil 19:704-8. 2007
    ....
  15. ncbi request reprint Cardiovascular pharmacotherapy and herbal medicines: the risk of drug interaction
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Int J Cardiol 98:1-14. 2005
    ..John's wort. Interaction between herbal medicine and cardiovascular drugs is a potentially important safety issue. Patients taking anticoagulants are at the highest risk...
  16. pmc Increased endocannabinoid levels reduce the development of precancerous lesions in the mouse colon
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Mol Med (Berl) 86:89-98. 2008
    ..The protective effect appears to involve caspase-3 (but not caspase-9) activation...
  17. pmc Cannabinoids and intestinal motility: welcome to CB2 receptors
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Br J Pharmacol 142:1201-2. 2004
    ..By minimizing the adverse psychotropic effects associated with brain cannabinoid receptors, the CB(2) receptor represents a new molecular target for the treatment of motility disorders associated with intestinal inflammation...
  18. ncbi request reprint Herb-drug interactions: an overview of the clinical evidence
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Fundam Clin Pharmacol 19:1-16. 2005
    ..However, for many of the interactions discussed here, the understanding of the mechanisms involved is incomplete. Taking herbal agents may represent a potential risk to patients under conventional pharmacotherapy...
  19. ncbi request reprint Inhibitory effect of cannabinoid agonists on gastric emptying in the rat
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Naunyn Schmiedebergs Arch Pharmacol 360:221-3. 1999
    ..These results suggest that cannabinoid agonists delay gastric emptying through activation of cannabinoid CB1 receptors, while the endogenous cannabinoid system does not seem to modulate gastric motility...
  20. pmc Modulation of peristalsis by cannabinoid CB(1) ligands in the isolated guinea-pig ileum
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Br J Pharmacol 129:984-90. 2000
    ..It is concluded that activation of CB(1) receptors reduces peristalsis efficiency in the isolated guinea-pig, and that the emptying phase of peristalsis could be tonically inhibited by the endogenous cannabinoid system...
  21. pmc Central and peripheral cannabinoid modulation of gastrointestinal transit in physiological states or during the diarrhoea induced by croton oil
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Br J Pharmacol 129:1627-32. 2000
    ..However, a peripheral site of action is suggested by the lack of effect of hexamethonium. In addition, croton oil-induced diarrhoea enhances the effect of cannabinoid agonists by a peripheral mechanism...
  22. doi request reprint Cannabinoids and the gut: new developments and emerging concepts
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II and Endocannabinoid Research Group, Naples, Italy
    Pharmacol Ther 126:21-38. 2010
    ..We focus on the pharmacological actions of cannabinoids in relation to GI disorders, highlighting recent data on genetic mutations in the endocannabinoid system in GI disease...
  23. pmc Cannabidiol, extracted from Cannabis sativa, selectively inhibits inflammatory hypermotility in mice
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II and Endocannabinoid Research Group, Naples, Italy
    Br J Pharmacol 154:1001-8. 2008
    ..However, the actions of cannabidiol in the digestive tract are largely unexplored. In the present study, we investigated the effect of cannabidiol on intestinal motility in normal (control) mice and in mice with intestinal inflammation...
  24. ncbi request reprint The role of cannabinoid receptors in intestinal motility, defaecation and diarrhoea in rats
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Eur J Pharmacol 384:37-42. 1999
    ....
  25. pmc Inhibitory effect of salvinorin A, from Salvia divinorum, on ileitis-induced hypermotility: cross-talk between kappa-opioid and cannabinoid CB(1) receptors
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 155:681-9. 2008
    ....
  26. ncbi request reprint Defaecation, intestinal fluid accumulation and motility in rodents: implications of cannabinoid CB1 receptors
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Naunyn Schmiedebergs Arch Pharmacol 359:65-70. 1999
    ..These results suggest that intestinal fluid accumulation and motility are inhibited by endogenous cannabinoid(s) acting at the cannabinoid CB1 receptors. This effect may be mediated by mechanisms involving muscarinic cholinoceptors...
