Matteo Nicola Dario Di Minno

Summary

Affiliation: Federico II University
Country: Italy

Publications

  1. doi request reprint Management of patients with long-term inhibitors: is immune tolerance an underestimated life-long solution?
    G Di Minno
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Haemophilia 19:18-23. 2013
  2. doi request reprint [New oral anticoagulants: recommendations, precautions and perspectives for use]
    Giovanni di Minno
    Clinica Medica, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi Federico II, Napoli, Italy
    G Ital Cardiol (Rome) 13:28S-37S. 2012
  3. pmc Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?
    Giovanni Tarantino
    Federico II University Medical School of Naples, Department of Clinical and Experimental Medicine, Naples, Italy
    J Transl Med 6:72. 2008
  4. doi request reprint Aspirin resistance and platelet turnover: a 25-year old issue
    G Di Minno
    Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    Nutr Metab Cardiovasc Dis 21:542-5. 2011
  5. doi request reprint Cost of care of haemophilia with inhibitors
    M N D Di Minno
    Reference Centre for Hemophilia and Thrombosis, Department of Clinical and Experimental Medicine, Federico II University, Via S Pansini 5, Naples, Italy
    Haemophilia 16:e190-201. 2010
  6. doi request reprint Homocysteine and arterial thrombosis: Challenge and opportunity
    Matteo N D Di Minno
    Department of Experimental and Clinical Medicine, Federico II University, Naples, Italy
    Thromb Haemost 103:942-61. 2010
  7. ncbi request reprint Polyunsaturated fatty acids, thrombosis and vascular disease
    Giovanni di Minno
    Clinica Medica, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Napoli Federico II, Italy
    Pathophysiol Haemost Thromb 32:361-4. 2002
  8. doi request reprint Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis
    Matteo Nicola Dario Di Minno
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Thromb Res 128:e43-8. 2011
  9. doi request reprint Assessing joint involvement in haemophilia by clinical rheumatologic scores. A pilot study on similarities with subjects with psoriatic arthritis
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    Clin Rheumatol 30:915-9. 2011
  10. doi request reprint Obesity and the prediction of minimal disease activity: a prospective study in psoriatic arthritis
    Matteo Nicola Dario Di Minno
    Federico II University, Naples, Italy
    Arthritis Care Res (Hoboken) 65:141-7. 2013

Collaborators

Detail Information

Publications73

  1. doi request reprint Management of patients with long-term inhibitors: is immune tolerance an underestimated life-long solution?
    G Di Minno
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Haemophilia 19:18-23. 2013
    ....
  2. doi request reprint [New oral anticoagulants: recommendations, precautions and perspectives for use]
    Giovanni di Minno
    Clinica Medica, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi Federico II, Napoli, Italy
    G Ital Cardiol (Rome) 13:28S-37S. 2012
    ..However, at present we do not know whether and how this information may be clinically useful. Their high cost is another major issue, and newer pharmacoeconomic studies are needed to evaluate their cost-effectiveness ratio vs warfarin...
  3. pmc Enhanced serum concentrations of transforming growth factor-beta1 in simple fatty liver: is it really benign?
    Giovanni Tarantino
    Federico II University Medical School of Naples, Department of Clinical and Experimental Medicine, Naples, Italy
    J Transl Med 6:72. 2008
    ..Transforming growth factor-beta1 released by hepatic stellate cells during chronic liver injury plays a critical role in liver apoptosis and fibrogenesis...
  4. doi request reprint Aspirin resistance and platelet turnover: a 25-year old issue
    G Di Minno
    Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    Nutr Metab Cardiovasc Dis 21:542-5. 2011
    ....
  5. doi request reprint Cost of care of haemophilia with inhibitors
    M N D Di Minno
    Reference Centre for Hemophilia and Thrombosis, Department of Clinical and Experimental Medicine, Federico II University, Via S Pansini 5, Naples, Italy
    Haemophilia 16:e190-201. 2010
    ....
