Ivan Gentile

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. ncbi request reprint Prevalence and titre of antibodies to cytomegalovirus and epstein-barr virus in patients with autism spectrum disorder
    Ivan Gentile
    Department of Clinical Medicine and Surgery Section of Infectious Diseases, Federico II University of Naples, Naples, Italy
    In Vivo 28:621-6. 2014
  2. ncbi request reprint Exposure to Varicella Zoster Virus is higher in children with autism spectrum disorder than in healthy controls. Results from a case-control study
    Ivan Gentile
    Department of Clinical Medicine and Surgery Section of Infectious Diseases, Federico II University of Naples, Naples, Italy
    In Vivo 28:627-31. 2014
  3. ncbi request reprint Prevalence of herpes simplex virus 1 and 2 antibodies in patients with autism spectrum disorders
    Ivan Gentile
    Department of Clinical Medicine and Surgery Section of Infectious Diseases, Federico II University of Naples, Naples, Italy
    In Vivo 28:667-71. 2014
  4. ncbi request reprint MK-5172 : a second-generation protease inhibitor for the treatment of hepatitis C virus infection
    Ivan Gentile
    University of Naples Federico II, Department of Clinical Medicine and Surgery Ed 18, Via S Pansini 5, I 80131 Naples, Italy 39 0 81 7463178 39 0 81 7463190
    Expert Opin Investig Drugs 23:719-28. 2014
  5. ncbi request reprint Daclatasvir: the first of a new class of drugs targeted against hepatitis C virus NS5A
    I Gentile
    Department of Clinical Medicine and Surgery Ed 18 University of Naples Federico II, Via S Pansini, 5 I 80131 Naples, Italy
    Curr Med Chem 21:1391-404. 2014
  6. doi request reprint Ledipasvir : a novel synthetic antiviral for the treatment of HCV infection
    Ivan Gentile
    University of Naples Federico II, Department of Clinical Medicine and Surgery, Via S Pansini 5, I 80131 Naples, Italy 39 081 746 3178 39 081 746 3190
    Expert Opin Investig Drugs 23:561-71. 2014
  7. ncbi request reprint Prevalence of HHV-6 and HHV-8 antibodies in patients with autism spectrum disorders
    Ivan Gentile
    Department of Clinical Medicine and Surgery Section of Infectious Diseases, Federico II University of Naples, Via S Pansini, 5, I 80131 Naples, Italy
    In Vivo 27:843-9. 2013
  8. ncbi request reprint Human platelet antigen-3 genotype predicts platelet count in patients with HCV infection
    Ivan Gentile
    Department of Clinical Medicine and Surgery, Section of Infectious Diseases, Federico II University of Naples, Via S Pansini 5, I 80131 Naples, Italy
    In Vivo 27:773-7. 2013
  9. ncbi request reprint A novel promising therapeutic option against hepatitis C virus: an oral nucleotide NS5B polymerase inhibitor sofosbuvir
    I Gentile
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Via S Pansini, 5 I 80131 Naples, Italy
    Curr Med Chem 20:3733-42. 2013
  10. ncbi request reprint Concomitant interferon-alpha and chemotherapy in hepatitis C and colorectal cancer: a case report
    Ivan Gentile
    Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples Federico II, Via S Pansini 5, I 80131 Naples, Italy
    In Vivo 27:527-9. 2013

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Prevalence and titre of antibodies to cytomegalovirus and epstein-barr virus in patients with autism spectrum disorder
    Ivan Gentile
    Department of Clinical Medicine and Surgery Section of Infectious Diseases, Federico II University of Naples, Naples, Italy
    In Vivo 28:621-6. 2014
    ..The aim of the present study was to evaluate the seropositivity rate and antibody titre to CMV and EBV in children with ASD compared to same-aged healthy controls...
  2. ncbi request reprint Exposure to Varicella Zoster Virus is higher in children with autism spectrum disorder than in healthy controls. Results from a case-control study
    Ivan Gentile
    Department of Clinical Medicine and Surgery Section of Infectious Diseases, Federico II University of Naples, Naples, Italy
    In Vivo 28:627-31. 2014
    ..The aim of the present study was to compare the exposure rate and titer of antibodies to Varicella Zoster Virus (VZV) in children with ASD and in healthy controls...