  27. ncbi request reprint NG-nitro-L-arginine methyl ester reduces senna- and cascara-induced diarrhoea and fluid secretion in the rat
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Eur J Pharmacol 301:137-42. 1996
    ..p. was without effect. These results suggest a possible involvement of NO in senna- and cascara-induced diarrhoea and fluid secretion...
  28. ncbi request reprint Effect of senna is not mediated by platelet-activating factor
    F Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Pharmacology 47:58-63. 1993
    ..Therefore, our data suggest that senna is well tolerated in animals and PAF does not mediate senna-induced laxation...
  29. ncbi request reprint The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A reduce inflammation-induced hypermotility in mice
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Neurogastroenterol Motil 20:142-8. 2008
    ..Gut inflammation increased the potency of salvinorin A; this effect was mediated by KOR, but it was not shared by U-50488, thus suggesting that salvinorin A may have target(s) other than KOR in the inflamed gut...
  30. doi request reprint Inhibitory effects of bromelain, a cysteine protease derived from pineapple stem (Ananas comosus), on intestinal motility in mice
    F Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, Naples, Italy
    Neurogastroenterol Motil 23:745-e331. 2011
    ..However, its effects on intestinal motility are largely unexplored. Thus, we investigated the effect of this plant-derived compound on intestinal contractility and transit in mice...
  31. ncbi request reprint Nitric oxide as a mediator of bisacodyl and phenolphthalein laxative action: induction of nitric oxide synthase
    T S Gaginella
    Department of Experimental Pharmacology, University of Naples, Federico II, Italy
    J Pharmacol Exp Ther 270:1239-45. 1994
    ..Furthermore, it appears that the NO is derived principally from activation of an inducible form of NO synthase...
  32. pmc The role of endocannabinoids in the regulation of gastric emptying: alterations in mice fed a high-fat diet
    V Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, National Research Council, Pozzuoli, Naples, Italy
    Br J Pharmacol 153:1272-80. 2008
    ..The purpose of the present study was to investigate the involvement of the endocannabinoid system in the regulation of gastric emptying in mice fed either a standard diet (STD) or a high-fat diet (HFD) for 14 weeks...
  33. ncbi request reprint Senna and the formation of aberrant crypt foci and tumors in rats treated with azoxymethane
    F Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Via D Montesano 80131 Naples, Italy
    Phytomedicine 12:501-5; discussion 505. 2005
    ..These results suggest that a chronic SE use does not predispose to colon cancer. By contrast, SE might exert an anti-tumoral activity on rat colon carcinogenesis...
  34. ncbi request reprint Effect of bisacodyl and cascara on growth of aberrant crypt foci and malignant tumors in the rat colon
    F Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Life Sci 69:1871-7. 2001
    ..The results of the present study indicate a possible promoting effect of bisacodyl on rat colon carcinogenesis (especially at higher doses) and absence of any promoting or initiating activity of a laxative and diarrhoeal dose of cascara...
  35. doi request reprint Prokinetic effect of a standardized yarrow (Achillea millefolium) extract and its constituent choline: studies in the mouse and human stomach
    F Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Neurogastroenterol Motil 24:164-71, e90. 2012
    ..Fam Asteraceae) preparations are traditional remedies used to treat dyspeptic complaints. Herein, we investigated the effect of a standardized dry water extract obtained from A. millefolium flowering tops (AME) on gastric motility...
  36. ncbi request reprint Relationship between nitric oxide and platelet-activating factor in castor-oil induced mucosal injury in the rat duodenum
    N Mascolo
    Department of Experimental Pharmacology, School of Pharmacy, Naples, Italy
    Naunyn Schmiedebergs Arch Pharmacol 353:680-4. 1996
    ..2-d]furan-5,9,12(4H)trione) 10 and 20 mg/kg i.p. Such findings suggest that endogenous nitric oxide could reduce PAF biosynthesis in castor oil-treated rats...