  6. doi request reprint Homocysteine and arterial thrombosis: Challenge and opportunity
    Matteo N D Di Minno
    Department of Experimental and Clinical Medicine, Federico II University, Naples, Italy
    Thromb Haemost 103:942-61. 2010
    ..Because of these uncertainties in the area, the data available do not provide support for routine screening and treatment for elevated Hcy to prevent CVD...
  7. ncbi request reprint Polyunsaturated fatty acids, thrombosis and vascular disease
    Giovanni di Minno
    Clinica Medica, Dipartimento di Medicina Clinica e Sperimentale, Universita degli Studi di Napoli Federico II, Italy
    Pathophysiol Haemost Thromb 32:361-4. 2002
    ....
  8. doi request reprint Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis
    Matteo Nicola Dario Di Minno
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Thromb Res 128:e43-8. 2011
    ..Methionine ingestion (100mg/kg) identifies subjects in whom fasting total homocysteine (tHcy) may be normal but the post-methionine load (PML) tHcy is abnormally high...
  9. doi request reprint Assessing joint involvement in haemophilia by clinical rheumatologic scores. A pilot study on similarities with subjects with psoriatic arthritis
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    Clin Rheumatol 30:915-9. 2011
    ..These pilot data provide the rationale for testing a systemic involvement in haemophiliacs by means of high-tech imaging and to start early-onset prophylaxis/treatment in this setting...
  10. doi request reprint Obesity and the prediction of minimal disease activity: a prospective study in psoriatic arthritis
    Matteo Nicola Dario Di Minno
    Federico II University, Naples, Italy
    Arthritis Care Res (Hoboken) 65:141-7. 2013
    ..We prospectively evaluated whether obesity impacts achievement of minimal disease activity (MDA) in subjects with psoriatic arthritis (PsA)...
  11. doi request reprint Hepatic steatosis and disease activity in subjects with psoriatic arthritis receiving tumor necrosis factor-α blockers
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Rheumatology Research Unit, Psoriatic Arthritis Clinic, Federico II University, Naples, Italy
    J Rheumatol 39:1042-6. 2012
    ..We prospectively evaluated changes in HS during treatment with TNF-α blockers...
  12. doi request reprint Cardiovascular risk in rheumatic patients: the link between inflammation and atherothrombosis
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Semin Thromb Hemost 38:497-505. 2012
    ....
  13. ncbi request reprint Perioperative handling of antiplatelet drugs. A critical appraisal
    Matteo Nicola Dario Di Minno
    Department of Clinical Medicine and Surgery, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    Curr Drug Targets 14:880-8. 2013
    ....
  14. doi request reprint Identifying high-risk individuals for cardiovascular disease: similarities between venous and arterial thrombosis in perspective. A 2011 update
    Matteo Nicola Dario Di Minno
    Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    Intern Emerg Med 7:9-13. 2012
    ..The value of routine screening for asymptomatic atherosclerosis (e.g. 2D echocardiography, microalbuminuria, arterial vessel ultrasonography) in these patients should be confirmed in future studies...
  15. doi request reprint Filling the gap between science & clinical practice: prevention of stroke recurrence
    Anna Russolillo
    Department of Experimental and Clinical Medicine, and Regional Reference Centre for Coagulation Disorders, Federico II University of Naples, Italy
    Thromb Res 129:3-8. 2012
    ....
  16. ncbi request reprint Antithrombotic drugs for older subjects. Guidelines formulated jointly by the Italian Societies of Haemostasis and Thrombosis (SISET) and of Gerontology and Geriatrics (SIGG)
    G Di Minno
    Cattedra di Gerontologia e Geriatria, , Clinica Medica, Dipartimento di Medicina Clinica e Sperimentale, Policlinico Federico II, Naples, Italy
    Nutr Metab Cardiovasc Dis 11:41-62. 2001
    ..In the absence of contraindications, thrombolysis for MI may be considered in the elderly...