  3. ncbi request reprint Prevalence of herpes simplex virus 1 and 2 antibodies in patients with autism spectrum disorders
    Ivan Gentile
    Department of Clinical Medicine and Surgery Section of Infectious Diseases, Federico II University of Naples, Naples, Italy
    In Vivo 28:667-71. 2014
    ..The aim of this study was to evaluate the seropositivity rate and antibody level of Herpes Simplex Virus 1 (HSV1) and Herpes Simplex Virus 2 (HSV2) in children with ASD compared to same-aged healthy controls...
  4. ncbi request reprint MK-5172 : a second-generation protease inhibitor for the treatment of hepatitis C virus infection
    Ivan Gentile
    University of Naples Federico II, Department of Clinical Medicine and Surgery Ed 18, Via S Pansini 5, I 80131 Naples, Italy 39 0 81 7463178 39 0 81 7463190
    Expert Opin Investig Drugs 23:719-28. 2014
    ..HCV infection is treated with pegylated interferon and ribavirin; the addition of a protease inhibitor (boceprevir or telaprevir) can also be considered for patients with genotype 1...
  5. ncbi request reprint Daclatasvir: the first of a new class of drugs targeted against hepatitis C virus NS5A
    I Gentile
    Department of Clinical Medicine and Surgery Ed 18 University of Naples Federico II, Via S Pansini, 5 I 80131 Naples, Italy
    Curr Med Chem 21:1391-404. 2014
    ..In conclusion, daclatasvir, especially in combinations with other antiviral agents, is a very promising drug for the treatment of chronic hepatitis C. ..
  6. doi request reprint Ledipasvir : a novel synthetic antiviral for the treatment of HCV infection
    Ivan Gentile
    University of Naples Federico II, Department of Clinical Medicine and Surgery, Via S Pansini 5, I 80131 Naples, Italy 39 081 746 3178 39 081 746 3190
    Expert Opin Investig Drugs 23:561-71. 2014
    ..Recently, the first interferon-free combination for patients with genotype 2 or 3 was approved in the USA and Europe, and several molecules are in an advanced phase of clinical development...
  7. ncbi request reprint Prevalence of HHV-6 and HHV-8 antibodies in patients with autism spectrum disorders
    Ivan Gentile
    Department of Clinical Medicine and Surgery Section of Infectious Diseases, Federico II University of Naples, Via S Pansini, 5, I 80131 Naples, Italy
    In Vivo 27:843-9. 2013
    ..The aim of the present study was to evaluate seropositivity rate and levels of antibodies to HHV6 and HHV-8 in children with ASD compared to controls...
  8. ncbi request reprint Human platelet antigen-3 genotype predicts platelet count in patients with HCV infection
    Ivan Gentile
    Department of Clinical Medicine and Surgery, Section of Infectious Diseases, Federico II University of Naples, Via S Pansini 5, I 80131 Naples, Italy
    In Vivo 27:773-7. 2013
    ..We evaluated whether the human platelet antigen (HPA) genotype could predict platelet count in HCV-positive patients...
  9. ncbi request reprint A novel promising therapeutic option against hepatitis C virus: an oral nucleotide NS5B polymerase inhibitor sofosbuvir
    I Gentile
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Via S Pansini, 5 I 80131 Naples, Italy
    Curr Med Chem 20:3733-42. 2013
    ..Safety and tolerability of sofosbuvir appear to be excellent. In conclusion, sofosbuvir especially in interferon-free combinations represents a very promising option in the treatment of chronic hepatitis C. ..
  10. ncbi request reprint Concomitant interferon-alpha and chemotherapy in hepatitis C and colorectal cancer: a case report
    Ivan Gentile
    Department of Clinical Medicine and Surgery, Section of Infectious Diseases, University of Naples Federico II, Via S Pansini 5, I 80131 Naples, Italy
    In Vivo 27:527-9. 2013
    ..Both treatments were well-tolerated and the patient completed the scheduled therapies. HCV infection was eradicated and the patient is free of neoplastic disease two years and 6 months after surgery. ..
  11. doi request reprint Etiopathogenesis of autism spectrum disorders: fitting the pieces of the puzzle together
    Ivan Gentile
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
    Med Hypotheses 81:26-35. 2013
    ....