  37. ncbi request reprint Effect of a propolis extract and caffeic acid phenethyl ester on formation of aberrant crypt foci and tumors in the rat colon
    F Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Fitoterapia 73:S38-43. 2002
    ..CAPE (50 mg/kg i.p.) reduced the formation of ACF and tumor induced by azoxymethane, while propolis ethanolic extract was without effect. These results suggest a potential anti-carcinogenesis of CAPE but not propolis...
  38. ncbi request reprint The role of constitutive and inducible nitric oxide synthase in senna- and cascara-induced diarrhoea in the rat
    A A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Eur J Pharmacol 323:93-7. 1997
    ..These findings suggest that senna probably exerts its laxative effect through stimulation of the constitutive isoform of NO synthase, while the inducible isoform of NO synthase also seems to be involved in the laxative effect of cascara...
  39. ncbi request reprint Effects of senna and its active compounds rhein and rhein-anthrone on PAF formation by rat colon
    N Mascolo
    Department of Experimental Pharmacology, University of Naples, Italy
    J Pharm Pharmacol 44:693-5. 1992
    ..Since PAF can mediate intestinal damage and acid phosphatase is a marker of cellular injury, we conclude that senna and its derivatives, rhein and rhein-anthrone, are well tolerated in rats...
  40. ncbi request reprint Endocannabinoids and the gut
    L Pinto
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Prostaglandins Leukot Essent Fatty Acids 66:333-41. 2002
    ..Interestingly, inhibitory effects of anandamide via non-CB(1) receptors and stimulatory effects via vanilloid receptors have also been proposed...
  41. ncbi request reprint Selective cannabinoid CB1 receptor-mediated inhibition of inducible nitric oxide synthase protein expression in C6 rat glioma cells
    G Esposito
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Neurochem 78:835-41. 2001
    ..These data suggest that selective cannabinoid CB1 receptor activation, by inhibiting iNOS expression and NO overproduction in glial cells, might be helpful in NO-mediated inflammation leading to neurodegeneration...
  42. ncbi request reprint The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea-pig ileum
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Neurogastroenterol Motil 18:69-75. 2006
    ..Salvinorin A might be the chemical ingredient responsible for this activity...
  43. ncbi request reprint Endocannabinoids as physiological regulators of colonic propulsion in mice
    Luisa Pinto
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Gastroenterology 123:227-34. 2002
    ..In the present study, we investigated the possible involvement of endocannabinoids in regulating intestinal propulsion in the mouse colon in vivo...
  44. doi request reprint Cannabinoid actions at TRPV channels: effects on TRPV3 and TRPV4 and their potential relevance to gastrointestinal inflammation
    L De Petrocellis
    Endocannabinoid Research Group, Institute of Cybernetics, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
    Acta Physiol (Oxf) 204:255-66. 2012
    ....
  45. ncbi request reprint Cannabinoids and gastrointestinal motility: animal and human studies
    G Aviello
    Department of Experimental Pharmacology and Endocannabinoid Research Group, University of Naples Federico II, Naples, Italy
    Eur Rev Med Pharmacol Sci 12:81-93. 2008
    ..Cannabinoids also reduce gastrointestinal motility in randomized clinical trials. Overall, modulation of the gut endogenous cannabinoid system may provide a useful therapeutic target for disorders of gastrointestinal motility...
  46. doi request reprint Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide
    R Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Neuroendocrinol 20:39-46. 2008
    ..Additionally, these acylethanolamides, whose gastric levels change in response to diet-induced obesity, alter gastrointestinal motility, which might contribute to their effect on food intake and nutrient absorption...
  47. ncbi request reprint Interactions between herbal medicines and prescribed drugs: a systematic review
    A A Izzo
    Department of Experimental Pharmacology, University of Naples 'Federico II, Naples, Italy
    Drugs 61:2163-75. 2001
    ..Healthcare professionals should ask their patients about the use of herbal products and consider the possibility of herb-drug interactions...