  17. doi request reprint Predictors of early minimal disease activity in patients with psoriatic arthritis treated with tumor necrosis factor-α blockers
    Salvatore Iervolino
    Department of Clinical and Experimental Medicine, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy
    J Rheumatol 39:568-73. 2012
    ..To identify predictors of early minimal disease activity in patients with psoriatic arthritis (PsA) receiving tumor necrosis factor-α (TNF-α) antagonists...
  18. doi request reprint Platelet reactivity and disease activity in subjects with psoriatic arthritis
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    J Rheumatol 39:334-6. 2012
    ..Individuals with psoriatic arthritis (PsA) are highly predisposed to vascular mortality. We evaluated the correlation between disease activity and platelet aggregation in individuals with PsA...
  19. doi request reprint Longer-acting factor VIII to overcome limitations in haemophilia management: the PEGylated liposomes formulation issue
    G Di Minno
    Department of Medicine, Federico II University, Reference Centre for Hemophilia and Thrombosis, Naples, Italy
    Haemophilia 16:2-6. 2010
    ..Data emerging from this phase II study will help collect relevant data to overcome current limitations in haemophilia management by employing treatment with longer-acting rFVIII...
  20. doi request reprint Discovertebral erosions in patients with enteropathic spondyloarthritis
    Rosario Peluso
    Rheumatology Research Unit, Gastroenterology Research Unit, Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy
    J Rheumatol 39:2332-40. 2012
    ..Our aim was to analyze the prevalence and the clinical features of DE in patients with enteropathic SpA (EA) using MRI...
  21. doi request reprint Exploring newer cardioprotective strategies: ω-3 fatty acids in perspective
    Matteo Nicola Dario Di Minno
    Department of Experimental and Clinical Medicine, Federico II University, Naples, Italy
    Thromb Haemost 104:664-80. 2010
    ..Major experimental data provide strength (biological plausibility) for these findings, and define directions for newer clinical trials with ω-3 fatty acids...
  22. doi request reprint Obesity and psoriatic arthritis: from pathogenesis to clinical outcome and management
    Anna Russolillo
    Department of Clinical and Experimental Medicine, Rheumatology Research Unit, Federico II University, Naples, Italy
    Rheumatology (Oxford) 52:62-7. 2013
    ..This review assesses the relationship between obesity and PsA according to the available literature...
  23. ncbi request reprint New anti-thrombotic drugs for stroke prevention
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, and Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    Curr Vasc Pharmacol 9:723-32. 2011
    ..We also discuss the major limitations of "traditional" antithrombotic drugs and report Phase III study results on safety and efficacy of new antiplatelet and anticoagulant drugs, with emphasis on stroke prevention...
  24. doi request reprint Prevalence of thyroid autoimmunity in patients with spondyloarthropathies
    Rosario Peluso
    Rheumatology Research Unit, Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy
    J Rheumatol 38:1371-7. 2011
    ..To evaluate the prevalence of chronic autoimmune thyroiditis or Hashimoto's thyroiditis (HT) in a group of patients with spondyloarthritis (SpA)...
  25. doi request reprint Diabetes, vascular complications and antiplatelet therapy: open problems
    A M Cerbone
    Department of Clinical and Experimental Medicine, Federico II University Hospital, Via S Pansini 5 Edificio 1, 80131, Naples, Italy
    Acta Diabetol 46:253-61. 2009
    ..Although these patients are at high thrombotic and haemorrhagic risk, they should nevertheless be considered eligible to undergo antithrombotic therapy, taking into account the individual's haemorrhagic risk...
  26. doi request reprint Risk factors and recurrent thrombotic episodes in patients with cerebral venous thrombosis
    Antonella Tufano
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University Hospital, Naples, Italy
    Blood Transfus 12:s337-42. 2014
    ..The role of gender-specific risk factors (pregnancy, oral contraceptives) is well established, whereas that of other acquired risk conditions is debated...