  12. ncbi request reprint Iron depletion before HCV antiviral therapy: a pilot, randomized, controlled trial
    Ivan Gentile
    Department of Public Medicine and Social Security, Section of Infectious Diseases, University Federico II, Naples, Italy
    J Clin Apher 24:190-6. 2009
    ..In conclusion phlebotomies do not increase the overall efficacy of antiviral therapy. However, the strong trend to higher SVR in naive patients undergoing phlebotomies warrants further investigation...
  13. ncbi request reprint Hemolytic anemia during pegylated IFN-alpha2b plus ribavirin treatment for chronic hepatitis C: ribavirin is not always the culprit
    Ivan Gentile
    Department of Public Medicine and Social Security, Institute of Infectious Diseases Ed 18, University of Naples Federico II, Naples, Italy
    J Interferon Cytokine Res 25:283-5. 2005
    ..This is the first case of IFN-related AHA during PEG-IFN plus ribavirin therapy. Physicians should be aware that PEG-IFN can be the cause of AHA during a ribavirin-containing regimen for chronic hepatitis C...
  14. ncbi request reprint Response to measles-mumps-rubella vaccine in children with autism spectrum disorders
    Ivan Gentile
    Department of Medical Translational Science, University of Naples, Federico II, Via S Pansini 5, Naples, Italy
    In Vivo 27:377-82. 2013
    ..The aim of our study was to evaluate the rate of seropositivity and the levels of antibodies against MMR antigens in a cohort of children with ASD compared to control children...
  15. ncbi request reprint In vivo antiviral activity of telbivudine against HIV-1: a case report
    Ivan Gentile
    Department of Clinical Medicine and Surgery, Section of Infectious Diseases Department of Cellular and Molecular Biology and Pathology, University of Naples Federico II, Naples, Italy
    Infez Med 21:216-9. 2013
    ..Our findings pose concerns of possible antiviral activity of telbivudine against HIV and therefore of selecting resistant mutations. ..
  16. ncbi request reprint Resolution of autoimmune thrombocytopenia associated with raltegravir use in an HIV-positive patient
    Ivan Gentile
    Dipartimento di Medicina Pubblica e Sicurezza Sociale, Sezione di Malattie Infettive, Universita di Napoli Federico II, Naples, Italy
    Platelets 24:574-7. 2013
    ..This consideration, if confirmed, could open new avenues in the treatment of autoimmune thrombocytopenia in the HIV setting. ..
  17. ncbi request reprint A retrospective study on HIV and syphilis
    Maria Foggia
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
    Infez Med 22:26-30. 2014
    ..Men who have sex with men (MSM) were the largest group. In the years 2002-2011, the incidence of syphilis in HIV-infected patients increased in our centre, notably among MSM. There is an urgent need for campaigns aiming to prevent STIs. ..
  18. pmc Sustained virological response: a milestone in the treatment of chronic hepatitis C
    Filomena Morisco
    Gastroenterology Unit, Dipartimento di Medicina Clinica e Chirurgia, University of Naples Federico II, 80131 Naples, Italy
    World J Gastroenterol 19:2793-8. 2013
    ..To evaluate the long-term eradication of hepatitis C virus (HCV) infection and liver-related complications in chronically infected patients that have achieved sustained virological response...
  19. doi request reprint A simple noninvasive score predicts gastroesophageal varices in patients with chronic viral hepatitis
    Ivan Gentile
    Department of Public Medicine and Social Security, Section of Infectious Diseases, University of Naples Federico II, Naples, Italy
    J Clin Gastroenterol 43:81-7. 2009
    ..Guidelines recommend upper endoscopic screening of cirrhotic patients for gastroesophageal varices. Cirrhosis is not always distinguishable from chronic hepatitis...
  20. ncbi request reprint A rare case of brainstem encephalitis by Listeria monocytogenes with isolated mesencephalic localization. Case report and review
    Laura Reynaud
    Department of Public Medicine and Social Security, Faculty of Medicine, University of Naples Federico II, 80131 Naples, Italy
    Diagn Microbiol Infect Dis 58:121-3. 2007
    ..Magnetic resonance imaging revealed an isolated mesencephalic lesion. Localization of this kind accounted for 3% of 111 cases reviewed...