  48. ncbi request reprint Inhibitory effect of ginger (Zingiber officinale) on rat ileal motility in vitro
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Life Sci 74:2889-96. 2004
    ....
  49. pmc Endocannabinoid overactivity and intestinal inflammation
    V Di Marzo
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078 Pozzuoli, Napoli, Italy
    Gut 55:1373-6. 2006
    ..The pathological significance of this "endocannabinoid overactivity" and its possible exploitation for therapeutic purposes are discussed here...
  50. pmc Effect of Boswellia serrata on intestinal motility in rodents: inhibition of diarrhoea without constipation
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, Italy
    Br J Pharmacol 148:553-60. 2006
    ..These results could explain, at least in part, the clinical efficacy of this Ayurvedic remedy in reducing diarrhoea in patients with inflammatory bowel disease...
  51. doi request reprint Antispasmodic effects and structure-activity relationships of labdane diterpenoids from Marrubium globosum ssp. libanoticum
    Daniela Rigano
    Department of Chemistry of Natural Products, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Nat Prod 72:1477-81. 2009
    ..Compound 9, which exerted antispasmodic activity, is likely the active ingredient of the extract. Preliminary structure-activity relationships for this class of compounds are suggested...
  52. ncbi request reprint The endocannabinoid system protects rat glioma cells against HIV-1 Tat protein-induced cytotoxicity. Mechanism and regulation
    Giuseppe Esposito
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Biol Chem 277:50348-54. 2002
    ..These findings show that the endocannabinoid system, through the modulation of the l-arginine/NO pathway, reduces HIV-1 Tat-induced cytotoxicity, and is itself regulated by HIV-1 Tat...
  53. ncbi request reprint The endocannabinoid system and the molecular basis of paralytic ileus in mice
    Nicola Mascolo
    Department of Experimental Pharmacology, University of Naples Federico II, 80131 Naples, Italy
    FASEB J 16:1973-5. 2002
    ....
  54. ncbi request reprint Inhibitory effect of the antidepressant St. John's wort (hypericum perforatum) on rat bladder contractility in vitro
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Urology 64:168-72. 2004
    ..To evaluate the effect of St. John's wort (SJW), an effective and safe herbal antidepressant, on rat bladder contractility. Recent data have suggested a strong association between depression and urinary incontinence...
  55. ncbi request reprint Pharmacological effects of Cimicifuga racemosa
    F Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Life Sci 73:1215-29. 2003
    ..racemosa possesses a central activity instead of a hormonal effect. Further biological and chemical investigations are required to define its mechanism of action and to identify the compounds responsible of its actions...
  56. ncbi request reprint New sesquiterpenes with intestinal relaxant effect from Celastrus paniculatus
    Francesca Borrelli
    Dipartimento di Farmacologia Sperimentale, Universita degli Studi di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    Planta Med 70:652-6. 2004
    ..6 +/- 12.2 %, 26.9 +/- 4.7 % and 7.27 +/- 1.7 %, respectively...
  57. ncbi request reprint Identification of a new sesquiterpene polyol ester from Celastrus paniculatus
    Nicola Borbone
    Dipartimento di Chimica delle Sostanze Naturali, Universita degli Studi di Napoli Federico II, Napoli, Italy
    Planta Med 73:792-4. 2007
    ..All four compounds produce at a concentration of 1 microg/mL a relaxant effect on the isolated rat ileum of 31.4 +/- 7.5, 24.3 +/- 9.6, 24.4 +/- 4.9, and 16.2 +/- 7.2 %, respectively...
  58. ncbi request reprint Spasmolytic effects of nonprenylated rotenoid constituents of Boerhaavia diffusa roots
    Francesca Borrelli
    Dipartimento di Farmacologia Sperimentale, Universita di Napoli Federico II, via D Montesano 49, 80131 Napoli, Italy
    J Nat Prod 69:903-6. 2006
    ..Preliminary structure-activity relationships for this class of compounds are suggested...