  27. doi request reprint Direct anticoagulant drugs to overcome limitations of vitamin K antagonists. A critical appraisal of data in atrial fibrillation patients
    Matteo Nicola Dario Di Minno
    Federico II University, Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Naples, Italy
    Expert Opin Emerg Drugs 18:9-23. 2013
    ..However, the inherent limitations of vitamin K antagonists (VKAs) have made the development of new oral anticoagulants necessary. Drugs directed against thrombin or the factor Xa are currently available...
  28. doi request reprint Prevention of venous thromboembolism in medical patients with thrombocytopenia or with platelet dysfunction: a review of the literature
    Antonella Tufano
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University of Naples, Italy
    Semin Thromb Hemost 37:267-74. 2011
    ..The need for VTE prophylaxis in patients on chronic treatment with aspirin and/or clopidogrel should be evaluated after assessing the individual risk-benefit ratio...
  29. doi request reprint Alcohol dosing and the heart: updating clinical evidence
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Semin Thromb Hemost 37:875-84. 2011
    ..Fourth, wine (ethanol with antioxidants) exhibits significantly higher anti-inflammatory effects than gin (ethanol without polyphenols), and thus in general wine should be preferred to liquor or beer...
  30. doi request reprint Cardiovascular risk factors and outcome in patients with retinal vein occlusion
    Mirko Di Capua
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University of Naples, Naples, Italy
    J Thromb Thrombolysis 30:16-22. 2010
    ..4 vs. 70.6%, P = 0.06). High rate of vascular recurrence is shown in patients with previous RVO, in which conventional cardiovascular risk factors play a major role, especially in BRVO and in older patients...
  31. doi request reprint Abnormally high prevalence of major components of the metabolic syndrome in subjects with early-onset idiopathic venous thromboembolism
    M N D Di Minno
    Department of Clinical and Experimental Medicine, Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    Thromb Res 127:193-7. 2011
    ..Although patients with idiopathic VTE are at higher than normal risk of asymptomatic atherosclerosis and of cardiovascular events, the impact of cardiovascular risk factors on VTE is poorly understood...
  32. doi request reprint Mutational spectrum of F8 gene and prothrombotic gene variants in haemophilia A patients from Southern Italy
    V Sanna
    Dipartimento di Biochimica e Biotecnologie Mediche, Universita degli Studi di Napoli Federico II, CEINGE Biotecnologie Avanzate, Via Comunale Margherita n 482, Naples, Italy
    Haemophilia 14:796-803. 2008
    ..Clinical impact of these findings needs large-scale studies to further define the role of these prothrombotic variants as possible modifier factors of HA phenotype...
  33. doi request reprint Lipid profile changes in patients with rheumatic diseases receiving a treatment with TNF-α blockers: a meta-analysis of prospective studies
    Matteo Nicola Dario Di Minno
    Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy
    Ann Med 46:73-83. 2014
    ..Some studies showed an anti-atherogenic effect of TNF-α blockers on lipid profile, but these data have been challenged...
  34. pmc Omega-3 fatty acids for the treatment of non-alcoholic fatty liver disease
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, 80131 Naples, Italy
    World J Gastroenterol 18:5839-47. 2012
    ..According to these data, it is important to consider that most of the beneficial effects of n-3 PUFAs can also be obtained by an equilibrate nutrition program...
  35. doi request reprint Relation of flow-mediated dilation to global arterial load: impact of hypertension and additional cardiovascular risk factors
    Vittorio Palmieri
    Cardiology Unit, Ospedale dei Pellegrini, ASL Napoli 1, Naples, Italy
    Int J Cardiol 152:225-30. 2011
    ..Therefore, we evaluated whether brachial artery flow-mediated dilation (FMD) is related to global arterial load...
  36. pmc Treatment of hemophilia: a review of current advances and ongoing issues
    Antonio Coppola
    Regional Reference Center for Coagulation Disorders, Federico II University Hospital, Naples, Italy
    J Blood Med 1:183-95. 2010
    ..Unfortunately, this is not true for more than two-thirds of persons with hemophilia, who live in developing countries...
