Affiliation: Federico II University
Porpora M, Sauchella S, Rinaldi L, Delle Donne R, Sepe M, Torres Quesada O, et al
. Counterregulation of cAMP-directed kinase activities controls ciliogenesis. Nat Commun. 2018;9:1224 pubmed publisher
..These findings unveil a pericentriolar kinase signalosome that efficiently links the cAMP cascade with the ubiquitin-proteasome system, thereby controlling essential aspects of ciliogenesis. ..
Rinaldi L, Delle Donne R, Borzacchiello D, Insabato L, Feliciello A. The role of compartmentalized signaling pathways in the control of mitochondrial activities in cancer cells. Biochim Biophys Acta Rev Cancer. 2018;1869:293-302 pubmed publisher
Sepe M, Lignitto L, Porpora M, Delle Donne R, Rinaldi L, Belgianni G, et al
. Proteolytic control of neurite outgrowth inhibitor NOGO-A by the cAMP/PKA pathway. Proc Natl Acad Sci U S A. 2014;111:15729-34 pubmed publisher
..Our findings unveil a novel mechanism that functionally couples cAMP signaling with the proteolytic turnover of NOGO-A, positively impacting on neurite outgrowth in mammalian brain. ..
Feliciello A, Cardone L, Garbi C, Ginsberg M, Varrone S, Rubin C, et al
. Yotiao protein, a ligand for the NMDA receptor, binds and targets cAMP-dependent protein kinase II(1). FEBS Lett. 1999;464:174-8 pubmed
..Co-assembly of Yotiao/PKAII complexes with NR1 subunits may promote cAMP-dependent modulation of NMDA receptor activity at synapses, thereby influencing brain development and synaptic plasticity. ..
Cardone L, Carlucci A, Affaitati A, Livigni A, DeCristofaro T, Garbi C, et al
. Mitochondrial AKAP121 binds and targets protein tyrosine phosphatase D1, a novel positive regulator of src signaling. Mol Cell Biol. 2004;24:4613-26 pubmed
..This represents the first example of physical and functional interaction between AKAPs and a protein tyrosine phosphatase. ..