  59. doi request reprint Inhibitory effect of the herbal antidepressant St. John's wort (Hypericum perforatum) on rat gastric motility
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Naunyn Schmiedebergs Arch Pharmacol 376:407-14. 2008
    ..If extended to humans, the inhibitory effect of SJW extract on gastric emptying in vivo could contribute, at least in part, to the clinical pharmacokinetic interactions between conventional medicines and this herbal antidepressant...
  60. ncbi request reprint Fatty acid amide hydrolase controls mouse intestinal motility in vivo
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Gastroenterology 129:941-51. 2005
    ..The physiologic role of FAAH in the gut is largely unexplored. In the present study, we evaluated the possible role of FAAH in regulating intestinal motility in mice in vivo...
  61. ncbi request reprint Isolation of new rotenoids from Boerhaavia diffusa and evaluation of their effect on intestinal motility
    Francesca Borrelli
    Dipartimento di Farmacologia Sperimentale, Universita di Napoli Federico II, via D Montesano 49, 80131 Naples, Italy
    Planta Med 71:928-32. 2005
    ..Three of them (boeravinone G, boeravinone E and compound 5) exhibited spasmolytic activity. Preliminary structure-activity relationships have been established highlighting the effect of substitutions on rings B and D...
  62. ncbi request reprint Cannabinoids for gastrointestinal diseases: potential therapeutic applications
    Giulia Di Carlo
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Expert Opin Investig Drugs 12:39-49. 2003
    ..Some cannabinoids are already in use clinically, for example, nabilone and delta(9)-tetrahydrocannabinol are used as antiemetics...
  63. pmc Herb-drug interactions with St John's wort (Hypericum perforatum): an update on clinical observations
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    AAPS J 11:710-27. 2009
    ..e., irinotecan, imatinib) drugs. Hyperforin, which is believed to contribute to the antidepressant action of St John's wort, is also strongly suspected to be responsible of most of the described interactions...
  64. ncbi request reprint Effectiveness and safety of ginger in the treatment of pregnancy-induced nausea and vomiting
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Obstet Gynecol 105:849-56. 2005
    ..This systematic review was aimed at assessing the evidence for or against the efficacy and safety of ginger (Zingiber officinale) therapy for nausea and vomiting during pregnancy...
  65. doi request reprint Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Mol Med (Berl) 87:1111-21. 2009
    ..In Caco-2 cells, cannabidiol reduced reactive oxygen species production and lipid peroxidation. In conclusion, cannabidiol, a likely safe compound, prevents experimental colitis in mice...
  66. pmc Role and regulation of acylethanolamides in energy balance: focus on adipocytes and beta-cells
    I Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry National Research Council, Naples, Italy
    Br J Pharmacol 152:676-90. 2007
    ..In beta-cells and human blood, OEA and PEA are down- or up-regulated under conditions of transient or chronic hyperglycaemia, respectively...
  67. ncbi request reprint A diterpenoid from Salvia cinnabarina inhibits mouse intestinal motility in vivo
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Planta Med 70:375-7. 2004
    ..p.) significantly reduced the antimotility effect of compound 1 (50 mg/kg). These results suggest that compound 1 inhibits gastrointestinal motility in mice. The effect could involve, at least in part, L-type Ca (2+) channels...
  68. ncbi request reprint A secoisopimarane diterpenoid from Salvia cinnabarina inhibits rat urinary bladder contractility in vitro
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Planta Med 70:185-8. 2004
    ..It is concluded that compound 1 inhibits rat bladder contractility with a mechanism involving, at least in part, NO production...
  69. ncbi request reprint Garlic (Allium sativum L.): adverse effects and drug interactions in humans
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Mol Nutr Food Res 51:1386-97. 2007
    ..Finally, garlic may enhance the pharmacological effect of anticoagulants (e. g. warfarin, fluindione) and reduce the efficacy of anti-AIDS drugs (i. e. saquinavir)...