  37. ncbi request reprint The first ambulatory screening on thromboembolism: a multicentre, cross-sectional, observational study on risk factors for venous thromboembolism
    G Di Minno
    Department of Experimental and Clinical Medicine, Policlinico Federico II, University of Naples, Naples, Italy
    J Thromb Haemost 3:1459-66. 2005
    ....
  38. ncbi request reprint Challenges in the prevention of venous thromboembolism in the elderly
    G Di Minno
    Centro di Coordinamento Regionale per le Emocoagulopatie, Dipartimento di Medicina Clinica e Sperimentale, AUP Federico II, Napoli, Italy
    J Thromb Haemost 2:1292-8. 2004
    ..Studies on the latter drugs, where most of the patients were > 65 years of age, further show that the fear of bleeding complications due to anticoagulation in the elderly is largely unjustified...
  39. ncbi request reprint Can serum TGF-beta 1 be used to evaluate the response to antiviral therapy of haemophilic patients with HCV-related chronic hepatitis?
    G Tarantino
    Department of Clinical and Experimental Medicine, Federico II University Medical School, Naples, Italy
    Int J Immunopathol Pharmacol 21:1007-12. 2008
    ..Interestingly, at a longer follow-up, two out of ten SVRs, who displayed the highest values of TGF-beta 1, relapsed. Serum TGF-beta 1 could be used to assess therapeutic outcome and short-term prognosis of HCV-related chronic hepatitis...
  40. doi request reprint Understanding inhibitor development in haemophilia A: towards clinical prediction and prevention strategies
    A Coppola
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Via S Pansini, 5 80131 Naples, Italy
    Haemophilia 16:13-9. 2010
    ....
  41. doi request reprint Bleeding symptoms at disease presentation and prediction of ensuing bleeding in inherited FVII deficiency
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Via S Pansini 5, 80131 Napoli, Italy
    Thromb Haemost 109:1051-9. 2013
    ..In conclusion, in FVII deficiency, the first major bleeding symptom is an independent predictor of the risk of subsequent major bleeds...
  42. doi request reprint Arthropathy in patients with moderate hemophilia a: a systematic review of the literature
    Matteo Nicola Dario Di Minno
    Department of Clinical Medicine and Surgery, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    Semin Thromb Hemost 39:723-31. 2013
    ..These data confirm that severity of hemophilia should not be defined only according to FVIII levels and that a relevant proportion of patients with nonsevere hemophilia might benefit from a "tailored early prophylaxis." ..
  43. doi request reprint Clinical judgment when using coagulation tests during direct oral anticoagulant treatment: a concise review
    Alessandro Di Minno
    Dipartimento di Farmacia, Universita degli Studi di Napoli Federico II, Napoli, Italy
    Semin Thromb Hemost 39:840-6. 2013
    ..In view of this, in addition to standardization, validation of such assays is mandatory before they can be used to make clinical decisions. ..
  44. doi request reprint Ultrasound-guided transversus abdominis plane block for retroperitoneal varicocele repair. Could it be an anesthesia method?
    Marco Milone
    University Federico II of Naples, Via Pansini 5, 80131, Naples, Italy
    Updates Surg 65:225-30. 2013
    ..Moreover, our results demonstrate that this method is more effective than spinal anesthesia in the pain control after varicocele repair...
  45. doi request reprint Safety and efficacy of barbed suture for gastrointestinal suture: a prospective and randomized study on obese patients undergoing gastric bypass
    Marco Milone
    Department of Advanced Biomedical Science, University of Naples Federico II, Naples, Italy
    J Laparoendosc Adv Surg Tech A 23:756-9. 2013
    ..The aim of this study was to establish the safety and efficacy of barbed suture for intestinal sutures to close the gastrojejunal anastomosis in obese patients undergoing gastric bypass...