  21. ncbi request reprint Investigational nucleoside and nucleotide polymerase inhibitors and their use in treating hepatitis C virus
    Ivan Gentile
    University of Naples Federico II, Department of Clinical Medicine and Surgery, Via S Pansini 5, I 80131 Naples, Italy 39 0 81 7463083 39 0 81 7463190
    Expert Opin Investig Drugs 23:1211-23. 2014
    ..However, an IFN-free combination (sofosbuvir and ribavirin) has been recently approved for genotypes 2 and 3 patients with many other drugs in preclinical and clinical development...
  22. ncbi request reprint Prevention of mother-to-child transmission of hepatitis B virus and hepatitis C virus
    Ivan Gentile
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Via S Pansini 5, Naples, Italy
    Expert Rev Anti Infect Ther 12:775-82. 2014
    ..We discuss the possibility of reducing mother-to-child HCV transmission using newly available antivirals or antivirals in the pipeline for the treatment of hepatitis C. ..
  23. ncbi request reprint Interferon-free therapies for chronic hepatitis C: toward a hepatitis C virus-free world?
    Ivan Gentile
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Via S Pansini 5, I 80131 Naples, Italy
    Expert Rev Anti Infect Ther 12:763-73. 2014
    ..If the problem of the high cost is overcome, interferon-free therapies will lead to what has long been a chimera, namely, an HCV-free world. ..
  24. ncbi request reprint Is it possible to predict HCV-related liver cirrhosis non-invasively through routine laboratory parameters?
    Ivan Gentile
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Naples, Italy
    Infez Med 22:11-8. 2014
    ..Further studies are required to compare the diagnostic performance of different non-invasive scores with the histologic evaluation and other non-invasive methods (fibroscan or fibrotest) on independent cohorts of patients...
  25. ncbi request reprint Anti-HBc positivity was associated with histological cirrhosis in patients with chronic hepatitis C
    Nicola Coppola
    Department of Mental Health and Public Medicine, Section of Infectious Diseases, Second University of Naples, Italy
    Ann Hepatol 13:20-6. 2013
    ..CONCLUSION. Our data support the idea that in patients with chronic hepatitis C the presence in serum of anti-HBc is associated with histological cirrhosis and is therefore a marker of clinical value...
  26. ncbi request reprint Ombitasvir: a potent pan-genotypic inhibitor of NS5A for the treatment of hepatitis C virus infection
    Ivan Gentile
    Department of Clinical Medicine and Surgery, University of Naples Federico II, Via S Pansini 5, I 80131 Naples, Italy
    Expert Rev Anti Infect Ther 12:1033-43. 2014
    ..However, coadministration of ombitasvir and other antivirals enhances its barrier to resistance. In conclusion, ombitasvir is a good drug to be used in IFN-free combinations for the treatment of chronic hepatitis C. ..
  27. pmc Is the drug-induced hypersensitivity syndrome (DIHS) due to human herpesvirus 6 infection or to allergy-mediated viral reactivation? Report of a case and literature review
    Ivan Gentile
    Department of Infectious Diseases and Legal Medicine Section of Infectious Diseases Ed 18 University of Naples Federico II, I 80131 Naples, Italy
    BMC Infect Dis 10:49. 2010
    ....
  28. pmc Hepatitis B in pregnancy
    Guglielmo Borgia
    Department of Public Medicine and Social Security, Section of Infectious Diseases, University of Naples Federico II, 80131 Naples, Italy
    World J Gastroenterol 18:4677-83. 2012
    ....
  29. ncbi request reprint Pernicious anemia during IFN-alpha treatment for chronic hepatitis C
    Guglielmo Borgia
    Department of Public Medicine and Social Security, Institute of Infectious Diseases Ed 18, University of Naples Federico II, Naples, Italy
    J Interferon Cytokine Res 23:11-2. 2003
    ..We recommend that particular attention be paid to such clinical and laboratory conditions as macrocytosis in administering IFN-alpha therapy for chronic hepatitis C...
  30. doi request reprint Antibiotic prophylaxis and risk of infections in thyroid surgery: results from a national study (UEC-Italian Endocrine Surgery Units Association)
    Maurizio De Palma
    Endocrinosurgery Unit, Department of General Surgery, Cardarelli Hospital, Naples, Italy
    Updates Surg 65:213-6. 2013
    ..In conclusion, our study shows that infection rate in thyroid surgery was 1 %. The use of an antibiotic prophylaxis was not associated with a protection from these infections...