  70. pmc Peripheral endocannabinoid dysregulation in obesity: relation to intestinal motility and energy processing induced by food deprivation and re-feeding
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Br J Pharmacol 158:451-61. 2009
    ..Here we evaluate endocannabinoid dysregulation in the small intestine of mice with diet-induced obesity (DIO) and in peripheral tissues of Zucker and lean rats following food deprivation and re-feeding...
  71. doi request reprint Role of acylethanolamides in the gastrointestinal tract with special reference to food intake and energy balance
    Francesca Borrelli
    Department of Experimental Pharmacology, University of Naples Federico II and Endocannabinoid Research Group, via D Montesano 49, 80131 Naples, Italy
    Best Pract Res Clin Endocrinol Metab 23:33-49. 2009
    ....
  72. ncbi request reprint Relaxant effect of capsazepine in the isolated rat ileum
    Emilia Nocerino
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Naunyn Schmiedebergs Arch Pharmacol 365:187-92. 2002
    ..We found no evidence to suggest that capsazepine is antagonizing an endogenous vanilloid...
  73. doi request reprint Endocannabinoid dysregulation in the pancreas and adipose tissue of mice fed with a high-fat diet
    Katarzyna M Starowicz
    Endocannabinoid Research Group, Consiglio Nazionale delle Ricerche, Pozzuoli, Italy
    Obesity (Silver Spring) 16:553-65. 2008
    ..Their pancreatic and adipose tissue levels are elevated during hyperglycemia and obesity, but the mechanisms underlying these alterations are not understood...
  74. doi request reprint Inhibitory effect of the anorexic compound oleoylethanolamide on gastric emptying in control and overweight mice
    Gabriella Aviello
    Endocannabinoid Research Group, Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Mol Med (Berl) 86:413-22. 2008
    ..The inhibitory effect of OEA on gastric emptying here observed might underlie part of the anorexic effects of this compound previously reported...
  75. doi request reprint Basal and fasting/refeeding-regulated tissue levels of endogenous PPAR-alpha ligands in Zucker rats
    Angelo A Izzo
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Obesity (Silver Spring) 18:55-62. 2010
    ..Changes in PEA levels might be relevant to the inflammatory state of Zucker rats...
  76. doi request reprint Inhibitory effect of caffeic acid phenethyl ester, a plant-derived polyphenolic compound, on rat intestinal contractility
    Gabriella Aviello
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    Eur J Pharmacol 640:163-7. 2010
    ..In conclusion our study shows that (i) CAPE relaxed myogenic contractions of rat ileum and that (ii) this effect occurs, at least in part, throughout a mechanism involving L-type Ca2+ channels...
  77. doi request reprint Silymarin BIO-C, an extract from Silybum marianum fruits, induces hyperprolactinemia in intact female rats
    Raffaele Capasso
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    Phytomedicine 16:839-44. 2009
    ..In conclusion, we have shown that an extract from S. marianum fruits significantly increases circulating prolactin levels in female rats; this effect seems to involve, at least in part, dopamine D(2) receptors...
  78. doi request reprint Dysregulation of peripheral endocannabinoid levels in hyperglycemia and obesity: Effect of high fat diets
    Isabel Matias
    Endocannabinoid Research Group, Institute of Biomolecular Chemistry, Consiglio Nazionale delle Ricerche, Pozzuoli NA, Italy
    Mol Cell Endocrinol 286:S66-78. 2008
    ..The potential implications of these and previous findings in the general framework of the proposed roles of the EC system in the control of metabolic, endocrine and cardiovascular and renal functions are discussed...
  79. ncbi request reprint Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells
    Teresa Iuvone
    Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy
    J Neurochem 89:134-41. 2004
    ....