  46. doi request reprint Factor VIII gene (F8) mutations as predictors of outcome in immune tolerance induction of hemophilia A patients with high-responding inhibitors
    A Coppola
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    J Thromb Haemost 7:1809-15. 2009
    ..Predictors of ITI outcome are still debated, and the role of F8 gene mutations in this is not well established...
  47. ncbi request reprint Reduced in vivo oxidative stress following 5-methyltetrahydrofolate supplementation in patients with early-onset thrombosis and 677TT methylenetetrahydrofolate reductase genotype
    Antonio Coppola
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    Br J Haematol 131:100-8. 2005
    ..In parallel with long-lasting tHcy-lowering effects, a short-course 5-MTHF supplementation reduces in vivo formation of 8-iso-PGF2alpha in this population, supporting the antioxidant protective effects of folate in vascular disease...
  48. pmc High prevalence of nonalcoholic fatty liver in patients with idiopathic venous thromboembolism
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Via S Pansini, 5, 80131 Naples, Italy
    World J Gastroenterol 16:6119-22. 2010
    ..to assess the prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with idiopathic venous thromboembolism (VTE)...
  49. doi request reprint Coronary artery disease, cerebral non-fatal ischemic stroke in retinal vein occlusion: an 8-yr follow-up
    M Di Capua
    Dept of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disease, Federico II University, Via Pansini 5, Naples, Italy
    Nutr Metab Cardiovasc Dis 22:23-7. 2012
    ..These data also argue for RVO as a vascular disease in which aggressive anti-hypertensive therapy to prevent stroke and/or myocardial infarction is needed...
  50. ncbi request reprint Serum concentrations of the tissue polypeptide specific antigen in patients suffering from non-alcoholic steatohepatitis
    G Tarantino
    Department of Clinical and Experimental Medicine, Federico II University Medical School, Naples, Italy
    Eur J Clin Invest 37:48-53. 2007
    ..Tissue polypeptide-specific antigen (TPS), a serological mirror of keratin 18, is widely used as a marker for various cancers. This antigen was assessed in three different groups who were overweight or obese...
  51. pmc Diabetes mellitus and cardiovascular prevention: the role and the limitations of currently available antiplatelet drugs
    A Tufano
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, University of Naples Federico II, 80131 Naples, Italy
    Int J Vasc Med 2011:250518. 2011
    ....
  52. ncbi request reprint Long-lasting intestinal bleeding in an old patient with multiple mucosal vascular abnormalities and Glanzmann's thrombasthenia: 3-year pharmacological management
    A Coppola
    Centro di Coordinamento Regionale per le Emocoagulopatie, Cattedra di Gastroenterologia, Dipartimento di Medicina Clinica e Sperimentale, Universita Federico II, Napoli, Italy
    J Intern Med 252:271-5. 2002
    ....
  53. ncbi request reprint Citizens and family doctors facing awareness and management of traditional cardiovascular risk factors: results from the Global Cardiovascular Risk Reduction Project (Help Your Heart Stay Young Study)
    A Celentano
    Department of Clinical and Experimental Medicine, Federico II University Hospital, Via S Pansini 5, Ed 1, 80131 Napoli, Italy
    Nutr Metab Cardiovasc Dis 13:211-7. 2003
    ....
  54. ncbi request reprint Stroke prevention: from available antiplatelet drugs to novel molecular targets
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Naples, Via S Pansini 5, 80131 Napoli, Italy
    Curr Drug Targets 14:3-12. 2013
    ..In this review, after summarizing major literature data about traditional and newer antiplatelet drugs, we will specifically focus on novel potential target candidates for antiplatelet therapy...
  55. doi request reprint Perioperative handling of patients on antiplatelet therapy with need for surgery
    Matteo Nicola Dario Di Minno
    Department of Experimental and Clinical Medicine, Federico II University, Via Sergio Pansini 5, 80131 Naples, Italy
    Intern Emerg Med 4:279-88. 2009
    ..Aprotinin decreases postoperative bleeding and transfusion rates in patients undergoing CABG and on clopidogrel during the days preceding surgery...