  80. ncbi request reprint The marijuana component cannabidiol inhibits beta-amyloid-induced tau protein hyperphosphorylation through Wnt/beta-catenin pathway rescue in PC12 cells
    Giuseppe Esposito
    Department of Experimental Pharmacology, Faculty of Pharmacy, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Mol Med (Berl) 84:253-8. 2006
    ..These results provide new molecular insight regarding the neuroprotective effect of cannabidiol and suggest its possible role in the pharmacological management of AD, especially in view of its low toxicity in humans...
  81. ncbi request reprint The spice sage and its active ingredient rosmarinic acid protect PC12 cells from amyloid-beta peptide-induced neurotoxicity
    Teresa Iuvone
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131 Naples, Italy
    J Pharmacol Exp Ther 317:1143-9. 2006
    ..Rosmarinic acid could contribute, at least in part, for sage-induced neuroprotective effect...
  82. ncbi request reprint Induction of nitric oxide synthase expression by Withania somnifera in macrophages
    Teresa Iuvone
    Department of Experimental Pharmacology, University of Naples Federico II, via D Montesano 49, 80131, Naples, Italy
    Life Sci 72:1617-25. 2003
    ..The increased NO production by macrophages could account, at least in part, for the immunostimulant properties of Withania somnifera...
  83. ncbi request reprint Structure-activity relationships for saponins from Allium hirtifolium and Allium elburzense and their antispasmodic activity
    Elisa Barile
    DISTAAM, Università degli Studi del Molise, Campobasso, Italy
    Planta Med 71:1010-8. 2005
    ..The observed effect therefore contributes to the explanation of the traditional use of onion and garlic in the treatment of disturbances of the gastrointestinal tract...
  84. ncbi request reprint Effects of the antidepressant St. John's wort (Hypericum perforatum) on rat and human vas deferens contractility
    Raffaele Capasso
    Departments of Experimental Pharmacology and Urology, University of Naples Federico II, Naples Italy
    J Urol 173:2194-7. 2005
    ..John's wort (SJW) (Hypericum perforatum) we evaluated the effect of this herbal antidepressant on rat and human vas deferens contractility...
  85. ncbi request reprint The sapogenin atroviolacegenin and its diglycoside atroviolaceoside from Allium atroviolaceum
    Behzad Zolfaghari
    Department of Pharmacognosy, Isfahan University of Medical Sciences, Hezar Jerib Avenue, 73461 Isfahan, Iran
    J Nat Prod 69:191-5. 2006
    ..The absence of activity for both atroviolacegenin and atroviolaceoside highlighted the key role of the furostanol-type aglycone moiety for antispasmodic activity...
  86. ncbi request reprint Free radical scavenging capacity and protective effect of Bacopa monniera L. on DNA damage
    Alessandra Russo
    Department of Biochemistry, Medical Chemistry and Molecular Biology, University of Catania, V le A Doria 6, 95125, Catania, Italy
    Phytother Res 17:870-5. 2003
    ..Moreover, this experimental evidence suggests that because of its antioxidant activity, this Ayurvedic drug may be useful in the treatment of human pathologies in which free radical production plays a key role...
  87. ncbi request reprint The gastrointestinal pharmacology of cannabinoids: an update
    Angela A Coutts
    School of Medical Sciences, College of Life Sciences and Medicine, University of Aberdeen, Institute of Medical Sciences, Foresterhill, Aberdeen AB25 2ZD, Scotland
    Curr Opin Pharmacol 4:572-9. 2004
    ..Endocannabinoids also activate cannabinoid CB(2) and vanilloid VR1 receptors in certain inflammatory states. Thus endocannabinoid metabolism could provide a useful therapeutic target for many gastrointestinal disorders...
  88. ncbi request reprint Synthesis by microwave irradiation and antidiarrhoeal activity of benzotriazinone and saccharine derivatives
    Ferdinando Fiorino
    Dipartimento di Chimica Farmaceutica e Tossicologica, Universita Degli Studi Di Napoli, Federico II, Napoli, Italy
    Arch Pharm (Weinheim) 338:548-55. 2005
    ..Good yields and short reaction times are the main advantages of our synthetic route. Among the tested compounds, compound 12 inhibited motility both in in-vitro and in-vivo tests...
  89. ncbi request reprint Marijuana for cholera therapy
    Angelo A Izzo
    Trends Pharmacol Sci 27:7-8. 2006
  90. ncbi request reprint Oral immunogenicity of a plant-made, subunit, tuberculosis vaccine
    M Manuela Rigano
    The Biodesign Institute at Arizona State University, School of Life Sciences, Arizona State University, Tempe, AZ 85287 4501, USA
    Vaccine 24:691-5. 2006
    ..In addition, a Th2 response was induced in the Peyer's patch. This is the first report of an orally delivered, subunit, tuberculosis vaccine priming an antigen-specific, Th1 response...
  91. ncbi request reprint Herbal medicine: the dangers of drug interaction
    Angelo A Izzo
    Trends Pharmacol Sci 23:358-91; author reply 359. 2002
  92. ncbi request reprint Effect of piperine, the active ingredient of black pepper, on intestinal secretion in mice
    Raffaele Capasso
    Department of Pharmaceutical Science, University of Salerno, Italy
    Life Sci 71:2311-7. 2002
    ..p.). These results suggest that piperine reduces castor oil-induced fluid secretion with a mechanism involving capsaicin-sensitive neurons, but not capsazepine-sensitive vanilloid receptors...
  93. ncbi request reprint Herbal medicine, cancer prevention and cyclooxygenase 2 inhibition
    Angelo A Izzo
    Trends Pharmacol Sci 24:218-9. 2003
  94. pmc The protective effect of the Mycobacterium bovis BCG vaccine is increased by coadministration with the Mycobacterium tuberculosis 72-kilodalton fusion polyprotein Mtb72F in M. tuberculosis-infected guinea pigs
    Lise Brandt
    Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins 80523, USA
    Infect Immun 72:6622-32. 2004
    ..Collectively, these data suggest that enhancing BCG is a valid vaccination strategy for tuberculosis that is worthy of clinical evaluation...
  95. ncbi request reprint Decreased survival of guinea pigs infected with Mycobacterium tuberculosis after multiple BCG vaccinations
    Randall J Basaraba
    Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    Vaccine 24:280-6. 2006
    ..These data indicate that multiple BCG vaccination, which is akin to super-infection with the living vaccine, leads to major organ failure pathology...
  96. ncbi request reprint Herbal medicines to treat Alzheimer's disease
    Angelo A Izzo
    Trends Pharmacol Sci 28:47-8. 2007
  97. ncbi request reprint Antispasmodic saponins from bulbs of red onion, Allium cepa L. var. Tropea
    Gabriella Corea
    Dipartimento di Chimica delle Sostanze Naturali, Universita di Napoli Federico II, via D Montesano 49, I 80131 Napoli, Italy
    J Agric Food Chem 53:935-40. 2005
    ..The new saponins were found to possess antispasmodic activity in the guinea pig isolated ileum; such an effect might contribute to explaining the traditional use of onion in the treatment of disturbances of the gastrointestinal tract...
  98. pmc Magnetic resonance imaging of pulmonary lesions in guinea pigs infected with Mycobacterium tuberculosis
    Susan L Kraft
    Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado 80523, USA
    Infect Immun 72:5963-71. 2004
    ..Further development of this technical approach could be very useful in tracking lesion size, number, and progression in the search for new tuberculosis vaccines...
  99. doi request reprint Mycobacterial infection induces the secretion of high-mobility group box 1 protein
    Ajay Grover
    Department of Microbiology, Colorado State University, Fort Collins, CO 80523, USA
    Cell Microbiol 10:1390-404. 2008
    ..We conclude that HMGB1 is secreted by macrophages during tuberculosis and it may act as a signal of tissue or cellular injury and enhances immune response...