  56. pmc Young adult obese subjects with and without insulin resistance: what is the role of chronic inflammation and how to weigh it non-invasively?
    Giovanni Tarantino
    Department of Clinical and Experimental Medicine, Federico II University Medical School of Naples, Italy
    J Inflamm (Lond) 6:6. 2009
    ..Metabolic syndrome is associated with a proinflammatory state that contributes to insulin resistance. Finally, a "metabolically benign obesity" that is not accompanied by insulin resistance has recently been postulated to exist...
  57. doi request reprint Differences of myocardial systolic deformation and correlates of diastolic function in competitive rowers and young hypertensives: a speckle-tracking echocardiography study
    Maurizio Galderisi
    Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
    J Am Soc Echocardiogr 23:1190-8. 2010
    ....
  58. doi request reprint Protein C and protein S changes in GH-deficient adults on r-HGH replacement therapy: correlations with PAI-1 and t-PA plasma levels
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Reference Centre for Coagulation Disorders, Federico II University, Naples, Italy
    Thromb Res 126:e434-8. 2010
    ..In GHD adults on replacement therapy with recombinant human GH (r-HGH), %Δ PAI-1 and %Δ t-PA are related to %Δ insulin changes...
  59. ncbi request reprint Influence of cardiovascular risk factors on relation between angiotensin converting enzyme-gene polymorphism and blood pressure in arterial hypertension
    A Celentano
    Department of Clinical and Experimental Medicine, Federico II University Hospital, School of Medicine, Naples, Italy
    J Hypertens 16:985-91. 1998
    ..The angiotensin-converting enzyme gene insertion (I)/deletion (D) polymorphism might be involved in the development of several cardiovascular diseases, but its role in humans remains controversial...
  60. ncbi request reprint The use of antithrombotic drugs in older people
    A Tufano
    Clinica Medica, Dipartimento di Medicina Clinica e Sperimentale, Policlinico Federico II, Napoli, Italy
    Minerva Med 93:13-26. 2002
    ..As to prophylaxis of VTE in surgery in subjects at high risk, adjusted-dose heparin or high-dose LMWHs are recommended. Finally, as to prevention of stroke in patients older than 75 with atrial fibrillation (AF), warfarin is of choice...
  61. ncbi request reprint Venous thromboembolism: which patients are truly at risk?
    G Di Minno
    Regional Reference Center for Blood Coagulation Disorders, University of Naples Federico II, Naples, Italy
    Acta Biomed 76:31-2. 2005
    ..In conclusion, individuals with deficiencies of natural anticoagulants, homozygotes due to mutation of Factor V Leiden or prothrombin and individuals with multiple risk factors may be defined as "high risk"...
  62. doi request reprint Antithrombotic treatment of splanchnic vein thrombosis: results of an international registry
    Walter Ageno
    Department of Clinical and Experimental Medicine, University of Insubria, Varese, Italy
    Semin Thromb Hemost 40:99-105. 2014
    ....
  63. doi request reprint Mild antithrombin deficiency and risk of recurrent venous thromboembolism: a prospective cohort study
    Matteo Nicola Dario Di Minno
    Department of Clinical Medicine and Surgery, Federico II University, Naples M N D Di M, R L and Department of Clinical Medicine, University of Insubria, Varese F D, W A, Italy
    Circulation 129:497-503. 2014
    ..No prospective data are available about the risk of recurrent VTE associated with mildly decreased antithrombin levels (70-80%)...
  64. pmc Mesoglycan: clinical evidences for use in vascular diseases
    Antonella Tufano
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, AOU Federico II Naples 80131, Italy
    Int J Vasc Med 2010:390643. 2010
    ..elastic compression stockings, and local care, and in the prevention of recurrences in patients with previous DVT following the standard course of oral anticoagulation treatment...
  65. doi request reprint Carotid intima-media thickness in psoriatic arthritis: differences between tumor necrosis factor-α blockers and traditional disease-modifying antirheumatic drugs
    Matteo Nicola Dario Di Minno
    Department of Clinical and Experimental Medicine, Regional Reference Centre for Coagulation Disorders, Federico II University, Via S Pansini 5, 80131, Naples, Italy
    Arterioscler Thromb Vasc Biol 31:705-12. 2011
    ..Tumor necrosis factor (TNF)-α, a major determinant of inflammation, is involved in atherosclerosis. Ultrasonographic carotid intima-media thickness (C-IMT) evaluation allows for subclinical atherosclerosis detection...
  66. doi request reprint Desmopressin in inherited disorders of platelet function
    A Coppola
    Regional Reference Centre for Coagulation Disorders, Department of Clinical and Experimental Medicine, Federico II University of Naples, Naples, Italy
    Haemophilia 14:31-9. 2008
    ..This review will focus the available clinical data and the open issues of DDAVP in this setting...
  67. doi request reprint Diagnostic value of abdominal free air detection on a plain chest radiograph in the early postoperative period: a prospective study in 648 consecutive patients who have undergone abdominal surgery
    Marco Milone
    University Federico II of Naples, Naples, Italy
    J Gastrointest Surg 17:1673-82. 2013
    ..To the best of our knowledge, this is the first study to evaluate the predictive value of free air (on a plain radiograph) for bowel perforation in a large prospective cohort of surgical patients...
  68. doi request reprint Pelvic adhesion and gonadotropin-releasing hormone analogue: effects of triptorelin acetate depot on coagulation and fibrinolytic activities
    Maria Antonietta Di Nardo
    Department of Obstetrical Gynecological and Urological Science and Reproductive Medicine, Federico II University, Naples, Italy
    Reprod Sci 19:615-22. 2012
    ..05), suggesting a possible critical role of the GnRH-a therapy in preventing postoperative adhesion development...
  69. pmc Drug-induced liver injury: is it somehow foreseeable?
    Giovanni Tarantino
    World J Gastroenterol 15:2817-33. 2009
    ..Physicians should always think of this adverse effect in the absence of other clear hepatic disease. Ethical and legal problems towards operators in the health care system are always matters to consider...
  70. pmc Could high levels of tissue polypeptide specific antigen, a marker of apoptosis detected in nonalcoholic steatohepatitis, improve after weight loss?
    Giovanni Tarantino
    Department of Clinical and Experimental Medicine, Federico II University, Medical School of Naples, Italy
    Dis Markers 26:55-63. 2009
    ..The aim of this study was to validate in patients suffering from NonAlcoholic SteatoHepatitis the clinical utility of this marker after different programs of weight reduction...
  71. ncbi request reprint Familial thrombophilia and the occurrence of fetal growth restriction
    P Martinelli
    Obstetrics and Gynecology Department of University Federico II, Naples, Italy
    Haematologica 86:428-31. 2001
    ..INTERPRETATION AND CONCLUSIONS: Present data indicate an association between prothrombotic genetic factors and FGR...
  72. ncbi request reprint Plasma folate, vitamin B(12), and total homocysteine and homozygosity for the C677T mutation of the 5,10-methylene tetrahydrofolate reductase gene in patients with Alzheimer's dementia. A case-control study
    A Postiglione
    Department of Clinical and Experimental Medicine, University Federico II, Naples, Italy
    Gerontology 47:324-9. 2001
    ..Moreover, the homozygous mutation (C677T) of the methylene tetrahydrofolate reductase (MTHFR) gene, related to a thermolabile type of the encoded enzyme, causes hyperhomocysteinemia by reducing the 5-methyltetrahydrofolate availability...
  73. ncbi request reprint Relations of left ventricular mass and systolic function to endothelial function and coronary flow reserve in healthy, new discovered hypertensive subjects
    V Palmieri
    Department of Clinical and Experimental Medicine, Federico II University School of Medicine, Naples, Italy
    J Hum Hypertens 19:941-50. 2005
    ....